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Illusion of inactivity:Revisiting progressive multiple sclerosis treatment paradigms
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作者 Tal Ganz Tamir Ben-Hur 《Neural Regeneration Research》 2026年第3期1134-1135,共2页
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v... Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven. 展开更多
关键词 inflammatory versus degenerative dichotomythis treatment paradigms illusion inactivity multiple sclerosis traditionallythe central nervous system cns which progressive multiple sclerosis active inflammation progressive multiple sclerosis pms
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AI-Driven Research Ecosystem: Unifying Human-AI Collaboration Models and New Research Thinking Paradigms
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作者 Feng Xiong Xinguo Yu +1 位作者 Hon Wai Leong Anran Ma 《教育技术与创新》 2025年第1期39-53,共15页
The integration of artificial intelligence(AI)is fundamentally reshaping the scientific research,giving rise to a new era of discovery and innovation.This paper explores this transformative shift,introducing an innova... The integration of artificial intelligence(AI)is fundamentally reshaping the scientific research,giving rise to a new era of discovery and innovation.This paper explores this transformative shift,introducing an innovative concept of the“AI-Driven Research Ecosystem”,a dynamic and collaborative research environment.Within this ecosystem,we focus on the unification of human-AI collaboration models and the emerging new research thinking paradigms.We analyze the multifaceted roles of AI within the research lifecycle,spanning from a passive tool to an active assistant and autonomous participants,and categorize these interactions into distinct human-AI collaboration models.Furthermore,we examine how the pervasive involvement of AI necessitates an evolution in human research thinking,emphasizing the significant roles of critical,creative,and computational thinking.Through a review of existing literature and illustrative case studies,this paper provides a comprehensive overview of the AI-driven research ecosystem,highlighting its potential for transforming scientific research.Our findings advance the current understanding of AI’s multiple roles in research and underscore its capacity to revolutionize both knowledge discovery and collaborative innovation,paving the way for a more integrated and impactful research paradigm. 展开更多
关键词 AI research ecosystem human–AI collaboration research thinking research paradigm
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Positioning Theory in Paradigms
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作者 付小秋 《海外英语》 2015年第12期204-205,共2页
This article discusses the importance of theory and paradigm to a researcher. It starts from introducing and analyzing thedefinition of the two terms, by using the theories in the field of intercultural communication ... This article discusses the importance of theory and paradigm to a researcher. It starts from introducing and analyzing thedefinition of the two terms, by using the theories in the field of intercultural communication as examples. To a good researcher, heneeds not only clarifying the paradigm his research is positioned, but also integrating the theories in his paradigm. 展开更多
关键词 THEORY paradigm interrelationship RESEARCH
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Paradigm Shifts or Methodology Changes ? Think Twice Before You Put Paradigms into Practice 被引量:1
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作者 Cormspondence: Yang Yonglin,Department Of Foreign Languages,Tsinghua University Beliing,P. R. China 《现代外语》 CSSCI 北大核心 1999年第4期420-420,共1页
ThepresentpaperaddressestheapplicabilityofKuhn'stheoryofparadigmshiftsandscientificrevolutionstothefieldoflanguageteaching.First,itillustratestheconceptionofparadigmshiftsandscientificrevolutions.Andthen,itsetsupt... ThepresentpaperaddressestheapplicabilityofKuhn'stheoryofparadigmshiftsandscientificrevolutionstothefieldoflanguageteaching.First,itillustratestheconceptionofparadigmshiftsandscientificrevolutions.Andthen,itsetsuptwotestsforexaminingtheissueofwhetherK... 展开更多
关键词 linguistic theory PSYCHOLOGY paradigm SHIFTS scientific REVOLUTIONS language teaching ECLECTICISM METHODOLOGY
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Low Power Computing Paradigms Based on Emerging Non-Volatile Nanodevices 被引量:1
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作者 G.-F.Wang W.Kang +4 位作者 Y.-Q.Cheng J.Nan J.-O.Klein Y.-G.Zhang W.-S.Zhao 《Journal of Electronic Science and Technology》 CAS 2014年第2期163-172,共10页
