Functional magnetic resonance imaging studies have shown that the insular cortex has a signif- icant role in pain identification and information integration, while the default mode network is associated with cognitive...Functional magnetic resonance imaging studies have shown that the insular cortex has a signif- icant role in pain identification and information integration, while the default mode network is associated with cognitive and memory-related aspects of pain perception. However, changes in the functional connectivity between the defauk mode network and insula during pain remain unclear. This study used 3.0 T functional magnetic resonance imaging scans in 12 healthy sub- jects aged 24.8 ± 3.3 years to compare the differences in the functional activity and connectivity of the insula and default mode network between the baseline and pain condition induced by intramuscular injection of hypertonic saline. Compared with the baseline, the insula was more functionally connected with the medial prefrontal and lateral temporal cortices, whereas there was lower connectivity with the posterior cingulate cortex, precuneus and inferior parietal lobule in the pain condition. In addition, compared with baseline, the anterior cingulate cortex exhibited greater connectivity with the posterior insula, but lower connectivity with the anterior insula, during the pain condition. These data indicate that experimental low back pain led to dysfunction in the connectivity between the insula and default mode network resulting from an impairment of the regions of the brain related to cognition and emotion, suggesting the impor- tance of the interaction between these regions in pain processing.展开更多
BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive ne...BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive network(CEN),allowing for a better understanding of cognitive deficits observed in mental disorders,as well as other characteristic psychopathological phenomena such as thought and behavior disorganization.AIM To investigate differential patterns of effective connectivity across distributed brain networks involved in schizophrenia(SCH)and mood disorders.METHODS The sample comprised 58 patients with either paranoid syndrome in the context of SCH(n=26)or depressive syndrome(Ds)(n=32),in the context of major depressive disorder or bipolar disorder.The methods used include rs-fMRI and subsequent dynamic causal modeling to determine the direction and strength of connections to and from various nodes in the DMN,SN and CEN.RESULTS A significant excitatory connection from the dorsal anterior cingulate cortex to the anterior insula(aI)was observed in the SCH patient group,whereas inhibitory connections from the precuneus to the ventrolateral prefrontal cortex and from the aI to the precuneus were observed in the Ds group.CONCLUSION The results delineate specific patterns associated with SCH and Ds and offer a better explanation of the underlying mechanisms of these disorders,and inform differential diagnosis and precise treatment targeting.展开更多
With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Yao Dezhong’s group at the Key Laboratory For NeuroInformation of Ministry of Education,Sc...With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Yao Dezhong’s group at the Key Laboratory For NeuroInformation of Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,reported enhanced functional connectivity(FC)and increased gray matter volume(GMV)of展开更多
