Objective: This study evaluates the impact of handshake and information support on patients’ outcomes during laparoscopic cholecystectomy. It examines the effects on their physiological and psychological responses an...Objective: This study evaluates the impact of handshake and information support on patients’ outcomes during laparoscopic cholecystectomy. It examines the effects on their physiological and psychological responses and overall satisfaction with nursing care. Methods: A total of 84 patients scheduled for laparoscopic cholecystectomy were selected through convenient sampling and randomly assigned to either the control group or the intervention group using a random number table. Each group consisted of 42 patients. The control group received standard surgical nursing care. In addition to standard care, the intervention group received handshake and information support from the circulating nurse before anesthesia induction. Vital signs were recorded before surgery and before anesthesia induction. Anxiety levels were measured using the State-Trait Anxiety Inventory (STAI) and the State-Anxiety Inventory (S-AI), while nursing satisfaction was assessed using a numerical rating scale. Results: No significant differences were found between the two groups in systolic and diastolic blood pressures before surgery and anesthesia induction (P > 0.05). However, there was a significant difference in heart rate before anesthesia induction (P Conclusion: Providing handshake and information support before anesthesia induction effectively reduces stress, alleviates anxiety, and enhances comfort and satisfaction among patients undergoing laparoscopic cholecystectomy.展开更多
In order to solve the problem of how to collect and manage large amount of location information and improve the accuracy of location service, interactive information supporting system based on ontology and location se...In order to solve the problem of how to collect and manage large amount of location information and improve the accuracy of location service, interactive information supporting system based on ontology and location service is presented in this paper. It can transmit special information about users＇ location to front-end instantaneously, so it is very convenient for their daily life. It makes full use of the available wireless communication, which is easy to arrange and convenient for users.展开更多
Considering the secure authentication problem for equipment support information network,a clustering method based on the business information flow is proposed. Based on the proposed method,a cluster-based distributed ...Considering the secure authentication problem for equipment support information network,a clustering method based on the business information flow is proposed. Based on the proposed method,a cluster-based distributed authentication mechanism and an optimal design method for distributed certificate authority( CA)are designed. Compared with some conventional clustering methods for network,the proposed clustering method considers the business information flow of the network and the task of the network nodes,which can decrease the communication spending between the clusters and improve the network efficiency effectively. The identity authentication protocols between the nodes in the same cluster and in different clusters are designed. From the perspective of the security of network and the availability of distributed authentication service,the definition of the secure service success rate of distributed CA is given and it is taken as the aim of the optimal design for distributed CA. The efficiency of providing the distributed certificate service successfully by the distributed CA is taken as the constraint condition of the optimal design for distributed CA. The determination method for the optimal value of the threshold is investigated. The proposed method can provide references for the optimal design for distributed CA.展开更多
The first part of the article provides an overview of the theoretical evidence, the main provisions, and the implementation strategy of information support for bioresource and ecosystem research in the north-west Paci...The first part of the article provides an overview of the theoretical evidence, the main provisions, and the implementation strategy of information support for bioresource and ecosystem research in the north-west Pacific, which has been conducted over the past 20 years in the Russian Far East Research Institute TINRO-Center. In short, the concept consists of a combination of the following four assertions: 1) For the steady and sustainable development of the Russian Far East, the entire Russian Federation and the Asia-Pacific Region in general, environmental, food, economic, and other security is required, which cannot be achieved without the rational use of bioresources based on the ecosystem approach to the management of aquatic bioresources. 