Interleukin-35(IL-35)is a novel protein comprising IL-12αand IL-27βchains.The IL12A and EBI3 genes are responsible for its production.The study of IL-35 has experienced a substantial increase in interest in recent y...Interleukin-35(IL-35)is a novel protein comprising IL-12αand IL-27βchains.The IL12A and EBI3 genes are responsible for its production.The study of IL-35 has experienced a substantial increase in interest in recent years,as demonstrated by many research papers.Recent clinical studies have shown that individuals who do not have a C-peptide have notably reduced amounts of IL-35 in their blood serum.This is accompanied by a drop in the percentage of IL-35+Treg cells,regulatory B cells,and CD8+FOXP3+cells that produce IL-35.This article em-phasizes the potential significance of IL-35 expression in governing the immune response and its involvement in chronic inflammatory autoimmune diabetes in pancreatic inflammation.It demonstrates IL-35's ability to regulate cytokine proportions,modulate B cells,and protect against autoimmune diabetes.However,further investigation is necessary to ascertain the precise mechanism of IL-35,and meticulous planning is essential for clinical studies.展开更多
AIM To evaluate the role of small bowel capsule endoscopy(SBCE)on the reclassification of colonic inflammatory bowel disease type unclassified(IBDU).METHODS We performed a multicenter,retrospective study including pat...AIM To evaluate the role of small bowel capsule endoscopy(SBCE)on the reclassification of colonic inflammatory bowel disease type unclassified(IBDU).METHODS We performed a multicenter,retrospective study including patients with IBDU undergoing SBCE,between 2002 and 2014.SBCE studies were reviewed and the inflammatory activity was evaluated by determining the Lewis score(LS).Inflammatory activity was considered significant and consistent with Crohn's disease(CD)when the LS≥135.The definitive diagnosis during follow-up(minimum 12 mo following SBCE)was based on the combination of clinical,analytical,imaging,endoscopic and histological elements.RESULTS Thirty-six patients were included,21 females(58%)with mean age at diagnosis of 33±13(15-64)years.The mean follow-up time after the SBCE was 52±41(12-156)mo.The SBCE revealed findings consistent with significant inflammatory activity in the small bowel(LS≥135)in 9 patients(25%);in all of them the diagnosis of CD was confirmed during follow-up.In 27 patients(75%),the SBCE revealed no significant inflammatory activity(LS<135);among these patients,the diagnosis of Ulcerative Colitis(UC)was established in 16 cases(59.3%),CD in 1 case(3.7%)and 10 patients(37%)maintained a diagnosis of IBDU during follow-up.A LS≥135 at SBCE had a sensitivity=90%,specificity=100%,positive predictive value=100%and negative predictive value=94%for the diagnosis of CD.CONCLUSION SBCE proved to be fundamental in the reclassification of patients with IBDU.Absence of significant inflammatory activity in the small intestine allowed exclusion of CD in 94%of cases.展开更多
This prospective study was designed to examine the combined influence of insulin resistance（IR）and inflammatory biomarker levels on type 2 diabetes mellitus（T2DM）among 1,903Inner Mongolians.
