In recent years,the rising prevalence of respiratory diseases,coupled with advancements in biotechnology and pharmacology,has positioned inhalable formulations as a preferred method of drug administration.This approac...In recent years,the rising prevalence of respiratory diseases,coupled with advancements in biotechnology and pharmacology,has positioned inhalable formulations as a preferred method of drug administration.This approach enables direct and rapid delivery of medication to the lungs,maximizing therapeutic effects while minimizing dosage and potential side effects.In this review,we meticulously examined current literature and clinical trial databases to present a comprehensive overview of three key areas:(1)inhalation devices currently utilized in clinical settings;(2)the clinical applications of approved inhalable formulations;and(3)preclinical research on inhalable treatments targeting various lung conditions,including pulmonary infections,tuberculosis,lung cancer,pulmonary fibrosis,as well as systemic diseases like Parkinson’s disease.The objective was to delve into both foundational research and the clinical use of inhalable formulations within the pharmaceutical field,with the aim of fostering their broader adoption and guiding the development of inhalable therapies for a more comprehensive range of diseases.展开更多
The respiratory tract is susceptible to various infections and can be affected by many serious diseases.Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases suc...The respiratory tract is susceptible to various infections and can be affected by many serious diseases.Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases such as malignancy.Direct delivery of vaccines to the respiratory tract could mimic the natural process of infection and shorten the delivery path,therefore unique mucosal immunity at the first line might be induced and the efficiency of delivery can be high.Despite considerable attempts at the development of respiratory vaccines,the rational formulation design still warrants attention,i.e.,how the formulation composition,particle properties,formulation type(liquid or solid),and devices would influence the immune outcome.This article reviews the recent advances in the formulation design and development of respiratory vaccines.The focus is on the state of the art of delivering antigenic com-pounds through the respiratory tract,overcoming the pulmonary bio-barriers,enhancing delivery effi-ciencies of respiratory vaccines as well as maintaining the stability of vaccines during storage and use.The choice of devices and the influence of deposition sites on vaccine efficiencies were also reviewed.展开更多
Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma,chronic obstructive pulmonary diseases and respiratory infections,and systemic diseases such as dia...Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma,chronic obstructive pulmonary diseases and respiratory infections,and systemic diseases such as diabetes.Most inhaled medicines could be cleared rapidly from the lungs and their therapeutic effects are transit.The inhaled medicines with extended pulmonary exposure may not only improve the patient compliance by reducing the frequency of drug administration,but also enhance the clinical benefits to the patients with improved therapeutic outcomes.This article systematically reviews the physical and chemical strategies to extend the pulmonary exposure of the inhaled medicines.It starts with an introduction of various physiological and pathophysiological barriers for designing inhaled medicines with extended lung exposure,which is followed by recent advances in various strategies to overcome these barriers.Finally,the applications of the inhaled medicines with extended lung exposure for the treatment of various diseases and the safety concerns associated to various strategies to extend the pulmonary exposure of the inhaled medicines are summarized.展开更多
文摘In recent years,the rising prevalence of respiratory diseases,coupled with advancements in biotechnology and pharmacology,has positioned inhalable formulations as a preferred method of drug administration.This approach enables direct and rapid delivery of medication to the lungs,maximizing therapeutic effects while minimizing dosage and potential side effects.In this review,we meticulously examined current literature and clinical trial databases to present a comprehensive overview of three key areas:(1)inhalation devices currently utilized in clinical settings;(2)the clinical applications of approved inhalable formulations;and(3)preclinical research on inhalable treatments targeting various lung conditions,including pulmonary infections,tuberculosis,lung cancer,pulmonary fibrosis,as well as systemic diseases like Parkinson’s disease.The objective was to delve into both foundational research and the clinical use of inhalable formulations within the pharmaceutical field,with the aim of fostering their broader adoption and guiding the development of inhalable therapies for a more comprehensive range of diseases.
基金supported by the Liaoning Pan Deng Xue Zhe Scholar(No.XLYC2002061,China)the National Natural Science Foundation of China(No.82173768)+4 种基金the Overseas Expertise Introduction Project for Discipline Innovation(“111 Project”)(No.D20029,China)D.C.acknowledges financial support from the Science and Technology Foundation of Liaoning Province(NO.2022-MS-241,China)the Ministry of Education Chunhui Program(2020)L.W.acknowledges the financial support from the National Natural Science Foundation of China(No.82204316)the China Postdoctoral Science Foundation(No.2021TQ0219 and 2022MD713776,China).
文摘The respiratory tract is susceptible to various infections and can be affected by many serious diseases.Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases such as malignancy.Direct delivery of vaccines to the respiratory tract could mimic the natural process of infection and shorten the delivery path,therefore unique mucosal immunity at the first line might be induced and the efficiency of delivery can be high.Despite considerable attempts at the development of respiratory vaccines,the rational formulation design still warrants attention,i.e.,how the formulation composition,particle properties,formulation type(liquid or solid),and devices would influence the immune outcome.This article reviews the recent advances in the formulation design and development of respiratory vaccines.The focus is on the state of the art of delivering antigenic com-pounds through the respiratory tract,overcoming the pulmonary bio-barriers,enhancing delivery effi-ciencies of respiratory vaccines as well as maintaining the stability of vaccines during storage and use.The choice of devices and the influence of deposition sites on vaccine efficiencies were also reviewed.
基金the Liaoning Pan Deng Xue Zhe scholarship for the financial support(China)Dongmei Cun thanks the financial support from the Guiding Project for Science and Technology of Liaoning Province(No.2019-ZD-0448,China)+1 种基金Minister of Education Chunhui Program(China)Hriday Bera thanks the National Natural Science Foundation of China(Nos.81850410554 and 82050410448)
文摘Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma,chronic obstructive pulmonary diseases and respiratory infections,and systemic diseases such as diabetes.Most inhaled medicines could be cleared rapidly from the lungs and their therapeutic effects are transit.The inhaled medicines with extended pulmonary exposure may not only improve the patient compliance by reducing the frequency of drug administration,but also enhance the clinical benefits to the patients with improved therapeutic outcomes.This article systematically reviews the physical and chemical strategies to extend the pulmonary exposure of the inhaled medicines.It starts with an introduction of various physiological and pathophysiological barriers for designing inhaled medicines with extended lung exposure,which is followed by recent advances in various strategies to overcome these barriers.Finally,the applications of the inhaled medicines with extended lung exposure for the treatment of various diseases and the safety concerns associated to various strategies to extend the pulmonary exposure of the inhaled medicines are summarized.
