Analyzed the support instable mode of sliding,tripping,and so on,and believed the key point of the support stability control of fully mechanized coal caving face with steep coal seams was to maintain that the seam tru...Analyzed the support instable mode of sliding,tripping,and so on,and believed the key point of the support stability control of fully mechanized coal caving face with steep coal seams was to maintain that the seam true angle was less than the hydraulic support instability critical angle.Through the layout of oblique face,the improvement of support setting load,the control of mining height and nonskid platform,the group support system of end face,the advance optimization of conveyor and support,and the other control tech- nical measures,the true angle of the seam is reduced and the instable critical angle of the support is increased,the hydraulic support stability of fully mechanized coal caving face with steep coal seams is effectively controlled.展开更多
The Kuroshio frontal instable processes （KFIP） in the East China Sea （ECS） not only have a great impact on the hydrologic characteristics,the pollutants drift,the distribution of seafloor sediment and the ships na...The Kuroshio frontal instable processes （KFIP） in the East China Sea （ECS） not only have a great impact on the hydrologic characteristics,the pollutants drift,the distribution of seafloor sediment and the ships navigation of the ECS,but also are closely related to the climate changes of the coastal areas of the ECS.However the frequency and area of occurrence of the KFIP have not been studied fully and detailedly.Because of its high spatial and temporal resolution,MODIS data is a kind of very good data source for surveying and researching the KFIP in the ECS.The aim of this study is to detect the KFIP in the ECS by using MODIS data,and to study the frequency and region of occurrence of the KFIP in the ECS.The selection has coverage of level 2 data of MODIS SST and Kd490 ranging from July 1,2002 to June 30,2009 of the ECS when there was no cloud impact or little.By using of the data,the minimum standard of the Kuroshio temperature fronts and the diffuse attenuation coefficient （Kd490） fronts of the ECS are given.Based on these standards and the curvature distinguish methods,the standard of curvature distinguish for the KFIP in the ECS are put forward.By making use of this standard,we study a total of 2073 satellite-derived images,and discover that as long as there is no cloud impact from January to May and October to December,the KFIP in the ECS are surely found in MODIS satellite images.From June to September,the frequency of occurrence can also reach to 82.9% at least.Moreover,it is obtained that there are three source regions of these instability processes,namely,（26°N,121.5°E） nearby,（27°N,125°E） nearby and （30°N,128°E） nearby.The differences of the characteristics of these instability processes which are generated in different regions are analyzed in the present study.展开更多
In this paper, we aim to control an instable chaotic oscillation in power system that is considered to be small system by using a linear state feedback controller. First we will analyze the stability of the mentioned ...In this paper, we aim to control an instable chaotic oscillation in power system that is considered to be small system by using a linear state feedback controller. First we will analyze the stability of the mentioned power system by means of modern nonlinear theory (Bifurcation and Chaos). Our model is based on a three bus power system that consists of multi generators containing both dynamic and static loads. They are considered to be in the form of an induction motor in parallel with a capacitor, as well as a combination of constant power along with load impedance, PQ. We consider the load reactive power as the control parameter. At this stage, after changing the control parameter, the study showed that the system is experiencing a subcritical Hopf bifurcation point. This leads to a chaos within the system period doubling path. We then discuss the system controllability and present that the all chaotic oscillations fade away through the linear controller that we impose on the system.展开更多
The instable combustion or oscillation combustion which occurs in three high capacity solid rocket motors using high energy composite propellant with finocyl grain is studied. The reasons of the acoustic combustion in...The instable combustion or oscillation combustion which occurs in three high capacity solid rocket motors using high energy composite propellant with finocyl grain is studied. The reasons of the acoustic combustion instability are also discussed. Three engineering methods that can eliminate combustion instability are proposed and discussed. The study shows that the combustion instability mainly depends on the propellant grain shape and nozzle structure. Some measures to reduce the acoustic energy and mass generation rate of combustion gas can be adopted. The test results indicate that the modified rocket motors can significantly eliminate the instable combustion and improve the motor internal ballistic performance.展开更多
AIM: To ascertain the adequacy of the microsatellite instability (MSI) as a prognostic indicator by assessing MSI status of patients with double primary gastric and colorectal cancer (DPGCC).METHODS: Sixteen patients ...AIM: To ascertain the adequacy of the microsatellite instability (MSI) as a prognostic indicator by assessing MSI status of patients with double primary gastric and colorectal cancer (DPGCC).METHODS: Sixteen patients were studied, all of whom exhibited sporadic DPGCC, and had no family history of hereditary non-polyposis colorectal cancer, according to the Amsterdam criteria. A total of 32 cancers from 16DPGCC patients, and 216 single primary CRC, were assessed for MSI in 5 microsatellite loci, BAT25, BAT26,D2S123, D5S346, and D17S250.RESULTS: MSI was observed in 6 (37.5%) of 16 GC and 4 (25.0%) of 16 CRC. Thirty tumors (13.9%) out of 216single primary CRC and one tumor (16.7%) out of 6 double primary CRC were found to be microsatellite unstable. Of the 6 GC with MSI in DPGCC, 5 (31.3%) were MSI-high and one (6.3%) was MSI-low. In 5 of 16 DPGCC patients,the cancer recurred in or adjacent to the anastomosis or metastasized to the kidney or lung. The MSI-high DPGCC cases were associated with a younger age of onset (47.5 years vs 62.5 years), higher frequency of lymph node metastasis (100% vs 25%), and advanced Dukes stage (C, 100% vs 41.7%), as well as a higher frequency of recurrence or metastasis (100% vs 8.3%). Only recurrence or metastasis showed statistical significance by Fisher's exact test.CONCLUSION: Our data suggest that MSI may play an important role in the development of DPGCC, and that it may be used clinically as a molecular predictive marker for recurrence or late metastasis of DPGCC.展开更多
The suppression of ablative Rayleigh–Taylor instability(ARTI)by a spatially modulated laser in inertial confinement fusion(ICF)is studied through numerical simulations.The results show that in the acceleration phase ...The suppression of ablative Rayleigh–Taylor instability(ARTI)by a spatially modulated laser in inertial confinement fusion(ICF)is studied through numerical simulations.The results show that in the acceleration phase of ICF implosion,the growth of ARTI can be suppressed by using a short-wavelength spatially modulated laser.The ARTI growth rate decreases as the wavelength of the spatially modulated laser decreases,and ARTI is completely suppressed after a certain wavelength has been reached.A spatially uniform laser is introduced to keep the state of motion of the implosion fluid consistent,and it is found that the proportion of the spatially modulated laser required for complete suppression of ARTI decreases as the wavelength continues to decrease.We also optimize the spatial intensity distribution of the spatially modulated laser.In addition,as the duration of the spatially modulated laser decreases,the proportion required for completely suppressing ARTI increases,but the required energy decreases.When the perturbation wavenumber decreases,the wavelength of the spatially modulated laser required for complete suppression of ARTI becomes longer.In the case of multimode perturbation,ARTI can also be significantly suppressed by a spatially modulated laser,and the perturbation amplitude can be reduced to less than 10% of that without a spatially modulated laser.We believe that the conclusions drawn from our simulations can provide the basis for new approaches to control ARTI in ICF.展开更多
