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Progression of injectivity damage with oily waste water in linear flow 被引量:1
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作者 Jin Lu Wojtanowicz Andrew K 《Petroleum Science》 SCIE CAS CSCD 2014年第4期550-562,共13页
Numerous laboratory experiments and field cases show that even very small amount of oil in injected water can cause severe injectivity damage. Although injectivity decline caused by oil droplets has been studied exper... Numerous laboratory experiments and field cases show that even very small amount of oil in injected water can cause severe injectivity damage. Although injectivity decline caused by oil droplets has been studied experimentally, there is still lack of an easy-to-use and widely accepted model to predict the decline behavior. In this work, we developed an analytical model to predict the time-dependent progress of the water permeability reduction in linear flow by analyzing experimental data obtained from linear core flooding. The model considers mass transfer of the oil phase from the produced water to the rock due capture effects by dispersion, advection and adsorption inside the rock. As the captured oil saturation increases, permeability reduces following the relative permeability drainage relationship. The reduction stabilizes when the oil saturation comes to an equilibrium value controlled by oil droplet size and injection velocity. The model is calibrated using published experimental data from prolonged core floods with oil- contaminated waste water. Theoretical runs of the model replicate all the effects known from experimental observations. Resulting from the model is a distributed change of permeability vs. time and distance from the point of injection that can be converted to the overall injectivity damage. 展开更多
关键词 Produced water injection injectivity decline permeability damage linear flow model filtration model
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Liquid injectivity in a SAG foam process:Effect of permeability
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作者 Jia-Kun Gong Yuan Wang +4 位作者 Ridhwan-Zhafri B.Kamarul Bahrim Raj-Deo Tewari Mohammad-Iqbal Mahamad Amir Rouhi Farajzadeh William Rossen 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期302-314,共13页
Foam is utilized in enhanced oil recovery and CO_(2) sequestration.Surfactant-alternating-gas(SAG)is a preferred approach for placing foam into reservoirs,due to it enhances gas injection and minimizes corrosion in fa... Foam is utilized in enhanced oil recovery and CO_(2) sequestration.Surfactant-alternating-gas(SAG)is a preferred approach for placing foam into reservoirs,due to it enhances gas injection and minimizes corrosion in facilities.Our previous studies with similar permeability cores show that during SAG injection,several banks occupy the area near the well where fluid exhibits distinct behaviour.However,underground reservoirs are heterogeneous,often layered.It is crucial to understand the effect of permeability on fluid behaviour and injectivity in a SAG process.In this work,coreflood experiments are conducted in cores with permeabilities ranging from 16 to 2300 mD.We observe the same sequence of banks in cores with different permeabilities.However,the speed at which banks propagate and their overall mobility can vary depending on permeability.At higher permeabilities,the gas-dissolution bank and the forced-imbibition bank progress more rapidly during liquid injection.The total mobilities of both banks decrease with permeability.By utilizing a bank-propagation model,we scale up our experimental findings and compare them to results obtained using the Peaceman equation.Our findings reveal that the liquid injectivity in a SAG foam process is misestimated by conventional simulators based on the Peaceman equation.The lower the formation permeability,the greater the error. 展开更多
关键词 Foam Enhanced oil recovery Surfactant-alternating-gas injectivity PERMEABILITY
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Characterization of Hereditary Rings ViaInjectivity and Projectivity Classes
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作者 于增海 段海生 《Chinese Quarterly Journal of Mathematics》 CSCD 1998年第2期27-30, ,共4页
In this note,some characterizations of hereditary rings using injectivity classes and projectivity classes are given.These results unify many well known results.
