Equipment maintenance management integrated information system is an important constituent part of enterprise IMS (Intelligent Manufacture System). The system should make the best of all kinds of information sources a...Equipment maintenance management integrated information system is an important constituent part of enterprise IMS (Intelligent Manufacture System). The system should make the best of all kinds of information sources around the enterprise, and meet the demand for agile production. This paper presents an implementation scheme of Integrated Equipment Maintenance Management Information System Based on Internet/Intranet and gives component division scheme of each tier. This scheme adopts a three-tiers mode of B/S (Browser/Server) and software programming module based on software reusing technology. This makes the system integrated and open, makes maintenance and updating convenient, and largely increases software safety and reusability.展开更多
Based on systematic analysis, an Integrated Plant Maintenance System (IPMS)is proposed in this paper to cope with challenges in plant maintenance. The characteristics of theIPMS are summarized and the necessity of its...Based on systematic analysis, an Integrated Plant Maintenance System (IPMS)is proposed in this paper to cope with challenges in plant maintenance. The characteristics of theIPMS are summarized and the necessity of its modeling is set forth. Based on the analysis andcomparison among structured, object-oriented and multi-agent modeling frameworks, a multi-agentmodeling framework is selected in this paper as a theoretical guidance and together with the Troposmethod for modeling, the system model of an integrated plant maintenance system is constructed. Thesystem model developed in this paper provides a guidance template for the Baling company in itsstepwise implementation of the IPMS.展开更多
Effective application of digital integrated management and maintenance systems is essential for successful operation and maintenance management of bridge projects.This article analyzes the application strategy of such...Effective application of digital integrated management and maintenance systems is essential for successful operation and maintenance management of bridge projects.This article analyzes the application strategy of such systems.It provides an overview of comprehensive digital management and maintenance of bridges,an analysis of the basic components of the integrated management and maintenance system,and its application strategies.This study aims to offer guidance for the application of the system and to improve the quality of modern bridge engineering management and maintenance work.展开更多
Chemo-/radioresistance of malignant tumors hampers cancer control and increases patient mortality.Efficient repair of damaged DNA is critical for the maintenance of genomic integrity and fidelity of genetic informatio...Chemo-/radioresistance of malignant tumors hampers cancer control and increases patient mortality.Efficient repair of damaged DNA is critical for the maintenance of genomic integrity and fidelity of genetic information.In reverse,increased DNA repair capability in cancer cells contributes to chemo-/radioresistance of malignant tumors.DNA double-strand break(DSB)is the most serious DNA damage and is also the principal molecular basis of radiotherapy.Upon DNA damage,the Ku80 is recruited and forms a critical DNA-PK complex at the DSB sites with Ku70 and the catalytic subunit(DNA-PKcs)to initiate DNA repair.How DNA-PK is assembled and activated is not fully understood.Based on the identification of radiation-reduced Ku80 K568 crotonylation through quantitative global lysine crotonylome analysis,we reveal that Ku80 K568 is crotonylated by p300-CBP-associated factor(PCAF).Upon DNA damage,the K568cr is decrotonylated by HDAC8(Histone deacetylase 8).Decrotonylation of K568cr empties this site for the subsequent SUMOylation of Ku80 by CBX4.The conversion of Ku80 from K568 crotonylation to SUMOylation facilitates the assembly of DNA-PK complex and autophosphorylation of DNA-PKcs S2056,consequently activating the DSB repair.Moreover,mutation disrupting the post-translational modification(PTM)of Ku80 K568 site sensitizes cancer cells to radiotherapy in tumorbearing nude mice models.This study elucidates the conversion model between two different forms of PTMs in the regulation of DNA-PK complex assembly and DSB repair,highlighting this model’s potential in controlling chemo-/radioresistance of malignant tumors,as well as expands the atlas of therapeutic targets.展开更多
文摘Equipment maintenance management integrated information system is an important constituent part of enterprise IMS (Intelligent Manufacture System). The system should make the best of all kinds of information sources around the enterprise, and meet the demand for agile production. This paper presents an implementation scheme of Integrated Equipment Maintenance Management Information System Based on Internet/Intranet and gives component division scheme of each tier. This scheme adopts a three-tiers mode of B/S (Browser/Server) and software programming module based on software reusing technology. This makes the system integrated and open, makes maintenance and updating convenient, and largely increases software safety and reusability.
基金theHunanProvince(China)DemonstrationProgramforInformatizationinManufactureun derGrantNo. Hnmie A 070,andHunanProvinceScienceandTechnologyDepartmentPlanProjectunderGrantNo.03GKY3057
文摘Based on systematic analysis, an Integrated Plant Maintenance System (IPMS)is proposed in this paper to cope with challenges in plant maintenance. The characteristics of theIPMS are summarized and the necessity of its modeling is set forth. Based on the analysis andcomparison among structured, object-oriented and multi-agent modeling frameworks, a multi-agentmodeling framework is selected in this paper as a theoretical guidance and together with the Troposmethod for modeling, the system model of an integrated plant maintenance system is constructed. Thesystem model developed in this paper provides a guidance template for the Baling company in itsstepwise implementation of the IPMS.
文摘Effective application of digital integrated management and maintenance systems is essential for successful operation and maintenance management of bridge projects.This article analyzes the application strategy of such systems.It provides an overview of comprehensive digital management and maintenance of bridges,an analysis of the basic components of the integrated management and maintenance system,and its application strategies.This study aims to offer guidance for the application of the system and to improve the quality of modern bridge engineering management and maintenance work.
基金supported by the National Natural Science Foundation of China(No.82230108,32171238,82173466,and 82273581).
文摘Chemo-/radioresistance of malignant tumors hampers cancer control and increases patient mortality.Efficient repair of damaged DNA is critical for the maintenance of genomic integrity and fidelity of genetic information.In reverse,increased DNA repair capability in cancer cells contributes to chemo-/radioresistance of malignant tumors.DNA double-strand break(DSB)is the most serious DNA damage and is also the principal molecular basis of radiotherapy.Upon DNA damage,the Ku80 is recruited and forms a critical DNA-PK complex at the DSB sites with Ku70 and the catalytic subunit(DNA-PKcs)to initiate DNA repair.How DNA-PK is assembled and activated is not fully understood.Based on the identification of radiation-reduced Ku80 K568 crotonylation through quantitative global lysine crotonylome analysis,we reveal that Ku80 K568 is crotonylated by p300-CBP-associated factor(PCAF).Upon DNA damage,the K568cr is decrotonylated by HDAC8(Histone deacetylase 8).Decrotonylation of K568cr empties this site for the subsequent SUMOylation of Ku80 by CBX4.The conversion of Ku80 from K568 crotonylation to SUMOylation facilitates the assembly of DNA-PK complex and autophosphorylation of DNA-PKcs S2056,consequently activating the DSB repair.Moreover,mutation disrupting the post-translational modification(PTM)of Ku80 K568 site sensitizes cancer cells to radiotherapy in tumorbearing nude mice models.This study elucidates the conversion model between two different forms of PTMs in the regulation of DNA-PK complex assembly and DSB repair,highlighting this model’s potential in controlling chemo-/radioresistance of malignant tumors,as well as expands the atlas of therapeutic targets.