The Reynolds-averaged Navier-Stokes(RANS)technique enables critical engineering predictions and is widely adopted.However,since this iterative computation relies on the fixed-point iteration,it may converge to unexpec...The Reynolds-averaged Navier-Stokes(RANS)technique enables critical engineering predictions and is widely adopted.However,since this iterative computation relies on the fixed-point iteration,it may converge to unexpected non-physical phase points in practice.We conduct an analysis on the phase-space characteristics and the fixed-point theory underlying the k-ε turbulence model,and employ the classical Kolmogorov flow as a framework,leveraging its direct numerical simulation(DNS)data to construct a one-dimensional(1D)system under periodic/fixed boundary conditions.The RANS results demonstrate that under periodic boundary conditions,the k-ε model exhibits only a unique trivial fixed point,with asymptotes capturing the phase portraits.The stability of this trivial fixed point is determined by a mathematically derived stability phase diagram,indicating the fact that the k-ε model will never converge to correct values under periodic conditions.In contrast,under fixed boundary conditions,the model can yield a stable non-trivial fixed point.The evolutionary mechanisms and their relationship with boundary condition settings systematically explain the inherent limitations of the k-ε model,i.e.,its deficiency in computing the flow field under periodic boundary conditions and sensitivity to boundary-value specifications under fixed boundary conditions.These conclusions are finally validated with the open-source code OpenFOAM.展开更多
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
Roof pre-fracture poses a considerable risk during the re-mining of residual coal above abandoned roadways,threatening the safety of the mining faces.This study employs a Winkler foundation beam model for mechanical a...Roof pre-fracture poses a considerable risk during the re-mining of residual coal above abandoned roadways,threatening the safety of the mining faces.This study employs a Winkler foundation beam model for mechanical analysis of roof structures and adopts a multivariate nonlinear analysis approach to explore the synergistic load-bearing effects within the'coal pillar-support-backfill body'system during the fill and re-mining processes above these roadways.The findings demonstrate that backfill mining significantly reduces stress concentrations in coal pillars and reduces excessive bending moments in roofs near abandoned roadways.The roof deflection equation incorporates three critical factors affecting stability during backfill mining:the width of the coal pillar(L_(3)),the working resistance of the support(q_(z)),and the elastic foundation coefficient of the backfill material(kcÞ.Under single-factor conditions,the impact sequence on roof stability in the coal pillar zone is·k_(c)>L_(3)>q_(z).Further,multivariate nonlinear analysis reveals the interactions within the'coal-support-backfill'structure,indicating that in terms of roof control,the interaction terms are ordered as L_(3)·k_(c)>q_(z)·k_(c)>L_(3)q_(z).Therefore,priority should be given to adjusting the coal pillar width and backfill strength,followed by modifications to the support resistance and backfill strength during the recovery of abandoned roadways.An improved understanding of these interactions will help optimize strategies for the recovery of residual coal through abandoned roadways,thereby enhancing the stability and safety of mining operations under complex geological conditions.展开更多
The rapid cycling synchrotron(RCS)at the China spallation neutron source operates as a high-intensity proton accelerator.The coupled bunch instability was observed during RCS beam commissioning,which significantly lim...The rapid cycling synchrotron(RCS)at the China spallation neutron source operates as a high-intensity proton accelerator.The coupled bunch instability was observed during RCS beam commissioning,which significantly limited the beam power.To investigate the dynamics of instability under an increased beam power,a pulsed octupole magnet with a gradient of 900 T/m^(3) was developed.The magnet system integrated an octupole magnet with a pulsed power supply.The field was carefully measured to examine the performance before its installation into the tunnel.After the installation of the magnets,beam measurements were performed to confirm the effectiveness of the instability mitigation on an actual proton beam.The measurement results show that the instability can be suppressed using the pulsed octupole magnet,particularly at the highenergy stage in an acceleration cycle,meeting the requirements for stable operation of the accelerator.Additionally,when the instability is completely suppressed through chromaticity optimization,octupole magnets can significantly enhance the RCS transmission efficiency,which is crucial for controlling beam loss.The pulsed octupole magnet offers significant progress in beam stability in the RCS,providing valuable experience for further beam power enhancement.展开更多
Colorectal cancer is the third most diagnosed cancer worldwide,and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups.This study performed a comprehensive analysis of mul...Colorectal cancer is the third most diagnosed cancer worldwide,and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups.This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort(TCGA-COADREAD),accessed through cBioPortal,to develop machine learning models for predicting progression-free survival(PFS)following immunotherapy.The dataset included clinical variables,genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog(KRAS),B-Raf Proto-Oncogene(BRAF),and Neuroblastoma RAS Viral Oncogene Homolog(NRAS),microsatellite instability(MSI)status,tumor mutation burden(TMB),and expression of immune checkpoint genes.Kaplan–Meier analysis showed that KRAS mutations were significantly associated with reduced PFS,while BRAF and NRAS mutations had no significant impact.MSI-high tumors exhibited elevated TMB and increased immune checkpoint expression,reflecting their immunologically active phenotype.We developed both survival and classification models,with the Extra Trees classifier achieving the best performance(accuracy=0.86,precision=0.67,recall=0.70,F1-score=0.68,AUC=0.84).These findings highlight the potential of combining genomic and immune biomarkers with machine learning to improve patient stratification and guide personalized immunotherapy decisions.An interactive web application was also developed to enable clinicians to input patient-specific molecular and clinical data and visualize individualized PFS predictions,supporting timely,data-driven treatment planning.展开更多
