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Numerical Simulation of Fluid Flow Inside a Molten Liquid Metal Droplet Located in an Electromagnetic Induction Generated by Two Different Inducting Currents
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作者 Alimata DIARRA Annie GAGNOUD +2 位作者 Jacqueline ETAY Andreas STEIN Rainer WUNDERLICH 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2012年第S1期127-130,共4页
Electromagnetic levitation of electrically conductive droplets by alternating magnetic fields is Sa technique used to measure the physical properties of liquid metallic alloys such as surface tension,viscosity,heat ca... Electromagnetic levitation of electrically conductive droplets by alternating magnetic fields is Sa technique used to measure the physical properties of liquid metallic alloys such as surface tension,viscosity,heat capacity.Experiments can be conducted in microgravity,to reduce electromagnetic stirring and shaping of the droplet.The inductor of the EML is composed of a single inductor which two types of voltage are imposed.This type of electrical installation generates a field to center the metallic droplet and another field to heat and excite it.We use a commercial code join to a homemade code to compute flows generated by inducting voltages recorded in the sounding rocket TEXUS-EML-2(Feb2008).In this flight,two samples(Cu75Co25 at%and A168,5Ni31,5 at%)of 8 mm diameter have been processed. 展开更多
关键词 electromagnetic levitation superposed inducting currents MICROGRAVITY electromagnetic stirring
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Outcomes of basiliximab vs alemtuzumab induction in kidney allograft recipients with matched immunological Profiles:A retrospective cohort study
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作者 Chukwuma A Chukwu Philip A Kalra +3 位作者 Marcus Lowe Kay Poulton Titus Augustine Anirudh Rao 《World Journal of Transplantation》 2026年第1期182-192,共11页
BACKGROUND The use of induction immunosuppression agents has improved kidney transplant outcomes,but selecting the optimal agent remains a point of debate.AIM To compare the long-term outcomes of kidney transplant rec... BACKGROUND The use of induction immunosuppression agents has improved kidney transplant outcomes,but selecting the optimal agent remains a point of debate.AIM To compare the long-term outcomes of kidney transplant recipients receiving alemtuzumab vs basiliximab induction,focusing on graft function,acute rejection,infection,malignancy,post-transplant glomerulonephritis,and survival,using a propensity score matched cohort design.METHODS Kidney transplant recipients who received alemtuzumab or basiliximab induction from 2014 to 2019 across two nephrology centres in Northwest England were evaluated.Propensity score matching at a 1:1.5 ratio ensured comparability between cohorts.Baseline characteristics,immunosuppression regimens,and outcomes were analyzed.Linear,binary logistic and Cox proportional hazard regression models.RESULTS A total of 436 recipients were included,with a median follow-up of 5.2 years.The matched cohort(n=262)had a mean age of 51.1±13.5 years;39%were female and 92%were white.There was no significant difference in the cumulative incidence of acute rejection[odds ratio(OR)=2.10;95%CI:0.9-4.9;P=0.110].Compared with basiliximab,alemtuzumab was associated with lower estimated glomerular filtration rate at 12 months(-6.6 mL/minute/1.73 m2;95%CI:-10.5 to-2.7;P<0.001)and higher risks of cytomegalovirus viremia(OR=3.2;95%CI:1.6-6.5;P<0.001),BK viremia(OR=2.4;95%CI:1.1-5.5;P=0.02),post-transplant malignancy(OR=6.2;95%CI:1.6-29.9;P=0.013),and death-censored graft loss(hazard ratio=3.6;95%CI:1.2-11.4;P=0.03).No significant differences were observed in post-transplant glomerulonephritis or recipient mortality.CONCLUSION In this propensity score-matched analysis,alemtuzumab induction was associated with lower graft function at 12 months and higher risks of viral infection,post-transplant malignancy,and graft loss compared with basiliximab.These findings highlight the need for further studies to confirm the long-term safety and effectiveness of alemtuzumab in kidney transplantation. 展开更多
关键词 Kidney transplantation Immunosuppression induction ALEMTUZUMAB BASILIXIMAB Graft outcomes
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Design of 400 V-10 kV Multi-Voltage Grades of Dual Winding Induction Generator for Grid Maintenance Vehicle
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作者 Tiankui Sun Shuyi Zhuang +3 位作者 Yongling Lu Wenqiang Xie Ning Guo Sudi Xu 《Energy Engineering》 2026年第1期356-372,共17页
