In the Sahel, the climate and the agricultural practices are the main factors used to observe regreening process. But the extension of the latter not being uniform in the farming fields, we can suppose that there are ...In the Sahel, the climate and the agricultural practices are the main factors used to observe regreening process. But the extension of the latter not being uniform in the farming fields, we can suppose that there are other factors that contribute to the re-greening of certain zones and not others. The infiltrability of soils is considered as an important factor for these changes in the last decades. The influence of re-greening on the infiltrability of soils in the southern strip of Niger was studied through a comparison of zones according to the type of sandy soils (Jigawa/Rerey), siltyclay (Guiéza), silty-sandy (Hako) and clay-silty-sandy (Laka). The evaluated parameters are the texture, the infiltrability and the ecological characteristics (specific index of regeneration “SIR” and the Importance Value Index “IVI”). The main conclusions were: the soils of Niger South-Central are characterized by a sandy texture for more than 80%. The soils which are very sandy (“Jigawa”, “Rerey” and “Guieza”) are more permeable and have more trees contrary to the soil Hako and Laka. Their encrusting has the tendency to reduce the vegetation cover on the soil. The infiltration measurements indicated that the rate of initial and stationary infiltration diminishes while going down towards the South. In fact, it has been recorded a rate of 123 mm/min of initial infiltration and 87 mm/min stationary in Dan Saga on the sandy soils against 76 mm/min and 65 mm/min in Daré respectively for the initial and stationary rate. Therefore, the infiltration seems to influence the density, the SIR and the IVI of the trees from the North towards the South. Some additional work is necessary in order to determine the contribution of Farmer Managed Natural Regeneration (FMNR) in the improvement of the quality of soils and the movement of water in the superficial zones of the soil.展开更多
Maintaining appropriate levels of soil infiltrability is important for avoiding undesirable levels of surface runoff and erosion and for maintaining adequate rates of soil and groundwater recharge.This study was condu...Maintaining appropriate levels of soil infiltrability is important for avoiding undesirable levels of surface runoff and erosion and for maintaining adequate rates of soil and groundwater recharge.This study was conducted with the aim of investigating the effects of Faidherbia albida(apple-ring acacia)and Vitellaria paradoxa(shea butter tree)trees and additions of inorganic fertilizer,leaves and compost on soil infiltrability in two agroforestry parkland systems in the western part of Burkina Faso.Infiltrability was measured before tilling both under and outside canopies of these trees,using tension disc and double-ring infiltrometers.The results show that infiltrability was 33%higher on average under than outside canopies in both agroforestry parkland systems.The compost,leaves and inorganic fertilizer did not improve infiltrability significantly during the study period.More than 75%of the infiltrability estimates obtained using ring infiltrometers outside the canopies were lower than 40 mm/h.In contrast,less than 10%of those obtained from under canopies were lower than this.This could have highly significant effects on run-off,erosion and recharge since rain intensity measurements collected over three years at 30 min intervals showed that up to 35%of the annual precipitation fell with intensities≥40 mm/h.The study demonstrates the potential of improving infiltrability and reducing surface runoff by managing trees appropriately in agroforestry systems in semi-arid tropics.展开更多
The soil infiltrability of hill-slope is important to such studies andpractices as hydrological process,crop water supply,irrigation practices,and soil erosion.A newmethod for measuring soil infiltrability on hill-slo...The soil infiltrability of hill-slope is important to such studies andpractices as hydrological process,crop water supply,irrigation practices,and soil erosion.A newmethod for measuring soil infiltrability on hill-slope under rainfall condition with run off-on-outwas advanced.Based on water(mass)balance,the mathematic models for soil infiltrability estimatedfrom the advances of runoff on soil surface and the water running out of the slope were derived.Experiments of 2 cases were conducted.CaseⅠwas done under a rainfall intensity of 20 mm/h,at aslope gradient of about 0°with a runoff/on length(area)ratio of 1:1.CaseⅡwas under arainfall intensity of 60 mm/h and a slope of 20°with a runoff/on length(area)ratio of 1:1.Double ring method was also used to measure the infiltrability for comparison purposes.Theexperiments were done with soil moisture of 10%.Required data were collected from laboratoryexperiments.The infiltrability curves were computed from the experimental data.The resultsindicate that the method can well conceptually represent the transient infiltrability process,withcapability to simulate the very high initial soil infiltrability.The rationalities of the methodand the models were validated.The errors of the method for the two cases were 1.82%/1.39%and4.49%/3.529%(Experimental/Model)respectively,as estimated by comparing the rainfall amount withthe infiltrated volume,to demonstrate the accuracy of the method.The transient and steadyinfiltrability measured with double ring was much lower than those with this new method,due towater supply limit and soil aggregates breaking down at initial infiltration stage.The method canovercome the short backs of the traditional sprinkler method and double ring method for soilinfil-traility.It can be used to measure the infiltrability of sloped surface underrainfall-runoff-erosion conditions,in the related studies.展开更多
This study investigated the expression characteristics and clinical significance of gamma-aminobutyric acid A(GABAA)receptor subunit gamma1(GABRG1)in glioma by integrating cancer and normal tissue data from multiple d...This study investigated the expression characteristics and clinical significance of gamma-aminobutyric acid A(GABAA)receptor subunit gamma1(GABRG1)in glioma by integrating cancer and normal tissue data from multiple databases and combining them with experimental evidence.The research revealed that GABRG1 exhibited low expression levels in glioma,and its low expression was closely associated with unfavorable clinical outcomes.Furthermore,a prognostic model with strong decision-making ability was constructed using multivariate Cox regression analysis,incorporating age,isocitric dehydrogenase(IDH)mutation status,O6-methylguanine-DNA methyltransferase(MGMT)methylation status,World Health Organization(WHO)grade,and GABRG1 expression.Additionally,GABRG1 might be associated with the expression of tumor-associated macrophages and was significantly linked to immune regulatory processes.This study provided a new target for immunotherapy in glioma and offered a novel indicator for predicting and evaluating the clinical prognosis of patients.展开更多
Water infiltration in loess is one of the most significant processes that can lead to geological disasters on the Loess Plateau in China.However,the spatiotemporal characteristics of infiltration in intact loess,parti...Water infiltration in loess is one of the most significant processes that can lead to geological disasters on the Loess Plateau in China.However,the spatiotemporal characteristics of infiltration in intact loess,particularly the heterogeneity of three-dimensional(3D)seepage and its relationship with soil properties,remain poorly understood.This study conducted field infiltration tests on a 3 m×3 m loess column,instrumented with 48 moisture sensors to monitor 3D seepage and infiltration rates.Both horizontal and vertical infiltration behaviors were analyzed,alongside a detailed characterization of soil physical properties.The results demonstrated that the water infiltration process was significantly heterogeneous in intact loess,with wetting front velocities varying considerably across profiles and depths,despite relatively uniform physical properties.The infiltration process also exhibited pronounced anisotropy,with vertical wetting front velocities at least 10 times higher than those of the horizontal velocities.The in situ tests indicated that the physical properties were not the primary factors influencing infiltration.However,the microfeatures that facilitated the formation of preferential pathways exerted the most significant influence on the water infiltration process in thick unsaturated loess.Additionally,prior infiltration events negatively impacted subsequent infiltration in thick unsaturated loess.These findings enhance the understanding of loess infiltration dynamics,providing insights into unsaturated flow processes and their implications for geological stability in loess regions.展开更多