Aiming at the problem of dynamic instability of hard-brittle jointed rock surrounding in deep tunnel/roadway engineering,combining with the support concepts of"coupling rigidity with flexibility"and"ove...Aiming at the problem of dynamic instability of hard-brittle jointed rock surrounding in deep tunnel/roadway engineering,combining with the support concepts of"coupling rigidity with flexibility"and"overcoming rigidity by flexibility",the prevention and control method with"rigid-flexible coupling(R-F-C)"was put forward.Through numerical simulation calculation,the impact damage process,acoustic emission(AE)evolution characteristics,and element stress/displacement evolution characteristics of unsupported surrounding rock structure model,rigid supporting surrounding rock structure model,and"R-F-C"supporting surrounding rock structure model under horizontal bidirectional impact loading were compared and analyzed.Based on the theory of stress wave propagation,the dynamic instability catastrophe mechanism of three kinds of supporting structure models induced by horizontal bidirectional impact loading was revealed.Based on the Mohr-Coulomb strength theory,the stress discrimination methods of dynamic catastrophe of surrounding rock induced by horizontal bidirectional impact loading under three kinds of supporting structures were proposed.Combined with the above numerical simulation study,the explosion impact physical and mechanical test of"R-F-C"surrounding rock supporting plate structure was further designed and carried out.Finally,combined with the"conceptual model of ball-cliff potential energy instability",the energy driving theory and energy transformation mechanism of impact-induced rockburst under three kinds of supporting structures were discussed deeply.The research results provided a scientific basis for further promoting the effective application of"R-F-C"supporting structure in the prevention and control of dynamic instability of deep tunnel/roadway surrounding rock.展开更多
The traditional transient stability assessment(TSA)model for power systems has three disadvantages:capturing critical information during faults is difficult,aperiodic and oscillatory unstable conditions are not distin...The traditional transient stability assessment(TSA)model for power systems has three disadvantages:capturing critical information during faults is difficult,aperiodic and oscillatory unstable conditions are not distinguished,and poor generalizability is exhibited by systems with high renewable energy penetration.To address these issues,a novel ResGRU architecture for TSA is proposed in this study.First,a residual neural network(ResNet)is used for deep feature extraction of transient information.Second,a bidirectional gated recurrent unit combined with a multi-attention mechanism(BiGRU-Attention)is used to establish temporal feature dependencies.Their combination constitutes a TSA framework based on the ResGRU architecture.This method predicts three transient conditions:oscillatory instability,aperiodic instability,and stability.The model was trained offline using stochastic gradient descent with a thermal restart(SGDR)optimization algorithm in the offline training phase.This significantly improves the generalizability of the model.Finally,simulation tests on IEEE 145-bus and 39-bus systems confirmed that the proposed method has higher adaptability,accuracy,scalability,and rapidity than the conventional TSA approach.The proposed model also has superior robustness for PMU incomplete configurations,PMU noisy data,and packet loss.展开更多
Combustion dynamics are a critical factor in determining the performance and reliabilityof a chemical propulsion engine.The underlying processes include liquid atomization,evaporation,mixing,and chemical reactions.Thi...Combustion dynamics are a critical factor in determining the performance and reliabilityof a chemical propulsion engine.The underlying processes include liquid atomization,evaporation,mixing,and chemical reactions.This paper presents a high-fidelity numerical study of liquidatomization and spray combustion under high-pressure conditions,emphasizing the effects of pres-sure oscillations on the flow evolution and combustion dynamics.The theoretical framework isbased on the three-dimensional conservation equations for multiphase flows and turbulent combus-tion.The numerical solution is achieved using a coupling method of volume-of-fluid and Lagran-gian particle tracking.The Zhuang-Kadota-Sutton(ZKS)high-pressure evaporation model andthe eddy breakup-Arrhenius combustion model are employed.Simulations are conducted for amodel combustion chamber with impinging-jet injectors using liquid oxygen and kerosene as pro-pellants.Both conditions with and without inlet and outlet pressure oscillations are considered.Thefindings reveal that pressure oscillations amplify flow fluctuations and can be characterized usingkey physical parameters such as droplet evaporation,chemical reaction,and chamber pressure.The spectral analysis uncovers the axial variations of the dominant and secondary frequenciesand their amplitudes in terms of the characteristic physical quantities.This research helps establisha methodology for exploring the coupling effect of liquid atomization and spray combustion.It alsoprovides practical insights into their responses to pressure oscillations during the occurrence ofcombustion instability.This information can be used to enhance the design and operation ofliquid-fueled propulsion engines.展开更多
The influence of the squeeze film between the tube and the support structure on flow-induced vibrations is a critical factor in tube bundles subjected to two-phase cross-flow.This aspect can significantly alter the th...The influence of the squeeze film between the tube and the support structure on flow-induced vibrations is a critical factor in tube bundles subjected to two-phase cross-flow.This aspect can significantly alter the threshold for fluidelastic instability and affect heat transfer efficiency.This paper presents a mathematical model incorporating the squeeze film force between the tube and the support structure.We aim to clarify the mechanisms underlying fluidelastic instability in tube bundle systems exposed to two-phase flow.Using a self-developed computer program,we performed numerical calculations to examine the influence of the squeeze film on the threshold of fluidelastic instability in the tube bundle system.Furthermore,we analyzed how the thickness and length of the squeeze film affect both the underlying mechanisms and the critical velocity of fluidelastic instability.展开更多
High microsatellite instability(MSI-H)colorectal cancer(CRC),caused by deficient mismatch repair,accounts for about 15%of all CRC cases and is more common in right-sided tumors.While early-stage MSI-H CRC has a relati...High microsatellite instability(MSI-H)colorectal cancer(CRC),caused by deficient mismatch repair,accounts for about 15%of all CRC cases and is more common in right-sided tumors.While early-stage MSI-H CRC has a relatively good prognosis,advanced cases often respond poorly to standard chemotherapy.Immune checkpoint inhibitors,such as pembrolizumab,have shown strong and lasting effects in MSI-H CRC.Pembrolizumab is now approved as a first-line treatment for metastatic MSI-H CRC due to its superior outcomes compared to traditional chemotherapy.CASE SUMMARY A 44-year-old male with MSI-H transverse colon cancer presented with hematochezia,abdominal pain,and significant weight loss.Imaging revealed a bulky tumor with invasion of adjacent structures and multiple liver lesions.A diverting ileostomy was performed followed by 36 cycles of pembrolizumab.The patient achieved a clinical and radiologic complete response.One month after completing the treatment,the patient underwent laparoscopic right hemicolectomy.A spontaneous transection of the colon at the original tumor site was unexpectedly identified.Final pathology confirmed pathological complete response(ypT0N0)with fibrosis.The patient recovered well after surgery,and follow-up showed no evidence of recurrence.CONCLUSION Immune checkpoint inhibitors may cause delayed structural damage to bowel tissue even after apparent complete tumor regression.展开更多