Traditional digital processing approaches are based on semiconductor transistors, which suffer from high power consumption, aggravating with technology node scaling. To solve definitively this problem, a number of eme... Traditional digital processing approaches are based on semiconductor transistors, which suffer from high power consumption, aggravating with technology node scaling. To solve definitively this problem, a number of emerging non-volatile nanodevices are under intense investigations. Meanwhile, novel computing circuits are invented to dig the full potential of the nanodevices. The combination of non-volatile nanodevices with suitable computing paradigms have many merits compared with the complementary metal-oxide-semiconductor transistor (CMOS) technology based structures, such as zero standby power, ultra-high density, non-volatility, and acceptable access speed. In this paper, we overview and compare the computing paradigms based on the emerging nanodevices towards ultra-low dissipation. 展开更多
关键词 Emerging nanodevices logic in memory low-power computing paradigms MEMRISTOR neuromorphic NORMALLY-OFF reconfigurable logic
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Computing Paradigms in Emerging Vehicular Environments:A Review 被引量:2
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作者 Lion Silva Naercio Magaia +5 位作者 Breno Sousa Anna Kobusińska António Casimiro Constandinos X.Mavromoustakis George Mastorakis Victor Hugo C.de Albuquerque 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第3期491-511,共21页
Determining how to structure vehicular network environments can be done in various ways.Here,we highlight vehicle networks’evolution from vehicular ad-hoc networks(VANET)to the internet of vehicles(Io Vs),listing the... Determining how to structure vehicular network environments can be done in various ways.Here,we highlight vehicle networks’evolution from vehicular ad-hoc networks(VANET)to the internet of vehicles(Io Vs),listing their benefits and limitations.We also highlight the reasons in adopting wireless technologies,in particular,IEEE 802.11 p and 5 G vehicle-toeverything,as well as the use of paradigms able to store and analyze a vast amount of data to produce intelligence and their applications in vehicular environments.We also correlate the use of each of these paradigms with the desire to meet existing intelligent transportation systems’requirements.The presentation of each paradigm is given from a historical and logical standpoint.In particular,vehicular fog computing improves on the deficiences of vehicular cloud computing,so both are not exclusive from the application point of view.We also emphasize some security issues that are linked to the characteristics of these paradigms and vehicular networks,showing that they complement each other and share problems and limitations.As these networks still have many opportunities to grow in both concept and application,we finally discuss concepts and technologies that we believe are beneficial.Throughout this work,we emphasize the crucial role of these concepts for the well-being of humanity. 展开更多
关键词 Computing paradigm CLOUD EDGE FOG internet of vehicle(IoV) vehicular networks
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Infrastructure-Based Vehicle Localization System for Indoor Parking Lots Using RGB-D Cameras 被引量:1
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作者 曹炳全 贺越生 +1 位作者 庄瀚洋 杨明 《Journal of Shanghai Jiaotong university(Science)》 EI 2023年第1期61-69,共9页
Accurate vehicle localization is a key technology for autonomous driving tasks in indoor parking lots,such as automated valet parking.Additionally,infrastructure-based cooperative driving systems have become a means t... Accurate vehicle localization is a key technology for autonomous driving tasks in indoor parking lots,such as automated valet parking.Additionally,infrastructure-based cooperative driving systems have become a means to realizing intelligent driving.In this paper,we propose a novel and practical vehicle localization system using infrastructure-based RGB-D cameras for indoor parking lots.In the proposed system,we design a depth data preprocessing method with both simplicity and efficiency to reduce the computational burden resulting from a large amount of data.Meanwhile,the hardware synchronization for all cameras in the sensor network is not implemented owing to the disadvantage that it is extremely cumbersome and would significantly reduce the scalability of our system in mass deployments.Hence,to address the problem of data distortion accompanying vehicle motion,we propose a vehicle localization method by performing template point cloud registration in distributed depth data.Finally,a complete hardware system was built to verify the feasibility of our solution in a real-world environment.Experiments in an indoor parking lot demonstrated the effectiveness and accuracy of the proposed vehicle localization system,with a maximum root mean squared error of 5 cm at 15Hz compared with the ground truth. 展开更多
关键词 infrastructure-based RGB-D camera vehicle localization point cloud registration
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Regions and Their Typical Paradigms for Soil and Water Conservation in China 被引量:2
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作者 DANG Xiaohu SUI Boyang +5 位作者 GAO Siwen LIU Guobin WANG Tao WANG Bing NING Duihu BI Wei 《Chinese Geographical Science》 SCIE CSCD 2020年第4期643-664,共22页