Zircons from the auriferous quartz vein in the Rushan gold deposit, Jiaodong Peninsula, have high common Pb contents (206Pbc = 2.00%—15.88%) and Th/U ratios (0.31—1.35), and trap primary CO2-H2O fluid inclusion simi...Zircons from the auriferous quartz vein in the Rushan gold deposit, Jiaodong Peninsula, have high common Pb contents (206Pbc = 2.00%—15.88%) and Th/U ratios (0.31—1.35), and trap primary CO2-H2O fluid inclusion similar to ore-forming fluids, indicating that they grew from high Th/U ratio ore-forming fluids responsible for gold min- eralization. SHRIMP U-Pb analyses of these zircons gave an age of 117±3 Ma comparable with the ages reported by the former researches in the other areas in the Jiaodong Penin- sula, which is interpreted as the age of gold mineralization at Rushan. The age of SHRIMP zircon U-Pb dating with 160±3 Ma from host rock Kunyushan monzogranite is different from that of the gold mineralization, indicating that there is no genetic relationship between gold mineralization and the granitic magmatism. SHRIMP U-Pb dating on hydrothermal zircons from auriferous quartz veins could be used to con- strain the timing of lode gold mineralization and the rela- tionship to relevant hydrothermal event.展开更多
Dysfunction of the interoceptive system is recognized as an important component of clinical symptoms,including anxiety,depression,psychosis,and other mental disorders.Non-invasive neuromodulation is an emerging clinic...Dysfunction of the interoceptive system is recognized as an important component of clinical symptoms,including anxiety,depression,psychosis,and other mental disorders.Non-invasive neuromodulation is an emerging clinical intervention approach,and over the past decade,research on non-invasive neuromodulation aimed at regulating interoception has rapidly developed.This review first outlines the pathways of interoceptive signals and assessment methods,then summarizes the interoceptive abnormalities in psychiatric disorders and current studies for non-invasive neuromodulation targeting interoception,including intervention modes,target sites,interoceptive measures,and potential neurobiological mechanisms.Finally,we discuss significant research challenges and future directions.展开更多
目的对比显微镜下经外侧裂-岛叶入路血肿清除术与神经内镜辅助经外侧裂-岛叶入路血肿清除术治疗基底核区脑出血的临床疗效。方法纳入204例自发性基底核区脑出血患者,按随机数字表分为神经内镜组(行神经内镜辅助经外侧裂-岛叶入路血肿清...目的对比显微镜下经外侧裂-岛叶入路血肿清除术与神经内镜辅助经外侧裂-岛叶入路血肿清除术治疗基底核区脑出血的临床疗效。方法纳入204例自发性基底核区脑出血患者,按随机数字表分为神经内镜组(行神经内镜辅助经外侧裂-岛叶入路血肿清除术,n=96)和显微镜组(行显微镜下经外侧裂-岛叶入路血肿清除术,n=108)。比较两组患者的手术时间、住院时间、血肿清除率及术后并发症发生情况(包括颅内感染、再出血、脑梗死、癫痫、消化道出血及肺部感染)。采用美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评估神经功能,格拉斯哥昏迷量表(Glasgow coma scale,GCS)评估意识状态,Barthel指数评估日常生活能力,术后6个月采用格拉斯哥预后量表(Glasgow outcome scale,GOS)评估总体恢复情况。结果两组患者术前血肿量与发病至手术时间差异无统计学意义(均P>0.05)。神经内镜组术后残余血肿量明显少于显微镜组,而血肿清除率明显高于显微镜组(均P<0.05)。神经内镜组手术时间与住院时间明显少于显微镜组,差异具有统计学意义(均P<0.05)。两组术后并发症发生率差异均无统计学意义(均P>0.05)。术后4周神经内镜组患者GCS评分高于显微镜组,而NIHSS评分低于显微镜组(均P<0.05)。术后3个月时,神经内镜组Barthel指数较显微镜组明显升高,差异具有统计学意义(P<0.05)。两组患者术后GOS评分恢复优良率差异无统计学意义(P>0.05)。结论神经内镜辅助经外侧裂-岛叶入路可更有效治疗基底核区脑出血,实现精准止血,减轻术后脑水肿,有助于改善患者短期神经功能及日常生活能力。然而,其在长期预后改善方面与显微镜辅助手术相比无显著优势。展开更多
目的评价3.0 T术中磁共振成像(intraoperative magnetic resonance imaging,iMRI)联合弥散张量成像(diffusion tensor imaging,DTI)锥体束示踪导航及术中神经电生理监测(intraoperative neurophysiologicalmonitoring,IONM)技术在各种...目的评价3.0 T术中磁共振成像(intraoperative magnetic resonance imaging,iMRI)联合弥散张量成像(diffusion tensor imaging,DTI)锥体束示踪导航及术中神经电生理监测(intraoperative neurophysiologicalmonitoring,IONM)技术在各种累及岛叶的胶质瘤切除手术中的应用价值。方法 2010年9月至2011年6月以3.0 T iMRI数字一体化神经外科手术中心为平台,在iMRI功能导航结合IONM下对18例累及岛叶的胶质瘤实施切除手术。其中对10例主侧半球肿瘤采用唤醒麻醉下术中直接皮质电刺激进行语言区定位。对所有18例岛叶胶质瘤,术中均采用DTI导航结合术中连续经皮质刺激运动诱发电位和皮质下电刺激进行锥体束定位。结果通过iMRI实时扫描,18例患者中有13例发现肿瘤残留,其中6例在iMRI实时影像导航下获得了进一步切除,使肿瘤的影像学全切除率从5/18提高至9/18。经Fisher检验,iMRI前、后的肿瘤切除率(包括全切除及次全切除)具有统计学意义(P=0.046)。9例因DTI导航或IONM提示切缘临近功能皮质或深部锥体束,而未强求全切除。10例主侧半球肿瘤患者中,术后近期(1周内)出现一过性语言功能障碍5例,随访至术后1个月,语言功能均恢复到术前水平或以上;18例患者中3例术后近期出现肢体运动功能障碍,随访至术后1个月,其中2例完全恢复。总体术后1个月的神经功能障碍仅1例。无iMRI及IONM相关的并发症发生。结论应用3.0 T iMRI术中实时影像导航联合DTI锥体束示踪成像技术及IONM技术有助于最大程度地安全切除岛叶胶质瘤。展开更多