关键词 hereditary ring injectivity classes projectivity classes
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Assessing roles of geochemical reactions on CO_(2)plume,injectivity and residual trapping
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作者 Abdiaziz Abdullahi Maalim Hisham Ben Mahmud Mojtaba Seyyedi 《Energy Geoscience》 2021年第4期327-336,共10页
With increasing CO_(2)concentration in the atmosphere,CO_(2)geo-aequestration has become a popular technique to counter the dangers of global warming resulting from high levels of CO_(2)in the atmosphere.This paper ex... With increasing CO_(2)concentration in the atmosphere,CO_(2)geo-aequestration has become a popular technique to counter the dangers of global warming resulting from high levels of CO_(2)in the atmosphere.This paper examins sequestration parameters such as CO_(2)plume behaviour,residual gas trapping and injectivity as a means of achieving safe and successful CO_(2)storage in saline aquifers.Mineral precipitation/dissolution rates are used to establish a relationship between these parameters and geochemical reactions in saline aquifers.To achieve this,mechanistic models(6 models with different inputs,created using CMG e GEM,2016 and WINPROP,2016)are simulated using input data from literature and studying changes in fluids and formation properties as well as mineral precipitation/dissolution rates in aquifers when subjected to different conditions in the different models.The results from the models show that high CO_(2)dissolution,which creates large CO_(2)plume,leads to high mineral dissolution/precipitation as results of increased fluid-rock interactions(geochemical reactions);whereas injectivity,although enhanced by CO_(2)-water cyclic injection,does not show much increase in bottom hole pressure when mineral trapping(thus geochemical reactions)is introduced into the model.Sensitivity study on residual gas trapping shows that high residual gas saturation leads to reduced mineral precipitation/dissolution due to the reduced amount of dissolved CO_(2)in brine.Also,rapid changes in the bottom hole pressure at high residual gas saturation means that a formation that fosters high residual gas trapping,rather than CO_(2)dissolution in brine,is more likely to experience injectivity issues during the sequestration process. 展开更多
关键词 Geochemical reactions CO_(2)plume Residual(gas)trapping injectivity Mineral precipitation Mineral dissolution
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A small-scale experimental study of CO_(2) enhanced injectivity methods of the high-rank coal 被引量:1
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作者 Qing-He Niu Li-Wen Cao +6 位作者 Shu-Xun Sang Wei Wang Wei Yuan Jiang-Fang Chang Xiao-Jun Jia Wei-Min Zheng Zeng-Xue Zhang 《Petroleum Science》 SCIE CAS CSCD 2021年第5期1427-1440,共14页
The attenuation of CO_(2)injectivity has become the biggest technical barrier for the application of CO_(2)enhanced coalbed methane recovery(CO_(2)-ECBM).Commonly,the intermittent CO_(2)injection,N2 displacing CO_(2)a... The attenuation of CO_(2)injectivity has become the biggest technical barrier for the application of CO_(2)enhanced coalbed methane recovery(CO_(2)-ECBM).Commonly,the intermittent CO_(2)injection,N2 displacing CO_(2)and pre-fracturing are the potential CO_(2)enhanced injectivity methods for coal reservoirs,but their mechanism and effectiveness remain to be clarified.This paper thus conducted small-scale experiments to simulate the working process of these engineering measures by an independently developed experimental device.Results show that the CO_(2)injectivity of coal is remarkably improved by the intermittent injection mode since the CO_(2)injection time is increased by folds and the loss of reservoir pressure can be complemented in time.The N_(2)displacing CO_(2)method promotes the desorption of CO_(2)and reduces the swelling strain,with the result that the permeability of coal is improved by 74.82%and 64.95%compared with the methods of the primary subcritical CO_(2)(Sub CO_(2))and supercritical CO_(2)(Sc CO_(2))injection.However,the permeability reduces again with the secondary CO_(2)injection.The permeability of the coal sample after pre-fracturing is averagely improved by 1-2 orders of magnitude,the irreversible permeability loss rate,average stress sensitivity coefficient and the permeability loss rate due to adsorption are averagely reduced by 95.885%,61.538%and 96.297%,respectively.This indicates that the permeability of coal after pre-fracturing is no longer sensitive to both the effective stress and Sc CO_(2)adsorption,the injectivity is thus improved and stable.The CO_(2)enhanced injectivity effects of the intermittent CO_(2)injection,the N_(2)displacing CO_(2)and the pre-fracturing are various,which thus can be selected individually or jointly to improve the CO_(2)injectivity according to the reservoir physical properties and geological conditions.This research deepens the understanding of the functional mechanism of CO_(2)enhanced injectivity methods and provides some guidance for their selection and application in engineering practices. 展开更多