We are intrigued by the issues of shock instability,with a particular emphasis on numerical schemes that address the carbuncle phenomenon by reducing dissipation rather than increasing it.For a specific class of plana...We are intrigued by the issues of shock instability,with a particular emphasis on numerical schemes that address the carbuncle phenomenon by reducing dissipation rather than increasing it.For a specific class of planar flow fields where the transverse direction exhibits vanishing but non-zero velocity components,such as a disturbed onedimensional(1D)steady shock wave,we conduct a formal asymptotic analysis for the Euler system and associated numerical methods.This analysis aims to illustrate the discrepancies among various low-dissipative numerical algorithms.Furthermore,a numerical stability analysis of steady shock is undertaken to identify the key factors underlying shock-stable algorithms.To verify the stability mechanism,a consistent,low-dissipation,and shock-stable HLLC-type Riemann solver is presented.展开更多
Self-excited longitudinal combustion instabilities were investigated in a hypergolic liquid bipropellant combustor, which applied single dual-swirl coaxial injector. Hot-fire tests were conducted for four different in...Self-excited longitudinal combustion instabilities were investigated in a hypergolic liquid bipropellant combustor, which applied single dual-swirl coaxial injector. Hot-fire tests were conducted for four different injector geometries, while extensive tests on injection conditions were carried out for each injector geometry. The synchronous measurement of the pressure and heat release rate was applied, successfully capturing the process of the pressure and heat release rate enhanced coupling and developing into in-phase oscillation. By calculating Rayleigh index at the head and middle section of the chamber, it is shown that Rayleigh index of the middle section is even higher than that of the head, indicating a long heat release zone. When the combustion instability occurs, the pressure in propellant manifolds also oscillates with the same frequency and lags behind the oscillation in the combustor. Compared to the oscillation in the outer injector manifold, the oscillation in the inner injector manifold shows a higher correlation with that in the chamber in amplitude and phase. Based on numerical simulations of the multiphase cold flow inside the injector and combustion process in the chamber, it is found that injector geometries affect longitudinal combustion instability by changing spray cone angle. The spray with small cone angle is more sensitive to the modulation of longitudinal pressure wave in combustion simulations, which is more likely to excite the longitudinal combustion instability. Meanwhile, the combustion instability may be related to the pulsating coherent structure generated by the spray fluctuation, which is determined by injection conditions. Besides, a positive feedback closed-loop system associated with the active fluctuation and passive oscillation of the spray is believed to excite and sustain the longitudinal combustion instability.展开更多
The surgical approach for patellar instability usually refers to reconstruction of the medial patellofemoral ligament associated with an osteotomy of the tibial tuberosity or a trochleoplasty when required.The medial ...The surgical approach for patellar instability usually refers to reconstruction of the medial patellofemoral ligament associated with an osteotomy of the tibial tuberosity or a trochleoplasty when required.The medial patellotibial ligament and the medial patellomeniscal ligament are secondary stabilizers of the patella.Despite this,both the medial patellotibial and patellofemoral ligaments aid in patellar rotation and tilt when the knee is flexed beyond 45°.The medial patellotibial ligament plays a particularly important role in the final stages of stretching in extension and between 40 degrees to 90 degrees of flexion.The clinical relevance and surgical indications for medial patellotibial ligament reconstruction associated with medial patellofemoral ligament reconstruction are still controversial.This editorial explores the surgical indications and clinical results for medial patellotibial ligament reconstruction to improve readers’understanding of this technique,especially because reported clinical outcomes have remained sparse.展开更多
The utilization of Inlet Guide Vane (IGV) plays a key factor in affecting the instability evolution. Existing literature mainly focuses on the effect of IGV on instability inception that occurs in the rotor region. Ho...The utilization of Inlet Guide Vane (IGV) plays a key factor in affecting the instability evolution. Existing literature mainly focuses on the effect of IGV on instability inception that occurs in the rotor region. However, with the emergence of compressor instability starting from the stator region, the mechanism of various instability inceptions that occurs in different blade rows due to the change of IGV angles should be further examined. In this study, experiments were focused on three types of instability inceptions observed previously in a 1.5-stage axial flow compressor. To analyze the conversion of stall evolutions, the compressor rotating speed was set to 17 160 r/min, at which both the blade loading in the stator hub region and rotor tip region were close to the critical value before final compressor stall. Meanwhile, the dynamic test points with high-response were placed to monitor the pressures both at the stator trailing edges and rotor tips. The results indicate that the variation of reaction determines the region where initial instability occurs. Indeed, negative pre-rotation of the inlet guide vane leads to high-reaction, initiating stall disturbance from the rotor region. Positive pre-rotation results in low-reaction, initiating stall disturbance from the stator region. Furthermore, the type of instability evolution is affected by the radial loading distribution under different IGV angles. Specifically, a spike-type inception occurs at the rotor blade tip with a large angle of attack at the rotor inlet (−2°, −4° and −6°). Meanwhile, the critical total pressure ratio at the rotor tip is 1.40 near stall. As the angle of attack decreases, the stator blade loading reaches its critical boundary, with a value of approximately 1.35. At this moment, if the rotor tip maintains high blade loading similar to the stator hub, the partial surge occurs (0° and +2°);otherwise, the hub instability occurs (+4° and +6°).展开更多
基金the National Natrual Science Foundation of China(50504014)
文摘Analyzed the support instable mode of sliding,tripping,and so on,and believed the key point of the support stability control of fully mechanized coal caving face with steep coal seams was to maintain that the seam true angle was less than the hydraulic support instability critical angle.Through the layout of oblique face,the improvement of support setting load,the control of mining height and nonskid platform,the group support system of end face,the advance optimization of conveyor and support,and the other control tech- nical measures,the true angle of the seam is reduced and the instable critical angle of the support is increased,the hydraulic support stability of fully mechanized coal caving face with steep coal seams is effectively controlled.