To ensure an uninterrupted power supply,mobile power sources(MPS)are widely deployed in power grids during emergencies.Comprising mobile emergency generators(MEGs)and mobile energy storage systems(MESS),MPS are capabl... To ensure an uninterrupted power supply,mobile power sources(MPS)are widely deployed in power grids during emergencies.Comprising mobile emergency generators(MEGs)and mobile energy storage systems(MESS),MPS are capable of supplying power to critical loads and serving as backup sources during grid contingencies,offering advantages such as flexibility and high resilience through electricity delivery via transportation networks.This paper proposes a design method for a 400 V–10 kV Dual-Winding Induction Generator(DWIG)intended for MEG applications,employing an improved particle swarmoptimization(PSO)algorithmbased on a back-propagation neural network(BPNN).A parameterized finite element(FE)model of the DWIG is established to derive constraints on its dimensional parameters,thereby simplifying the optimization space.Through sensitivity analysis between temperature rise and electromagnetic loss of the DWIG,the main factors influencing the machine’s temperature are identified,and electromagnetic loss is determined as the optimization objective.To obtain an accurate fitting function between electromagnetic loss and dimensional parameters,the BPNN is employed to predict the nonlinear relationship between the optimization objective and the parameters.The Latin hypercube sampling(LHS)method is used for random sampling in the FE model analysis for training,testing,and validation,which is then applied to compute the cost function in the PSO.Based on the relationships obtained by the BPNN,the PSO algorithm evaluates the fitness and cost functions to determine the optimal design point.The proposed optimization method is validated by comparing simulation results between the initial design and the optimized design. 展开更多
关键词 Dual winding induction generator mobile emergency generator optimization design BP neural network
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Induction therapy in kidney transplant recipients:A consensus statement of Indian Society of Organ Transplantation
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作者 Vivek B Kute Manish Ramesh Balwani +25 位作者 Jigar B Shrimali Amit Pasari Vijay Kher Mohan Punabhai Patel Deodatta Chafekar Swarnalata Guditi Pratik Das Gireesh Mathihally Siddaiah Suraj Mohan Godara Vinant Bhargava Anurag Gupta Vishal Ramteke Nishant Deshpande Priyanka Tolani Narayan Prasad Radhika Krishna Patil Ravi Mohanka Sandeep Mahajan Sourabh Sharma Subho Banerjee Divyesh P Engineer Dhananjai Agarwal Pranjal Kashiv Arpita Lahiri Dinesh Khullar Aneesh Srivastava 《World Journal of Transplantation》 2026年第1期17-31,共15页
Kidney transplantation(KT)accounts for nearly three-fourths of organ transplants in India,with living donors contributing to 82%of cases.Induction immunosuppression is essential to optimize initial immunosuppression,r... Kidney transplantation(KT)accounts for nearly three-fourths of organ transplants in India,with living donors contributing to 82%of cases.Induction immunosuppression is essential to optimize initial immunosuppression,reduce acute rejections,and enable tailored use of maintenance agents.Rabbit anti-thymocyte globulin(rATG)and interleukin-2 receptor anatagonists(IL-2RA/IL-2RBs)are the most widely used induction therapies.However,data on induction practices across India are limited.To evaluate induction immunosuppression practices across KT centers in India and establish a consensus for different subsets of KT recipients.A nationwide online survey was conducted by the Indian Society of Organ Transplantation(ISOT)among its members(400 KT centers).Responses were analyzed to assess induction practices across diverse donor types,age groups,and immunological risk profiles.Heterogeneity in practices prompted consensus building using a modified Delphi process.Literature review and expert panel discussions(April 2024)were followed by structured voting,and 16 consensus statements were finalized.Of 400 centers approached,254 participated.rATG was the most commonly used induction therapy,followed by IL-2RBs;alemtuzumab was least used.Significant heterogeneity was observed in type,dose,and duration of induction therapy.Consensus recommendations were framed:rATG for high immunological risk recipients and deceased donor KTs;IL-2RB or low-dose rATG for low immunological risk;rituximab in ABOincompatible KTs;and tailoring based on age,diabetes,donor type,infection risk,and affordability.This first ISOT consensus provides 16 India-specific statements on induction therapy in KT.It emphasizes risk-stratified,evidenceinformed,and context-appropriate induction strategies,supporting standardization of care across the country. 展开更多
关键词 Kidney transplant Induction therapy Rabbit anti-thymocyte globulin IL-2 receptor blockers RITUXIMAB CONSENSUS Indian Society of Organ Transplantation
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校准式呼吸诱导描记技术在阻塞性睡眠呼吸暂停低通气综合征患者筛查准确性研究
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作者 侯金程 米晓琳 谷牧 《中国耳鼻咽喉头颈外科》 2025年第10期665-667,共3页
目的探讨校准式呼吸诱导描记技术(calibrated respiratory inductance plethysmography,cRIP)在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者筛查的准确性,分析其在评估病情严重程度中的优势及局限性。方法选取2023年1月~2024年12月在辽... 目的探讨校准式呼吸诱导描记技术(calibrated respiratory inductance plethysmography,cRIP)在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者筛查的准确性,分析其在评估病情严重程度中的优势及局限性。方法选取2023年1月~2024年12月在辽宁省人民医院耳鼻咽喉科就诊并接受多导睡眠监测(PSG)的67例患者,其中男43例,女24例,年龄18~65(45.34±9.13)岁。利用系统配套软件对原始数据分别采用口鼻气流和cRIP进行记录分析,并比较不同分析方式下各呼吸暂停事件的相关性。结果根据口鼻气流监测的呼吸暂停低通气指数(AHI)数值,将患者分为非OSAHS组(n=10例)、轻度OSAHS组(n=11例)、中度OSAHS组(n=23例)和重度OSAHS组(n=23例)。cRIP和口鼻气流监测的AHI呈正相关(r=0.930,P<0.001),提示cRIP在总体呼吸事件评估中具有良好的准确性。进一步分析各类型呼吸事件的相关性,其中中枢性呼吸暂停指数(CAI)、阻塞性呼吸暂停指数(OAI)和混合性呼吸暂停指数(MAI)均呈中强度正相关(r分别为0.762、0.622、0.613,P<0.001),而低通气指数(HI)呈弱相关(r=0.347,P=0.008)。cRIP和口鼻气流测得的AHI数值在非OSAHS组、轻度OSAHS组和中度OSAHS组比较差异无统计学意义(P均>0.05),而cRIP测得的AHI数值在重度OSAHS组中低于口鼻气流结果,差异有统计学意义(P<0.05)。结论cRIP和口鼻气流测得的AHI在OSAHS诊断中的相关性良好,表明cRIP在评估呼吸事件方面具有较高的准确性。特别是在轻、中度OSAHS患者中,cRIP表现出较高的敏感性,是临床检查的重要补充,具有潜在的筛查价值。 展开更多