2) For the inventory, appraisal, monitoring, forecasting of the state of and management the natural water resources when applying this approach, statistically relevant quantitative information is required on the greatest possible number of constituents of marine biocenosis of the north-western Pacific for the longest possible period of time, which is only available at the TINRO-Center. 3) This valuable data should be organized into databases, based on which geo-information and other electronic information systems are prepared, and based on these map atlases and reference books on natural water resources, using automated workplaces created especially for this. 4) The resulting unique information support will be of great value not only for practical purposes, but also for science, both applied and fundamental. Next comes a summary of the many years of work on the practical implementation of this concept and the key achievements in this field obtained by the TINRO-Center by the end of 2015 are reviewed. At the end, some plans for the near future are outlined.展开更多
This paper presents a new integrated information retrieval support system （IIRSS） which can help Web search engines retrieve cross-lingual information from hereto geneous resources stored in multi-databases in Intra...This paper presents a new integrated information retrieval support system （IIRSS） which can help Web search engines retrieve cross-lingual information from hereto geneous resources stored in multi-databases in Intranet. The IIRSS, with a three-layer architecture, can cooperate with other application servers running in Intranet. By using intelligent agents to collect information and to create indexes on the-fly, using an access control strategy to confine a user to browsing those accessible documents for him/her through a single portal, and using a new cross-lingual translation tool to help the search engine retrieve documents, the new system provides controllable information access with different authorizations, personalized services, and real-time information retrieval.展开更多
OBJECTIVE:To evaluate the efficacy and safety of Yunpiqiangshen gel(运脾强肾浸膏)which composed of eleven herbs on quality of life(QOL)improvement.METHODS:We enrolled 180 patients lasted from January 2020 to December ...OBJECTIVE:To evaluate the efficacy and safety of Yunpiqiangshen gel(运脾强肾浸膏)which composed of eleven herbs on quality of life(QOL)improvement.METHODS:We enrolled 180 patients lasted from January 2020 to December 2021.Seventy-eight patients received standards of care(control group)and 76 patients received Yunpiqiangshen gel[Traditional Chinese Medicine,(TCM)group]for 6 months in statistical analysis.The primary outcome assessed using Kidney Disease Quality of Life Short Form Questionnaire version 1.3(KDQOL-SFTM 1.3),including Short Form Health Survey(SF-36)and Kidney Disease Targeted Areas(KDTA)scores.The second outcomes included the TCM syndrome score,Fatigue Assessment Instrument(FAI)score,Modified Quantitative Subjective Global Assessment(MQSGA)score,anthropometric indicators,and blood chemical testing.Adverse events,including decompensated gastrointestinal symptoms,were evaluated.RESULTS:The results showed that the mean change of SF-36(75±13 vs 64±16,F=6.070,P=0.015)and KDTA(76±7 vs 70±9,F=4.118,P=0.044)scores in the TCM group had an improvement(increase)from baseline,as compared with the control group.Yunpiqiangshen gel also resulted in a significant improvement in almost dimensions of QOL.At the end of follow-up,the imputed percentage of patients in the response rate of TCM syndrome was greater in the TCM group than in the control group(76.32%vs 20.51%,χ^(2)=48.02,P=0.000).The fatigue,soreness of waist,anorexia,abdominal distension,loose stool,and constipation were alleviated after Yunpiqiangshen gel therapy.The FAI(98.58±25.08 vs 131.21±31.85,F=8.745,P=0.004)and MQSGA(10.13±2.84 vs 12.83±3.85,F=11.396,P=0.001)scores in the TCM group had an improvement(reduce)from baseline compared with the control group.A higher level of albumin of patients in the TCM group compared with the control group.Diarrhea,vomit,and loose stool were more common in the TCM group,but generally mild in severity.CONCLUSION:Compared with the standards of care,added Yunpiqiangshen gel was a safe and effective therapy for improving QOL in dialysis patients.展开更多