关键词 Supercritical CO_(2) Permeability Intermittent injection N_(2)displacing CO_(2) PRE-FRACTURING
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A novel injectivity decline prediction model for waterflooding with analytical solutions and field applications
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作者 Huifeng Liu Yuri Osipov +3 位作者 Zebo Yuan Siqing Xu Jorge Costa Gomes Zhangxin Chen 《Petroleum》 2025年第6期784-799,共16页
Well injectivity decline during waterflooding is primarily attributed to retention of injected particles within pores,subsequently blocking flow channels in near-wellbore regions.Developing a predictive model to descr... Well injectivity decline during waterflooding is primarily attributed to retention of injected particles within pores,subsequently blocking flow channels in near-wellbore regions.Developing a predictive model to describe this problem holds significant value as it can inform the development of strategies aimed at preventing or mitigating such damage.Previous research has typically assumed a linear suspension flow or a constant filtration coefficient,which does not represent the near-wellbore suspension flow very well.In this paper,an analytical model for the radial suspension transport in porous media is derived based on the Langmuirian blocking filtration mechanism.Considering the dimensionless distance from the wellbore as a small parameter,we attain the analytical solution through an asymptotic expansion.To provide a basis for comparison,we also obtain numerical solutions using Shampine's code,which is based on the explicit central finite difference method.Comparison of the analytical and numerical solutions shows that their difference errors remain below 5%under waterflooding conditions.Based on the analytical solution for retained particle concentration,expressions for injection pressure,damage factor and damaged zone radius are also derived and are also expressed explicitly.In the end,we discuss two practical applications of our model:evaluation of existing acidizing jobs and designing new acidizing jobs,based on real field data from Tarim Basin,western China.The results indicate our model is practical in field operations. 展开更多
关键词 WATERFLOODING injectivity decline Langmuirian blocking Filtration coefficient Damage zone Analytical model
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On the Curvature and Injectivity Radius Growth and Topology of Null Hypersurfaces in Lorentzian Manifolds
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作者 Ménédore Karimumuryango Domitien Ndayirukiye Nibaruta Gilbert 《Journal of Applied Mathematics and Physics》 2025年第9期3151-3162,共12页
We consider an associated Riemannian metric induced by a rigging defined on a neighborhood of the null hypersurface in a Lorentzian manifold,and we connect this null geometry with the associated Riemannian geometry.Us... We consider an associated Riemannian metric induced by a rigging defined on a neighborhood of the null hypersurface in a Lorentzian manifold,and we connect this null geometry with the associated Riemannian geometry.Using a rigging defined on some open set containing the lightlike hypersurface,we introduce a global geometric invariant Rad^(ζ)(M)related to injectivity radius to a closed complete noncompact null hypersurface in a Lorentzian manifold.Using some comparison theorems from non-degenerated geometry,we give the relationship between geometry and topology of a closed complete noncompact null hypersurface with associated Riemannian metric and the asymptotic properties of injectivity radiuses at infinity. 展开更多
关键词 injectivity Radius RIGGING Topology Lorentzian Manifold Lightlike Hypersurface
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On the Flatness and Injectivity of Dual Modules(II)
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作者 黄兆泳 唐金玉 《Journal of Mathematical Research and Exposition》 CSCD 北大核心 2001年第3期377-383,共7页
For a commtative ring R and an injective cogenerator E in the category of R-modules, we characterize QF rings, IF rings and semihereditary rings by using the properties of the dual modules with respect to E.
关键词 QF rings FLATNESS injectivity dual modules.
