Epigenetics refers to heritable changes in gene function that occur without alterations to the DNA sequence.Major epigenetic mechanisms include DNA methylation,histone modifications,chromatin remodeling,and the regula...Epigenetics refers to heritable changes in gene function that occur without alterations to the DNA sequence.Major epigenetic mechanisms include DNA methylation,histone modifications,chromatin remodeling,and the regulatory ac-tions of small RNAs and long noncoding RNAs(Allis and Jenuwein,2016).These layers of regulation are essential for modulating gene expression and are widely involved in the regulation of plant growth and development,as well as in responses to environmental cues(Hemenway and Gehring,2023).展开更多
Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal ...Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.展开更多
Objective: To investigate the current status of inheritance and development of folk traditional Chinese medicine in Linfen City, analyze practitioner characteristics, inheritance modes, and social acceptance, and to p...Objective: To investigate the current status of inheritance and development of folk traditional Chinese medicine in Linfen City, analyze practitioner characteristics, inheritance modes, and social acceptance, and to provide references for standardized management and rational development of folk traditional Chinese medicine. Methods: A questionnaire-based survey was conducted from January to December 2025 among folk traditional Chinese medicine practitioners, medical staff, and urban and rural residents in Linfen City. The survey content included basic characteristics of practitioners, inheritance modes, practice status, and levels of recognition of folk traditional Chinese medicine among different population groups. An Excel database was established, and descriptive statistical analysis was performed using SPSS version 26.0. Results: A total of 349 participants were surveyed, including 99 folk traditional Chinese medicine practitioners, 100 medical staff members, and 150 urban and rural residents. Most practitioners were middle-aged or elderly, had more than 10 years of practice experience, primarily inherited their skills through apprenticeship or family transmission, and had a relatively low proportion of systematic theoretical training in traditional Chinese medicine. Residents showed a high level of acceptance of folk traditional Chinese medicine, whereas medical staff demonstrated a relatively cautious attitude. Conclusion: Folk traditional Chinese medicine in Linfen City has a certain social foundation and practical value;however, further improvements are needed in standardized inheritance, management mechanisms, and sustainable development.展开更多
The microstructure and mechanical properties of Ti-Zr deoxidized low carbon microalloyed steel after‘quenching+tempering’(Q+T)and‘quenching+intercritical quenching+tempering’(Q+IQ+T)heat treatment were analyzed us...The microstructure and mechanical properties of Ti-Zr deoxidized low carbon microalloyed steel after‘quenching+tempering’(Q+T)and‘quenching+intercritical quenching+tempering’(Q+IQ+T)heat treatment were analyzed using the metallographic microscope,scanning electron microscope,electron probe microanalyzer,electronic universal testing machine and impact testing machine.The effect of element segregation band after hot rolling on the anisotropy of microstructure and mechanical properties of subsequent heat treatment was investigated.The results show that the essence of improving the banded structure by oxide metallurgy technology in the hot rolling process is to promote the formation of intragranular ferrite to break the bainite band,but the element segregation band produced during hot rolling will be inherited to the subsequent heat treatment process.After Q+T heat treatment,the microstructure is mainly martensite,and there is no obvious banded structure.The shear transformation of martensite weakens the influence of alloying element segregation and avoids the directionality of microstructure and the anisotropy of mechanical properties.After Q+IQ+T heat treatment,the martensite/ferrite bands or continuous martensite bands appear in the microstructure,and with the increase in intercritical quenching temperature,continuous martensite bands become more obvious.The appearance of banded structure aggravates the difference of mechanical properties in all directions,especially the difference of plasticity and toughness in longitudinal and transverse directions.Therefore,the banded structure can be avoided by regulating the nucleation rate difference between the element enrichment and depleted zones during the heat treatment process.The alloying elements segregation is a necessary condition for the formation of banded structure after heat treatment,but it is not a sufficient condition.展开更多
Photoreceptor degeneration is a major cause of vision impairment in retinal diseases,for which no effective treatment currently exists.Previous research by our team demonstrated that Lycium barbarum glycopeptide and l...Photoreceptor degeneration is a major cause of vision impairment in retinal diseases,for which no effective treatment currently exists.Previous research by our team demonstrated that Lycium barbarum glycopeptide and luteolin can independently promote photoreceptor survival and function in degenerated mouse retinas,although with limited efficacy.This study evaluated whether a combination of Lycium barbarum glycopeptide and luteolin provides enhanced therapeutic benefits compared with either compound alone.Wild-type mice received a daily oral gavage of Lycium barbarum glycopeptide and luteolin for 7 days prior to intraperitoneal injection of N-nitroso-N-methylurea to induce photoreceptor damage.The treatment continued for an additional week after injury.Retinal structure and function were subsequently assessed using electroretinogram recordings,visual behavior testing,and immunostaining.Western blot analysis was conducted to investigate the underlying protective mechanisms.The results showed that the Lycium barbarum glycopeptide-luteolin mixture significantly increased photoreceptor survival,improved retinal light response,and enhanced visual behavior.Importantly,the combination outperformed either compound alone in protective efficacy.Mechanistic analysis indicated that the mixture suppressed retinal inflammation and modulated the extracellular signal-regulated kinase and Bcl-2-associated X protein/B-cell lymphoma 2 signaling pathways.These findings suggest that the combination of Lycium barbarum glycopeptide and luteolin represents a promising therapeutic strategy for photoreceptor degeneration.展开更多