The impact mechanism of vegetation on slope soil water infiltration and stability in the loess areas of the northeastern Qinghai-Tibet Plateau remains unclear.Understanding this mechanism is crucial for regional ecolo...The impact mechanism of vegetation on slope soil water infiltration and stability in the loess areas of the northeastern Qinghai-Tibet Plateau remains unclear.Understanding this mechanism is crucial for regional ecological restoration and shallow geological disaster prevention.This study investigated slopes covered by Caragana korshinskii Kom.by employing double-ring infiltration tests to explore the permeability characteristics and influencing factors of root-containing soils and to propose an appropriate infiltration model.Considering the synergistic effects of the canopy and roots,the hydrological response and stability of vegetation-covered slopes under rainfall infiltration conditions were evaluated through numerical simulation analysis.The results revealed that within the main root distribution layer(0-0.5 m),the initial and average infiltration rates and the permeability coefficient of the root-soil composite were significantly higher than those of bare land.Coarse roots with diameters of>5 mm were the key contributors to enhancement of the infiltration capacity.The dry density,fine particle content,and initial water content of the soil around the roots were negatively correlated with the infiltration process.The Horton model effectively reproduced the infiltration process under the canopy and on bare land.The roots significantly accelerated the advance of the slope wetting front during rainfall infiltration,whereas the canopy delayed its onset and progression.The rainfall infiltration process on vegetation-covered slopes was divided into three stages:the equilibrium infiltration stage,optimal infiltration stage beneath the canopy,and secondary equilibrium stage.Vegetation enhances slope stability through coupling of the canopy and root,with an order of canopy-root mode>root mode>bare slope.Under heavy rainfall conditions,the direct contribution of canopy interception to slope stability is limited,and its primary role is to delay the occurrence of instability.During this period,the mechanical effect of roots becomes the dominant mechanism in slope protection.展开更多
Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML...Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML)has emerged as a powerful data analysis tool,widely applied in the prediction,diagnosis,and mechanistic study of kidney transplant rejection.This mini-review systematically summarizes the recent applications of ML techniques in post-kidney transplant rejection,covering areas such as the construction of predictive models,identification of biomarkers,analysis of pathological images,assessment of immune cell infiltration,and formulation of personalized treatment strategies.By integrating multi-omics data and clinical information,ML has significantly enhanced the accuracy of early rejection diagnosis and the capability for prognostic evaluation,driving the development of precision medicine in the field of kidney transplantation.Furthermore,this article discusses the challenges faced in existing research and potential future directions,providing a theoretical basis and technical references for related studies.展开更多
Unmanned combat aerial vehicles require lightweight,stealth-capable exhaust systems.However,traditional metallic nozzles increase radar detectability and reduce range,while advanced composites offer high performance b...Unmanned combat aerial vehicles require lightweight,stealth-capable exhaust systems.However,traditional metallic nozzles increase radar detectability and reduce range,while advanced composites offer high performance but are expensive.Therefore,to improve the operational range and survivability of unmanned combat aerial vehicles,a lightweight,high-temperature-resistant,oxidation-resistant,and low-observable composite exhaust nozzle is developed to replace conventional metallic straight-type nozzles.The nozzle features a double serpentine shape to reduce radar and infrared signatures and is manufactured as a monolithic structure using the filament winding process,accommodating the complex geometry and large size(length:1.8 m,width:0.8 m).The exhaust nozzle consists of a ceramic matrix composite made of silicon carbide fibers and a silicon oxycarbide matrix,which absorbs and scatters radio frequency signals while withstanding prolonged exposure to high-temperature(700℃)oxidizing environments typical of engine exhaust gases.The polysiloxane resin used to produce the silicon oxycarbide matrix poses significant challenges owing to its low tackiness and high viscosity variations depending on the presence of nanoparticles,making filament winding difficult.These challenges are addressed by optimizing resin viscosity and winding pattern design.As a result,the tensile strength of the composite specimens fabricated with the optimized viscosity increases by 228.03% before pyrolysis and 97.68%after pyrolysis,compared with that of the non-optimized specimens.In addition,the density and tensile strength of the composite processed via three cycles of polymer infiltration and pyrolysis increased by 13.08% and 80.37%,respectively,compared to those of the non-densified composite.High-temperature oxidation and flame tests demonstrate exceptional thermal and oxidative stability.Furthermore,when compared with carbon fiber-reinforced ceramic matrix composites,the developed composite exhibits a permittivity at least two levels lower and a reflection loss below7 dB within the frequency range of 9.3-10.9 GHz,underscoring its superior electromagnetic stealth performance.展开更多
Acute eosinophilic pneumonia(AEP) is a pulmonary condition characterized by acute febrile illness and respiratory distress,with bilateral pulmonary infiltrates,particularly eosinophilic infiltration of the lungs.^([1]...Acute eosinophilic pneumonia(AEP) is a pulmonary condition characterized by acute febrile illness and respiratory distress,with bilateral pulmonary infiltrates,particularly eosinophilic infiltration of the lungs.^([1])Amiodarone,a widely applied antiarrhythmic agent,has been reported as a potential cause of drug-induced AEP.^([2]) Most reported cases of amiodarone-induced AEP typically occur following prolonged exposure for two months or more.展开更多
Objectives:Bladder cancer(BCa)progression is closely linked to the immune microenvironment.However,the key molecules that regulate this microenvironment and their specific mechanisms remain poorly understood.This stud...Objectives:Bladder cancer(BCa)progression is closely linked to the immune microenvironment.However,the key molecules that regulate this microenvironment and their specific mechanisms remain poorly understood.This study aims to identify a key molecule and elucidate its mechanisms,providing a theoretical basis for identifying novel therapeutic targets.Methods:Immune microenvironment-related genes in BCa were identified using The Cancer Genome Atlas and Shanghai Tenth People’s Hospital datasets.Proteasome 26S subunit non-ATPase 2(PSMD2)expression was validated via quantitative polymerase chain reaction(qPCR),Western blot(WB)analysis,and immunofluorescence(IF).In vitro and in vivo experiments confirmed the role of PSMD2 in cell proliferation,invasion,and migration.Kyoto encyclopedia of genes and genomes(KEGG)and Gene Ontology(GO)analyses were conducted to assess PSMD2’s influence on immune microenvironment remodeling.A pathomics model predicted PSMD2 expression in patients with BCa.Results:PSMD2 was identified as a critical factor in BCa,with high expression correlating with poor prognosis and tumor progression.Mechanistically,PSMD2 enhances malignancy by promoting mitogen-activated protein kinase kinase(MEK)and extracellular signal-regulated kinase(ERK)phosphorylation within the mitogen-activated protein kinase(MAPK)signaling pathway.Combined bioinformatics and experimental analyses reveal that PSMD2 downregulates chemokine(C-X-C motif)ligand 14(CXCL14)expression and secretion via the MAPK pathway,thereby remodeling the immune microenvironment and driving tumor progression.Pathomics analysis further supports the potential of PSMD2 expression as a predictive marker in BCa tissues.Conclusion:PSMD2 is overexpressed in BCa and significantly correlates with poor prognosis and tumor progression.It promotes malignant development and immune microenvironment remodeling through the MAPK pathway.Pathological analysis can predict PSMD2 expression,offering valuable insights into immunotherapy responses and survival outcomes.