Objective To summarize the clinical feature and our experience of surgical skills on the insula lesions. Methods The clinical manifestation and pathological characters of 30 cases of insula lesion were studied retrosp...Objective To summarize the clinical feature and our experience of surgical skills on the insula lesions. Methods The clinical manifestation and pathological characters of 30 cases of insula lesion were studied retrospectively. Results In the 30 cases of insula lesion, 21 lesions located in the dominant hemisphere. Seizure occurred as an initial symptom in 29 cases. Pathology examination found glioma in 26 cases, AVM in 1 case and cavernous angioma in 3 cases. Conclusion Seizure is usually the initial manifestation of insula lesion. Low-grade glioma and other benign lesions are the major pathological findings in the insula area.展开更多
目的探讨经侧裂-岛叶人路显微手术对基底节区高血压脑出血的疗效。方法回顾性分析2010年1月-2013年6月64例基底节高血压脑出血患者临床资料。其中41例行经侧裂-岛叶入路显微手术(A组);另23例行常规骨瓣开颅手术(B组),比较2组治疗效果及...目的探讨经侧裂-岛叶人路显微手术对基底节区高血压脑出血的疗效。方法回顾性分析2010年1月-2013年6月64例基底节高血压脑出血患者临床资料。其中41例行经侧裂-岛叶入路显微手术(A组);另23例行常规骨瓣开颅手术(B组),比较2组治疗效果及近远期预后。结果 A组手术时间(115.35±46.23)min、术后自动睁眼时间(5.22±3.43)h均短于B组(212.43±58.24)min、(8.74±4.51)h(P<0.05)。术后7 d A组GCS评分(11.92±2.73)分高于B组(9.85±2.46)分(P<0.05)。术后48 h行CT复查,A组血肿大部分清除率为80.49%(33/41)优于B组的56.52%(13/23)(P<0.05)。观察组与对照组并发症发生率无明显差异(39.02%vs.47.83%,P>0.05)。术后3个月随访,A组优良率为60.98%(25/41),明显高于B组的34.78%(8/23)(P<0.05)。术后12个月随访,A组优良率为72.50%(29/40),明显高于B组的47.62%(10/21)(P<0.05)。结论经侧裂-岛叶入路显微手术治疗脑出血是一种损伤小、疗效好、并发症少的治疗方法。展开更多
基金supported by the Science and Technology Foundation of Guangdong Province of China,No.2012B031800305
文摘Functional magnetic resonance imaging studies have shown that the insular cortex has a signif- icant role in pain identification and information integration, while the default mode network is associated with cognitive and memory-related aspects of pain perception. However, changes in the functional connectivity between the defauk mode network and insula during pain remain unclear. This study used 3.0 T functional magnetic resonance imaging scans in 12 healthy sub- jects aged 24.8 ± 3.3 years to compare the differences in the functional activity and connectivity of the insula and default mode network between the baseline and pain condition induced by intramuscular injection of hypertonic saline. Compared with the baseline, the insula was more functionally connected with the medial prefrontal and lateral temporal cortices, whereas there was lower connectivity with the posterior cingulate cortex, precuneus and inferior parietal lobule in the pain condition. In addition, compared with baseline, the anterior cingulate cortex exhibited greater connectivity with the posterior insula, but lower connectivity with the anterior insula, during the pain condition. These data indicate that experimental low back pain led to dysfunction in the connectivity between the insula and default mode network resulting from an impairment of the regions of the brain related to cognition and emotion, suggesting the impor- tance of the interaction between these regions in pain processing.