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On Maximal Injectivity 被引量:3
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作者 Ming Yi WANG Guo ZHAO 《Acta Mathematica Sinica,English Series》 SCIE CSCD 2005年第6期1451-1458,共8页
A right R-module E over a ring R is said to be maximally injective in case for any maximal right ideal m of R, every R-homomorphism f : m → E can be extended to an R-homomorphism f^1 : R → E. In this paper, we fir... A right R-module E over a ring R is said to be maximally injective in case for any maximal right ideal m of R, every R-homomorphism f : m → E can be extended to an R-homomorphism f^1 : R → E. In this paper, we first construct an example to show that maximal injectivity is a proper generalization of injectivity. Then we prove that any right R-module over a left perfect ring R is maximally injective if and only if it is injective. We also give a partial affirmative answer to Faith's conjecture by further investigating the property of maximally injective rings. Finally, we get an approximation to Faith's conjecture, which asserts that every injective right R-module over any left perfect right self-injective ring R is the injective hull of a projective submodule. 展开更多
关键词 Maximal injectivity Quasi-Frobenius rings Faith's conjecture
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A simulation study of water injection and gas injectivity scenarios in a fractured carbonate reservoir:A comparative study 被引量:5
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作者 Afshin Davarpanah Behnam Mirshekari A.Armin Razmjoo 《Petroleum Research》 2019年第3期250-256,共7页
Regarding the enormous demands of numerous industries to fossil fuels,it is essential to select the proper enhanced oil recovery approaches for vertical and horizontal wells to supply the demands with the optimum expe... Regarding the enormous demands of numerous industries to fossil fuels,it is essential to select the proper enhanced oil recovery approaches for vertical and horizontal wells to supply the demands with the optimum expenditure.Water and gas injectivity as the secondary enhanced oil recovery techniques would be preferentially considered regarding their low costs of performances rather than chemical recovery and thermal techniques.Injected gas tends to push oil through pores or cracks in the matrix block and lead them to the production well.Therefore,injection of gas may significantly increase the recovery factor in these reservoirs.In this research,different injection scenarios in a fractured carbonate reservoir in the west of Iran are being simulated by the PVT modules of Eclipse software.The purpose of this research is to analyze the possibility of gradually increasing the extent of recovery by injecting carbon dioxide,methane,and water,and different injectivity patterns are considered in this research.The selection of injectivity patterns is severely based on the highest recycling rate of gas injection on different injection scenarios,and the injectivity scenarios were being compared with the natural depletion scenario.Consequently,Co2 injection(about 60%)had the highest oil recovery factor and CH4 and TB(about 54%and 53%)injectivity scenarios had the second and third highest rate of the oil recovery factor. 展开更多
关键词 Fractured carbonated reservoir Gas injection scenarios Co2 injection Oil recovery factor injectivity patterns
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Preliminary assessment of CO_(2) injectivity in carbonate storage sites 被引量:1
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作者 Arshad Raza Raoof Gholami +3 位作者 Reza Rezaee Chua Han Bing Ramasamy Nagarajan Mohamed Ali Hamid 《Petroleum》 2017年第1期144-154,共11页
Depleted gas reservoirs are used for a large-scale carbon dioxide(CO_(2))storage and reduction of the greenhouse gas released into the atmosphere.To identify a suitable depleted reservoir,it is essential to do a preli... Depleted gas reservoirs are used for a large-scale carbon dioxide(CO_(2))storage and reduction of the greenhouse gas released into the atmosphere.To identify a suitable depleted reservoir,it is essential to do a preliminary and comprehensive assessment of key storage factors such as storage capacity,injectivity,trapping mechanisms,and containment.However,there are a limited number of studies providing a preliminary assessment of CO_(2) injectivity potential in depleted gas reservoirs prior to a CO_(2) storage operation.The aim of this study is to provide a preliminary assessment of a gas field located in Malaysia for its storage potential based on subsurface characterization prior to injection.Evaluation of the reservoir interval based on the facies,cores,and wireline log data of a well located in the field indicated that the pore type and fabrics analysis is very beneficial to identify suitable locations for a successful storage practice.Although the results obtained are promising,it is recommended to combine this preliminary assessment with the fluid-mineral interactions analysis before making any judgment about reliability of storage sites. 展开更多
关键词 CO_(2)storage injectivity Carbonate reservoir Lithofacies PETROPHYSICS
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Injectivity theorems on compact complex manifolds
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作者 Chunle Huang 《Science China Mathematics》 SCIE CSCD 2018年第6期1089-1098,共10页
We use analytic methods in this paper to prove some new Enoki type injeetivity theorems on compact complex manifolds which generalize more or less the original Enoki injectivity theorem.
