In a recent publication in Cell,Hsu and colleagues describe a novel kind of extracellular vesicle that is involved in the resolution of inflammation.Such large_ageing_neutrophil-derived,vesicles(LAND-Vs)that express C...In a recent publication in Cell,Hsu and colleagues describe a novel kind of extracellular vesicle that is involved in the resolution of inflammation.Such large_ageing_neutrophil-derived,vesicles(LAND-Vs)that express CD55^(+) and CD47^(+) are protected against efferocytosis and exhibit anti-inflammatory functions by inhibiting the complement activation.These findings reveal an important functional switch of neutrophils throughout the course of inflammation and identify a novel class of EVs that mediate neutrophil action beyond their limited lifespan,which may open new modes of therapeutic interference in various inflammatory conditions.展开更多
基金funded by institutional funds from the Georg-Speyer-Haus,the LOEWE Center Frankfurt Cancer Institute(FCl)funded by the Hessen State Ministry for Higher Education,Research and the Arts,as well as grants from the Deutsche Forschungsgemeinschaft(FOR2438:Gr1916/11-1,SFB1292-Project ID:318346496-TP16,SFB1479-Project ID:441891347-P02,GRK2336)the German Federal Ministry of Education and Research(BMBF+1 种基金01KD2206Q/SATURN3)the European Research Council(Advanced Grant PLASTICAN-101021078).
文摘In a recent publication in Cell,Hsu and colleagues describe a novel kind of extracellular vesicle that is involved in the resolution of inflammation.Such large_ageing_neutrophil-derived,vesicles(LAND-Vs)that express CD55^(+) and CD47^(+) are protected against efferocytosis and exhibit anti-inflammatory functions by inhibiting the complement activation.These findings reveal an important functional switch of neutrophils throughout the course of inflammation and identify a novel class of EVs that mediate neutrophil action beyond their limited lifespan,which may open new modes of therapeutic interference in various inflammatory conditions.