关键词 睡眠呼吸暂停 阻塞性(Sleep Apnea Obstructive) 校准式呼吸诱导描记技术(calibrated respiratory inductance plethysmography cRIP) 筛查(screening)
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In vivo Haploid Induction via Parthenogenesis Gene ToPAR in Rice 被引量:1
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作者 XIONG Jie JI Yajie +3 位作者 YANG Shenlin QIU Xianjin QIAN Qian WANG Kejian 《Rice science》 2025年第3期273-276,I0001-I0004,共8页
Doubled haploid(DH)technology has revolutionized crop breeding by enabling the production of homozygous lines in a single generation.In vivo haploid induction(HI)offers a more widely applicable approach that can signi... Doubled haploid(DH)technology has revolutionized crop breeding by enabling the production of homozygous lines in a single generation.In vivo haploid induction(HI)offers a more widely applicable approach that can significantly improve DH breeding efficiency.ToPAR,a parthenogenesis gene,originally identified in dandelion(Taraxacum officinale),has been characterized.Researchers have successfully induced haploid embryo-like structures and haploid offspring in lettuce and foxtail millet,respectively. 展开更多
关键词 parthenogenesis geneoriginally RICE vivo haploid induction vivo haploid induction hi offers PARTHENOGENESIS topar production homozygous lines foxtail milletrespectively
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DNA demethylation is involved in nitric oxide-induced flowering in tomato 被引量:1
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作者 Xuemei Hou Meimei Shi +6 位作者 Zhuohui Zhang Yandong Yao Yihua Li Changxia Li Wenjin Yu Chunlei Wang Weibiao Liao 《Journal of Integrative Agriculture》 2025年第5期1769-1785,共17页
Flowering is one of the most important phenological periods,as it determines the timing of fruit maturation and seed dispersal.To date,both nitric oxide(NO)and DNA demethylation have been reported to regulate flowerin... Flowering is one of the most important phenological periods,as it determines the timing of fruit maturation and seed dispersal.To date,both nitric oxide(NO)and DNA demethylation have been reported to regulate flowering in plants.However,there is no compelling experimental evidence for a relationship between NO and DNA demethylation during plant flowering.In this study,an NO donor and a DNA methylation inhibitor were used to investigate the involvement of DNA demethylation in NO-mediated tomato(Solanum lycopersicum cv.Micro-Tom)flowering.The results showed that the promoting effect of NO on tomato flowering was dose-dependent,with the greatest positive effect observed at 10μmol L^(-1) of the NO donor S-nitrosoglutathione(GSNO).Treatment with 50μmol L^(-1) of the DNA methylation inhibitor 5-azacitidine(5-AzaC)also significantly promoted tomato flowering.Moreover,GSNO and 5-AzaC increased the peroxidase(POD)and catalase(CAT)activities and cytokinin(CTK)and proline contents,while they reduced the gibberellic acid(GA3)and indole-3-acetic acid(IAA)contents.Co-treatment with GSNO and 5-AzaC accelerated the positive effects of GSNO and 5-AzaC in promoting tomato flowering.Meanwhile,compared with a GSNO or 5-AzaC treatment alone,co-treatment with GSNO+5-AzaC significantly increased the global DNA demethylation levels in different tissues of tomato.The results also indicate that DNA demethylation may be involved in NO-induced flowering.The expression of flowering genes was significantly altered by the GSNO+5-AzaC treatment.Five of these flowering induction genes,ARGONAUTE 4(AGO4A),SlSP3D/SINGLE FLOWER TRUSS(SFT),MutS HOMOLOG 1(MSH1),ZINC FINGER PROTEIN 2(ZFP2),and FLOWERING LOCUS D(FLD),were selected as candidate genes for further study.An McrBC-PCR analysis showed that DNA demethylation of the SFT gene in the apex and the FLD gene in the stem might be involved in NO-induced flowering.Therefore,this study shows that NO might promote tomato flowering by mediating the DNA demethylation of flowering induction genes,and it provides direct evidence for a synergistic effect of NO and DNA demethylation in promoting tomato flowering. 展开更多
关键词 S-NITROSOGLUTATHIONE 5-azacitidine flowering induction genes tomato flowering
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Support electron inductive effect of Pd-Mn/Ni foam catalyst for robust electrocatalytic hydrodechlorination 被引量:1
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作者 Junxi Li Chao Feng +2 位作者 Chong Chen Yuan Pan Yunqi Liu 《Journal of Environmental Sciences》 2025年第3期288-300,共13页
Structural regulation of Pd-based electrocatalytic hydrodechlorination(EHDC)catalyst for constructing high-efficient cathode materials with low noble metal content and high atom utilization is crucial but still challe... Structural regulation of Pd-based electrocatalytic hydrodechlorination(EHDC)catalyst for constructing high-efficient cathode materials with low noble metal content and high atom utilization is crucial but still challenging.Herein,a support electron inductive effect of Pd-Mn/Ni foam catalyst was proposed via in-situ Mn doping to optimize the electronic structure of the Ni foam(NF),which can inductive regulation of Pd for improving the EHDC performance.The mass activity and current efficiency of Pd-Mn/NF catalyst are 2.91 and 1.34 times superior to that of Pd/NF with 2,4-dichlorophenol as model compound,respectively.The Mn-doped interlayer optimized the electronic structure of Pd by bringing the d-state closer to the Fermi level than Pd on the NF surface,which optimizied the binding of EHDC intermediates.Additionally,the Mn-doped interlayer acted as a promoter for generating H∗and accelerating the EHDC reaction.This work presents a simple and effective regulation strategy for constructing high-efficient cathode catalyst for the EHDC of chlorinated organic compounds. 展开更多