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)is one of the most prevalent and aggressive forms of liver cancer,with high morbidity and poor prognosis due to late diagnosis and limited treatment options.Despite advances in ...BACKGROUND Hepatocellular carcinoma(HCC)is one of the most prevalent and aggressive forms of liver cancer,with high morbidity and poor prognosis due to late diagnosis and limited treatment options.Despite advances in understanding its molecular mechanisms,effective biomarkers for early detection and targeted therapy remain scarce.Zinc finger protein 71(ZNF71),a zinc-finger protein,has been implicated in various cancers,yet its role in HCC remains largely unexplored.This gap in knowledge underscores the need for further investigation into the ZNF71 of potential as a diagnostic or therapeutic target in HCC.AIM To explore the expression levels,clinical relevance,and molecular mechanisms of ZNF71 in the progression of HCC.METHODS The study evaluated ZNF71 expression in 235 HCC specimens and 13 noncancerous liver tissue samples using immunohistochemistry.High-throughput datasets were employed to assess the differential expression of ZNF71 in HCC and its association with clinical and pathological features.The impact of ZNF71 on HCC cell line growth was examined through clustered regularly interspaced short palindromic repeat knockout screens.Co-expressed genes were identified and analyzed for enrichment using LinkedOmics and Sangerbox 3.0,focusing on significant correlations(P<0.01,correlation coefficient≥0.3).Furthermore,the relationship between ZNF71 expression and immune cell infiltration was quantified using TIMER2.0.RESULTS ZNF71 showed higher expression in HCC tissues vs non-tumorous tissues,with a significant statistical difference(P<0.05).Data from the UALCAN platform indicated increased ZNF71 levels across early to mid-stage HCC,correlating with disease severity(P<0.05).High-throughput analysis presented a standardized mean difference in ZNF71 expression of 0.55(95%confidence interval[CI]:0.34-0.75).The efficiency of ZNF71 mRNA was evaluated,yielding an area under the curve of 0.78(95%CI:0.75-0.82),a sensitivity of 0.63(95%CI:0.53-0.72),and a specificity of 0.82(95%CI:0.73-0.89).Diagnostic likelihood ratios were positive at 3.61(95%CI:2.41-5.41)and negative at 0.45(95%CI:0.36-0.56).LinkedOmics analysis identified strong positive correlations of ZNF71 with genes such as ZNF470,ZNF256,and ZNF285.Pathway enrichment analyses highlighted associations with herpes simplex virus type 1 infection,the cell cycle,and DNA replication.Negative correlations involved metabolic pathways,peroxisomes,and fatty acid degradation.TIMER2.0 analysis demonstrated positive correlations of high ZNF71 expression with various immune cell types,including CD4^(+)T cells,B cells,regulatory T cells,monocytes,macrophages,and myeloid dendritic cells.CONCLUSION ZNF71 is significantly upregulated in HCC,correlating with the disease’s clinical and pathological stages.It appears to promote HCC progression through mechanisms involving the cell cycle and metabolism and is associated with immune cell infiltration.These findings suggest that ZNF71 could be a novel target for diagnosing and treating HCC.展开更多
Background:Heat shock protein B8(HSPB8)is implicated in autophagy,and its aberrant expression has been linked to both the ini-tiation and progression of tumors.However,the role and function of HSPB8 in colorectal canc...Background:Heat shock protein B8(HSPB8)is implicated in autophagy,and its aberrant expression has been linked to both the ini-tiation and progression of tumors.However,the role and function of HSPB8 in colorectal cancer(CRC)and across multiple cancer types remain unclear.This study aimed to map the transcriptome of autophagy-related genes in CRC and to conduct a pan-cancer analysis of HSPB8 as both a prognostic and immunological biomarker.Methods:We performed bioinformatics analyses on GSE113513 and GSE74602 to identify differentially expressed genes(DEGs)in CRC.These DEGs were then compared with autophagy-related genes to identify critical overlapping genes.The Kaplan-Meier plotter was used to verify the ex-pression of autophagy-linked DEGs and evaluate its prognostic value.The protein expression of Hub gene in CRC was analyzed using the Human Protein Atlas database.The cBioPortal was used to analyze the type and frequency of Hub gene mutations.The TIMER(Tumor Immune Estimation Resource)database was used to study the correlation between HSPB8 and immune infiltration in CRC.Results:In total,825 DEGs were identified,including 8 autophagy-linked DEGs:ATIC,MYC,HSPB8,TNFSF10,BCL2,TP53INP2,ITPR1,and NKX2-3.Survival analysis showed that increased HSPB8 expression significantly correlates with poor prognosis in patients with CRC(p<0.05).HSPB8 was also found to be differentially expressed in various cancer types,correlating with both prognosis and immune infiltration.Further,changes in HSPB8 methylation and phosphorylation status were observed across several cancers,suggesting potential regulatory mechanisms.Therefore,HSPB8 may serve as a crucial prognostic and immunological biomarker in CRC and other cancers.Conclusions:This study provides new insights into the role of autophagy-related genes in cancer progression and highlights HSPB8 as a potential target for cancer diagnostics and therapy.展开更多
To effectively regulate the grain boundary infiltration in CoCrFeMnNi high-entropy alloy(Cantor alloys,HEA)caused by the violent atomic interdiffusion,the higher configuration entropy on Cantor alloys surface was desi...To effectively regulate the grain boundary infiltration in CoCrFeMnNi high-entropy alloy(Cantor alloys,HEA)caused by the violent atomic interdiffusion,the higher configuration entropy on Cantor alloys surface was designed and realized via eutectic high-entropy(EHEA)transformation.Meanwhile,to effectively alleviate the residual stress caused by the notable difference in the thermal expansion coefficient(CTE)between Cantor alloys and Zr-3 alloys,a cladding layer was applied to the HEA surface using laser cladding technology of Nb,followed by brazing to Zr-3 alloys with Zr63.2Cu filler.The cladding layer’s microstructure comprised Nbss and FCC+(Co,Ni)_(2) Nb eutectic structure,resulting from an in-situ reaction between Cantor alloys and Nb.The Nbss and FCC demonstrated good plasticity,and the(Co,Ni)_(2) Nb Laves phase provided increased strength,endowing both good plastic deformation ability and strength of the cladding layer.Notably,the existence of EHEA in the laser cladding layer made the Cantor alloy entropy from 1.61 R to 1.77 R,greatly enhancing its thermal stability and suppressing the grave grain boundary infiltration.Joints produced via laser cladding with Nb-assisted brazing exhibited a complex microstructure(HEA/Nbss+FCC+(Co,Ni)_(2)Nb/(Zr,Nb)(Cr,Mn)_(2)+(Zr,Nb)ss/(Zr,Nb)_(2)(Cu,Ni,Co,Fe)+(Zr,Nb)(Cr,Mn)_(2)+(Zr,Nb)ss/Zr-3) and a significantly improved shear strength of 242.8 MPa at 1010℃ for 10 min,42.4%higher than that of directly brazed joints.This improvement was attributed to reduced grain boundary infiltration,alleviated residual stress due to CTE disparity,and eliminated micro-cracks in the brazing seam.This study presents an effective solution for reducing residual stresses and achieving reliable bonding between Cantor alloys and Zr-3 alloys,with potential applications in brazing CoCrFeNi-based HEA and Zr-3 due to the beneficial eutectic reaction between CoCrFeNi and Nb.展开更多
Background:Cisplatin(DDP)has been used in the treatment of various human cancers.However,DDP alone lacks efficacy in treating triple-negative breast cancer(TNBC),and its clinical application is often hampered by side ...Background:Cisplatin(DDP)has been used in the treatment of various human cancers.However,DDP alone lacks efficacy in treating triple-negative breast cancer(TNBC),and its clinical application is often hampered by side effects.Astragalus polysaccharide(APS)is one of the active components extracted from Astragalus membranaceus and has gained attention for its various biological properties.This research is aimed to evaluate the effectiveness of a combination of APS and DDP on TNBC and explore the potential mechanisms.Methods:The efficacy and mechanisms of single or combined treatment were evaluated using Cell Counting Kit-8(CCK8)assay,Annexin V-fluorescein isothiocyanate(FITC)/propidium iodide(PI)staining,wound healing assay,trans-well invasion/migration assay,hematoxylin-eosin(HE)staining,immunohistochemical(IHC)staining,Western Blot(WB)analysis,and fluorescence-activated cell sorting(FACS).An orthotopic model of TNBC was used to assess the in vivo treatment efficacy of single or combination treatment.Results:APS significantly enhanced the anti-proliferative,anti-migratory,and anti-invasive effects of DDP on TNBC cells.The combination of APS and DDP downregulated anti-apoptotic genes(Bcl2 and Bcl-xL)while upregulating pro-apoptotic genes(Puma,Cle-Caspase3,Cle-PARP),leading to enhanced apoptosis.This combination treatment increased E-cadherin levels,decreased Vimentin,Snail,Slug,and Twist levels,and effectively suppressed epithelial-mesenchymal transition(EMT)-associated cell invasion.In the orthotopic model of TNBC,a synergistic reduction in tumor growth was observed in mice treated with APS and DDP.Additionally,the combination of APS and DDP induced the infiltration of CD8+T lymphocytes into the tumor immune microenvironment.Conclusion:The combination of APS and DDP exhibits more potent tumor inhibition and anti-tumor immunity than either agent alone,representing a novel approach to enhance therapeutic efficacy without increasing the side effects of DDP.展开更多