基金the special funds for marine commonweal research under contract No.200705027variability of the subtropical gyre in North Pacific and its impacts on dynamic environment of China marginal seas under contract No.2007CB411800defense industrial technology development program and the special funds for basic scientific research project of the First Institute of Oceanography,SOA under contract No.2010G12
文摘The Kuroshio frontal instable processes （KFIP） in the East China Sea （ECS） not only have a great impact on the hydrologic characteristics,the pollutants drift,the distribution of seafloor sediment and the ships navigation of the ECS,but also are closely related to the climate changes of the coastal areas of the ECS.However the frequency and area of occurrence of the KFIP have not been studied fully and detailedly.Because of its high spatial and temporal resolution,MODIS data is a kind of very good data source for surveying and researching the KFIP in the ECS.The aim of this study is to detect the KFIP in the ECS by using MODIS data,and to study the frequency and region of occurrence of the KFIP in the ECS.The selection has coverage of level 2 data of MODIS SST and Kd490 ranging from July 1,2002 to June 30,2009 of the ECS when there was no cloud impact or little.By using of the data,the minimum standard of the Kuroshio temperature fronts and the diffuse attenuation coefficient （Kd490） fronts of the ECS are given.Based on these standards and the curvature distinguish methods,the standard of curvature distinguish for the KFIP in the ECS are put forward.By making use of this standard,we study a total of 2073 satellite-derived images,and discover that as long as there is no cloud impact from January to May and October to December,the KFIP in the ECS are surely found in MODIS satellite images.From June to September,the frequency of occurrence can also reach to 82.9% at least.Moreover,it is obtained that there are three source regions of these instability processes,namely,（26°N,121.5°E） nearby,（27°N,125°E） nearby and （30°N,128°E） nearby.The differences of the characteristics of these instability processes which are generated in different regions are analyzed in the present study.
文摘In this paper, we aim to control an instable chaotic oscillation in power system that is considered to be small system by using a linear state feedback controller. First we will analyze the stability of the mentioned power system by means of modern nonlinear theory (Bifurcation and Chaos). Our model is based on a three bus power system that consists of multi generators containing both dynamic and static loads. They are considered to be in the form of an induction motor in parallel with a capacitor, as well as a combination of constant power along with load impedance, PQ. We consider the load reactive power as the control parameter. At this stage, after changing the control parameter, the study showed that the system is experiencing a subcritical Hopf bifurcation point. This leads to a chaos within the system period doubling path. We then discuss the system controllability and present that the all chaotic oscillations fade away through the linear controller that we impose on the system.
文摘The instable combustion or oscillation combustion which occurs in three high capacity solid rocket motors using high energy composite propellant with finocyl grain is studied. The reasons of the acoustic combustion instability are also discussed. Three engineering methods that can eliminate combustion instability are proposed and discussed. The study shows that the combustion instability mainly depends on the propellant grain shape and nozzle structure. Some measures to reduce the acoustic energy and mass generation rate of combustion gas can be adopted. The test results indicate that the modified rocket motors can significantly eliminate the instable combustion and improve the motor internal ballistic performance.
文摘AIM: To ascertain the adequacy of the microsatellite instability (MSI) as a prognostic indicator by assessing MSI status of patients with double primary gastric and colorectal cancer (DPGCC).METHODS: Sixteen patients were studied, all of whom exhibited sporadic DPGCC, and had no family history of hereditary non-polyposis colorectal cancer, according to the Amsterdam criteria. A total of 32 cancers from 16DPGCC patients, and 216 single primary CRC, were assessed for MSI in 5 microsatellite loci, BAT25, BAT26,D2S123, D5S346, and D17S250.RESULTS: MSI was observed in 6 (37.5%) of 16 GC and 4 (25.0%) of 16 CRC. Thirty tumors (13.9%) out of 216single primary CRC and one tumor (16.7%) out of 6 double primary CRC were found to be microsatellite unstable. Of the 6 GC with MSI in DPGCC, 5 (31.3%) were MSI-high and one (6.3%) was MSI-low. In 5 of 16 DPGCC patients,the cancer recurred in or adjacent to the anastomosis or metastasized to the kidney or lung. The MSI-high DPGCC cases were associated with a younger age of onset (47.5 years vs 62.5 years), higher frequency of lymph node metastasis (100% vs 25%), and advanced Dukes stage (C, 100% vs 41.7%), as well as a higher frequency of recurrence or metastasis (100% vs 8.3%). Only recurrence or metastasis showed statistical significance by Fisher's exact test.CONCLUSION: Our data suggest that MSI may play an important role in the development of DPGCC, and that it may be used clinically as a molecular predictive marker for recurrence or late metastasis of DPGCC.
基金supported by the National Natural Science Foundation of China(NSFC)(Nos.12074399,12204500,and 12004403)the Key Projects of Intergovernmental International Scientific and Technological Innovation Cooperation(No.2021YFE0116700)+1 种基金the Shanghai Natural Science Foundation(No.20ZR1464400)the Shanghai Sailing Program(No.22YF1455300).