关键词 PALLADIUM Structural Regulation Electrocatalytic hydrodechlorination Support electron inductive effect
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Design and Parametric Optimization of a Doublesided Linear Induction Motor for Hyperloop Pod 被引量:1
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作者 Bahaddin Goksun Ismet Sen +3 位作者 Musap Kuzucu Bati Eren Ergun Ilhan Kocaarslan Mehmet Onur Gulbahce 《CES Transactions on Electrical Machines and Systems》 2025年第1期36-45,共10页
The hyperloop idea,which is one of the most ecofriendly,low-carbon emissions,and fossil fuel-efficient modes of transportation,has recently become quite popular.In this study,a double-sided linear induction motor(LIM)... The hyperloop idea,which is one of the most ecofriendly,low-carbon emissions,and fossil fuel-efficient modes of transportation,has recently become quite popular.In this study,a double-sided linear induction motor(LIM)with 500 W of output power,60 N of thrust force and 200 V/38.58 Hz of supply voltage was designed to be used in hyperloop development competition hosted by the scientific and technological research council of turkey(TüB?TAK)rail transportation technologies institute(RUTE).In contrast to the studies in the literature,concentrated winding is preferred instead of distributed winding due to mechanical constraints.The electromagnetic design of LIM,whose mechanical and electrical requirements were determined considering the hyperloop development competition,was carried out by following certain steps.Then,the designed model was simulated and analyzed by finite element method(FEM),and the necessary optimizations have been performed to improve the motor characteristics.By examining the final model,the applicability of the concentrated winding type LIM for hyperloop technology has been investigated.Besides,the effects of primary material,railway material,and mechanical air-gap length on LIM performance were also investigated.In the practical phase of the study,the designed LIM has been prototyped and tested.The validation of the experimental results was achieved through good agreement with the finite element analysis results. 展开更多
关键词 Finite element analysis(FEA) Hyperloop Linear induction motor(LIM) Motor design
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Industrial Untapped Rotational Kinetic Energy Assessment for Sustainable Energy Recycling 被引量:1
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作者 See Wei Jing Md Tanjil Sarker +2 位作者 Gobbi Ramasamy Siva Priya Thiagarajah Fazlul Aman 《Energy Engineering》 2025年第3期905-927,共23页
Electrical energy can be harvested from the rotational kinetic energy of moving bodies,consisting of both mechanical and kinetic energy as a potential power source through electromagnetic induction,similar to wind ene... Electrical energy can be harvested from the rotational kinetic energy of moving bodies,consisting of both mechanical and kinetic energy as a potential power source through electromagnetic induction,similar to wind energy applications.In industries,rotational bodies are commonly present in operations,yet this kinetic energy remains untapped.This research explores the energy generation characteristics of two rotational body types,disk-shaped and cylinder-shaped under specific experimental setups.The hardware setup included a direct current(DC)motor driver,power supply,DC generator,mechanical support,and load resistance,while the software setup involved automation testing tools and data logging.Electromagnetic induction was used to harvest energy,and experiments were conducted at room temperature(25℃)with controlled variables like speed and friction.Results showed the disk-shaped body exhibited higher energy efficiency than the cylinder-shaped body,largely due to lower mechanical losses.The disk required only two bearings,while the cylinder required four,resulting in lower bearing losses for the disk.Additionally,the disk experienced only air friction,whereas the cylinder encountered friction from a soft,uneven rubber material,increasing surface contact losses.Under a 40 W resistive load,the disk demonstrated a 17.1%energy loss due to mechanical friction,achieving up to 15.55 J of recycled energy.Conversely,the cylinder body experienced a 48.05%energy loss,delivering only 51.95%of energy to the load.These insights suggest significant potential for designing efficient energy recycling systems in industrial settings,particularly in manufacturing and processing industries where rotational machinery is prevalent.Despite its lower energy density,this system could be beneficially integrated with energy storage solutions,enhancing sustainability in industrial practices. 展开更多
关键词 Rotational kinetic energy electromagnetic induction energy harvesting disk-shaped body cylinder-shaped body energy efficiency mechanical loss industrial energy recycling sustainable energy solutions