OBJECTIVE:To investigate the efficacy of Longteng Tongluo recipe(龙藤通络方,LTTL)combined with threestep analgesia for the treatment of lung cancer pain,and the changes in serum miRNA expressions before-and after trea...OBJECTIVE:To investigate the efficacy of Longteng Tongluo recipe(龙藤通络方,LTTL)combined with threestep analgesia for the treatment of lung cancer pain,and the changes in serum miRNA expressions before-and after treatment with LTTL and its correlation with lung cancer pain.The possible mechanism underlying LTTL effects on the treatment of lung cancer pain was conducted.METHODS:The pilot study was conducted at the oncology ward of the Yueyang Hospital and the Longhua Hospital between March 2018 and October 2019.A prospective,single-blind,placebo controlled,randomized clinical trial of LTTL or placebo combined with three-step analgesia treatments were administered to 24 cancer pain patients diagnosed with lung cancer.Analgesic efficacy was investigated as the primary outcome.Equivalent morphine consumption and numerical rating scale(NRS)scores were used as the secondary outcome.In the present study,we utilized deep sequencing techniques to compare the differential miRNA expressions in serum samples obtained from two groups:the lung cancer pain treatment group(LTTL+three-step analgesia)and the control group(placebo+three-step analgesia).Next,we employed the target prediction database to investigate the target genes for differential miRNA expressions and Gene Ontology(GO)analysis along with Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis to examine the roles and the major biochemical and signaling pathways related to the differentially expressed target genes,respectively.RESULTS:LTTL treatment significantly reduces the NRS score(P=0.021)as compared to those before treatment,along with significant reductions in the total morphine equivalent consumption(P=0.007)and the average daily equivalent morphine consumption(P=0.003)as opposed to the control group.The expressions of 31 miRNAs differed considerably between the two groups of patients(≥2 times up-modulated or down-regulated between these groups,P<0.05).For instance,the miRNAs expression levels for patients before treatment(has-miR-2110 and has-miR-7d-3p)were significantly enhanced as compared to the healthy people,after LTTL treatment,the expressions of miR-2110 and miR-7d-3p in patients with lung cancer pain reduced significantly.Studies show that the above two miRNAs were significantly associated with lung cancer pain,which could mediate lung cancer pain.Furthermore,we identified 355 genes as potential targets of the 31 differentially expressed miRNAs.Pathway enrichment analyses using KEGG and GO analysis indicated that these target genes may play a crucial role in the development and modulation of lung cancer pain.CONCLUSION:LTTL demonstrated a discernible impact on alleviating lung cancer pain and its mechanism of action may be related to the downregulation of has-miR-2110 and has-miR-7d-3p expressions.This pilot study provides support for further exploration of LTTL in patients with lung cancer pain.展开更多
Japanese convenience store chain Seven-Eleven Japan (hereinafter 'SEJ') has been profitable for 30 years by constantly anticipating changing trends regardless of the severe business environment. In this paper,...Japanese convenience store chain Seven-Eleven Japan (hereinafter 'SEJ') has been profitable for 30 years by constantly anticipating changing trends regardless of the severe business environment. In this paper, the knowledge creation process and its supportive systems in SEJ to examine how information system can support knowledge creation are described. Using case study method, the knowledge creation theory is applied to SEJ, and the results show that facilitating 'dialogue' and reinforcing 'creative routine' might be the most important functions of information system to support knowledge creation.展开更多
Informal support constitutes an important means of and resource for solving the problem of the elderly. However, the elderly population in China tend to be influenced by consanguinity values when choosing informal sup...Informal support constitutes an important means of and resource for solving the problem of the elderly. However, the elderly population in China tend to be influenced by consanguinity values when choosing informal support resources. In general, this takes the form of the core nature of consanguinity in their social networks, an obstinate psychological preference for blood relations and the extension of this to all relationships, pursuit of goals marked by comprehensive needs and ethical exchange as the principle of association. In actual practice, a basic model has taken shape involving two kinds of resources, differential functions and a decreasing order of choice, as well as the cultural trait of the continuous breaking up of informal support networks. While this choice model and cultural trait are to a certain extent conducive to old people＇s utilization of informal support resources, it inhibits their full use of such resources.展开更多
In the version of this article initially published,the supporting information was incorrectly uploaded,which was a mistake not attributable to the authors.The correct version has now been replaced.
The publisher regrets that the Supporting Information of this paper was wrongly uploaded during production.The publisher would like to apologize to the authors and for any inconvenience caused.