关键词 injectivity theorems complete Kahler manifolds L2-methods L2 Dolbeault lemma
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Injectivity radius bound of Ricci flow with positive Ricci curvature and applications
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作者 Li MA Anqiang ZHU 《Frontiers of Mathematics in China》 SCIE CSCD 2013年第5期1129-1137,共9页
We study the injectivity radius bound for 3-d Ricci flow with bounded curvature. As applications, we show the long time existence of the Ricci flow with positive Ricci curvature and with curvature decay condition at i... We study the injectivity radius bound for 3-d Ricci flow with bounded curvature. As applications, we show the long time existence of the Ricci flow with positive Ricci curvature and with curvature decay condition at infinity. We partially settle a question of Chow-Lu-Ni [Hamilton's Ricci Flow, p. 302]. 展开更多
关键词 injectivity radius bound Ricci flow positive Ricci curvature global solution
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Comparative Study on the Efficacy and Safety of Faricimab and Conbercept in the Treatment of Diabetic Macular Edema
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作者 Xiaoqin Zhao Jie Wang 《Journal of Clinical and Nursing Research》 2026年第1期387-393,共7页
Objective:To compare the clinical efficacy and safety of intravitreal injection of faricimab and conbercept in the treatment of diabetic macular edema(DME).Methods:A total of 50 patients diagnosed with DME in our hosp... Objective:To compare the clinical efficacy and safety of intravitreal injection of faricimab and conbercept in the treatment of diabetic macular edema(DME).Methods:A total of 50 patients diagnosed with DME in our hospital from January 2023 to May 2025 were selected and randomly divided into an observation group and a control group,with 25 cases in each group,using a random number table method.The observation group received intravitreal injection of faricimab,while the control group received intravitreal injection of conbercept.Both groups adopted a loading phase plus maintenance phase treatment regimen.The best-corrected visual acuity(BCVA,expressed in logMAR)and central subfield thickness(CST)of the two groups were compared before treatment and at 1,3,and 6 months after treatment,and the incidence of adverse events during treatment was recorded.Results:The logMAR BCVA in the observation group was lower than that in the control group at 3 and 6 months after treatment(both p<0.05).The CST in the observation group was smaller than that in the control group at 1,3,and 6 months after treatment(all p<0.05).There was no statistically significant difference in the overall incidence of adverse events between the two groups(χ^(2)=0.189,p=0.663).Conclusion:Both intravitreal injections of faricimab and conbercept are effective in improving visual acuity and reducing macular edema in patients with DME,with good safety profiles.However,faricimab demonstrates superior efficacy in the medium to long term(3 and 6 months)compared to conbercept,making it more suitable for long-term treatment of patients with DME. 展开更多
关键词 Diabetic macular edema Faricimab Conbercept Intravitreal injection EFFICACY SAFETY
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A comparison of porous sandstone fracturing induced by increasing fluid pressure or decreasing confining pressure:Stress-path and rate-dependence effects
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作者 Xu Han Lei Wang +2 位作者 Erik Rybacki Marco Bohnhoff Georg Dresen 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期151-165,共15页
When a porous rock is subjected to overall compressive loading,either increasing pore pressure or decreasing confining pressure could result in rock failure.The stress path and the applied pressure change rate may aff... When a porous rock is subjected to overall compressive loading,either increasing pore pressure or decreasing confining pressure could result in rock failure.The stress path and the applied pressure change rate may affect the initiation and propagation of fractures within brittle materials.Understanding the physical mechanisms leading to failure is crucial for underground engineering applications and geo-energy exploration and storage.We conducted triaxial compression experiments on porous Bentheim sandstone samples at different stress paths and pressure change rates.First,at a constant confining pressure of 35 MPa and pore pressure of 5 MPa,intact cylindrical samples were axially loaded up to about 85%of the peak strength.Subsequently,the axial piston position was fixed,and then either the pore pressure was increased or the confining pressure was decreased at two different rates(0.5 MPa/min or 2 MPa/min),leading to final catastrophic failure.The mechanical results revealed that samples subjected to higher rates of decreasing effective confining pressure exhibited larger stress drop rates,higher slip rates,higher total breakdown work,higher rates of acoustic emissions(AEs)before failure,and higher post-failure AE decay rates.In contrast,the applied stress path did not significantly affect rock failure characteristics.Comparison of located AE events with post-mortem microstructures of deformed samples shows a good agreement.The AE source type determined from the P-wave first-motion polarity shows that shear failure dominated the fracture process when approaching failure.Gutenberg-Richter b-values revealed a significant decrease before failure in all tests.Our results indicate that,in contrast to the stress path,the rate of effective stress change strongly affects fracturing behavior and AE rate changes. 展开更多