Objective:This study was undertaken to evaluate the clinical efficacy of Western medicine combined with Chinese medicine for pelvic inflammatory disease(damp-heat and stasis type).Methods:Seventy-four patients who wer...Objective:This study was undertaken to evaluate the clinical efficacy of Western medicine combined with Chinese medicine for pelvic inflammatory disease(damp-heat and stasis type).Methods:Seventy-four patients who were diagnosed with pelvic inflammatory disease(damp-heat and stasis type)by our hospital during July 2021 to July 2022 were randomized into two groups:the participants in the control group received conventional Western medicine treatment,and the participants in the study group received Western medicine combined with Chinese medicine.Results:After treatment,the total effectiveness of the control group(72.98%)was significantly lower than that of the study group(94.59%),(P<0.05);the whole blood viscosity high cut,whole blood viscosity low cut,fibrinogen and plasma viscosity of the control group were all lower than those of the study group(P<0.05);the levels of CRP,IL-6,and TNF-αin the control group were higher and IL-2 levels in the control group were lower than those in the study group(P<0.05).Conclusion:Western medicine combined with Chinese medicine is more effective in curing damp-heat and stasis-type pelvic inflammatory disease by improving the blood rheological indexes and lowering the level of inflammatory factors.展开更多
文摘Interleukin-35(IL-35)is a novel protein comprising IL-12αand IL-27βchains.The IL12A and EBI3 genes are responsible for its production.The study of IL-35 has experienced a substantial increase in interest in recent years,as demonstrated by many research papers.Recent clinical studies have shown that individuals who do not have a C-peptide have notably reduced amounts of IL-35 in their blood serum.This is accompanied by a drop in the percentage of IL-35+Treg cells,regulatory B cells,and CD8+FOXP3+cells that produce IL-35.This article em-phasizes the potential significance of IL-35 expression in governing the immune response and its involvement in chronic inflammatory autoimmune diabetes in pancreatic inflammation.It demonstrates IL-35's ability to regulate cytokine proportions,modulate B cells,and protect against autoimmune diabetes.However,further investigation is necessary to ascertain the precise mechanism of IL-35,and meticulous planning is essential for clinical studies.
文摘AIM To evaluate the role of small bowel capsule endoscopy(SBCE)on the reclassification of colonic inflammatory bowel disease type unclassified(IBDU).METHODS We performed a multicenter,retrospective study including patients with IBDU undergoing SBCE,between 2002 and 2014.SBCE studies were reviewed and the inflammatory activity was evaluated by determining the Lewis score(LS).Inflammatory activity was considered significant and consistent with Crohn's disease(CD)when the LS≥135.The definitive diagnosis during follow-up(minimum 12 mo following SBCE)was based on the combination of clinical,analytical,imaging,endoscopic and histological elements.RESULTS Thirty-six patients were included,21 females(58%)with mean age at diagnosis of 33±13(15-64)years.The mean follow-up time after the SBCE was 52±41(12-156)mo.The SBCE revealed findings consistent with significant inflammatory activity in the small bowel(LS≥135)in 9 patients(25%);in all of them the diagnosis of CD was confirmed during follow-up.In 27 patients(75%),the SBCE revealed no significant inflammatory activity(LS<135);among these patients,the diagnosis of Ulcerative Colitis(UC)was established in 16 cases(59.3%),CD in 1 case(3.7%)and 10 patients(37%)maintained a diagnosis of IBDU during follow-up.A LS≥135 at SBCE had a sensitivity=90%,specificity=100%,positive predictive value=100%and negative predictive value=94%for the diagnosis of CD.CONCLUSION SBCE proved to be fundamental in the reclassification of patients with IBDU.Absence of significant inflammatory activity in the small intestine allowed exclusion of CD in 94%of cases.
基金supported by the National Natural Science Foundation of China[Grant No.81773509][Grant No.81102190]
文摘This prospective study was designed to examine the combined influence of insulin resistance（IR）and inflammatory biomarker levels on type 2 diabetes mellitus（T2DM）among 1,903Inner Mongolians.
文摘Objective:This study was undertaken to evaluate the clinical efficacy of Western medicine combined with Chinese medicine for pelvic inflammatory disease(damp-heat and stasis type).Methods:Seventy-four patients who were diagnosed with pelvic inflammatory disease(damp-heat and stasis type)by our hospital during July 2021 to July 2022 were randomized into two groups:the participants in the control group received conventional Western medicine treatment,and the participants in the study group received Western medicine combined with Chinese medicine.Results:After treatment,the total effectiveness of the control group(72.98%)was significantly lower than that of the study group(94.59%),(P<0.05);the whole blood viscosity high cut,whole blood viscosity low cut,fibrinogen and plasma viscosity of the control group were all lower than those of the study group(P<0.05);the levels of CRP,IL-6,and TNF-αin the control group were higher and IL-2 levels in the control group were lower than those in the study group(P<0.05).Conclusion:Western medicine combined with Chinese medicine is more effective in curing damp-heat and stasis-type pelvic inflammatory disease by improving the blood rheological indexes and lowering the level of inflammatory factors.