Based on the service characteristics of fuel elements for molten salt reactors,they need to have a high power density,resistance to coolant infiltration,and excellent thermodynamic properties.To solve the problem of t...Based on the service characteristics of fuel elements for molten salt reactors,they need to have a high power density,resistance to coolant infiltration,and excellent thermodynamic properties.To solve the problem of the graphite used in the fuel element for these reactors being susceptible to molten salt infiltration,carbon black(CB)was added to increase the density of the graphite,and a fuel element(TRISO(tri-structural isotropic)fuel particles were randomly distributed in the modified graphite matrix)was prepared by cold isostatic pressing process.An out-of-pile performance study shows that the densification and pore structure of the modified graphite matrix were improved,as was the resistance to molten salt infiltration.The median pore size of the modified graphite was reduced from 673 to 433 nm and the threshold pressure for molten salt(FLiBe,66%(molar fraction)LiF and 34%BeF_(2))infiltration was increased from 0.88 to 1.37 MPa.The isotropic CB made the graphite matrix less anisotropic,while its thermal conductivity and compressive strength were reduced due to the difficult graphitization of CB.Fuel elements containing 20%(volume fraction)TRISO particles were prepared.Numerical simulations show that the power and temperature distribution of the fuel were in line with the design requirements.The modified graphite matrix had a higher density,smaller pores,a lower anisotropy and a greater resistance to FLiBe infiltration.展开更多
Background:NDC80 is pivotal in cell division,particularly in regulating the G2/M transition and mitotic progression.Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors.F...Background:NDC80 is pivotal in cell division,particularly in regulating the G2/M transition and mitotic progression.Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors.Further analysis has suggested that its high expression is significantly associated with an elevated pathological grade,increased metastatic risk,and shortened overall survival in patients with cancer.However,its precise role in pan-cancer development,progression,and prognosis remains unclear.Methods:We conducted a multi-omics analysis of NDC80 using genomic,transcriptomic,and proteomic data from 33 cancer types in The Cancer Genome Atlas,Clinical Proteomic Tumor Analysis Consortium,Genotype-Tissue Expression,and Human Protein Atlas.Results:The results demonstrated frequent NDC80 mutations across multiple malignancies and significantly elevated expression in tumor tissues compared with that in their normal counterparts,correlating with worse overall and disease-free survival.Moreover,NDC80 expression was strongly associated with oncogenic pathways,key protein regulators,cellular components,myeloid-derived suppressor cell infiltration,ESTIMATE scores,and cancer-related signaling networks.Conclusions:These findings underscore the potential of NDC80 as a prognostic biomarker and therapeutic target for cancer treatment.展开更多
During the exploitation of sandstone gas reservoirs,natural fractures near the wellbore affect water infiltration and pore evolution;however,the impact mechanisms of these fractures remain unclear.This study utilized ...During the exploitation of sandstone gas reservoirs,natural fractures near the wellbore affect water infiltration and pore evolution;however,the impact mechanisms of these fractures remain unclear.This study utilized real-time nuclear magnetic resonance(RT-NMR)technology to investigate the influence of near-wellbore fracture angle(a)at 0°,15°,30°,and 45°on water infiltration,migration patterns,and pore evolution mechanisms during water injection.Throughout the experiments,T_(2)curves and magnetic resonance imaging(MRI)were monito red in real time during the water injection process.The pore evolution and water infiltration were translated by the evolution of T_(2)curves and MRI.The results show that increasing injection pressure(P_(inj))transforms adsorption pores into seepage pores,leading to enhanced pore damage.Pore damage predominantly occurs during the rapid pressurization stage and is concentrated around the near-wellbore fracture.The maximum infiltration area and rate were observed at α=0°,while the minimum values occurred at α=45°,which can be attributed to the significant influence of a on water infiltration and migration pathways.The increasing inclination of the infiltration front with a is attributed to the fact that the rate of water infiltration along the fracture wall is always higher than that at the fracture tip.In field fracturing,it is recommended to adjust the perforation direction to align with the natural fracture orientation and optimize pressurization strategies by reducing the slow pressurization duration while extending the rapid pressurization stage.These findings can provide important guidance for setting fracturing sections and optimizing injection parameters in sandstone gas reservoir exploitation.展开更多
In order to determine the bulk density of refractory raw materials,the so-called water method following the Archimedes principle is normally used.This is where the effect of water displacement on the mass of the sampl...In order to determine the bulk density of refractory raw materials,the so-called water method following the Archimedes principle is normally used.This is where the effect of water displacement on the mass of the sample is used to determine the bulk volume of the sample grains.During this test procedure,the surface of water infiltrated sample grains must be dried with a wet towel.Experience shows,that this drying step is the main root cause for variation in reproducibility of results and even repeatability of tests.A new spin dryer(centrifuge)was developed and introduced to automate this surface drying step,and is now included as a new method in ISO 8840:2021.The paper discusses the improvement of measurement with the new approach and industrial experiences from two big industrial players in the raw material business.展开更多
文摘In the Sahel, the climate and the agricultural practices are the main factors used to observe regreening process. But the extension of the latter not being uniform in the farming fields, we can suppose that there are other factors that contribute to the re-greening of certain zones and not others. The infiltrability of soils is considered as an important factor for these changes in the last decades. The influence of re-greening on the infiltrability of soils in the southern strip of Niger was studied through a comparison of zones according to the type of sandy soils (Jigawa/Rerey), siltyclay (Guiéza), silty-sandy (Hako) and clay-silty-sandy (Laka). The evaluated parameters are the texture, the infiltrability and the ecological characteristics (specific index of regeneration “SIR” and the Importance Value Index “IVI”). The main conclusions were: the soils of Niger South-Central are characterized by a sandy texture for more than 80%. The soils which are very sandy (“Jigawa”, “Rerey” and “Guieza”) are more permeable and have more trees contrary to the soil Hako and Laka. Their encrusting has the tendency to reduce the vegetation cover on the soil. The infiltration measurements indicated that the rate of initial and stationary infiltration diminishes while going down towards the South. In fact, it has been recorded a rate of 123 mm/min of initial infiltration and 87 mm/min stationary in Dan Saga on the sandy soils against 76 mm/min and 65 mm/min in Daré respectively for the initial and stationary rate. Therefore, the infiltration seems to influence the density, the SIR and the IVI of the trees from the North towards the South. Some additional work is necessary in order to determine the contribution of Farmer Managed Natural Regeneration (FMNR) in the improvement of the quality of soils and the movement of water in the superficial zones of the soil.