关键词 Porous sandstone Fluid injection Effective confining pressure changing rate Stress path
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A bio-healing method for underground long rock fractures with high bridging rate
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作者 Qi-Chen Dai Xiao-Hua Pan +1 位作者 Chao-Sheng Tang Bin Shi 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第2期1359-1367,共9页
One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation... One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation(MICP)technology has emerged as a promising bio-healing method for rock fractures with small apertures.In this study,a new“three-stage”injection strategy-based MICP(TS-MICP)bio-healing method was proposed,aiming to achieve a“three-high”performance that includes high bridging rate,high mechanical strength,and high homogeneity.A series of meter-scale rock fracture models were prepared to conduct TS-MICP grouting tests.Compared with the traditional injection strategy-based biohealing methods,the TS-MICP method significantly improved the bridging rate(32.1%e89.5%),mechanical properties(0.138e1.023 MPa),and homogeneity of CaCO_(3)precipitation(334.4%).Additionally,it achieved a higher material utilization rate(1.72 times higher),reducing the consumption of cementation solution(CS)by 258.8%,thereby demonstrating greater potential for field applications.The underlying mechanism for achieving high bridging rate and high homogeneity in CaCO_(3)precipitation can be attributed to the synergistic effects of the coupling injection strategy,which optimizes the advantages at each stage.In stage I,under the influence of gravity,the rapid flocculation and hydrogen bonding interactions of organic matter lead to formation of the dense and high-strength CaCO_(3)precipitation at the bottom using a low-concentration bacterial suspension(BS).This process establishes bridging steps along the wall sides for subsequent uniform CaCO_(3)precipitation.In stage II,concentrated BS is utilized to produce looser CaCO_(3)flocculation,which precipitates uniformly on the pre-existing bridging steps.In stage III,a two-step injection strategy was employed to reinforce the loose CaCO_(3)crystals formed in stages I and II,and finally forms a strong bridging effect with“three-high”performance. 展开更多
关键词 Microbial-induced calcium carbonate precipitation(MICP)healing Meter-scale fracture Three-stage injection strategy High bridging rate
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The Impact of Double-puncture Tympanic Membrane Puncture and Tympanic Cavity Drug Injection on the Complication Rate of Acute Secretory Otitis Media
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作者 Wei Zheng 《Proceedings of Anticancer Research》 2026年第1期54-60,共7页
Objective:To explore the therapeutic effect of double-puncture tympanic membrane puncture and tympanic cavity drug injection in patients with acute secretory otitis media.Methods:A total of 84 patients with acute secr... Objective:To explore the therapeutic effect of double-puncture tympanic membrane puncture and tympanic cavity drug injection in patients with acute secretory otitis media.Methods:A total of 84 patients with acute secretory otitis media admitted to our hospital from June 2024 to June 2025 were selected and randomly divided into two groups by drawing lots.The control group(42 cases)was treated with the traditional single-puncture tympanic membrane puncture and tympanic cavity drug injection method,while the observation group(42 cases)was treated with the double-puncture tympanic membrane puncture and tympanic cavity drug injection method.The therapeutic effects of the two groups were compared.Results:The overall treatment response rate,overall complication rate,time to symptom relief,and improvement in hearing threshold in the observation group were all superior to those in the control group,with statistically significant differences(P<0.05).Conclusion:For acute secretory otitis media,the treatment method of double-puncture tympanic membrane puncture and tympanic cavity drug injection demonstrates definite efficacy,significantly reducing the incidence of complications,accelerating symptom relief,and improving hearing function,making it worthy of promotion. 展开更多