文摘The suppression of ablative Rayleigh–Taylor instability(ARTI)by a spatially modulated laser in inertial confinement fusion(ICF)is studied through numerical simulations.The results show that in the acceleration phase of ICF implosion,the growth of ARTI can be suppressed by using a short-wavelength spatially modulated laser.The ARTI growth rate decreases as the wavelength of the spatially modulated laser decreases,and ARTI is completely suppressed after a certain wavelength has been reached.A spatially uniform laser is introduced to keep the state of motion of the implosion fluid consistent,and it is found that the proportion of the spatially modulated laser required for complete suppression of ARTI decreases as the wavelength continues to decrease.We also optimize the spatial intensity distribution of the spatially modulated laser.In addition,as the duration of the spatially modulated laser decreases,the proportion required for completely suppressing ARTI increases,but the required energy decreases.When the perturbation wavenumber decreases,the wavelength of the spatially modulated laser required for complete suppression of ARTI becomes longer.In the case of multimode perturbation,ARTI can also be significantly suppressed by a spatially modulated laser,and the perturbation amplitude can be reduced to less than 10% of that without a spatially modulated laser.We believe that the conclusions drawn from our simulations can provide the basis for new approaches to control ARTI in ICF.
基金Project supported by the National Natural Science Foundation of China(Nos.12372214 and U2341231)。
文摘The Reynolds-averaged Navier-Stokes(RANS)technique enables critical engineering predictions and is widely adopted.However,since this iterative computation relies on the fixed-point iteration,it may converge to unexpected non-physical phase points in practice.We conduct an analysis on the phase-space characteristics and the fixed-point theory underlying the k-ε turbulence model,and employ the classical Kolmogorov flow as a framework,leveraging its direct numerical simulation(DNS)data to construct a one-dimensional(1D)system under periodic/fixed boundary conditions.The RANS results demonstrate that under periodic boundary conditions,the k-ε model exhibits only a unique trivial fixed point,with asymptotes capturing the phase portraits.The stability of this trivial fixed point is determined by a mathematically derived stability phase diagram,indicating the fact that the k-ε model will never converge to correct values under periodic conditions.In contrast,under fixed boundary conditions,the model can yield a stable non-trivial fixed point.The evolutionary mechanisms and their relationship with boundary condition settings systematically explain the inherent limitations of the k-ε model,i.e.,its deficiency in computing the flow field under periodic boundary conditions and sensitivity to boundary-value specifications under fixed boundary conditions.These conclusions are finally validated with the open-source code OpenFOAM.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金support from National Natural Science Foundation of China(Grant No.52474142)The National Science Fund for Distinguished Young Scholars(No.51925402),Chinathe China Postdoctoral Science Foundation(Grant No.2021M702049).
文摘Roof pre-fracture poses a considerable risk during the re-mining of residual coal above abandoned roadways,threatening the safety of the mining faces.This study employs a Winkler foundation beam model for mechanical analysis of roof structures and adopts a multivariate nonlinear analysis approach to explore the synergistic load-bearing effects within the'coal pillar-support-backfill body'system during the fill and re-mining processes above these roadways.The findings demonstrate that backfill mining significantly reduces stress concentrations in coal pillars and reduces excessive bending moments in roofs near abandoned roadways.The roof deflection equation incorporates three critical factors affecting stability during backfill mining:the width of the coal pillar(L_(3)),the working resistance of the support(q_(z)),and the elastic foundation coefficient of the backfill material(kcÞ.Under single-factor conditions,the impact sequence on roof stability in the coal pillar zone is·k_(c)>L_(3)>q_(z).Further,multivariate nonlinear analysis reveals the interactions within the'coal-support-backfill'structure,indicating that in terms of roof control,the interaction terms are ordered as L_(3)·k_(c)>q_(z)·k_(c)>L_(3)q_(z).Therefore,priority should be given to adjusting the coal pillar width and backfill strength,followed by modifications to the support resistance and backfill strength during the recovery of abandoned roadways.An improved understanding of these interactions will help optimize strategies for the recovery of residual coal through abandoned roadways,thereby enhancing the stability and safety of mining operations under complex geological conditions.
基金supported by the Guangdong Basic and Applied Basic Research Foundation,China(No.2021B1515140007).
文摘The rapid cycling synchrotron(RCS)at the China spallation neutron source operates as a high-intensity proton accelerator.The coupled bunch instability was observed during RCS beam commissioning,which significantly limited the beam power.To investigate the dynamics of instability under an increased beam power,a pulsed octupole magnet with a gradient of 900 T/m^(3) was developed.The magnet system integrated an octupole magnet with a pulsed power supply.The field was carefully measured to examine the performance before its installation into the tunnel.After the installation of the magnets,beam measurements were performed to confirm the effectiveness of the instability mitigation on an actual proton beam.The measurement results show that the instability can be suppressed using the pulsed octupole magnet,particularly at the highenergy stage in an acceleration cycle,meeting the requirements for stable operation of the accelerator.Additionally,when the instability is completely suppressed through chromaticity optimization,octupole magnets can significantly enhance the RCS transmission efficiency,which is crucial for controlling beam loss.The pulsed octupole magnet offers significant progress in beam stability in the RCS,providing valuable experience for further beam power enhancement.
基金funded by the Research,Development,and Innovation Authority(RDIA)—Kingdom of Saudi Arabia(Grant No.13292-psu-2023-PSNU-R-3-1-EF-).
文摘Colorectal cancer is the third most diagnosed cancer worldwide,and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups.This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort(TCGA-COADREAD),accessed through cBioPortal,to develop machine learning models for predicting progression-free survival(PFS)following immunotherapy.The dataset included clinical variables,genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog(KRAS),B-Raf Proto-Oncogene(BRAF),and Neuroblastoma RAS Viral Oncogene Homolog(NRAS),microsatellite instability(MSI)status,tumor mutation burden(TMB),and expression of immune checkpoint genes.Kaplan–Meier analysis showed that KRAS mutations were significantly associated with reduced PFS,while BRAF and NRAS mutations had no significant impact.MSI-high tumors exhibited elevated TMB and increased immune checkpoint expression,reflecting their immunologically active phenotype.We developed both survival and classification models,with the Extra Trees classifier achieving the best performance(accuracy=0.86,precision=0.67,recall=0.70,F1-score=0.68,AUC=0.84).These findings highlight the potential of combining genomic and immune biomarkers with machine learning to improve patient stratification and guide personalized immunotherapy decisions.An interactive web application was also developed to enable clinicians to input patient-specific molecular and clinical data and visualize individualized PFS predictions,supporting timely,data-driven treatment planning.