文摘BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive network(CEN),allowing for a better understanding of cognitive deficits observed in mental disorders,as well as other characteristic psychopathological phenomena such as thought and behavior disorganization.AIM To investigate differential patterns of effective connectivity across distributed brain networks involved in schizophrenia(SCH)and mood disorders.METHODS The sample comprised 58 patients with either paranoid syndrome in the context of SCH(n=26)or depressive syndrome(Ds)(n=32),in the context of major depressive disorder or bipolar disorder.The methods used include rs-fMRI and subsequent dynamic causal modeling to determine the direction and strength of connections to and from various nodes in the DMN,SN and CEN.RESULTS A significant excitatory connection from the dorsal anterior cingulate cortex to the anterior insula(aI)was observed in the SCH patient group,whereas inhibitory connections from the precuneus to the ventrolateral prefrontal cortex and from the aI to the precuneus were observed in the Ds group.CONCLUSION The results delineate specific patterns associated with SCH and Ds and offer a better explanation of the underlying mechanisms of these disorders,and inform differential diagnosis and precise treatment targeting.
文摘With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Yao Dezhong’s group at the Key Laboratory For NeuroInformation of Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,reported enhanced functional connectivity(FC)and increased gray matter volume(GMV)of
文摘Zircons from the auriferous quartz vein in the Rushan gold deposit, Jiaodong Peninsula, have high common Pb contents (206Pbc = 2.00%—15.88%) and Th/U ratios (0.31—1.35), and trap primary CO2-H2O fluid inclusion similar to ore-forming fluids, indicating that they grew from high Th/U ratio ore-forming fluids responsible for gold min- eralization. SHRIMP U-Pb analyses of these zircons gave an age of 117±3 Ma comparable with the ages reported by the former researches in the other areas in the Jiaodong Penin- sula, which is interpreted as the age of gold mineralization at Rushan. The age of SHRIMP zircon U-Pb dating with 160±3 Ma from host rock Kunyushan monzogranite is different from that of the gold mineralization, indicating that there is no genetic relationship between gold mineralization and the granitic magmatism. SHRIMP U-Pb dating on hydrothermal zircons from auriferous quartz veins could be used to con- strain the timing of lode gold mineralization and the rela- tionship to relevant hydrothermal event.
基金supported by grants from the National Natural Science Foundation of China(82101582)the Shanghai Science and Technology Committee(22Y11903600 and 23Y11906000)the Shanghai Municipal Health Commission(202240266).