文摘Maintaining appropriate levels of soil infiltrability is important for avoiding undesirable levels of surface runoff and erosion and for maintaining adequate rates of soil and groundwater recharge.This study was conducted with the aim of investigating the effects of Faidherbia albida(apple-ring acacia)and Vitellaria paradoxa(shea butter tree)trees and additions of inorganic fertilizer,leaves and compost on soil infiltrability in two agroforestry parkland systems in the western part of Burkina Faso.Infiltrability was measured before tilling both under and outside canopies of these trees,using tension disc and double-ring infiltrometers.The results show that infiltrability was 33%higher on average under than outside canopies in both agroforestry parkland systems.The compost,leaves and inorganic fertilizer did not improve infiltrability significantly during the study period.More than 75%of the infiltrability estimates obtained using ring infiltrometers outside the canopies were lower than 40 mm/h.In contrast,less than 10%of those obtained from under canopies were lower than this.This could have highly significant effects on run-off,erosion and recharge since rain intensity measurements collected over three years at 30 min intervals showed that up to 35%of the annual precipitation fell with intensities≥40 mm/h.The study demonstrates the potential of improving infiltrability and reducing surface runoff by managing trees appropriately in agroforestry systems in semi-arid tropics.
基金supported by the Chinese Academy of Sciences(Grant No.KZCX3-SW)the State Key Basic Research Development Projects of China(Grant No.2002CB111502).
文摘The soil infiltrability of hill-slope is important to such studies andpractices as hydrological process,crop water supply,irrigation practices,and soil erosion.A newmethod for measuring soil infiltrability on hill-slope under rainfall condition with run off-on-outwas advanced.Based on water(mass)balance,the mathematic models for soil infiltrability estimatedfrom the advances of runoff on soil surface and the water running out of the slope were derived.Experiments of 2 cases were conducted.CaseⅠwas done under a rainfall intensity of 20 mm/h,at aslope gradient of about 0°with a runoff/on length(area)ratio of 1:1.CaseⅡwas under arainfall intensity of 60 mm/h and a slope of 20°with a runoff/on length(area)ratio of 1:1.Double ring method was also used to measure the infiltrability for comparison purposes.Theexperiments were done with soil moisture of 10%.Required data were collected from laboratoryexperiments.The infiltrability curves were computed from the experimental data.The resultsindicate that the method can well conceptually represent the transient infiltrability process,withcapability to simulate the very high initial soil infiltrability.The rationalities of the methodand the models were validated.The errors of the method for the two cases were 1.82%/1.39%and4.49%/3.529%(Experimental/Model)respectively,as estimated by comparing the rainfall amount withthe infiltrated volume,to demonstrate the accuracy of the method.The transient and steadyinfiltrability measured with double ring was much lower than those with this new method,due towater supply limit and soil aggregates breaking down at initial infiltration stage.The method canovercome the short backs of the traditional sprinkler method and double ring method for soilinfil-traility.It can be used to measure the infiltrability of sloped surface underrainfall-runoff-erosion conditions,in the related studies.
基金Supported by the National Natural Science Foundation of China(82271340,82071368)the Outstanding Youth Funding of Harbin Medical University(HYD2020JQ0016)the Horizontal Subject(86010900)。
文摘This study investigated the expression characteristics and clinical significance of gamma-aminobutyric acid A(GABAA)receptor subunit gamma1(GABRG1)in glioma by integrating cancer and normal tissue data from multiple databases and combining them with experimental evidence.The research revealed that GABRG1 exhibited low expression levels in glioma,and its low expression was closely associated with unfavorable clinical outcomes.Furthermore,a prognostic model with strong decision-making ability was constructed using multivariate Cox regression analysis,incorporating age,isocitric dehydrogenase(IDH)mutation status,O6-methylguanine-DNA methyltransferase(MGMT)methylation status,World Health Organization(WHO)grade,and GABRG1 expression.Additionally,GABRG1 might be associated with the expression of tumor-associated macrophages and was significantly linked to immune regulatory processes.This study provided a new target for immunotherapy in glioma and offered a novel indicator for predicting and evaluating the clinical prognosis of patients.
基金supported by the National Natural Science Foundation of China(Grant No.42372307)the Natural Science Basic Research Program of Shaanxi Province(Grant No.2020JC-07)the SCEGC-XJTU Joint Research Center for Future City Construction and Management Innovation,Shaanxi Provincial Land Engineering Construction Group,and Xi’an Jiaotong University(Grant No.20221220).
文摘Water infiltration in loess is one of the most significant processes that can lead to geological disasters on the Loess Plateau in China.However,the spatiotemporal characteristics of infiltration in intact loess,particularly the heterogeneity of three-dimensional(3D)seepage and its relationship with soil properties,remain poorly understood.This study conducted field infiltration tests on a 3 m×3 m loess column,instrumented with 48 moisture sensors to monitor 3D seepage and infiltration rates.Both horizontal and vertical infiltration behaviors were analyzed,alongside a detailed characterization of soil physical properties.The results demonstrated that the water infiltration process was significantly heterogeneous in intact loess,with wetting front velocities varying considerably across profiles and depths,despite relatively uniform physical properties.The infiltration process also exhibited pronounced anisotropy,with vertical wetting front velocities at least 10 times higher than those of the horizontal velocities.The in situ tests indicated that the physical properties were not the primary factors influencing infiltration.However,the microfeatures that facilitated the formation of preferential pathways exerted the most significant influence on the water infiltration process in thick unsaturated loess.Additionally,prior infiltration events negatively impacted subsequent infiltration in thick unsaturated loess.These findings enhance the understanding of loess infiltration dynamics,providing insights into unsaturated flow processes and their implications for geological stability in loess regions.
基金funded by Science and Technology Program of Qinghai Province of China(2024-SF-129)the National Natural Science Foundation of China(42002283).