基金Project(2023AH051167)supported by the Natural Science Research Project of Anhui Educational Committee,ChinaProject(AHBP2024B-04)supported by the Foundation of Anhui Engineering Research Center of New Explosive Materials and Blasting Technology,China+1 种基金Project(GXZDSYS2023103)supported by the Open Fund for Anhui Key Laboratory of Mining Construction Engineering,ChinaProjects(52274071,52404155)supported by the National Natural Science Foundation of China。
文摘Aiming at the problem of dynamic instability of hard-brittle jointed rock surrounding in deep tunnel/roadway engineering,combining with the support concepts of"coupling rigidity with flexibility"and"overcoming rigidity by flexibility",the prevention and control method with"rigid-flexible coupling(R-F-C)"was put forward.Through numerical simulation calculation,the impact damage process,acoustic emission(AE)evolution characteristics,and element stress/displacement evolution characteristics of unsupported surrounding rock structure model,rigid supporting surrounding rock structure model,and"R-F-C"supporting surrounding rock structure model under horizontal bidirectional impact loading were compared and analyzed.Based on the theory of stress wave propagation,the dynamic instability catastrophe mechanism of three kinds of supporting structure models induced by horizontal bidirectional impact loading was revealed.Based on the Mohr-Coulomb strength theory,the stress discrimination methods of dynamic catastrophe of surrounding rock induced by horizontal bidirectional impact loading under three kinds of supporting structures were proposed.Combined with the above numerical simulation study,the explosion impact physical and mechanical test of"R-F-C"surrounding rock supporting plate structure was further designed and carried out.Finally,combined with the"conceptual model of ball-cliff potential energy instability",the energy driving theory and energy transformation mechanism of impact-induced rockburst under three kinds of supporting structures were discussed deeply.The research results provided a scientific basis for further promoting the effective application of"R-F-C"supporting structure in the prevention and control of dynamic instability of deep tunnel/roadway surrounding rock.
基金financially supported by State Key Laboratory of HVDC No.SKLHVDC-2023-KF-03.
文摘The traditional transient stability assessment(TSA)model for power systems has three disadvantages:capturing critical information during faults is difficult,aperiodic and oscillatory unstable conditions are not distinguished,and poor generalizability is exhibited by systems with high renewable energy penetration.To address these issues,a novel ResGRU architecture for TSA is proposed in this study.First,a residual neural network(ResNet)is used for deep feature extraction of transient information.Second,a bidirectional gated recurrent unit combined with a multi-attention mechanism(BiGRU-Attention)is used to establish temporal feature dependencies.Their combination constitutes a TSA framework based on the ResGRU architecture.This method predicts three transient conditions:oscillatory instability,aperiodic instability,and stability.The model was trained offline using stochastic gradient descent with a thermal restart(SGDR)optimization algorithm in the offline training phase.This significantly improves the generalizability of the model.Finally,simulation tests on IEEE 145-bus and 39-bus systems confirmed that the proposed method has higher adaptability,accuracy,scalability,and rapidity than the conventional TSA approach.The proposed model also has superior robustness for PMU incomplete configurations,PMU noisy data,and packet loss.
基金supported by the National Natural Science Foundation of China(Nos.U23B6009 and 12272050)。
文摘Combustion dynamics are a critical factor in determining the performance and reliabilityof a chemical propulsion engine.The underlying processes include liquid atomization,evaporation,mixing,and chemical reactions.This paper presents a high-fidelity numerical study of liquidatomization and spray combustion under high-pressure conditions,emphasizing the effects of pres-sure oscillations on the flow evolution and combustion dynamics.The theoretical framework isbased on the three-dimensional conservation equations for multiphase flows and turbulent combus-tion.The numerical solution is achieved using a coupling method of volume-of-fluid and Lagran-gian particle tracking.The Zhuang-Kadota-Sutton(ZKS)high-pressure evaporation model andthe eddy breakup-Arrhenius combustion model are employed.Simulations are conducted for amodel combustion chamber with impinging-jet injectors using liquid oxygen and kerosene as pro-pellants.Both conditions with and without inlet and outlet pressure oscillations are considered.Thefindings reveal that pressure oscillations amplify flow fluctuations and can be characterized usingkey physical parameters such as droplet evaporation,chemical reaction,and chamber pressure.The spectral analysis uncovers the axial variations of the dominant and secondary frequenciesand their amplitudes in terms of the characteristic physical quantities.This research helps establisha methodology for exploring the coupling effect of liquid atomization and spray combustion.It alsoprovides practical insights into their responses to pressure oscillations during the occurrence ofcombustion instability.This information can be used to enhance the design and operation ofliquid-fueled propulsion engines.
基金financially supported by the National Natural Science Foundation of China(Grant No.12072336).
文摘The influence of the squeeze film between the tube and the support structure on flow-induced vibrations is a critical factor in tube bundles subjected to two-phase cross-flow.This aspect can significantly alter the threshold for fluidelastic instability and affect heat transfer efficiency.This paper presents a mathematical model incorporating the squeeze film force between the tube and the support structure.We aim to clarify the mechanisms underlying fluidelastic instability in tube bundle systems exposed to two-phase flow.Using a self-developed computer program,we performed numerical calculations to examine the influence of the squeeze film on the threshold of fluidelastic instability in the tube bundle system.Furthermore,we analyzed how the thickness and length of the squeeze film affect both the underlying mechanisms and the critical velocity of fluidelastic instability.