Background:The historical trajectory of TCM appropriate technologies spans from their primordial origins in daily life practices,through the systematization of classical theoretical frameworks,to modern scientific val...Background:The historical trajectory of TCM appropriate technologies spans from their primordial origins in daily life practices,through the systematization of classical theoretical frameworks,to modern scientific validation and health management applications.Methods:Employing literature review and historical analysis methodologies,this study systematically traces and synthesizes the entire developmental pathway of TCM appropriate technologies.Results:The analysis reveals the intrinsic developmental patterns of these technologies and underscores their practical significance in“preventive treatment”and chronic condition management.A key exemplar of modern innovation is presented:the Hand Twelve Jing-Well Points Exercise.This non-invasive technique adapts the classical Jing-Well Points(jǐng xué)theory,extending its traditional functions in emergency care and brain health from a focus on“treating established diseases”to the paradigm of“preventive treatment.”Conclusion:This research provides a comprehensive case study for the systematic investigation of TCM appropriate technologies.It elucidates a model of inheritance and innovation within modern healthcare systems and offers a theoretical foundation for the promotion and cultural dissemination of these practices.展开更多
Medical history summary:The child has suffered from episodic joint pain in the lower extremities since childhood,with occurrences ranging from 1 to 3 times daily,predominantly during rainy,cold,and humid weather,as we...Medical history summary:The child has suffered from episodic joint pain in the lower extremities since childhood,with occurrences ranging from 1 to 3 times daily,predominantly during rainy,cold,and humid weather,as well as in the afternoons and evenings.Symptoms and signs:The primary manifestation is episodic pain in the distal extremities,predominantly in the lower limbs,knees,and ankles.Occasionally,the pain may ascend to the elbows,wrists,and palms,and may occasionally affect the proximal extremities and waist.Diagnostic methods:Nerve biopsy and related pathological examinations,along with whole exome sequencing,are helpful for diagnosis,particularly the detection of variants in the SCN11A gene.Treatment approaches:(1)Pharmacotherapy:Sodium channel blockers and nonsteroidal anti-inflammatory drugs such as ibuprofen and naproxen can alleviate pain.(2)Neuromodulation techniques:Techniques such as transcranial magnetic stimulation(TMS)and spinal cord stimulation(SCS)can be employed to improve symptoms.(3)Psychotherapy:Cognitive-behavioral therapy(CBT),relaxation training,or psychological counseling can enhance the patient’s coping abilities.Clinical outcome:Pain relief can be achieved with analgesic medication in children,and pain symptoms generally persist until adulthood,gradually diminishing or even disappearing.Patients can reduce the frequency of episodes by staying warm and avoiding cold and damp conditions.展开更多
In the year 2026,the world cultural exchanges will continue to develop,while the international public opinion environment remainsdive rseand complex.Looking back at this pivotal moment in history,the life journey of S...In the year 2026,the world cultural exchanges will continue to develop,while the international public opinion environment remainsdive rseand complex.Looking back at this pivotal moment in history,the life journey of Sunny Wu,Chairman of the Hong Kong Doyens’Club,resonates perfectly with the national development.展开更多
BACKGROUND Early renal artery thrombosis after kidney transplantation is rare but often leads to graft loss.Prompt diagnosis and intervention are essential,particularly in patients with inherited thrombophilias such a...BACKGROUND Early renal artery thrombosis after kidney transplantation is rare but often leads to graft loss.Prompt diagnosis and intervention are essential,particularly in patients with inherited thrombophilias such as factor V Leiden(FVL)mutation.CASE SUMMARY A kidney transplant recipient with FVL mutation developed an acute transplant renal artery thrombosis.The immediate post-operative Doppler ultrasonography revealed thrombosis of the main and inferior polar renal arteries.Emergent thrombectomy and separate arterial re-anastomoses were performed after cold perfusion with heparinized saline and vasodilator solution.Reperfusion was successful with immediate urine output and gradual improvement in renal function.The patient was discharged on direct oral anticoagulation therapy.CONCLUSION Early detection and surgical intervention can preserve graft function in posttransplant renal artery thrombosis even in patients at high risk.展开更多
