Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.Thi...Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria,incorporating both human and mosquito populations.We aim to identify the key factors driving the endemic spread of malaria,determine feasible solutions,and provide insights that lead to the development of effective prevention and management strategies.We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and endemic equilibrium points.Stability analyses indicate that the disease-free equilibrium is locally and globally stable when the reproductive number is below one,whereas an endemic equilibrium persists when this threshold is exceeded.Sensitivity analysis identifies the most influential mosquito-related parameters,particularly the bite rate and mosquito mortality,in controlling the spread of malaria.Furthermore,we extend our model to include a treatment compartment and three disease-preventive control variables such as antimalaria drug treatments,use of larvicides,and the use of insecticide-treated mosquito nets for optimal control analysis.The results show that optimal use of mosquito nets,use of larvicides for mosquito population control,and treatment can lower the basic reproduction number and control malaria transmission with minimal intervention costs.The analysis of disease control strategies and findings offers valuable information for policymakers in designing cost-effective strategies to combat malaria.展开更多
Global Navigation Satellite System(GNSS)-based continuous and accurate train positioning is one of the key technologies for advanced train operations such as train virtual coupling.However,GNSS-based train positioning...Global Navigation Satellite System(GNSS)-based continuous and accurate train positioning is one of the key technologies for advanced train operations such as train virtual coupling.However,GNSS-based train positioning faces significant challenges in real-world scenarios due to environmental complexities and signal interferences.Considering this issue,this paper presents an approach for modeling and performance analysis of GNSS-based train positioning systems using Colored Petri Nets(CPNs).By systematically modeling the GNSS signal reception and processing process,the performance of the positioning system under various environment scenarios is evaluated.The system model integrates three types of interference signals(i.e.,Amplitude Modulation(AM)signals,Frequency Modulation(FM)signals,and pulse signals)while incorporating environmental factors such as terrain obstructions and tunnel shielding.Additionally,the Extended Kalman Filter(EKF)algorithm is employed to process GNSS observation data,providing accurate train position estimations.The simulation results demonstrate that signal interferences and complex environmental conditions significantly affect the GNSS-based positioning accuracy.This study offers a comprehensive framework for evaluating the performance of GNSS-based train positioning systems in different scenarios,highlighting critical factors that influence positioning accuracy and stability.展开更多
Sepsis is a life-threatening condition caused by a dysregulated host response to infection,with its high mortality closely linked to excessive neutrophil activation and the release of neutrophil extracellular traps(NE...Sepsis is a life-threatening condition caused by a dysregulated host response to infection,with its high mortality closely linked to excessive neutrophil activation and the release of neutrophil extracellular traps(NETs).While NETs play a critical role in antimicrobial immunity,their overproduction can lead to tissue damage and multiple organ dysfunction,exacerbating the pathological progression of sepsis.This study focuses on the role of palmitoyltransferase ZDHHC18 in sepsis,proposing that it may regulate the formation of neutrophil NETs through palmitoylation,thereby promoting the onset of sepsis.Currently,there is no research,domestically or internationally,on the role of ZDHHC18 in NETs during sepsis.Therefore,exploring potential therapeutic strategies—such as inhibiting ZDHHC18 to mitigate the pathological effects of sepsis—could provide new insights for treating sepsis-related inflammatory diseases.展开更多
The paper primarily focuses on social safety nets and their effectiveness in poverty alleviation.Social Safety Net(SSN)programs pertain to social service initiatives aimed at providing temporary assistance to individu...The paper primarily focuses on social safety nets and their effectiveness in poverty alleviation.Social Safety Net(SSN)programs pertain to social service initiatives aimed at providing temporary assistance to individuals or groups facing vulnerabilities or unexpected hardships,such as those with lower incomes.Poverty poses a significant obstacle to the progress of social development,and its impacts are worsened by various factors including insecurity,frequent flooding,and droughts in Somalia.A total of 342 households in the Banadir region of Somalia were interviewed for the social safety nets(SSN)study.Data collection in the study was facilitated through the utilization of Kobo Toolbox,while the data analysis was conducted using EViews v.12.The results obtained from the ADP and PP tests indicated that all variables exhibited stationarity at the level.The Impact Assessment(IA)reveals a positive correlation with Household Income and Poverty Indices(HIPI),suggesting a risk of dependency without a strategic exit strategy,potentially leading to a 26%increase in poverty levels.A well-executed Program Implementation and Design(PID)can result in a 33%increase in income and poverty indices.Recipients perceive the Social Safety Net(PSSN)as reducing poverty and increasing income by 11%.Therefore,the study recommends integrating beneficiaries into the urban economy through sustainable livelihood options.Finally,the Somali government should prioritize the implementation of sustainable livelihood programs to mitigate dependency and alleviate poverty among SSN beneficiaries.展开更多
基金supported by the Deanship of Scientific Research,Vice Presidency for Graduate Studies and Scientific Research,King Faisal University,Saudi Arabia[Grant No.KFU252959].