Digital technologies have changed the way supply chain operations are structured.In this article,we conduct systematic syntheses of literature on the impact of new technologies on supply chains and the related cyber r...Digital technologies have changed the way supply chain operations are structured.In this article,we conduct systematic syntheses of literature on the impact of new technologies on supply chains and the related cyber risks.A taxonomic/cladistic approach is used for the evaluations of progress in the area of supply chain integration in the Industrial Internet of Things and Industry 4.0,with a specific focus on the mitigation of cyber risks.An analytical framework is presented,based on a critical assessment with respect to issues related to new types of cyber risk and the integration of supply chains with new technologies.This paper identifies a dynamic and self-adapting supply chain system supported with Artificial Intelligence and Machine Learning(AI/ML)and real-time intelligence for predictive cyber risk analytics.The system is integrated into a cognition engine that enables predictive cyber risk analytics with real-time intelligence from IoT networks at the edge.This enhances capacities and assist in the creation of a comprehensive understanding of the opportunities and threats that arise when edge computing nodes are deployed,and when AI/ML technologies are migrated to the periphery of IoT networks.展开更多
We study the recovery conditions of weighted mixedl2/lp minimization for block sparse signal reconstruction from compressed measurements when partial block support information is available.We show theoretically that t...We study the recovery conditions of weighted mixedl2/lp minimization for block sparse signal reconstruction from compressed measurements when partial block support information is available.We show theoretically that the extended block restricted isometry property can ensure robust recovery when the data fidelity constraint is expressed in terms of anlq norm of the residual error,thus establishing a setting wherein we are not restricted to Gaussian measurement noise.We illustrate the results with a series of numerical experiments.展开更多
Digital technologies have changed the way supply chain operations are structured.In this article,we conduct systematic syntheses of literature on the impact of new technologies on supply chains and the related cyber r...Digital technologies have changed the way supply chain operations are structured.In this article,we conduct systematic syntheses of literature on the impact of new technologies on supply chains and the related cyber risks.A taxonomic/cladistic approach is used for the evaluations of progress in the area of supply chain integration in the Industrial Internet of Things and Industry 4.0,with a specific focus on the mitigation of cyber risks.An analytical framework is presented,based on a critical assessment with respect to issues related to new types of cyber risk and the integration of supply chains with new technologies.This paper identifies a dynamic and self-adapting supply chain system supported with Artificial Intelligence and Machine Learning(AI/ML)and real-time intelligence for predictive cyber risk analytics.The system is integrated into a cognition engine that enables predictive cyber risk analytics with real-time intelligence from IoT networks at the edge.This enhances capacities and assist in the creation of a comprehensive understanding of the opportunities and threats that arise when edge computing nodes are deployed,and when AI/ML technologies are migrated to the periphery of IoT networks.展开更多
In the Research Article“Correlation of PCSK1 with nonalco-holic fatty liver disease in a Han Chinese population:A case-control observational study”,the authors have identified some errors in the financial support in...In the Research Article“Correlation of PCSK1 with nonalco-holic fatty liver disease in a Han Chinese population:A case-control observational study”,the authors have identified some errors in the financial support information[1].The correct funding information for this paper is as follows:This work was supported by Innovation Funding in Shanghai(Nos.20JC1418600 and 18JC1413100),the National Nature Science Foundation of China(Nos.82071262 and 81671326),Natural Science Foundation of Shanghai(Nos.20ZR1427200,20511101900,and 21ZR1433000),Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01),the Shanghai Leading Academic Discipline Project(No.B205),and Natural Science Foundation of Chongqing(cstc2021jcyj-msxmX0674).展开更多
文摘Objective: This study evaluates the impact of handshake and information support on patients’ outcomes during laparoscopic cholecystectomy. It examines the effects on their physiological and psychological responses and overall satisfaction with nursing care. Methods: A total of 84 patients scheduled for laparoscopic cholecystectomy were selected through convenient sampling and randomly assigned to either the control group or the intervention group using a random number table. Each group consisted of 42 patients. The control group received standard surgical nursing care. In addition to standard care, the intervention group received handshake and information support from the circulating nurse before anesthesia induction. Vital signs were recorded before surgery and before anesthesia induction. Anxiety levels were measured using the State-Trait Anxiety Inventory (STAI) and the State-Anxiety Inventory (S-AI), while nursing satisfaction was assessed using a numerical rating scale. Results: No significant differences were found between the two groups in systolic and diastolic blood pressures before surgery and anesthesia induction (P > 0.05). However, there was a significant difference in heart rate before anesthesia induction (P Conclusion: Providing handshake and information support before anesthesia induction effectively reduces stress, alleviates anxiety, and enhances comfort and satisfaction among patients undergoing laparoscopic cholecystectomy.