N6-methyladenosine(m^(6)A)modification of mRNA is a critical post-transcriptional regulatory mechanism that modulates mRNA metabolism and neuronal function.The m^(6)A reader YTHDF1 has been shown to enhance the transl...N6-methyladenosine(m^(6)A)modification of mRNA is a critical post-transcriptional regulatory mechanism that modulates mRNA metabolism and neuronal function.The m^(6)A reader YTHDF1 has been shown to enhance the translational efficiency of m^(6)A-modified mRNAs in the brain and is essential for learning and memory.However,its role in the mature retina remains unclear.Herein,we report a novel role of Ythdf1 in the maintenance of retinal function using a genetic knockout model.Loss of Ythdf1 resulted in impaired scotopic electroretinogram(ERG)responses and progressive retinal degeneration.Detailed analyses of rod photoreceptors confirmed substantial degenerative changes in the absence of ciliary defects.Single-cell RNA sequencing revealed comprehensive molecular alterations across all retinal cell types in Ythdf1-deficient retinas.Integrative analysis of methylated RNA immunoprecipitation(MeRIP)sequencing and RIP sequencing identified Tulp1 and Dhx38,two inheritable retinal degeneration disease-associated gene homologs,as direct targets of YTHDF1 in the retina.Specifically,YTHDF1 recognized and bound m^(6)A-modified Tulp1 and Dhx38 mRNA at the coding sequence(CDS),enhancing their translational efficiency without altering mRNA levels.Collectively,these findings highlight the essential role of YTHDF1 in preserving visual function and reveal a novel regulatory mechanism of m^(6)A reader proteins in retinal degeneration,identifying potential therapeutic targets for severe retinopathies.展开更多
Liver transplantation is hindered by organ shortage. The potential way to relieve this issue is to expand the donor pool via extending the donor criteria and make full use of all available grafts. The concept of “no-...Liver transplantation is hindered by organ shortage. The potential way to relieve this issue is to expand the donor pool via extending the donor criteria and make full use of all available grafts. The concept of “no-donor” liver transplantation allows grafts to be recovered from other liver recipients. This review summarizes the current clinical practice of “no-donor” liver transplantation, focusing on the experiences of Chinese transplant teams. Domino liver transplantation was introduced by Furtado in 1995 and implemented later in 2013 in China, and novel donor indications including some essential-to-treat inherited metabolic liver-based diseases have emerged. The concept of cross-auxiliary domino liver transplantation brings a further expansion of the domino liver graft pool, and the first pair of liver transplantation performed “rigorously without donation” was accomplished in our center in 2018. Our experience with this original transplantation procedure is hereby reviewed. In order to further promote and make successful “no-donor” liver transplantation, close co-operation between researchers, surgeons, physicians, organ procurement organizations, as well as ethical committees is required.展开更多
The Yangtze River Economic Belt is the birthplace of the world s rice farming culture,and is the origin of common rice(Oryza sativa L.),wild rice(Oryza Rufipogon Griff.),medicinal rice(Oryza officinalis Wall.ex G.Watt...The Yangtze River Economic Belt is the birthplace of the world s rice farming culture,and is the origin of common rice(Oryza sativa L.),wild rice(Oryza Rufipogon Griff.),medicinal rice(Oryza officinalis Wall.ex G.Watt),and wart-grain rice(Oryza granate Nees et Arn.ex Hook.f.).Rice culture is the main theme of agricultural culture in this economic belt and an outstanding representative of excellent traditional Chinese culture.This study provides an overview of the history of rice cultivation in the belt from the prehistory,post-history and modern progress.It studies the agricultural cultural heritage resources of the whole rice industry chain from the biological genetic resources,world cultural heritage,key cultural relics protection units,national archaeological site parks,movable cultural relics,important agricultural cultural heritage,intangible cultural heritage,China time-honored brands,historical names,traditional markers,tribute culture,archival and documentary heritage.It also analyzes the six main problems in the inheritance and development of rice farming culture,and proposes 8 strategies,including promoting the inheritance and innovative development of excellent traditional Chinese culture through the inheritance of rice farming culture,promoting the Exploration of the Origins of Chinese Civilization Project through rice farming culture,and creating the Yangtze River National Cultural Park with rice farming culture as the main theme.展开更多
At the global themed event of 2025 Lanting Culture Salon:Chinese Calligraphy,we witnessed the inheritance and innovation of the art of calligraphy.Artists,based on the traditional calligraphy,incorporated new creativi...At the global themed event of 2025 Lanting Culture Salon:Chinese Calligraphy,we witnessed the inheritance and innovation of the art of calligraphy.Artists,based on the traditional calligraphy,incorporated new creativity and elements,having the art of calligraphy radiate new vitality and vigor.These activities broke through the traditional exhibition mode by adopting innovative forms such as digital interaction,cross-border creation and immersive experiences.This allowed the visitors to experience the charm of the art of calligraphy through interaction,further promoting communication and popularization of calligraphy culture.展开更多
Perched on crimson shoulders,Potala ascends a celestial stairway.Alabaster walls cradle golden roofs.Ancient stones murmur mantras,corridors breathe incense.Shadows dance with prayer flags,weaving time into silk.A sac...Perched on crimson shoulders,Potala ascends a celestial stairway.Alabaster walls cradle golden roofs.Ancient stones murmur mantras,corridors breathe incense.Shadows dance with prayer flags,weaving time into silk.A sacred place in pilgrims'hearts,it guards the soul of this snowy plateau stretching vastly across western China.展开更多