关键词 Acute secretory otitis media Double puncture Tympanic membrane puncture and tympanic cavity drug injection COMPLICATIONS
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Successful rescue activation of unfertilized oocytes with calcium ionophore(A23187)in a case of recurrent ICSI fertilization failure:A case report
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作者 Akash More Vilas Chimurkar +2 位作者 Namrata Choudhary Dipali More Sanket Mahajan 《Asian pacific Journal of Reproduction》 2026年第1期45-48,共4页
Rationale:This case report describes a couple with recurrent fertilization failure despite undergoing multiple cycles of intracytoplasmic sperm injection(ICSI).The principal clinical concern was suspected oocyte activ... Rationale:This case report describes a couple with recurrent fertilization failure despite undergoing multiple cycles of intracytoplasmic sperm injection(ICSI).The principal clinical concern was suspected oocyte activation deficiency(OAD),in which fertilization is impeded due to the oocyte’s inability to initiate embryogenesis,commonly attributed to inadequate intracellular calcium(Ca^(2+))release following sperm injection.Patient concerns:The couple repeatedly experienced complete or near-complete fertilization failure in previous ICSI cycles,raising suspicion of an underlying oocyte activation defect.Diagnosis:Based on the repeated absence of fertilization post-ICSI and clinical history,a diagnosis of suspected OAD leading to recurrent ICSI fertilization failure was considered.Interventions:Artificial oocyte activation(AOA)using the calcium ionophore A23187 was performed.After ICSI,unfertilized oocytes were exposed to the ionophore to induce Ca^(2+)influx,simulating physiological calcium oscillations essential for oocyte activation.The efficacy of intervention was evaluated through subsequent embryonic development,morphological grading,and chromosomal integrity.Outcomes:Following AOA treatment,successful oocyte activation occurred,resulting in the formation of high-grade embryos with normal developmental progression.Chromosomal analysis revealed no detectable abnormalities,indicating genomic stability.Lessons:Calcium ionophore–mediated AOA may serve as an effective adjunct in cases of recurrent ICSI failure attributed to OAD.This case highlights the importance of individualized therapeutic strategies in assisted reproduction;however,further research is needed to refine protocols,validate broader clinical efficacy,and assess long-term safety,including potential epigenetic risks. 展开更多
关键词 Oocyte activation deficiency Intracytoplasmic sperm injection Artificial oocyte activation Calcium ionophore A23187 Fertilization failure Assisted reproductive technology
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Gorenstein flatness and injectivity over Gorenstein rings 被引量:2
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作者 SONG WeiLing HUANG ZhaoYong 《Science China Mathematics》 SCIE 2008年第2期215-218,共4页
Let R be a Gorenstein ring.We prove that if I is an ideal of R such that R/I is a semi-simple ring,then the Gorenstein flat dimension of R/I as a right R-module and the Gorenstein injective dimension of R/I as a left ... Let R be a Gorenstein ring.We prove that if I is an ideal of R such that R/I is a semi-simple ring,then the Gorenstein flat dimension of R/I as a right R-module and the Gorenstein injective dimension of R/I as a left R-module are identical.In addition,we prove that if R→S is a homomorphism of rings and SE is an injective cogenerator for the category of left S-modules,then the Gorenstein flat dimension of S as a right R-module and the Gorenstein injective dimension of E as a left R-module are identical.We also give some applications of these results. 展开更多
关键词 Gorenstein flat Gorenstein injective Gorenstein rings 16E10 16E30
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Injectivity and projectivity in analysis and topology
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作者 HADWIN Don PAULSEN Vern I 《Science China Mathematics》 SCIE 2011年第11期2347-2359,共13页
We give new proofs of many injectivity results in analysis that make more careful use of the duality between abelian C*-algebras and topological spaces. We then extend many of these ideas to incorporate the case of a ... We give new proofs of many injectivity results in analysis that make more careful use of the duality between abelian C*-algebras and topological spaces. We then extend many of these ideas to incorporate the case of a group action. This approach gives new insight into Hamana's theory of G-injective operator spaces and G-injective envelopes. Our new proofs of these classic results, use only topological methods and eliminate the need for results from the theory of Boolean algebras and AW*-algebras. 展开更多
关键词 INJECTIVE MULTIPLIERS operator space Banach-Stone
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