In a recent study in Cell,Morrison et al.1 identified Ugcg and B4galt5 as super-enhancer–driven genes essential for glycosphingolipid synthesis in natural killer(NK)cells and cytotoxic T cells.Genetic deletion or pha...In a recent study in Cell,Morrison et al.1 identified Ugcg and B4galt5 as super-enhancer–driven genes essential for glycosphingolipid synthesis in natural killer(NK)cells and cytotoxic T cells.Genetic deletion or pharmacologic inhibition of UGCG disrupted cytotoxic granules,induced apoptosis,and blocked NK and CD8^(+)T cell expansion during viral infection,underscoring the critical role of glycosphingolipid metabolism in lymphocyte identity and effector function.展开更多
基金Supported by DACCPM Innovation Grant 232129,245130Eleanor and Myles Shores Fellowship 241317(Y.J.)+2 种基金Scientific research funds of Zhejiang Province Health Department 2024ky205Hangzhou Municipal Health Commission ZD20250235Natural Science Foundation of Zhejiang province LMS25H160023(S.C.).
文摘In a recent study in Cell,Morrison et al.1 identified Ugcg and B4galt5 as super-enhancer–driven genes essential for glycosphingolipid synthesis in natural killer(NK)cells and cytotoxic T cells.Genetic deletion or pharmacologic inhibition of UGCG disrupted cytotoxic granules,induced apoptosis,and blocked NK and CD8^(+)T cell expansion during viral infection,underscoring the critical role of glycosphingolipid metabolism in lymphocyte identity and effector function.