The color and pattern of watermelon rind are crucial external traits that directly affect consumer preferences.Watermelons with stripes having a stronger color than the background rind are ideal for studying stripe pa...The color and pattern of watermelon rind are crucial external traits that directly affect consumer preferences.Watermelons with stripes having a stronger color than the background rind are ideal for studying stripe patterns in plants,while there is still limited knowledge about the genetic mechanisms underlying stripe coloration due to the lack of germplasm resources.In this study,we focused on a watermelon germplasm with colorless stripes,and genetic analysis revealed that the trait is controlled by a single recessive gene.The gene Clsc(Citrullus lanatus stripe coloration),which is responsible for the colorless stripe,was localized into a 147.6 kb region on Chr9 by linkage analysis in a large F2 mapping population.Further analysis revealed that the Cla97C09G175170 gene encodes the APRR2 transcription factor,plays a crucial role in determining the watermelon colorless stripe phenotype and was deduced to be related to chlorophyll synthesis and chloroplast development.Physiological experiments indicated that Cla97C09G175170 may significantly influence chloroplast development and chlorophyll synthesis in watermelon.The results of this study provide a better understanding of the molecular mechanism of stripe coloration in watermelon and can be useful in the development of marker-assisted selection(MAS)for new watermelon cultivars.展开更多
Roots and reverence:The New Years Eve of ancestral traditions Unlike many Chinese families,who spend the New Years Eve watching the CCTV New Years Gala,my family assembles in the clan hall to honor our ancestors.This ...Roots and reverence:The New Years Eve of ancestral traditions Unlike many Chinese families,who spend the New Years Eve watching the CCTV New Years Gala,my family assembles in the clan hall to honor our ancestors.This ritual has been passed down for generations,and now it is our turn to carry it forward.展开更多
Traditional architecture,as a crucial component of human cultural heritage,conveys significant historical context and cultural significance while reflecting regional traits and national identity.Nevertheless,in the fa...Traditional architecture,as a crucial component of human cultural heritage,conveys significant historical context and cultural significance while reflecting regional traits and national identity.Nevertheless,in the face of rapid modernization,traditional architecture is encountering challenges on an unprecedented scale.This study focuses on examining the strategies for preserving and transforming traditional architecture.By evaluating the importance,issues,and obstacles associated with safeguarding traditional architecture,this paper seeks to propose effective and rational conservation approaches and transformation techniques,ultimately aiming to ensure the sustainable development and cultural continuity of traditional architecture.展开更多
Chinese medicine,as a treasure of China’s traditional culture,has a long history and deep cultural heritage,and talents are the first resource for the development of Chinese medicine.In ancient times,there were many ...Chinese medicine,as a treasure of China’s traditional culture,has a long history and deep cultural heritage,and talents are the first resource for the development of Chinese medicine.In ancient times,there were many famous Chinese medicine practitioners with excellent medical skills and fame,and their main ways of success were through teaching and family tradition.The cultivation of high medical ethics,benevolence and love,and helping the world and the people is the source of motivation for success;familiarizing oneself with the classics,understanding the humanities,and being knowledgeable about things past and present is an important way for success;practicing diligently,learning from all the strengths,and observing the right and innovating is the key to success.This paper analyzes the growth path of ancient Chinese medicine masters and discusses the advantages and shortcomings of contemporary Chinese medicine talent training,with a view to providing certain references for the cultivation of Chinese medicine talents.展开更多
A recent discovery in rice has revealed an elegant trick of nature:crops can teach their later generations to survive the cold through inherited memories written in chemical marks on the DNA letters,representing the f...A recent discovery in rice has revealed an elegant trick of nature:crops can teach their later generations to survive the cold through inherited memories written in chemical marks on the DNA letters,representing the first clear demonstration of what scientists call the“inheritance of acquired characteristics”-a phenomenon that biologists have debated for over two centuries.展开更多
With their high economic value and cultural significance,modern roses are one of the most important ornamental plants.Because of their complicated genetic background and tetraploid nature,the creation of high-density ...With their high economic value and cultural significance,modern roses are one of the most important ornamental plants.Because of their complicated genetic background and tetraploid nature,the creation of high-density genetic maps of roses has been a challenge that has slowed the pace of molecular breeding for modern roses.The current construction of tetraploid genetic maps based on existing diploid rose genomes could lead to inaccurate marker information and genotyping results.Therefore,we generated the first high-quality tetraploid genome of Rosa chinensis‘Yunzheng Xiawei.'Utilizing Illumina,PacBio,and Hi-C sequencing technologies,we assembled a genome of 858.59 Mb with 14pseudo-chromosomes.Mode of inheritance analysis using PolyOrigin indicated that modern roses show both quadrivalent and bivalent pairing.Based on this reference genome,high-density genetic maps were constructed using MSTmap with nearly saturated markers.Quantitative trait locus(QTL)analysis was conducted using WinQTLCart and R/qtl for flavonoids and carotenoids,and 11 QTL clusters were identified.By combining the genome annotation,phylogenetic analyses,and gene expression analyses,we were able to identify several key genes related to flavonoid and carotenoid biosynthesis.This study provides the basis for further genetic analyses of highly heterozygous tetraploid roses and could facilitate the progress of marker-assisted selection in modern roses.展开更多
基金supported by the National Natural Science Foundation of China(32230005).