基金funded by the National High Technology Research and Development Program of China (2006AA10Z239)the Key Technologies R&D Program of China during the 11th Five-Year Plan period (2006BAD10A05)
文摘In order to solve the problem of how to collect and manage large amount of location information and improve the accuracy of location service, interactive information supporting system based on ontology and location service is presented in this paper. It can transmit special information about users＇ location to front-end instantaneously, so it is very convenient for their daily life. It makes full use of the available wireless communication, which is easy to arrange and convenient for users.
基金National Natural Science Foundation of China(No.61271152)Natural Science Foundation of Hebei Province,China(No.F2012506008)the Original Innovation Foundation of Ordnance Engineering College,China(No.YSCX0903)
文摘Considering the secure authentication problem for equipment support information network,a clustering method based on the business information flow is proposed. Based on the proposed method,a cluster-based distributed authentication mechanism and an optimal design method for distributed certificate authority( CA)are designed. Compared with some conventional clustering methods for network,the proposed clustering method considers the business information flow of the network and the task of the network nodes,which can decrease the communication spending between the clusters and improve the network efficiency effectively. The identity authentication protocols between the nodes in the same cluster and in different clusters are designed. From the perspective of the security of network and the availability of distributed authentication service,the definition of the secure service success rate of distributed CA is given and it is taken as the aim of the optimal design for distributed CA. The efficiency of providing the distributed certificate service successfully by the distributed CA is taken as the constraint condition of the optimal design for distributed CA. The determination method for the optimal value of the threshold is investigated. The proposed method can provide references for the optimal design for distributed CA.
文摘The first part of the article provides an overview of the theoretical evidence, the main provisions, and the implementation strategy of information support for bioresource and ecosystem research in the north-west Pacific, which has been conducted over the past 20 years in the Russian Far East Research Institute TINRO-Center. In short, the concept consists of a combination of the following four assertions: 1) For the steady and sustainable development of the Russian Far East, the entire Russian Federation and the Asia-Pacific Region in general, environmental, food, economic, and other security is required, which cannot be achieved without the rational use of bioresources based on the ecosystem approach to the management of aquatic bioresources. 2) For the inventory, appraisal, monitoring, forecasting of the state of and management the natural water resources when applying this approach, statistically relevant quantitative information is required on the greatest possible number of constituents of marine biocenosis of the north-western Pacific for the longest possible period of time, which is only available at the TINRO-Center. 3) This valuable data should be organized into databases, based on which geo-information and other electronic information systems are prepared, and based on these map atlases and reference books on natural water resources, using automated workplaces created especially for this. 4) The resulting unique information support will be of great value not only for practical purposes, but also for science, both applied and fundamental. Next comes a summary of the many years of work on the practical implementation of this concept and the key achievements in this field obtained by the TINRO-Center by the end of 2015 are reviewed. At the end, some plans for the near future are outlined.
基金Supported by the National Natural Science Foun-dation of China (60173010)
文摘This paper presents a new integrated information retrieval support system （IIRSS） which can help Web search engines retrieve cross-lingual information from hereto geneous resources stored in multi-databases in Intranet. The IIRSS, with a three-layer architecture, can cooperate with other application servers running in Intranet. By using intelligent agents to collect information and to create indexes on the-fly, using an access control strategy to confine a user to browsing those accessible documents for him/her through a single portal, and using a new cross-lingual translation tool to help the search engine retrieve documents, the new system provides controllable information access with different authorizations, personalized services, and real-time information retrieval.