China is experiencing conflicts between its large population and scarce arable land,and between a demand for high productivity and the severe soil erosion of arable land.Since 1949,China has committed to soil and wate... China is experiencing conflicts between its large population and scarce arable land,and between a demand for high productivity and the severe soil erosion of arable land.Since 1949,China has committed to soil and water conservation(SWC),for which eight regions and 41 subregions have been developed to improve the environment and increase land productivity.To obtain information from the regional planning and strategies for SWC and to explore whether SWC practices simultaneously contribute to soil conservation,ecosystem functioning,and the livelihoods of local farmers,and to summarize the successful experiences of various SWC paradigms with distinct characteristics and mechanisms of soil erosion,this paper systematically presents seven SWC regions(excluding the Tibetan Plateau region)and 14 typical SWC paradigms,focusing on erosion mechanisms and the key challenges or issues in the seven regions as well as on the core problems,main objectives,key technologies,and the performance of the 14 typical paradigms.In summary,the 14 typical SWC paradigms successfully prevent and control local soil erosion,and have largely enhanced,or at least do not harm,the livelihoods of local farmers.However,there remain many challenges and issues on SWC and socioeconomic development that need to be addressed in the seven SWC regions.China,thus,still has a long way to go in successfully gaining the win-win objective of SWC and human aspects of development. 展开更多
关键词 regions for soil and water conservation soil erosion dryland farming collapse erosion karst rocky desertification typical paradigm for soil and water conservation
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Assembling Paradigms of Programming in Software Engeneering 被引量:1
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作者 Eraterina M. Lavrischeva 《Journal of Software Engineering and Applications》 2016年第6期296-317,共22页
Assembling paradigms programming are based on the reuses in any programming language (PL) with the passport data of their settings in WSDL. The method of assembling is formal and secures co-operation of the different ... Assembling paradigms programming are based on the reuses in any programming language (PL) with the passport data of their settings in WSDL. The method of assembling is formal and secures co-operation of the different reuses (module, object, component, service and so on) being developed. A formal means of these paradigms creation with help of interfaces is presented. Interface IDL (Stub, Skeleton) is containing data and operations for transmission data to other standard elements linked and describes in the standard language IDL. Assembling will be realized by integration of reuses elements in these paradigms on the instrumental-technological complex (ITC). 展开更多
关键词 paradigm ASSEMBLING Theory Interface Reuses OBJECT Component Service Program Systems INTEROPERABILITY Multilanguages REENGINEERING
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Analysis on New Paradigms of Informatization in the Countryside
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作者 Fei XUE Lina WANG 《Asian Agricultural Research》 2014年第1期72-74,共3页
Through the analyses of several typical paradigms of informatization in the countryside,the status of informatization in the countryside and some unresolved issues were studied. A new way was proposed to develop rural... Through the analyses of several typical paradigms of informatization in the countryside,the status of informatization in the countryside and some unresolved issues were studied. A new way was proposed to develop rural information with embedded mobile phone terminal,and to explore an inexpensive and efficient information services paradigm for the future development in the countryside. 展开更多
关键词 INFORMATIZATION in the COUNTRYSIDE NEW paradigm In
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Multidimensional Design Paradigms for Data Warehouses: A Systematic Mapping Study
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作者 Ania Cravero Samuel Sepúlveda 《Journal of Software Engineering and Applications》 2014年第1期53-61,共9页
Data warehouses (DW) must integrate information from the different areas and sources of an organization in order to extract knowledge relevant to decision-making. The DW development is not an easy task, which is why v... Data warehouses (DW) must integrate information from the different areas and sources of an organization in order to extract knowledge relevant to decision-making. The DW development is not an easy task, which is why various design approaches have been put forward. These approaches can be classified in three different paradigms according to the origin of the information requirements: supply-driven, demand-driven, and hybrids of these. This article compares the methodologies for the multidimensional design of DW through a systematic mapping as research methodology. The study is presented for each paradigm, the main characteristics of the methodologies, their notations and problem areas exhibited in each one of them. The results indicate that there is no follow-up to the complete process of implementing a DW in either an academic or industrial environment;however, there is also no evidence that the attempt is made to address the design and development of a DW by applying and comparing different methodologies existing in the field. 展开更多