文摘Epigenetics refers to heritable changes in gene function that occur without alterations to the DNA sequence.Major epigenetic mechanisms include DNA methylation,histone modifications,chromatin remodeling,and the regulatory ac-tions of small RNAs and long noncoding RNAs(Allis and Jenuwein,2016).These layers of regulation are essential for modulating gene expression and are widely involved in the regulation of plant growth and development,as well as in responses to environmental cues(Hemenway and Gehring,2023).
基金Supported by the Project of National Social Science Fund of China(22CMZ015).
文摘Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.
文摘Objective: To investigate the current status of inheritance and development of folk traditional Chinese medicine in Linfen City, analyze practitioner characteristics, inheritance modes, and social acceptance, and to provide references for standardized management and rational development of folk traditional Chinese medicine. Methods: A questionnaire-based survey was conducted from January to December 2025 among folk traditional Chinese medicine practitioners, medical staff, and urban and rural residents in Linfen City. The survey content included basic characteristics of practitioners, inheritance modes, practice status, and levels of recognition of folk traditional Chinese medicine among different population groups. An Excel database was established, and descriptive statistical analysis was performed using SPSS version 26.0. Results: A total of 349 participants were surveyed, including 99 folk traditional Chinese medicine practitioners, 100 medical staff members, and 150 urban and rural residents. Most practitioners were middle-aged or elderly, had more than 10 years of practice experience, primarily inherited their skills through apprenticeship or family transmission, and had a relatively low proportion of systematic theoretical training in traditional Chinese medicine. Residents showed a high level of acceptance of folk traditional Chinese medicine, whereas medical staff demonstrated a relatively cautious attitude. Conclusion: Folk traditional Chinese medicine in Linfen City has a certain social foundation and practical value;however, further improvements are needed in standardized inheritance, management mechanisms, and sustainable development.
基金supported by the National Natural Science Foundation of China(No.52304358)Young Elite Scientists Sponsorship Program by CAST(No.YESS20230462).
文摘The microstructure and mechanical properties of Ti-Zr deoxidized low carbon microalloyed steel after‘quenching+tempering’(Q+T)and‘quenching+intercritical quenching+tempering’(Q+IQ+T)heat treatment were analyzed using the metallographic microscope,scanning electron microscope,electron probe microanalyzer,electronic universal testing machine and impact testing machine.The effect of element segregation band after hot rolling on the anisotropy of microstructure and mechanical properties of subsequent heat treatment was investigated.The results show that the essence of improving the banded structure by oxide metallurgy technology in the hot rolling process is to promote the formation of intragranular ferrite to break the bainite band,but the element segregation band produced during hot rolling will be inherited to the subsequent heat treatment process.After Q+T heat treatment,the microstructure is mainly martensite,and there is no obvious banded structure.The shear transformation of martensite weakens the influence of alloying element segregation and avoids the directionality of microstructure and the anisotropy of mechanical properties.After Q+IQ+T heat treatment,the martensite/ferrite bands or continuous martensite bands appear in the microstructure,and with the increase in intercritical quenching temperature,continuous martensite bands become more obvious.The appearance of banded structure aggravates the difference of mechanical properties in all directions,especially the difference of plasticity and toughness in longitudinal and transverse directions.Therefore,the banded structure can be avoided by regulating the nucleation rate difference between the element enrichment and depleted zones during the heat treatment process.The alloying elements segregation is a necessary condition for the formation of banded structure after heat treatment,but it is not a sufficient condition.
基金Natural Science Foundation of Guangdong Province,No.2023A1515012397(to YX)the National Natural Science Foundation of China,No.82074169(to XM)+2 种基金the Guangdong Basic and Applied Basic Research Foundation,No.2021A1515012473(to XM)and Project of Administration of Traditional Chinese Medicine of Guangdong Province,No.20202045(to XM)Aier Eye Hospital Group,No.AF2019001(to ST,KFS,YX,and XM).