基金Jiangsu Science and Technology Development Project of Chinese Medicine:Yunpiqiangshen Improves Quality of Life in Dialysis Patients in Basis of Zou's Theory of Kidney Disease(ZD201904)Jiangsu Province Hospital of Chinese Medicine Peak Talent Program:Study on Promotion of Rehabilitation of Dialysis Patients by Traditional Chinese Medicine(Y2021RC10)+2 种基金National Natural Science Foundation of China:Study of Astragalus on Peritoneum Function by Myostatin-mediated Protein Turnover of Skeletal Muscle Cells(82004295)Science and Technology Planning Project of Jiangsu Province:Mechanism Study of Astragalus on Peritoneal Fibrosis by Pyroptosis of Peritoneal Mesothelial Cell via Peritoneal Mesothelial Cell(BK20211393)Outstanding Young Doctor's Fund of Jiangsu Province Hospital of Chinese Medicine:Traditional Chinese Medicine Improves Quality of Life in Chronic Renal Disease(2023QB0133)。
文摘OBJECTIVE:To evaluate the efficacy and safety of Yunpiqiangshen gel(运脾强肾浸膏)which composed of eleven herbs on quality of life(QOL)improvement.METHODS:We enrolled 180 patients lasted from January 2020 to December 2021.Seventy-eight patients received standards of care(control group)and 76 patients received Yunpiqiangshen gel[Traditional Chinese Medicine,(TCM)group]for 6 months in statistical analysis.The primary outcome assessed using Kidney Disease Quality of Life Short Form Questionnaire version 1.3(KDQOL-SFTM 1.3),including Short Form Health Survey(SF-36)and Kidney Disease Targeted Areas(KDTA)scores.The second outcomes included the TCM syndrome score,Fatigue Assessment Instrument(FAI)score,Modified Quantitative Subjective Global Assessment(MQSGA)score,anthropometric indicators,and blood chemical testing.Adverse events,including decompensated gastrointestinal symptoms,were evaluated.RESULTS:The results showed that the mean change of SF-36(75±13 vs 64±16,F=6.070,P=0.015)and KDTA(76±7 vs 70±9,F=4.118,P=0.044)scores in the TCM group had an improvement(increase)from baseline,as compared with the control group.Yunpiqiangshen gel also resulted in a significant improvement in almost dimensions of QOL.At the end of follow-up,the imputed percentage of patients in the response rate of TCM syndrome was greater in the TCM group than in the control group(76.32%vs 20.51%,χ^(2)=48.02,P=0.000).The fatigue,soreness of waist,anorexia,abdominal distension,loose stool,and constipation were alleviated after Yunpiqiangshen gel therapy.The FAI(98.58±25.08 vs 131.21±31.85,F=8.745,P=0.004)and MQSGA(10.13±2.84 vs 12.83±3.85,F=11.396,P=0.001)scores in the TCM group had an improvement(reduce)from baseline compared with the control group.A higher level of albumin of patients in the TCM group compared with the control group.Diarrhea,vomit,and loose stool were more common in the TCM group,but generally mild in severity.CONCLUSION:Compared with the standards of care,added Yunpiqiangshen gel was a safe and effective therapy for improving QOL in dialysis patients.