文摘High microsatellite instability(MSI-H)colorectal cancer(CRC),caused by deficient mismatch repair,accounts for about 15%of all CRC cases and is more common in right-sided tumors.While early-stage MSI-H CRC has a relatively good prognosis,advanced cases often respond poorly to standard chemotherapy.Immune checkpoint inhibitors,such as pembrolizumab,have shown strong and lasting effects in MSI-H CRC.Pembrolizumab is now approved as a first-line treatment for metastatic MSI-H CRC due to its superior outcomes compared to traditional chemotherapy.CASE SUMMARY A 44-year-old male with MSI-H transverse colon cancer presented with hematochezia,abdominal pain,and significant weight loss.Imaging revealed a bulky tumor with invasion of adjacent structures and multiple liver lesions.A diverting ileostomy was performed followed by 36 cycles of pembrolizumab.The patient achieved a clinical and radiologic complete response.One month after completing the treatment,the patient underwent laparoscopic right hemicolectomy.A spontaneous transection of the colon at the original tumor site was unexpectedly identified.Final pathology confirmed pathological complete response(ypT0N0)with fibrosis.The patient recovered well after surgery,and follow-up showed no evidence of recurrence.CONCLUSION Immune checkpoint inhibitors may cause delayed structural damage to bowel tissue even after apparent complete tumor regression.
基金Project supported by the National Natural Science Foundation of China(Nos.12471367 and12361076)the Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region(Nos.NJZY19186,NJZY22036,and NJZY23003)。
文摘We are intrigued by the issues of shock instability,with a particular emphasis on numerical schemes that address the carbuncle phenomenon by reducing dissipation rather than increasing it.For a specific class of planar flow fields where the transverse direction exhibits vanishing but non-zero velocity components,such as a disturbed onedimensional(1D)steady shock wave,we conduct a formal asymptotic analysis for the Euler system and associated numerical methods.This analysis aims to illustrate the discrepancies among various low-dissipative numerical algorithms.Furthermore,a numerical stability analysis of steady shock is undertaken to identify the key factors underlying shock-stable algorithms.To verify the stability mechanism,a consistent,low-dissipation,and shock-stable HLLC-type Riemann solver is presented.
基金support from the National Natural Science Foundation of China(No.12002386).
文摘Self-excited longitudinal combustion instabilities were investigated in a hypergolic liquid bipropellant combustor, which applied single dual-swirl coaxial injector. Hot-fire tests were conducted for four different injector geometries, while extensive tests on injection conditions were carried out for each injector geometry. The synchronous measurement of the pressure and heat release rate was applied, successfully capturing the process of the pressure and heat release rate enhanced coupling and developing into in-phase oscillation. By calculating Rayleigh index at the head and middle section of the chamber, it is shown that Rayleigh index of the middle section is even higher than that of the head, indicating a long heat release zone. When the combustion instability occurs, the pressure in propellant manifolds also oscillates with the same frequency and lags behind the oscillation in the combustor. Compared to the oscillation in the outer injector manifold, the oscillation in the inner injector manifold shows a higher correlation with that in the chamber in amplitude and phase. Based on numerical simulations of the multiphase cold flow inside the injector and combustion process in the chamber, it is found that injector geometries affect longitudinal combustion instability by changing spray cone angle. The spray with small cone angle is more sensitive to the modulation of longitudinal pressure wave in combustion simulations, which is more likely to excite the longitudinal combustion instability. Meanwhile, the combustion instability may be related to the pulsating coherent structure generated by the spray fluctuation, which is determined by injection conditions. Besides, a positive feedback closed-loop system associated with the active fluctuation and passive oscillation of the spray is believed to excite and sustain the longitudinal combustion instability.
文摘The surgical approach for patellar instability usually refers to reconstruction of the medial patellofemoral ligament associated with an osteotomy of the tibial tuberosity or a trochleoplasty when required.The medial patellotibial ligament and the medial patellomeniscal ligament are secondary stabilizers of the patella.Despite this,both the medial patellotibial and patellofemoral ligaments aid in patellar rotation and tilt when the knee is flexed beyond 45°.The medial patellotibial ligament plays a particularly important role in the final stages of stretching in extension and between 40 degrees to 90 degrees of flexion.The clinical relevance and surgical indications for medial patellotibial ligament reconstruction associated with medial patellofemoral ligament reconstruction are still controversial.This editorial explores the surgical indications and clinical results for medial patellotibial ligament reconstruction to improve readers’understanding of this technique,especially because reported clinical outcomes have remained sparse.
基金support of the National Natural Science Foundation of China(No.52322603)the Science Center for Gas Turbine Project of China(Nos.P2022-B-II-004-001 and P2023-B-II-001-001)+1 种基金the Fundamental Research Funds for the Central Universities,Chinathe Beijing Nova Program of China(Nos.20220484074 and 20230484479).
文摘The utilization of Inlet Guide Vane (IGV) plays a key factor in affecting the instability evolution. Existing literature mainly focuses on the effect of IGV on instability inception that occurs in the rotor region. However, with the emergence of compressor instability starting from the stator region, the mechanism of various instability inceptions that occurs in different blade rows due to the change of IGV angles should be further examined. In this study, experiments were focused on three types of instability inceptions observed previously in a 1.5-stage axial flow compressor. To analyze the conversion of stall evolutions, the compressor rotating speed was set to 17 160 r/min, at which both the blade loading in the stator hub region and rotor tip region were close to the critical value before final compressor stall. Meanwhile, the dynamic test points with high-response were placed to monitor the pressures both at the stator trailing edges and rotor tips. The results indicate that the variation of reaction determines the region where initial instability occurs. Indeed, negative pre-rotation of the inlet guide vane leads to high-reaction, initiating stall disturbance from the rotor region. Positive pre-rotation results in low-reaction, initiating stall disturbance from the stator region. Furthermore, the type of instability evolution is affected by the radial loading distribution under different IGV angles. Specifically, a spike-type inception occurs at the rotor blade tip with a large angle of attack at the rotor inlet (−2°, −4° and −6°). Meanwhile, the critical total pressure ratio at the rotor tip is 1.40 near stall. As the angle of attack decreases, the stator blade loading reaches its critical boundary, with a value of approximately 1.35. At this moment, if the rotor tip maintains high blade loading similar to the stator hub, the partial surge occurs (0° and +2°);otherwise, the hub instability occurs (+4° and +6°).