文摘Photoreceptor degeneration is a major cause of vision impairment in retinal diseases,for which no effective treatment currently exists.Previous research by our team demonstrated that Lycium barbarum glycopeptide and luteolin can independently promote photoreceptor survival and function in degenerated mouse retinas,although with limited efficacy.This study evaluated whether a combination of Lycium barbarum glycopeptide and luteolin provides enhanced therapeutic benefits compared with either compound alone.Wild-type mice received a daily oral gavage of Lycium barbarum glycopeptide and luteolin for 7 days prior to intraperitoneal injection of N-nitroso-N-methylurea to induce photoreceptor damage.The treatment continued for an additional week after injury.Retinal structure and function were subsequently assessed using electroretinogram recordings,visual behavior testing,and immunostaining.Western blot analysis was conducted to investigate the underlying protective mechanisms.The results showed that the Lycium barbarum glycopeptide-luteolin mixture significantly increased photoreceptor survival,improved retinal light response,and enhanced visual behavior.Importantly,the combination outperformed either compound alone in protective efficacy.Mechanistic analysis indicated that the mixture suppressed retinal inflammation and modulated the extracellular signal-regulated kinase and Bcl-2-associated X protein/B-cell lymphoma 2 signaling pathways.These findings suggest that the combination of Lycium barbarum glycopeptide and luteolin represents a promising therapeutic strategy for photoreceptor degeneration.
基金supported by the Tianjin Municipal Education Commission Scientific Research Plan Project(Grant No.2022ZD042).
文摘Background:The historical trajectory of TCM appropriate technologies spans from their primordial origins in daily life practices,through the systematization of classical theoretical frameworks,to modern scientific validation and health management applications.Methods:Employing literature review and historical analysis methodologies,this study systematically traces and synthesizes the entire developmental pathway of TCM appropriate technologies.Results:The analysis reveals the intrinsic developmental patterns of these technologies and underscores their practical significance in“preventive treatment”and chronic condition management.A key exemplar of modern innovation is presented:the Hand Twelve Jing-Well Points Exercise.This non-invasive technique adapts the classical Jing-Well Points(jǐng xué)theory,extending its traditional functions in emergency care and brain health from a focus on“treating established diseases”to the paradigm of“preventive treatment.”Conclusion:This research provides a comprehensive case study for the systematic investigation of TCM appropriate technologies.It elucidates a model of inheritance and innovation within modern healthcare systems and offers a theoretical foundation for the promotion and cultural dissemination of these practices.
文摘Medical history summary:The child has suffered from episodic joint pain in the lower extremities since childhood,with occurrences ranging from 1 to 3 times daily,predominantly during rainy,cold,and humid weather,as well as in the afternoons and evenings.Symptoms and signs:The primary manifestation is episodic pain in the distal extremities,predominantly in the lower limbs,knees,and ankles.Occasionally,the pain may ascend to the elbows,wrists,and palms,and may occasionally affect the proximal extremities and waist.Diagnostic methods:Nerve biopsy and related pathological examinations,along with whole exome sequencing,are helpful for diagnosis,particularly the detection of variants in the SCN11A gene.Treatment approaches:(1)Pharmacotherapy:Sodium channel blockers and nonsteroidal anti-inflammatory drugs such as ibuprofen and naproxen can alleviate pain.(2)Neuromodulation techniques:Techniques such as transcranial magnetic stimulation(TMS)and spinal cord stimulation(SCS)can be employed to improve symptoms.(3)Psychotherapy:Cognitive-behavioral therapy(CBT),relaxation training,or psychological counseling can enhance the patient’s coping abilities.Clinical outcome:Pain relief can be achieved with analgesic medication in children,and pain symptoms generally persist until adulthood,gradually diminishing or even disappearing.Patients can reduce the frequency of episodes by staying warm and avoiding cold and damp conditions.
文摘In the year 2026,the world cultural exchanges will continue to develop,while the international public opinion environment remainsdive rseand complex.Looking back at this pivotal moment in history,the life journey of Sunny Wu,Chairman of the Hong Kong Doyens’Club,resonates perfectly with the national development.
文摘BACKGROUND Early renal artery thrombosis after kidney transplantation is rare but often leads to graft loss.Prompt diagnosis and intervention are essential,particularly in patients with inherited thrombophilias such as factor V Leiden(FVL)mutation.CASE SUMMARY A kidney transplant recipient with FVL mutation developed an acute transplant renal artery thrombosis.The immediate post-operative Doppler ultrasonography revealed thrombosis of the main and inferior polar renal arteries.Emergent thrombectomy and separate arterial re-anastomoses were performed after cold perfusion with heparinized saline and vasodilator solution.Reperfusion was successful with immediate urine output and gradual improvement in renal function.The patient was discharged on direct oral anticoagulation therapy.CONCLUSION Early detection and surgical intervention can preserve graft function in posttransplant renal artery thrombosis even in patients at high risk.