基金a Special Clinical Research Initiative for the Health Business Sponsored by the Shanghai Municipal Health Commission:a Multicenter Randomized Controlled Clinical Study of Longteng Tongluo Recipe for the Treatment of Lung Cancer Pain(202040155)Xinglin Youth Talent Training System of Shanghai University of Traditional Chinese Medicine Xinglin Young Scholars:Study The Mechanism of Longteng Tongluo Recipe in Cancer Pain based on The Theory of Tonifying Yuan Qi and Detoxification(RC-2017-02-02)+2 种基金the Shanghai Municipal Science and Technology Commission's Special Biomedical Technology Support Plan:External Treatment of Cancer Pain of Traditional Chinese Medicine to Promote Percutaneous Absorption of Ultrasound Instrument(20S31904100)Science and Technology Commission of Shanghai Municipality:Shanghai Clinical Research Center of Traditional Chinese Medicine Oncology(21MC1930500)Science Foundation of Yueyang Hospital:Discussion on the Anti-apoptotic Effect of Qidongning Prescription on Lung Cancer Based on Energy Metabolismin Disorder of Mitochondria(2021yygq05)。
文摘OBJECTIVE:To investigate the efficacy of Longteng Tongluo recipe(龙藤通络方,LTTL)combined with threestep analgesia for the treatment of lung cancer pain,and the changes in serum miRNA expressions before-and after treatment with LTTL and its correlation with lung cancer pain.The possible mechanism underlying LTTL effects on the treatment of lung cancer pain was conducted.METHODS:The pilot study was conducted at the oncology ward of the Yueyang Hospital and the Longhua Hospital between March 2018 and October 2019.A prospective,single-blind,placebo controlled,randomized clinical trial of LTTL or placebo combined with three-step analgesia treatments were administered to 24 cancer pain patients diagnosed with lung cancer.Analgesic efficacy was investigated as the primary outcome.Equivalent morphine consumption and numerical rating scale(NRS)scores were used as the secondary outcome.In the present study,we utilized deep sequencing techniques to compare the differential miRNA expressions in serum samples obtained from two groups:the lung cancer pain treatment group(LTTL+three-step analgesia)and the control group(placebo+three-step analgesia).Next,we employed the target prediction database to investigate the target genes for differential miRNA expressions and Gene Ontology(GO)analysis along with Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis to examine the roles and the major biochemical and signaling pathways related to the differentially expressed target genes,respectively.RESULTS:LTTL treatment significantly reduces the NRS score(P=0.021)as compared to those before treatment,along with significant reductions in the total morphine equivalent consumption(P=0.007)and the average daily equivalent morphine consumption(P=0.003)as opposed to the control group.The expressions of 31 miRNAs differed considerably between the two groups of patients(≥2 times up-modulated or down-regulated between these groups,P<0.05).For instance,the miRNAs expression levels for patients before treatment(has-miR-2110 and has-miR-7d-3p)were significantly enhanced as compared to the healthy people,after LTTL treatment,the expressions of miR-2110 and miR-7d-3p in patients with lung cancer pain reduced significantly.Studies show that the above two miRNAs were significantly associated with lung cancer pain,which could mediate lung cancer pain.Furthermore,we identified 355 genes as potential targets of the 31 differentially expressed miRNAs.Pathway enrichment analyses using KEGG and GO analysis indicated that these target genes may play a crucial role in the development and modulation of lung cancer pain.CONCLUSION:LTTL demonstrated a discernible impact on alleviating lung cancer pain and its mechanism of action may be related to the downregulation of has-miR-2110 and has-miR-7d-3p expressions.This pilot study provides support for further exploration of LTTL in patients with lung cancer pain.
文摘Japanese convenience store chain Seven-Eleven Japan (hereinafter 'SEJ') has been profitable for 30 years by constantly anticipating changing trends regardless of the severe business environment. In this paper, the knowledge creation process and its supportive systems in SEJ to examine how information system can support knowledge creation are described. Using case study method, the knowledge creation theory is applied to SEJ, and the results show that facilitating 'dialogue' and reinforcing 'creative routine' might be the most important functions of information system to support knowledge creation.
基金sponsored by the MOE Project of Key Research Institute of Humanities and Social Sciences in Universities
文摘Informal support constitutes an important means of and resource for solving the problem of the elderly. However, the elderly population in China tend to be influenced by consanguinity values when choosing informal support resources. In general, this takes the form of the core nature of consanguinity in their social networks, an obstinate psychological preference for blood relations and the extension of this to all relationships, pursuit of goals marked by comprehensive needs and ethical exchange as the principle of association. In actual practice, a basic model has taken shape involving two kinds of resources, differential functions and a decreasing order of choice, as well as the cultural trait of the continuous breaking up of informal support networks. While this choice model and cultural trait are to a certain extent conducive to old people＇s utilization of informal support resources, it inhibits their full use of such resources.