关键词 MULTIDIMENSIONAL DESIGN paradigms DATA Warehouses Systematic MAPPING
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On the Study of Chinese Politics: Field Experience and Theoretical Paradigms ( Symposium )
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作者 YANG Xue-dong WANG Xiang-min +4 位作者 LUO Xing-zuo CHEN Yao CHI Jian-dong GENG Shu CHEN Wei 《华东师范大学学报(哲学社会科学版)》 CSSCI 北大核心 2017年第1期172-177,共6页
Contemporary Chinese political research usually adopts three basic methods of field investigation,theoretical creation and practical participation,which respectively correspond to the life logic,theoretical logic and ... Contemporary Chinese political research usually adopts three basic methods of field investigation,theoretical creation and practical participation,which respectively correspond to the life logic,theoretical logic and practical logic in political functioning.Field investigation has become an important approach to"understanding Chinese politics"and promoting the localization of contemporary Chinese political research.Meanwhile,the new perspective of theoretical field besides empirical field marks the self-awareness and transition of the methodology in Chinese political research.To study Chinese experience itself,we should not only consciously focus upon China,but also continuously promote experience based on field research,as well as perfect and improve the research through the interaction between experience,theory and practice.The popular paradigms at home and abroad,including"authoritarianism"and"a developmental country",fail to explain Chinese experience and Chinese political development,so we still need a theoretical paradigm more appropriate to Chinese experience and practice. 展开更多
关键词 Chinese politics field experience theoretical paradigm METHODOLOGY
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Dew Computing and Transition of Internet Computing Paradigms
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作者 WANG Yingwei Karolj Skala +3 位作者 Andy Rindos Marjan Gusev YANG Shuhui PAN Yi 《ZTE Communications》 2017年第4期30-37,共8页
The goal of this paper focuses on the development of dew computing, including its origins, research status, development status,and its impact on the transition history of Internet computing paradigms. By gathering and... The goal of this paper focuses on the development of dew computing, including its origins, research status, development status,and its impact on the transition history of Internet computing paradigms. By gathering and studying all the research papers related to dew computing that we are aware of, we found that these papers can be classified into three groups: dew computing early explorations, dew computing feature research, and dew computing application research. Commercial development in the dew computing area also has progressed fast recently; many dew computing products were developed and put into the market. To distinguish dew computing from other Internet computing paradigms and to reveal its essential features, we analyze the transition history of the Internet computing paradigms from information location and distribution aspects. Online impact and redundancy rate are two indices introduced to perform the analysis. The analysis reveals that dew computing is significantly different from other Internet computing paradigms. 展开更多
关键词 dew computing cloud computing online impact redundancy rate Internet computing paradigm
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Architecture and Paradigms of microeconomics
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作者 Naihuan JIAO 《International Journal of Technology Management》 2014年第6期35-37,共3页
The main content of microeconomics is research and study of economic theory, which is an important branch of Western economics. After 200 years of development, microeconomics has become a" Queen" of the social scien... The main content of microeconomics is research and study of economic theory, which is an important branch of Western economics. After 200 years of development, microeconomics has become a" Queen" of the social sciences that have complete system, logical, and many branches. It studies the behavior of individual economic and its interacting theory in the market economy, in order to explain the market mechanism how to configure resources and its need of government intervention in microeconomic activities. Speaking from the specific content, it can be divided into supply and demand, theory of consumer utility, theory of production and costs on producers, factors on the factor market, market competition and theory of non- competitive market, general equilibrium and welfare economics, market failure. 展开更多
关键词 ARCHITECTURE paradigms microeconomics.