基金supported by the National Natural Science Foundation of China(82371083,82471100,82121003,82271084)Program of Science and Technology International Cooperation Project of Qinghai province(China)(2022-HZ-814)。
文摘N6-methyladenosine(m^(6)A)modification of mRNA is a critical post-transcriptional regulatory mechanism that modulates mRNA metabolism and neuronal function.The m^(6)A reader YTHDF1 has been shown to enhance the translational efficiency of m^(6)A-modified mRNAs in the brain and is essential for learning and memory.However,its role in the mature retina remains unclear.Herein,we report a novel role of Ythdf1 in the maintenance of retinal function using a genetic knockout model.Loss of Ythdf1 resulted in impaired scotopic electroretinogram(ERG)responses and progressive retinal degeneration.Detailed analyses of rod photoreceptors confirmed substantial degenerative changes in the absence of ciliary defects.Single-cell RNA sequencing revealed comprehensive molecular alterations across all retinal cell types in Ythdf1-deficient retinas.Integrative analysis of methylated RNA immunoprecipitation(MeRIP)sequencing and RIP sequencing identified Tulp1 and Dhx38,two inheritable retinal degeneration disease-associated gene homologs,as direct targets of YTHDF1 in the retina.Specifically,YTHDF1 recognized and bound m^(6)A-modified Tulp1 and Dhx38 mRNA at the coding sequence(CDS),enhancing their translational efficiency without altering mRNA levels.Collectively,these findings highlight the essential role of YTHDF1 in preserving visual function and reveal a novel regulatory mechanism of m^(6)A reader proteins in retinal degeneration,identifying potential therapeutic targets for severe retinopathies.
基金supported by grants from Capital’s Funds for Health Improvement and Research (2024–1–2022)Beijing Nat-ural Science Foundation (7244318)。
文摘Liver transplantation is hindered by organ shortage. The potential way to relieve this issue is to expand the donor pool via extending the donor criteria and make full use of all available grafts. The concept of “no-donor” liver transplantation allows grafts to be recovered from other liver recipients. This review summarizes the current clinical practice of “no-donor” liver transplantation, focusing on the experiences of Chinese transplant teams. Domino liver transplantation was introduced by Furtado in 1995 and implemented later in 2013 in China, and novel donor indications including some essential-to-treat inherited metabolic liver-based diseases have emerged. The concept of cross-auxiliary domino liver transplantation brings a further expansion of the domino liver graft pool, and the first pair of liver transplantation performed “rigorously without donation” was accomplished in our center in 2018. Our experience with this original transplantation procedure is hereby reviewed. In order to further promote and make successful “no-donor” liver transplantation, close co-operation between researchers, surgeons, physicians, organ procurement organizations, as well as ethical committees is required.
基金Supported by Social Science Foundation of Hubei Province(HBSKJJ20243227)Doctoral Initiation Project of Hubei University of Science and Technology(BK201819).
文摘The Yangtze River Economic Belt is the birthplace of the world s rice farming culture,and is the origin of common rice(Oryza sativa L.),wild rice(Oryza Rufipogon Griff.),medicinal rice(Oryza officinalis Wall.ex G.Watt),and wart-grain rice(Oryza granate Nees et Arn.ex Hook.f.).Rice culture is the main theme of agricultural culture in this economic belt and an outstanding representative of excellent traditional Chinese culture.This study provides an overview of the history of rice cultivation in the belt from the prehistory,post-history and modern progress.It studies the agricultural cultural heritage resources of the whole rice industry chain from the biological genetic resources,world cultural heritage,key cultural relics protection units,national archaeological site parks,movable cultural relics,important agricultural cultural heritage,intangible cultural heritage,China time-honored brands,historical names,traditional markers,tribute culture,archival and documentary heritage.It also analyzes the six main problems in the inheritance and development of rice farming culture,and proposes 8 strategies,including promoting the inheritance and innovative development of excellent traditional Chinese culture through the inheritance of rice farming culture,promoting the Exploration of the Origins of Chinese Civilization Project through rice farming culture,and creating the Yangtze River National Cultural Park with rice farming culture as the main theme.
文摘At the global themed event of 2025 Lanting Culture Salon:Chinese Calligraphy,we witnessed the inheritance and innovation of the art of calligraphy.Artists,based on the traditional calligraphy,incorporated new creativity and elements,having the art of calligraphy radiate new vitality and vigor.These activities broke through the traditional exhibition mode by adopting innovative forms such as digital interaction,cross-border creation and immersive experiences.This allowed the visitors to experience the charm of the art of calligraphy through interaction,further promoting communication and popularization of calligraphy culture.
文摘Perched on crimson shoulders,Potala ascends a celestial stairway.Alabaster walls cradle golden roofs.Ancient stones murmur mantras,corridors breathe incense.Shadows dance with prayer flags,weaving time into silk.A sacred place in pilgrims'hearts,it guards the soul of this snowy plateau stretching vastly across western China.
基金supported by grants from theKey Scientific and Technological Project of Henan Province,China(222102110124)the Joint Fund of Science and Technology Research and Development Plan,Henan Province,China(222103810009)+4 种基金the National Natural Science Foundation of China(32172574,3217180560)the Funding of Joint Research on Agricultural Varieties Improvement of Henan Province,China(2022010503)the Major Science and Technology Project of Henan Province,China(221100110400)the Natural Science Foundation of Henan,China(222300420050)the Science and Technology Innovation Talent Support Program of Henan Province,China(23HASTIT034).