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An experimental and computational investigation on structural evolution of the In_(2)O_(3)catalyst during the induction period of CO_(2)hydrogenation 被引量:1
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作者 Zhangqian Wei Mingxiu Wang +6 位作者 Xinnan Lu Zixuan Zhou Ziqi Tang Chunran Chang Yong Yang Shenggang Li Peng Gao 《Chinese Journal of Catalysis》 2025年第5期301-313,共13页
As one of the most important industrially viable methods for carbon dioxide(CO_(2))utilization,methanol synthesis serves as a platform for production of green fuels and commodity chemicals.For sustainable methanol syn... As one of the most important industrially viable methods for carbon dioxide(CO_(2))utilization,methanol synthesis serves as a platform for production of green fuels and commodity chemicals.For sustainable methanol synthesis,In_(2)O_(3)is an ideal catalyst and has garnered significant attention.Herein,cubic In_(2)O_(3)nanoparticles were prepared via the precipitation method and evaluated for CO_(2)hydrogenation to produce methanol.During the initial 10 h of reaction,CO_(2)conversion gradually increased,accompanied by a slow decrease of methanol selectivity,and the reaction reached equilibrium after 10-20 h on stream.This activation and induction stage may be attributed to the sintering of In_(2)O_(3)nanoparticles and the creation of more oxygen vacancies on In_(2)O_(3)surfaces.Further experimental studies demonstrate that hydrogen induction created additional oxygen vacancies during the catalyst activation stage,enhancing the performance of In_(2)O_(3)catalyst for CO_(2)hydrogenation.Density functional theory calculations and microkinetic simulations further demonstrated that surfaces with higher oxygen vacancy coverages or hydroxylated surfaces formed during this induction period can enhance the reaction rate and increase the CO_(2)conversion.However,they predominantly promote the formation of CO instead of methanol,leading to reduced methanol selectivity.These predictions align well with the above-mentioned experimental observations.Our work thus provides an in-depth analysis of the induction stage of the CO_(2)hydrogenation process on In_(2)O_(3)nano-catalyst,and offers valuable insights for significantly improving the CO_(2)reactivity of In_(2)O_(3)-based catalysts while maintaining long-term stability. 展开更多
关键词 In_(2)O_(3) CO_(2)hydrogenation Methanol production Induction and activation Structural evolution
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Masquelet technique using an allogeneic cortical bone graft for a large bone defect:A case report
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作者 Hai-Yang Zong Yu Liu +2 位作者 Xing Yin Wei Zhou Nan Li 《World Journal of Clinical Cases》 SCIE 2025年第5期36-43,共8页
BACKGROUND The induced-membrane technique was initially described by Masquelet as an effective treatment for large bone defects,especially those caused by infection.Here,we report a case of chronic osteomyelitis of th... BACKGROUND The induced-membrane technique was initially described by Masquelet as an effective treatment for large bone defects,especially those caused by infection.Here,we report a case of chronic osteomyelitis of the radius associated with a 9 cm bone defect,which was filled with a large allogeneic cortical bone graft from a bone bank.Complete bony union was achieved after 14 months of follow-up.Previous studies have used autogenous bone as the primary bone source for the Masquelet technique;in our case,the exclusive use of allografts is as successful as the use of autologous bone grafts.With the advent of bone banks,it is possible to obtain an unlimited amount of allograft,and the Masquelet technique may be further improved based on this new way of bone grafting.CASE SUMMARY In this study,we reported a case of repair of a long bone defect in a 40-year-old male patient,which was characterized by the utilization of allograft cortical bone combined with the Masquelet technique for the treatment of the patient's long bone defect in the forearm.The patient's results of functional recovery of the forearm were surprising,which further deepens the scope of application of Masquelet technique and helps to strengthen the efficacy of Masquelet technique in the treatment of long bones indeed.CONCLUSION Allograft cortical bone combined with the Masquelet technique provides a new method of treatment to large bone defect. 展开更多
关键词 OSTEOMYELITIS Bone defect Allogeneic cortical bone Masquelet technique Membrane induction technique Case report
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Multi-Objective Dynamic Induction Research of Ship Routes in the Context of Low Carbon Shipping
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作者 He Zhang Junfeng Dong Siyuan Kong 《哈尔滨工程大学学报(英文版)》 2025年第3期593-605,共13页