文摘The impact mechanism of vegetation on slope soil water infiltration and stability in the loess areas of the northeastern Qinghai-Tibet Plateau remains unclear.Understanding this mechanism is crucial for regional ecological restoration and shallow geological disaster prevention.This study investigated slopes covered by Caragana korshinskii Kom.by employing double-ring infiltration tests to explore the permeability characteristics and influencing factors of root-containing soils and to propose an appropriate infiltration model.Considering the synergistic effects of the canopy and roots,the hydrological response and stability of vegetation-covered slopes under rainfall infiltration conditions were evaluated through numerical simulation analysis.The results revealed that within the main root distribution layer(0-0.5 m),the initial and average infiltration rates and the permeability coefficient of the root-soil composite were significantly higher than those of bare land.Coarse roots with diameters of>5 mm were the key contributors to enhancement of the infiltration capacity.The dry density,fine particle content,and initial water content of the soil around the roots were negatively correlated with the infiltration process.The Horton model effectively reproduced the infiltration process under the canopy and on bare land.The roots significantly accelerated the advance of the slope wetting front during rainfall infiltration,whereas the canopy delayed its onset and progression.The rainfall infiltration process on vegetation-covered slopes was divided into three stages:the equilibrium infiltration stage,optimal infiltration stage beneath the canopy,and secondary equilibrium stage.Vegetation enhances slope stability through coupling of the canopy and root,with an order of canopy-root mode>root mode>bare slope.Under heavy rainfall conditions,the direct contribution of canopy interception to slope stability is limited,and its primary role is to delay the occurrence of instability.During this period,the mechanical effect of roots becomes the dominant mechanism in slope protection.
文摘Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML)has emerged as a powerful data analysis tool,widely applied in the prediction,diagnosis,and mechanistic study of kidney transplant rejection.This mini-review systematically summarizes the recent applications of ML techniques in post-kidney transplant rejection,covering areas such as the construction of predictive models,identification of biomarkers,analysis of pathological images,assessment of immune cell infiltration,and formulation of personalized treatment strategies.By integrating multi-omics data and clinical information,ML has significantly enhanced the accuracy of early rejection diagnosis and the capability for prognostic evaluation,driving the development of precision medicine in the field of kidney transplantation.Furthermore,this article discusses the challenges faced in existing research and potential future directions,providing a theoretical basis and technical references for related studies.
基金supported by the Agency for Defense Development Grant Funded by the Korean Government(Grant No.912822501).
文摘Unmanned combat aerial vehicles require lightweight,stealth-capable exhaust systems.However,traditional metallic nozzles increase radar detectability and reduce range,while advanced composites offer high performance but are expensive.Therefore,to improve the operational range and survivability of unmanned combat aerial vehicles,a lightweight,high-temperature-resistant,oxidation-resistant,and low-observable composite exhaust nozzle is developed to replace conventional metallic straight-type nozzles.The nozzle features a double serpentine shape to reduce radar and infrared signatures and is manufactured as a monolithic structure using the filament winding process,accommodating the complex geometry and large size(length:1.8 m,width:0.8 m).The exhaust nozzle consists of a ceramic matrix composite made of silicon carbide fibers and a silicon oxycarbide matrix,which absorbs and scatters radio frequency signals while withstanding prolonged exposure to high-temperature(700℃)oxidizing environments typical of engine exhaust gases.The polysiloxane resin used to produce the silicon oxycarbide matrix poses significant challenges owing to its low tackiness and high viscosity variations depending on the presence of nanoparticles,making filament winding difficult.These challenges are addressed by optimizing resin viscosity and winding pattern design.As a result,the tensile strength of the composite specimens fabricated with the optimized viscosity increases by 228.03% before pyrolysis and 97.68%after pyrolysis,compared with that of the non-optimized specimens.In addition,the density and tensile strength of the composite processed via three cycles of polymer infiltration and pyrolysis increased by 13.08% and 80.37%,respectively,compared to those of the non-densified composite.High-temperature oxidation and flame tests demonstrate exceptional thermal and oxidative stability.Furthermore,when compared with carbon fiber-reinforced ceramic matrix composites,the developed composite exhibits a permittivity at least two levels lower and a reflection loss below7 dB within the frequency range of 9.3-10.9 GHz,underscoring its superior electromagnetic stealth performance.
基金supported by the Anhui Provincial Health and Medical Research Project (AHWJ2023A30277)。
文摘Acute eosinophilic pneumonia(AEP) is a pulmonary condition characterized by acute febrile illness and respiratory distress,with bilateral pulmonary infiltrates,particularly eosinophilic infiltration of the lungs.^([1])Amiodarone,a widely applied antiarrhythmic agent,has been reported as a potential cause of drug-induced AEP.^([2]) Most reported cases of amiodarone-induced AEP typically occur following prolonged exposure for two months or more.
基金supported by the National Natural Science Foundation of China Commission,Youth Project(No.82203150,No.82302304)Anhui Health Commission Research Project(No.2024Aa30184)+7 种基金The Bengbu City Health and Medical Research Project(BBWK2024A103)Cultivation grant for clinical and basic integration research of Shanghai Tenth People’s Hospital(SYYYRH2025020)Doctoral Workstation Foundation of Guangdong Second Provincial General Hospital,China(Grant No.2022BSGZ011)Elevate Engineering Foundation of Guangdong Second Provincial General Hospital,China(Grant No.TJGC2022009)Science and Technology Program of Guangzhou,China(2024A04J4159)China Postdoctoral Science Foundation(2021M702137)Natural Science Foundation of Chongqing(cstc2021jcyj-msxmX1176)Chongming District Sustainable Development Science and Technology Innovation Initiative Project(CKY2022-30).
文摘Objectives:Bladder cancer(BCa)progression is closely linked to the immune microenvironment.However,the key molecules that regulate this microenvironment and their specific mechanisms remain poorly understood.This study aims to identify a key molecule and elucidate its mechanisms,providing a theoretical basis for identifying novel therapeutic targets.Methods:Immune microenvironment-related genes in BCa were identified using The Cancer Genome Atlas and Shanghai Tenth People’s Hospital datasets.Proteasome 26S subunit non-ATPase 2(PSMD2)expression was validated via quantitative polymerase chain reaction(qPCR),Western blot(WB)analysis,and immunofluorescence(IF).In vitro and in vivo experiments confirmed the role of PSMD2 in cell proliferation,invasion,and migration.Kyoto encyclopedia of genes and genomes(KEGG)and Gene Ontology(GO)analyses were conducted to assess PSMD2’s influence on immune microenvironment remodeling.A pathomics model predicted PSMD2 expression in patients with BCa.Results:PSMD2 was identified as a critical factor in BCa,with high expression correlating with poor prognosis and tumor progression.Mechanistically,PSMD2 enhances malignancy by promoting mitogen-activated protein kinase kinase(MEK)and extracellular signal-regulated kinase(ERK)phosphorylation within the mitogen-activated protein kinase(MAPK)signaling pathway.Combined bioinformatics and experimental analyses reveal that PSMD2 downregulates chemokine(C-X-C motif)ligand 14(CXCL14)expression and secretion via the MAPK pathway,thereby remodeling the immune microenvironment and driving tumor progression.Pathomics analysis further supports the potential of PSMD2 expression as a predictive marker in BCa tissues.Conclusion:PSMD2 is overexpressed in BCa and significantly correlates with poor prognosis and tumor progression.It promotes malignant development and immune microenvironment remodeling through the MAPK pathway.Pathological analysis can predict PSMD2 expression,offering valuable insights into immunotherapy responses and survival outcomes.
基金Supported by Joint Project on Regional High Incidence Diseases Research of Guangxi Natural Science Foundation,No.2024GXNSFAA010057 and No.2024GXNSFAA010085Natural Science Foundation of Guangxi,China,No.2022GXNSFBA035657+2 种基金Guangxi Zhuang Autonomous Region Health Commission Self-Financed Scientific Research Project,No.Z20210764Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project,No.GXZYA20230270 and No.GXZYA20240305Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University(2022).