文摘Dysfunction of the interoceptive system is recognized as an important component of clinical symptoms,including anxiety,depression,psychosis,and other mental disorders.Non-invasive neuromodulation is an emerging clinical intervention approach,and over the past decade,research on non-invasive neuromodulation aimed at regulating interoception has rapidly developed.This review first outlines the pathways of interoceptive signals and assessment methods,then summarizes the interoceptive abnormalities in psychiatric disorders and current studies for non-invasive neuromodulation targeting interoception,including intervention modes,target sites,interoceptive measures,and potential neurobiological mechanisms.Finally,we discuss significant research challenges and future directions.
文摘目的对比显微镜下经外侧裂-岛叶入路血肿清除术与神经内镜辅助经外侧裂-岛叶入路血肿清除术治疗基底核区脑出血的临床疗效。方法纳入204例自发性基底核区脑出血患者,按随机数字表分为神经内镜组(行神经内镜辅助经外侧裂-岛叶入路血肿清除术,n=96)和显微镜组(行显微镜下经外侧裂-岛叶入路血肿清除术,n=108)。比较两组患者的手术时间、住院时间、血肿清除率及术后并发症发生情况(包括颅内感染、再出血、脑梗死、癫痫、消化道出血及肺部感染)。采用美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评估神经功能,格拉斯哥昏迷量表(Glasgow coma scale,GCS)评估意识状态,Barthel指数评估日常生活能力,术后6个月采用格拉斯哥预后量表(Glasgow outcome scale,GOS)评估总体恢复情况。结果两组患者术前血肿量与发病至手术时间差异无统计学意义(均P>0.05)。神经内镜组术后残余血肿量明显少于显微镜组,而血肿清除率明显高于显微镜组(均P<0.05)。神经内镜组手术时间与住院时间明显少于显微镜组,差异具有统计学意义(均P<0.05)。两组术后并发症发生率差异均无统计学意义(均P>0.05)。术后4周神经内镜组患者GCS评分高于显微镜组,而NIHSS评分低于显微镜组(均P<0.05)。术后3个月时,神经内镜组Barthel指数较显微镜组明显升高,差异具有统计学意义(P<0.05)。两组患者术后GOS评分恢复优良率差异无统计学意义(P>0.05)。结论神经内镜辅助经外侧裂-岛叶入路可更有效治疗基底核区脑出血,实现精准止血,减轻术后脑水肿,有助于改善患者短期神经功能及日常生活能力。然而,其在长期预后改善方面与显微镜辅助手术相比无显著优势。
文摘目的评价3.0 T术中磁共振成像(intraoperative magnetic resonance imaging,iMRI)联合弥散张量成像(diffusion tensor imaging,DTI)锥体束示踪导航及术中神经电生理监测(intraoperative neurophysiologicalmonitoring,IONM)技术在各种累及岛叶的胶质瘤切除手术中的应用价值。方法 2010年9月至2011年6月以3.0 T iMRI数字一体化神经外科手术中心为平台,在iMRI功能导航结合IONM下对18例累及岛叶的胶质瘤实施切除手术。其中对10例主侧半球肿瘤采用唤醒麻醉下术中直接皮质电刺激进行语言区定位。对所有18例岛叶胶质瘤,术中均采用DTI导航结合术中连续经皮质刺激运动诱发电位和皮质下电刺激进行锥体束定位。结果通过iMRI实时扫描,18例患者中有13例发现肿瘤残留,其中6例在iMRI实时影像导航下获得了进一步切除,使肿瘤的影像学全切除率从5/18提高至9/18。经Fisher检验,iMRI前、后的肿瘤切除率(包括全切除及次全切除)具有统计学意义(P=0.046)。9例因DTI导航或IONM提示切缘临近功能皮质或深部锥体束,而未强求全切除。10例主侧半球肿瘤患者中,术后近期(1周内)出现一过性语言功能障碍5例,随访至术后1个月,语言功能均恢复到术前水平或以上;18例患者中3例术后近期出现肢体运动功能障碍,随访至术后1个月,其中2例完全恢复。总体术后1个月的神经功能障碍仅1例。无iMRI及IONM相关的并发症发生。结论应用3.0 T iMRI术中实时影像导航联合DTI锥体束示踪成像技术及IONM技术有助于最大程度地安全切除岛叶胶质瘤。
文摘Objective To summarize the clinical feature and our experience of surgical skills on the insula lesions. Methods The clinical manifestation and pathological characters of 30 cases of insula lesion were studied retrospectively. Results In the 30 cases of insula lesion, 21 lesions located in the dominant hemisphere. Seizure occurred as an initial symptom in 29 cases. Pathology examination found glioma in 26 cases, AVM in 1 case and cavernous angioma in 3 cases. Conclusion Seizure is usually the initial manifestation of insula lesion. Low-grade glioma and other benign lesions are the major pathological findings in the insula area.
文摘目的探讨经侧裂-岛叶人路显微手术对基底节区高血压脑出血的疗效。方法回顾性分析2010年1月-2013年6月64例基底节高血压脑出血患者临床资料。其中41例行经侧裂-岛叶入路显微手术(A组);另23例行常规骨瓣开颅手术(B组),比较2组治疗效果及近远期预后。结果 A组手术时间(115.35±46.23)min、术后自动睁眼时间(5.22±3.43)h均短于B组(212.43±58.24)min、(8.74±4.51)h(P<0.05)。术后7 d A组GCS评分(11.92±2.73)分高于B组(9.85±2.46)分(P<0.05)。术后48 h行CT复查,A组血肿大部分清除率为80.49%(33/41)优于B组的56.52%(13/23)(P<0.05)。观察组与对照组并发症发生率无明显差异(39.02%vs.47.83%,P>0.05)。术后3个月随访,A组优良率为60.98%(25/41),明显高于B组的34.78%(8/23)(P<0.05)。术后12个月随访,A组优良率为72.50%(29/40),明显高于B组的47.62%(10/21)(P<0.05)。结论经侧裂-岛叶入路显微手术治疗脑出血是一种损伤小、疗效好、并发症少的治疗方法。