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Locomotion Paradigms of Topological Space in Shakespeare’s Double Falsehood
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作者 CHEN Xiao-feng 《Journal of Literature and Art Studies》 2023年第4期248-257,共10页
In the 16th and 17th century,Britain was constantly strained by sporadic plagues,famines,fires and political conflicts.As a response in literature,Shakespeare has constructed an annular locomotion paradigm in Fletcher... In the 16th and 17th century,Britain was constantly strained by sporadic plagues,famines,fires and political conflicts.As a response in literature,Shakespeare has constructed an annular locomotion paradigm in Fletcher and his collaboration work Cardenio.Be more specific,the locomotion routes can be exemplified in Möbius strip,a rhizome system,a reciprocating juxtaposition between the foreground and the background,either of which finally runs to an annular schema.The annular in narration corresponds with The Globe theater and the round world.Shakespeare may express his expectation and prospect for the uprising bourgeoise and the newly found world by the resurrection theme in literature. 展开更多
关键词 locomotion paradigms topological space SHAKESPEARE Cardenio
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Notification Oriented and Object Oriented Paradigms Comparison via Sale System
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作者 Jean M.Simao Danillo L.Belmonte +7 位作者 Adriano F.Ronszcka Robson R.Linhares Glauber Z.Valenca Roni F.Banaszewski Joao A.Fabro Cesar A.Tacla Paulo C.Stadzisz Márcio V.Batista 《Journal of Software Engineering and Applications》 2012年第9期695-710,共16页
This paper presents a new programming paradigm named Notification-Oriented Paradigm (NOP) and analyses the performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structur... This paper presents a new programming paradigm named Notification-Oriented Paradigm (NOP) and analyses the performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structure, and execute software, which would allow causal-knowledge organization and decoupling better than standard solutions based upon current paradigms. These paradigms are essentially Imperative Paradigm (IP) and Declarative Paradigm (DP). In short, DP solutions are considered easier to use than IP solutions due to the concept of high-level programming. However, they are considered slower in execution and lesser flexible in development. Anyway, both paradigms present similar drawbacks such as redundant causal-evaluation and strongly coupled entities, which decrease software performance and processing distribution feasibility. These problems exist due to an orientation to a monolithic inference mechanism based on sequential evaluation searching on passive computational entities. NOP proposes another way to structure software and make its inferences, which is based on small, collaborative, and decoupled computational entities whose interaction happens through precise notifications. This paper presents a quantitative comparison between two equivalent implementations of a sale system, one developed according to the principles of Object-Oriented Paradigm (OOP/IP) in C++ and other developed according to the principles of NOP based on a NOP framework in C++. The results showed that NOP implementation obtained quite equivalent results with respect to OOP implementation. This happened because the NOP framework uses considerable expensive data-structures over C++. Thus, it is necessary a new compiler to NOP in order to actually use its potentiality. 展开更多
关键词 NOTIFICATION ORIENTED paradigm NOTIFICATION ORIENTED INFERENCE NOP and OOP COMPARISON
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A new human-computer interaction paradigm: Agent interaction model based on large models and its prospects
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作者 Yang LIU 《虚拟现实与智能硬件(中英文)》 2025年第3期237-266,共30页
This study examines the advent of agent interaction(AIx)as a transformative paradigm in humancomputer interaction(HCI),signifying a notable evolution beyond traditional graphical interfaces and touchscreen interaction... This study examines the advent of agent interaction(AIx)as a transformative paradigm in humancomputer interaction(HCI),signifying a notable evolution beyond traditional graphical interfaces and touchscreen interactions.Within the context of large models,AIx is characterized by its innovative interaction patterns and a plethora of application scenarios that hold great potential.The paper highlights the pivotal role of AIx in shaping the future landscape of the large model industry,emphasizing its adoption and necessity from a user's perspective.This study underscores the pivotal role of AIx in dictating the future trajectory of a large model industry by emphasizing the importance of its adoption and necessity from a