文摘BACKGROUND Hepatocellular carcinoma(HCC)is one of the most prevalent and aggressive forms of liver cancer,with high morbidity and poor prognosis due to late diagnosis and limited treatment options.Despite advances in understanding its molecular mechanisms,effective biomarkers for early detection and targeted therapy remain scarce.Zinc finger protein 71(ZNF71),a zinc-finger protein,has been implicated in various cancers,yet its role in HCC remains largely unexplored.This gap in knowledge underscores the need for further investigation into the ZNF71 of potential as a diagnostic or therapeutic target in HCC.AIM To explore the expression levels,clinical relevance,and molecular mechanisms of ZNF71 in the progression of HCC.METHODS The study evaluated ZNF71 expression in 235 HCC specimens and 13 noncancerous liver tissue samples using immunohistochemistry.High-throughput datasets were employed to assess the differential expression of ZNF71 in HCC and its association with clinical and pathological features.The impact of ZNF71 on HCC cell line growth was examined through clustered regularly interspaced short palindromic repeat knockout screens.Co-expressed genes were identified and analyzed for enrichment using LinkedOmics and Sangerbox 3.0,focusing on significant correlations(P<0.01,correlation coefficient≥0.3).Furthermore,the relationship between ZNF71 expression and immune cell infiltration was quantified using TIMER2.0.RESULTS ZNF71 showed higher expression in HCC tissues vs non-tumorous tissues,with a significant statistical difference(P<0.05).Data from the UALCAN platform indicated increased ZNF71 levels across early to mid-stage HCC,correlating with disease severity(P<0.05).High-throughput analysis presented a standardized mean difference in ZNF71 expression of 0.55(95%confidence interval[CI]:0.34-0.75).The efficiency of ZNF71 mRNA was evaluated,yielding an area under the curve of 0.78(95%CI:0.75-0.82),a sensitivity of 0.63(95%CI:0.53-0.72),and a specificity of 0.82(95%CI:0.73-0.89).Diagnostic likelihood ratios were positive at 3.61(95%CI:2.41-5.41)and negative at 0.45(95%CI:0.36-0.56).LinkedOmics analysis identified strong positive correlations of ZNF71 with genes such as ZNF470,ZNF256,and ZNF285.Pathway enrichment analyses highlighted associations with herpes simplex virus type 1 infection,the cell cycle,and DNA replication.Negative correlations involved metabolic pathways,peroxisomes,and fatty acid degradation.TIMER2.0 analysis demonstrated positive correlations of high ZNF71 expression with various immune cell types,including CD4^(+)T cells,B cells,regulatory T cells,monocytes,macrophages,and myeloid dendritic cells.CONCLUSION ZNF71 is significantly upregulated in HCC,correlating with the disease’s clinical and pathological stages.It appears to promote HCC progression through mechanisms involving the cell cycle and metabolism and is associated with immune cell infiltration.These findings suggest that ZNF71 could be a novel target for diagnosing and treating HCC.
基金supported by the NationalNatural Science Foundation of China(no.32360888)the Jiangxi Students’Platform for Innovation and Entrepreneurship Training Program(no.202411843023).
文摘Background:Heat shock protein B8(HSPB8)is implicated in autophagy,and its aberrant expression has been linked to both the ini-tiation and progression of tumors.However,the role and function of HSPB8 in colorectal cancer(CRC)and across multiple cancer types remain unclear.This study aimed to map the transcriptome of autophagy-related genes in CRC and to conduct a pan-cancer analysis of HSPB8 as both a prognostic and immunological biomarker.Methods:We performed bioinformatics analyses on GSE113513 and GSE74602 to identify differentially expressed genes(DEGs)in CRC.These DEGs were then compared with autophagy-related genes to identify critical overlapping genes.The Kaplan-Meier plotter was used to verify the ex-pression of autophagy-linked DEGs and evaluate its prognostic value.The protein expression of Hub gene in CRC was analyzed using the Human Protein Atlas database.The cBioPortal was used to analyze the type and frequency of Hub gene mutations.The TIMER(Tumor Immune Estimation Resource)database was used to study the correlation between HSPB8 and immune infiltration in CRC.Results:In total,825 DEGs were identified,including 8 autophagy-linked DEGs:ATIC,MYC,HSPB8,TNFSF10,BCL2,TP53INP2,ITPR1,and NKX2-3.Survival analysis showed that increased HSPB8 expression significantly correlates with poor prognosis in patients with CRC(p<0.05).HSPB8 was also found to be differentially expressed in various cancer types,correlating with both prognosis and immune infiltration.Further,changes in HSPB8 methylation and phosphorylation status were observed across several cancers,suggesting potential regulatory mechanisms.Therefore,HSPB8 may serve as a crucial prognostic and immunological biomarker in CRC and other cancers.Conclusions:This study provides new insights into the role of autophagy-related genes in cancer progression and highlights HSPB8 as a potential target for cancer diagnostics and therapy.
基金supported by the National Natural Science Foundation of China(Grant Nos.52275321 and 52205348)the Shandong Natural Science Foundation(Grant No.ZR2023JQ021)+3 种基金the Taishan Scholars Foundation of Shandong Province(No.tsqn 201812128)the Innovation Scientists and Technicians Troop Projects of Henan Province(No.204200510031)the Heilongjiang Touyan Innovation Team Program(No.HITTY-20190013)supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIP)(Nos.NRF-2021R1A2C3006662 and NRF-2022R1A5A1030054).
文摘To effectively regulate the grain boundary infiltration in CoCrFeMnNi high-entropy alloy(Cantor alloys,HEA)caused by the violent atomic interdiffusion,the higher configuration entropy on Cantor alloys surface was designed and realized via eutectic high-entropy(EHEA)transformation.Meanwhile,to effectively alleviate the residual stress caused by the notable difference in the thermal expansion coefficient(CTE)between Cantor alloys and Zr-3 alloys,a cladding layer was applied to the HEA surface using laser cladding technology of Nb,followed by brazing to Zr-3 alloys with Zr63.2Cu filler.The cladding layer’s microstructure comprised Nbss and FCC+(Co,Ni)_(2) Nb eutectic structure,resulting from an in-situ reaction between Cantor alloys and Nb.The Nbss and FCC demonstrated good plasticity,and the(Co,Ni)_(2) Nb Laves phase provided increased strength,endowing both good plastic deformation ability and strength of the cladding layer.Notably,the existence of EHEA in the laser cladding layer made the Cantor alloy entropy from 1.61 R to 1.77 R,greatly enhancing its thermal stability and suppressing the grave grain boundary infiltration.Joints produced via laser cladding with Nb-assisted brazing exhibited a complex microstructure(HEA/Nbss+FCC+(Co,Ni)_(2)Nb/(Zr,Nb)(Cr,Mn)_(2)+(Zr,Nb)ss/(Zr,Nb)_(2)(Cu,Ni,Co,Fe)+(Zr,Nb)(Cr,Mn)_(2)+(Zr,Nb)ss/Zr-3) and a significantly improved shear strength of 242.8 MPa at 1010℃ for 10 min,42.4%higher than that of directly brazed joints.This improvement was attributed to reduced grain boundary infiltration,alleviated residual stress due to CTE disparity,and eliminated micro-cracks in the brazing seam.This study presents an effective solution for reducing residual stresses and achieving reliable bonding between Cantor alloys and Zr-3 alloys,with potential applications in brazing CoCrFeNi-based HEA and Zr-3 due to the beneficial eutectic reaction between CoCrFeNi and Nb.