文摘The color and pattern of watermelon rind are crucial external traits that directly affect consumer preferences.Watermelons with stripes having a stronger color than the background rind are ideal for studying stripe patterns in plants,while there is still limited knowledge about the genetic mechanisms underlying stripe coloration due to the lack of germplasm resources.In this study,we focused on a watermelon germplasm with colorless stripes,and genetic analysis revealed that the trait is controlled by a single recessive gene.The gene Clsc(Citrullus lanatus stripe coloration),which is responsible for the colorless stripe,was localized into a 147.6 kb region on Chr9 by linkage analysis in a large F2 mapping population.Further analysis revealed that the Cla97C09G175170 gene encodes the APRR2 transcription factor,plays a crucial role in determining the watermelon colorless stripe phenotype and was deduced to be related to chlorophyll synthesis and chloroplast development.Physiological experiments indicated that Cla97C09G175170 may significantly influence chloroplast development and chlorophyll synthesis in watermelon.The results of this study provide a better understanding of the molecular mechanism of stripe coloration in watermelon and can be useful in the development of marker-assisted selection(MAS)for new watermelon cultivars.
文摘Roots and reverence:The New Years Eve of ancestral traditions Unlike many Chinese families,who spend the New Years Eve watching the CCTV New Years Gala,my family assembles in the clan hall to honor our ancestors.This ritual has been passed down for generations,and now it is our turn to carry it forward.
文摘Traditional architecture,as a crucial component of human cultural heritage,conveys significant historical context and cultural significance while reflecting regional traits and national identity.Nevertheless,in the face of rapid modernization,traditional architecture is encountering challenges on an unprecedented scale.This study focuses on examining the strategies for preserving and transforming traditional architecture.By evaluating the importance,issues,and obstacles associated with safeguarding traditional architecture,this paper seeks to propose effective and rational conservation approaches and transformation techniques,ultimately aiming to ensure the sustainable development and cultural continuity of traditional architecture.
基金supported by the National Natural Science Foundation of China(Grant No.82260925)Yunnan Provincial High-level Scientific and Technological Talents and Innovative Teams Selection Special Project(Grant No.202305AS350007)+2 种基金Yunnan Provincial Major Scientific and Technological Special Project Program for Biomedicine(Grant No.202402AA310028)Yunnan Province’s High-level Talent Cultivation Project for Successors in Traditional Chinese Medicine Disciplines(Yun Cai She[2024]No.103)Yunnan Provincial Key Laboratory of Dai and Yi Medicine Open Research Topics(2024SS24010).
文摘Chinese medicine,as a treasure of China’s traditional culture,has a long history and deep cultural heritage,and talents are the first resource for the development of Chinese medicine.In ancient times,there were many famous Chinese medicine practitioners with excellent medical skills and fame,and their main ways of success were through teaching and family tradition.The cultivation of high medical ethics,benevolence and love,and helping the world and the people is the source of motivation for success;familiarizing oneself with the classics,understanding the humanities,and being knowledgeable about things past and present is an important way for success;practicing diligently,learning from all the strengths,and observing the right and innovating is the key to success.This paper analyzes the growth path of ancient Chinese medicine masters and discusses the advantages and shortcomings of contemporary Chinese medicine talent training,with a view to providing certain references for the cultivation of Chinese medicine talents.
文摘A recent discovery in rice has revealed an elegant trick of nature:crops can teach their later generations to survive the cold through inherited memories written in chemical marks on the DNA letters,representing the first clear demonstration of what scientists call the“inheritance of acquired characteristics”-a phenomenon that biologists have debated for over two centuries.
基金supported by National Natural Science Foundation of China(Grant No.32071818)。
文摘With their high economic value and cultural significance,modern roses are one of the most important ornamental plants.Because of their complicated genetic background and tetraploid nature,the creation of high-density genetic maps of roses has been a challenge that has slowed the pace of molecular breeding for modern roses.The current construction of tetraploid genetic maps based on existing diploid rose genomes could lead to inaccurate marker information and genotyping results.Therefore,we generated the first high-quality tetraploid genome of Rosa chinensis‘Yunzheng Xiawei.'Utilizing Illumina,PacBio,and Hi-C sequencing technologies,we assembled a genome of 858.59 Mb with 14pseudo-chromosomes.Mode of inheritance analysis using PolyOrigin indicated that modern roses show both quadrivalent and bivalent pairing.Based on this reference genome,high-density genetic maps were constructed using MSTmap with nearly saturated markers.Quantitative trait locus(QTL)analysis was conducted using WinQTLCart and R/qtl for flavonoids and carotenoids,and 11 QTL clusters were identified.By combining the genome annotation,phylogenetic analyses,and gene expression analyses,we were able to identify several key genes related to flavonoid and carotenoid biosynthesis.This study provides the basis for further genetic analyses of highly heterozygous tetraploid roses and could facilitate the progress of marker-assisted selection in modern roses.