文摘In the version of this article initially published,the supporting information was incorrectly uploaded,which was a mistake not attributable to the authors.The correct version has now been replaced.
文摘The publisher regrets that the Supporting Information of this paper was wrongly uploaded during production.The publisher would like to apologize to the authors and for any inconvenience caused.
基金This work was funded by the UK EPSRC[grant number:EP/S035362/1,EP/N023013/1,EP/N02334X/1]and by the Cisco Research Centre[grant number 1525381].
文摘Digital technologies have changed the way supply chain operations are structured.In this article,we conduct systematic syntheses of literature on the impact of new technologies on supply chains and the related cyber risks.A taxonomic/cladistic approach is used for the evaluations of progress in the area of supply chain integration in the Industrial Internet of Things and Industry 4.0,with a specific focus on the mitigation of cyber risks.An analytical framework is presented,based on a critical assessment with respect to issues related to new types of cyber risk and the integration of supply chains with new technologies.This paper identifies a dynamic and self-adapting supply chain system supported with Artificial Intelligence and Machine Learning(AI/ML)and real-time intelligence for predictive cyber risk analytics.The system is integrated into a cognition engine that enables predictive cyber risk analytics with real-time intelligence from IoT networks at the edge.This enhances capacities and assist in the creation of a comprehensive understanding of the opportunities and threats that arise when edge computing nodes are deployed,and when AI/ML technologies are migrated to the periphery of IoT networks.
文摘We study the recovery conditions of weighted mixedl2/lp minimization for block sparse signal reconstruction from compressed measurements when partial block support information is available.We show theoretically that the extended block restricted isometry property can ensure robust recovery when the data fidelity constraint is expressed in terms of anlq norm of the residual error,thus establishing a setting wherein we are not restricted to Gaussian measurement noise.We illustrate the results with a series of numerical experiments.
基金funded by the UK EPSRC[grant number:EP/S035362/1,EP/N023013/1,EP/N02334X/1]by the Cisco Research Centre[grant number 1525381].
文摘Digital technologies have changed the way supply chain operations are structured.In this article,we conduct systematic syntheses of literature on the impact of new technologies on supply chains and the related cyber risks.A taxonomic/cladistic approach is used for the evaluations of progress in the area of supply chain integration in the Industrial Internet of Things and Industry 4.0,with a specific focus on the mitigation of cyber risks.An analytical framework is presented,based on a critical assessment with respect to issues related to new types of cyber risk and the integration of supply chains with new technologies.This paper identifies a dynamic and self-adapting supply chain system supported with Artificial Intelligence and Machine Learning(AI/ML)and real-time intelligence for predictive cyber risk analytics.The system is integrated into a cognition engine that enables predictive cyber risk analytics with real-time intelligence from IoT networks at the edge.This enhances capacities and assist in the creation of a comprehensive understanding of the opportunities and threats that arise when edge computing nodes are deployed,and when AI/ML technologies are migrated to the periphery of IoT networks.
文摘In the Research Article“Correlation of PCSK1 with nonalco-holic fatty liver disease in a Han Chinese population:A case-control observational study”,the authors have identified some errors in the financial support information[1].The correct funding information for this paper is as follows:This work was supported by Innovation Funding in Shanghai(Nos.20JC1418600 and 18JC1413100),the National Nature Science Foundation of China(Nos.82071262 and 81671326),Natural Science Foundation of Shanghai(Nos.20ZR1427200,20511101900,and 21ZR1433000),Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01),the Shanghai Leading Academic Discipline Project(No.B205),and Natural Science Foundation of Chongqing(cstc2021jcyj-msxmX0674).