基金the Xuzhou Science and Technology Bureau,No.KC23186,Jiangsu Provincial Key Laboratory of New Drug Research and Clinical Pharmacy Project(No.XZSYSKF2023013)Key Medical Disciplines of Jiangsu Province’s 14th Five-Year Plan(ZDXK202237).
文摘Background:Cisplatin(DDP)has been used in the treatment of various human cancers.However,DDP alone lacks efficacy in treating triple-negative breast cancer(TNBC),and its clinical application is often hampered by side effects.Astragalus polysaccharide(APS)is one of the active components extracted from Astragalus membranaceus and has gained attention for its various biological properties.This research is aimed to evaluate the effectiveness of a combination of APS and DDP on TNBC and explore the potential mechanisms.Methods:The efficacy and mechanisms of single or combined treatment were evaluated using Cell Counting Kit-8(CCK8)assay,Annexin V-fluorescein isothiocyanate(FITC)/propidium iodide(PI)staining,wound healing assay,trans-well invasion/migration assay,hematoxylin-eosin(HE)staining,immunohistochemical(IHC)staining,Western Blot(WB)analysis,and fluorescence-activated cell sorting(FACS).An orthotopic model of TNBC was used to assess the in vivo treatment efficacy of single or combination treatment.Results:APS significantly enhanced the anti-proliferative,anti-migratory,and anti-invasive effects of DDP on TNBC cells.The combination of APS and DDP downregulated anti-apoptotic genes(Bcl2 and Bcl-xL)while upregulating pro-apoptotic genes(Puma,Cle-Caspase3,Cle-PARP),leading to enhanced apoptosis.This combination treatment increased E-cadherin levels,decreased Vimentin,Snail,Slug,and Twist levels,and effectively suppressed epithelial-mesenchymal transition(EMT)-associated cell invasion.In the orthotopic model of TNBC,a synergistic reduction in tumor growth was observed in mice treated with APS and DDP.Additionally,the combination of APS and DDP induced the infiltration of CD8+T lymphocytes into the tumor immune microenvironment.Conclusion:The combination of APS and DDP exhibits more potent tumor inhibition and anti-tumor immunity than either agent alone,representing a novel approach to enhance therapeutic efficacy without increasing the side effects of DDP.
文摘Based on the service characteristics of fuel elements for molten salt reactors,they need to have a high power density,resistance to coolant infiltration,and excellent thermodynamic properties.To solve the problem of the graphite used in the fuel element for these reactors being susceptible to molten salt infiltration,carbon black(CB)was added to increase the density of the graphite,and a fuel element(TRISO(tri-structural isotropic)fuel particles were randomly distributed in the modified graphite matrix)was prepared by cold isostatic pressing process.An out-of-pile performance study shows that the densification and pore structure of the modified graphite matrix were improved,as was the resistance to molten salt infiltration.The median pore size of the modified graphite was reduced from 673 to 433 nm and the threshold pressure for molten salt(FLiBe,66%(molar fraction)LiF and 34%BeF_(2))infiltration was increased from 0.88 to 1.37 MPa.The isotropic CB made the graphite matrix less anisotropic,while its thermal conductivity and compressive strength were reduced due to the difficult graphitization of CB.Fuel elements containing 20%(volume fraction)TRISO particles were prepared.Numerical simulations show that the power and temperature distribution of the fuel were in line with the design requirements.The modified graphite matrix had a higher density,smaller pores,a lower anisotropy and a greater resistance to FLiBe infiltration.
基金supported by grants from the Weifang Municipal Health Commission Research Programme Project(No.WFWSJK-2023-032)the Weifang Science and Technology Development Project(No.2023YX053)the Weifang Young Medical Talent Support Program Funding。
文摘Background:NDC80 is pivotal in cell division,particularly in regulating the G2/M transition and mitotic progression.Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors.Further analysis has suggested that its high expression is significantly associated with an elevated pathological grade,increased metastatic risk,and shortened overall survival in patients with cancer.However,its precise role in pan-cancer development,progression,and prognosis remains unclear.Methods:We conducted a multi-omics analysis of NDC80 using genomic,transcriptomic,and proteomic data from 33 cancer types in The Cancer Genome Atlas,Clinical Proteomic Tumor Analysis Consortium,Genotype-Tissue Expression,and Human Protein Atlas.Results:The results demonstrated frequent NDC80 mutations across multiple malignancies and significantly elevated expression in tumor tissues compared with that in their normal counterparts,correlating with worse overall and disease-free survival.Moreover,NDC80 expression was strongly associated with oncogenic pathways,key protein regulators,cellular components,myeloid-derived suppressor cell infiltration,ESTIMATE scores,and cancer-related signaling networks.Conclusions:These findings underscore the potential of NDC80 as a prognostic biomarker and therapeutic target for cancer treatment.
基金supported by National Natural Science Foundation of China(Nos.52364004,52464005)The Youth Talent Growth Project of Guizhou Provincial Department of Education(No.Qian Jiao Ji[2024]18)+3 种基金Postgraduate Research Fund of Guizhou Province in 2024(No.2024YJSKYJJ067)Basic Research Project of Guizhou University(No.[2023]40)Guizhou Provincial Basic Research Program(Natural Science)(No.Qian Ke He Ji Chu-ZK[2024]Yi Ban011)Research Fund for Talents of Guizhou University(No.Gui Da Ren Ji He Zi(2023)24)。
文摘During the exploitation of sandstone gas reservoirs,natural fractures near the wellbore affect water infiltration and pore evolution;however,the impact mechanisms of these fractures remain unclear.This study utilized real-time nuclear magnetic resonance(RT-NMR)technology to investigate the influence of near-wellbore fracture angle(a)at 0°,15°,30°,and 45°on water infiltration,migration patterns,and pore evolution mechanisms during water injection.Throughout the experiments,T_(2)curves and magnetic resonance imaging(MRI)were monito red in real time during the water injection process.The pore evolution and water infiltration were translated by the evolution of T_(2)curves and MRI.The results show that increasing injection pressure(P_(inj))transforms adsorption pores into seepage pores,leading to enhanced pore damage.Pore damage predominantly occurs during the rapid pressurization stage and is concentrated around the near-wellbore fracture.The maximum infiltration area and rate were observed at α=0°,while the minimum values occurred at α=45°,which can be attributed to the significant influence of a on water infiltration and migration pathways.The increasing inclination of the infiltration front with a is attributed to the fact that the rate of water infiltration along the fracture wall is always higher than that at the fracture tip.In field fracturing,it is recommended to adjust the perforation direction to align with the natural fracture orientation and optimize pressurization strategies by reducing the slow pressurization duration while extending the rapid pressurization stage.These findings can provide important guidance for setting fracturing sections and optimizing injection parameters in sandstone gas reservoir exploitation.
文摘In order to determine the bulk density of refractory raw materials,the so-called water method following the Archimedes principle is normally used.This is where the effect of water displacement on the mass of the sample is used to determine the bulk volume of the sample grains.During this test procedure,the surface of water infiltrated sample grains must be dried with a wet towel.Experience shows,that this drying step is the main root cause for variation in reproducibility of results and even repeatability of tests.A new spin dryer(centrifuge)was developed and introduced to automate this surface drying step,and is now included as a new method in ISO 8840:2021.The paper discusses the improvement of measurement with the new approach and industrial experiences from two big industrial players in the raw material business.