文摘Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria,incorporating both human and mosquito populations.We aim to identify the key factors driving the endemic spread of malaria,determine feasible solutions,and provide insights that lead to the development of effective prevention and management strategies.We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and endemic equilibrium points.Stability analyses indicate that the disease-free equilibrium is locally and globally stable when the reproductive number is below one,whereas an endemic equilibrium persists when this threshold is exceeded.Sensitivity analysis identifies the most influential mosquito-related parameters,particularly the bite rate and mosquito mortality,in controlling the spread of malaria.Furthermore,we extend our model to include a treatment compartment and three disease-preventive control variables such as antimalaria drug treatments,use of larvicides,and the use of insecticide-treated mosquito nets for optimal control analysis.The results show that optimal use of mosquito nets,use of larvicides for mosquito population control,and treatment can lower the basic reproduction number and control malaria transmission with minimal intervention costs.The analysis of disease control strategies and findings offers valuable information for policymakers in designing cost-effective strategies to combat malaria.
基金supported by the National Key Research and Development Program of China(2023YFB3907300)the Fundamental Research Funds for the Central Universities(2024JBMC002)the National Natural Science Foundation of China(T2222015,U2268206).
文摘Global Navigation Satellite System(GNSS)-based continuous and accurate train positioning is one of the key technologies for advanced train operations such as train virtual coupling.However,GNSS-based train positioning faces significant challenges in real-world scenarios due to environmental complexities and signal interferences.Considering this issue,this paper presents an approach for modeling and performance analysis of GNSS-based train positioning systems using Colored Petri Nets(CPNs).By systematically modeling the GNSS signal reception and processing process,the performance of the positioning system under various environment scenarios is evaluated.The system model integrates three types of interference signals(i.e.,Amplitude Modulation(AM)signals,Frequency Modulation(FM)signals,and pulse signals)while incorporating environmental factors such as terrain obstructions and tunnel shielding.Additionally,the Extended Kalman Filter(EKF)algorithm is employed to process GNSS observation data,providing accurate train position estimations.The simulation results demonstrate that signal interferences and complex environmental conditions significantly affect the GNSS-based positioning accuracy.This study offers a comprehensive framework for evaluating the performance of GNSS-based train positioning systems in different scenarios,highlighting critical factors that influence positioning accuracy and stability.
文摘Sepsis is a life-threatening condition caused by a dysregulated host response to infection,with its high mortality closely linked to excessive neutrophil activation and the release of neutrophil extracellular traps(NETs).While NETs play a critical role in antimicrobial immunity,their overproduction can lead to tissue damage and multiple organ dysfunction,exacerbating the pathological progression of sepsis.This study focuses on the role of palmitoyltransferase ZDHHC18 in sepsis,proposing that it may regulate the formation of neutrophil NETs through palmitoylation,thereby promoting the onset of sepsis.Currently,there is no research,domestically or internationally,on the role of ZDHHC18 in NETs during sepsis.Therefore,exploring potential therapeutic strategies—such as inhibiting ZDHHC18 to mitigate the pathological effects of sepsis—could provide new insights for treating sepsis-related inflammatory diseases.
文摘The paper primarily focuses on social safety nets and their effectiveness in poverty alleviation.Social Safety Net(SSN)programs pertain to social service initiatives aimed at providing temporary assistance to individuals or groups facing vulnerabilities or unexpected hardships,such as those with lower incomes.Poverty poses a significant obstacle to the progress of social development,and its impacts are worsened by various factors including insecurity,frequent flooding,and droughts in Somalia.A total of 342 households in the Banadir region of Somalia were interviewed for the social safety nets(SSN)study.Data collection in the study was facilitated through the utilization of Kobo Toolbox,while the data analysis was conducted using EViews v.12.The results obtained from the ADP and PP tests indicated that all variables exhibited stationarity at the level.The Impact Assessment(IA)reveals a positive correlation with Household Income and Poverty Indices(HIPI),suggesting a risk of dependency without a strategic exit strategy,potentially leading to a 26%increase in poverty levels.A well-executed Program Implementation and Design(PID)can result in a 33%increase in income and poverty indices.Recipients perceive the Social Safety Net(PSSN)as reducing poverty and increasing income by 11%.Therefore,the study recommends integrating beneficiaries into the urban economy through sustainable livelihood options.Finally,the Somali government should prioritize the implementation of sustainable livelihood programs to mitigate dependency and alleviate poverty among SSN beneficiaries.