To improve the efficiency of ship traffic in frequently traded sea areas and respond to the national“dual-carbon”strategy,a multi-objective ship route induction model is proposed.Considering the energy-saving and en... To improve the efficiency of ship traffic in frequently traded sea areas and respond to the national“dual-carbon”strategy,a multi-objective ship route induction model is proposed.Considering the energy-saving and environmental issues of ships,this study aims to improve the transportation efficiency of ships by providing a ship route induction method.Ship data from a certain bay during a defined period are collected,and an improved backpropagation neural network algorithm is used to forecast ship traffic.On the basis of the forecasted data and ship route induction objectives,dynamic programming of ship routes is performed.Experimental results show that the routes planned using this induction method reduce the combined cost by 17.55%compared with statically induced routes.This method has promising engineering applications in improving ship navigation efficiency,promoting energy conservation,and reducing emissions. 展开更多
关键词 Dynamic route induction Low-carbon shipping Short-term vessel flow prediction Multi-objective induction model Maritime transport efficiency
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Value of tofacitinib extended induction therapy in patients with moderate-to-severe ulcerative colitis:A real-world 52-week follow-up study
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作者 Maria Tzouvala Eirini Zacharopoulou +25 位作者 Maria Kalafateli Nikos Viazis Andreas Psistakis Angeliki Theodoropoulou Ioannis Drygiannakis Konstantinos Karmiris Ioannis E Koutroubakis Polyxeni Kevrekidou Kostas Soufleris Marios Katsaros Olga Giouleme Fotios Fousekis Konstantinos Katsanos Dimitrios Christodoulou Aikaterini Gaki Evgenia Papathanasiou Giorgos Bamias Evanthia Zampeli Spyridon Michopoulos Nikolaos Kyriakos Christos Veretanos Konstantinos Argyriou Andreas Kapsoritakis George Tribonias Gerassimos J Mantzaris Christos Liatsos 《World Journal of Gastroenterology》 2025年第42期90-102,共13页
BACKGROUND Tofacitinib is an oral,selective Janus kinase inhibitor that is approved for the treatment of ulcerative colitis(UC).The 8-week induction protocol involves the administration of 10 mg twice daily(bid)with t... BACKGROUND Tofacitinib is an oral,selective Janus kinase inhibitor that is approved for the treatment of ulcerative colitis(UC).The 8-week induction protocol involves the administration of 10 mg twice daily(bid)with the possibility of extending the induction period to 16 weeks.The maintenance dose of tofacitinib is either 5 mg or 10 mg bid.AIM To assess predictors for clinical remission and drug persistence in patients with UC receiving the extended induction tofacitinib protocol.METHODS This was a real-world multicenter retrospective study in patients with moderateto-severe UC.Patients received physician-directed extended induction tofacitinib treatment.We collected clinical and demographic data at baseline and data regarding clinical,laboratory,and endoscopic evaluations,therapeutic modifications,and adverse events at the 52-week follow-up.Possible predictors for clinical remission at week 52 was the primary endpoint.Differences between patients receiving 5 mg bid vs 10 mg bid at week 52 and identification of predictors for treatment persistence were secondary endpoints.RESULTS Thirty-seven consecutive patients from 11 medical centers were included[51.4%males with median age 39(17-64)years].Twenty-eight patients continued treatment until week 52(75.7%)with 67.9%receiving 10 mg tofacitinib;all had prior history of biologic use.We observed that 57.1%of patients achieved clinical remission(66.7%in the 5 mg tofacitinib group and 52.6%in the 10 mg tofacitinib group,P=0.483).De-escalation to 5 mg tofacitinib was attempted in 17 patients with a success rate of 52.9%.Prior biologic use was significantly more frequent in patients treated with 10 mg tofacitinib.Active smoking was significantly associated with treatment discontinuation at week 52.We identified eight adverse events,and only one led to treatment discontinuation.CONCLUSION Our results supported the extended induction strategy with tofacitinib in selected patients with UC.Patients with prior failure of advanced therapies particularly benefitted,highlighting the importance of personalized maintenance regimens. 展开更多
关键词 Ulcerative colitis Tofacitinib Extended induction PREDICTORS Efficacy Safety Real-world study
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Reevaluating aminosalicylates role in maintaining remission in ulcerative colitis:Systematic review and meta-analysis in the era of biologics
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作者 Themba Mudege Jonathan Soldera 《World Journal of Meta-Analysis》 2025年第4期35-49,共15页
BACKGROUND Oral 5-aminosalicylic acid(5-ASA)has been a cornerstone treatment for mild to moderate ulcerative colitis(UC),traditionally used to maintain remission.With the rise of advanced therapies(biologics and small... BACKGROUND Oral 5-aminosalicylic acid(5-ASA)has been a cornerstone treatment for mild to moderate ulcerative colitis(UC),traditionally used to maintain remission.With the rise of advanced therapies(biologics and small molecules),the role of 5-ASA has come under renewed scrutiny.While earlier systematic reviews affirmed its efficacy compared to placebo,these did not account for the advent of advanced therapies.AIM To assess the efficacy and safety of oral 5-ASA in maintaining remission in quiescent UC,compared to placebo,alternative 5-ASA formulations,and advanced therapies,in the era of biologics and small molecules.METHODS It was systematically searched MEDLINE,EMBASE,and the Cochrane Library,alongside conference proceedings(European