user-centric perspective.The fundamental drivers of AIx include the introduction of novel capabilities,replication of capabilities(both anthropomorphic and superhuman),migration of capabilities,aggregation of intelligence,and multiplication of capabilities.These elements are essential for propelling innovation,expanding the frontiers of capability,and realizing the exponential superposition of capabilities,thereby mitigating labor redundancy and addressing a spectrum of human needs.Furthermore,this study provides an in-depth analysis of the structural components and operational mechanisms of agents supported by large models.Such advancements significantly enhance the capacity of agents to tackle complex problems and provide intelligent services,thereby facilitating a more intuitive,adaptive,and personalized engagement between humans and machines.The study further delineates four principal categories of interaction patterns that encompass eight distinct modalities of interaction,corresponding to twenty-one specific scenarios,including applications in smart home systems,health assistance,and elderly care.This emphasizes the significance of this new paradigm in advancing HCI,fostering technological advancements,and redefining user experiences.However,it also acknowledges the challenges and ethical considerations that accompany this paradigm shift,recognizing the need for a balanced approach to harness the full potential of AIx in modern society. 展开更多
关键词 Interaction paradigm Agent interaction Large models
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Paradigm Shift:Construction of the “One-on- One” Teaching Model in Nursing Education for Neurology Nursing Students
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作者 Youxian Tan Yu Huang +1 位作者 Li Mo Xianying Tang 《Journal of Clinical and Nursing Research》 2025年第9期81-87,共7页
With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neu... With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neurology.This paper focuses on nursing education for neurology nursing students and explores the construction of the“one-on-one”teaching model,aiming to achieve a paradigm shift in nursing education.By analyzing the current status of neurology nursing education,this paper identifies the problems in traditional teaching models.Combining the advantages of the“one-on-one”teaching model,it elaborates on the construction path of this model from aspects such as the selection and training of teaching instructors,the design of teaching content,the innovation of teaching methods,and the improvement of the teaching evaluation system.The research shows that the“one-on-one”teaching model can significantly enhance nursing students’mastery of professional knowledge,clinical operation skills,communication skills,and emergency response capabilities,as well as strengthen their professional identity and sense of responsibility.It provides an effective way to cultivate high-quality nursing talents who can meet the needs of neurology nursing work and promotes the innovative development of nursing education. 展开更多
关键词 NEUROLOGY Nursing students One-on-one teaching model Nursing education paradigm shift
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Research on the Paradigm Reconstruction of Interpreting Pedagogy Driven by Generative AI
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作者 Huiying Yang Yefeng Qiao Mengmeng Liu 《Journal of Contemporary Educational Research》 2025年第8期85-93,共9页
This paper explores the paradigm reconstruction of interpreting pedagogy driven by generative AI technology.With the breakthroughs of AI technologies such as ChatGPT in natural language processing,traditional interpre... This paper explores the paradigm reconstruction of interpreting pedagogy driven by generative AI technology.With the breakthroughs of AI technologies such as ChatGPT in natural language processing,traditional interpreting education faces dual challenges of technological substitution and pedagogical transformation.Based on Kuhn’s paradigm theory,the study analyzes the limitations of three traditional interpreting teaching paradigms,language-centric,knowledge-based,and skill-acquisition-oriented,and proposes a novel“teacher-AI-learner”triadic collaborative paradigm.Through reconstructing teaching subjects,environments,and curriculum systems,the integration of real-time translation tools and intelligent terminology databases facilitates the transition from static skill training to dynamic human-machine collaboration.The research simultaneously highlights challenges in technological ethics and curriculum design transformation pressures,emphasizing the necessity to balance technological empowerment with humanistic education. 展开更多
关键词 Generative AI Interpreting pedagogy paradigm reconstruction Human-machine collaboration Technological ethics
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