Crohn’s and Colitis Organisation,British Society of Gastroenterology),for randomized controlled trials published between 2003 and 2024 in English.Eligible studies involved oral 5-ASA therapies for quiescent UC with a minimum treatment duration of six months.Outcomes included failure to maintain remission,adverse events,and serious adverse events(SAEs).Data were analyzed using Cochrane methods,with GRADE assessing evidence certainty.RESULTS From 44 studies(9967 participants),5-ASA was superior to placebo in maintaining remission,with 37%of 5-ASA users relapsing at 6-12 months compared to 55%of placebo users[risk ratios(RR):0.68;95%CI:0.61-0.76;high-certainty evidence].SAEs were rare and comparable between groups(RR:0.60;95%CI:0.19-1.84;low-certainty evidence).Comparative analyses suggested 5-ASA remains a viable option alongside advanced therapies,with notable differences in cost and safety profiles.CONCLUSION 5-ASA remains effective and safe for maintaining remission in quiescent UC,even in the advanced therapy era.However,tailored approaches are needed to balance efficacy,safety,and cost in clinical practice.This study provides critical insights to guide therapeutic strategies and underscores the enduring relevance of 5-ASA. 展开更多
关键词 Colitis ulcerative MESALAMINE Remission induction Biological therapy SULFASALAZINE
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Accelerating wheat breeding by haploid induction
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作者 Na Zhang Xiaolong Qi +14 位作者 Lei Wu Zongkuan Wang Hongbo Ma Xuecheng Zhu Jing Liu Wenjing Niu Shuwei Guo Yi He Peng Jiang Wei Wang Shaojiang Chen Xiu’e Wang Zhongfu Ni Chenxu Liu Dongtao Liu 《The Crop Journal》 2025年第5期1363-1371,共9页
The identification of haploid induction genes has promoted the advancement of several breeding technologies.Haploid induction genes in wheat,coupled with visual marker,have led to the establishment of a novel in vivo ... The identification of haploid induction genes has promoted the advancement of several breeding technologies.Haploid induction genes in wheat,coupled with visual marker,have led to the establishment of a novel in vivo doubled-haploid(DH)technology.When combined with dominant male sterile genes,this innovative DH method presents a promising avenue for high-throughput production of DH lines.Furthermore,the application of haploid induction genes has facilitated the establishment of other innovative breeding technologies,such as HI-Edit and cyto-swapping in creating cytoplasmic male sterility lines,as well as synthetic apomixis.This review summarizes the progress of DH technology in wheat and presents examples of application of haploid induction genes in accelerating breeding practices,aiming to promote the development of these innovative technologies in wheat and enhancing wheat breeding efficiency. 展开更多
关键词 WHEAT HAPLOID Haploid induction Doubled haploid Hybrid breeding
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In-situ reaction monitoring and kinetics study of photochemical reactions by optical focusing inductive electrospray mass spectrometry
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作者 Yongyi Li Jin Han +1 位作者 Xiangyu Wang Zhenwei Wei 《Chinese Chemical Letters》 2025年第9期564-568,共5页
The investigation of reaction kinetics is the key to understanding the nature of reaction processes.However,monitoring fast photochemical reactions by mass spectrometry remains challenging.Herein,we developed an optic... The investigation of reaction kinetics is the key to understanding the nature of reaction processes.However,monitoring fast photochemical reactions by mass spectrometry remains challenging.Herein,we developed an optical focusing inductive electrospray(OF-iESI)mass spectrometry platform for real-time and in-situ photoreaction monitoring.Coaxial irradiation from back of nanoelectrospray emitter with a taper section was utilized,so the emitter could act as optical lens to help achieving much larger optical power density at emitter tip compared to other sections,which allowed for in-situ reaction monitoring of photoreactions.Through theoretical calculations,the highest optical power density region volume was ca.45 nL.We also integrated a controller for the laser source(450 nm),enabling the modulation of pulse duration(>1 ms).This facilitates the study of photochemical reaction kinetics.The in-situ capability of this device was proved by capturing the short-lived photogenerated intermediates during the dehydrogenation of tetrahydroquinoline.This device was further used to investigate the kinetics of triplet energy transfer based Paternò-Büchi reaction.The reaction order has hitherto remained undetermined while the result of OF-iESI suggested it followed pseudo-second-order reaction kinetics.The short-lived donor-acceptor collision complex intermediate was also successfully identified by tandem mass spectrometry. 展开更多
关键词 Mass spectrometry Inductive electrospray Reaction monitoring Reaction intermediates Photochemical reaction
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Suppression of electromagnetic crosstalk in kinetic inductance detector arrays by redesigning the pixel arrangement
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作者 Houceng Huang Shilin Sun +4 位作者 Xiandong Shi Yuechen Zhao Yaqian Zhang Dejun Liu Weijie Du 《Astronomical Techniques and Instruments》 2025年第4期239-245,共7页
Superconducting kinetic inductance detectors(KIDs)are considered to be a highly promising technique for the large-scale imaging of millimeter and submillimeter waves in astronomy.As the pixel density and the array siz... Superconducting kinetic inductance detectors(KIDs)are considered to be a highly promising technique for the large-scale imaging of millimeter and submillimeter waves in astronomy.As the pixel density and the array size increase,the electromagnetic crosstalk inevitably becomes a problem that prevents increasing the multiplexing during the development of larger KIDs arrays.In this work,an effective method is introduced to suppress the electromagnetic crosstalk and achieve a compact pixel distribution and small frequency intervals.The electromagnetic crosstalk is first analyzed by simulating the behavior of two neighboring pixels,and the physical distance and the frequency interval are optimized.Then,the arrangement of the pixels on the whole array is redesigned using a genetic algorithm to satisfy the requirements.The simulation results reveal that the normalized electromagnetic crosstalk can be reduced to 0.5%on an 8×8 array.Larger arrays of 16×16 pixels have been fabricated and measured to validate this method,and the results reveal that both the resonance property and survival rate of pixels are improved effectively with this method.This method will be very helpful for designing high-multiplexing KIDs arrays within a limited bandwidth. 展开更多
关键词 Kinetic inductance detector CROSSTALK Submillimeter wave RESONATOR
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Rational designation of electromagnetic interface for low-temperature CO_(2) reforming CH_(4)
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作者 Jin Chen Shuangyong Su +3 位作者 Chunqi Wang Hangyu Duan Zhen Xu Hongpeng Jia 《Journal of Environmental Sciences》 2025年第11期769-781,共13页
CO_(2) and CH_(4) as major causes of global warming could both be eliminated to produce syngas undermild conditions through dry reforming methane driven by electromagnetic induction heating(EMIH-controlled DRM).Using ... CO_(2) and CH_(4) as major causes of global warming could both be eliminated to produce syngas undermild conditions through dry reforming methane driven by electromagnetic induction heating(EMIH-controlled DRM).Using EMIH-configured characterization and density functional theory,it is shownthat the EMIH-induced negative electric field at the electromagnetic interface facilitates CO_(2) dissociation and atomic oxygen transfer,which is the source of the promoting effect of EMIH.By employing pure H2 in a one-step high-temperature reduction process,the interfacial effect between the NiMgAl compound and the Fe fiber could be improved,thereby increasing the influence of the EMIH-induced electric field.Consequently,the R-NiMgAl/Fe fiber catalyst with EMIH achieves about 90%conversions of CH_(4) and CO_(2) at 500℃,while traditional heating-driven DRM on R-NiMgAl requires 700℃ to accomplish the same result. 展开更多
关键词 Electromagnetic induction heating Dry reforming METHANE Carbon dioxide SYNGAS
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Impact of Handshake and Information Support on Patients’ Physiological and Psychological States before Anesthesia Induction for Laparoscopic Cholecystectomy
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作者 Yi Liu Jing Wang +3 位作者 Xiangying Pi Zumei Gao Xiaohui Li Qian Sun 《Journal of Biosciences and Medicines》 2025年第2期58-66,共9页
Objective: This study evaluates the impact of handshake and information support on patients’ outcomes during laparoscopic cholecystectomy. It examines the effects on their physiological and psychological responses an... Objective: This study evaluates the impact of handshake and information support on patients’ outcomes during laparoscopic cholecystectomy. It examines the effects on their physiological and psychological responses and overall satisfaction with nursing care. Methods: A total of 84 patients scheduled for laparoscopic cholecystectomy were selected through convenient sampling and randomly assigned to either the control group or the intervention group using a random number table. Each group consisted of 42 patients. The control group received standard surgical nursing care. In addition to standard care, the intervention group received handshake and information support from the circulating nurse before anesthesia induction. Vital signs were recorded before surgery and before anesthesia induction. Anxiety levels were measured using the State-Trait Anxiety Inventory (STAI) and the State-Anxiety Inventory (S-AI), while nursing satisfaction was assessed using a numerical rating scale. Results: No significant differences were found between the two groups in systolic and diastolic blood pressures before surgery and anesthesia induction (P > 0.05). However, there was a significant difference in heart rate before anesthesia induction (P Conclusion: Providing handshake and information support before anesthesia induction effectively reduces stress, alleviates anxiety, and enhances comfort and satisfaction among patients undergoing laparoscopic cholecystectomy. 展开更多
关键词 HANDSHAKE Information Support Anesthesia Induction Preoperative Anxiety
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