A β cyclodextrin derivative bearing seven cationic arms and its singly charged analogue, i.e., per-6- deoxy-f-（1-methylimidazol-3-ium-3-yl）-β-cyclodextrin （3） and mono-fi-deoxy-6-（1-methylimidazol- 3-ium-3-yl）...A β cyclodextrin derivative bearing seven cationic arms and its singly charged analogue, i.e., per-6- deoxy-f-（1-methylimidazol-3-ium-3-yl）-β-cyclodextrin （3） and mono-fi-deoxy-6-（1-methylimidazol- 3-ium-3-yl）-β-cyclodextrin （4） were synthesized and fully characterized. Their induced aggregation behaviours towards two anionic surfactant, that is, sodium dodecyl sulfonate （SDS） and dioctyl sodium sulfosuccinate （Aerosol OT, AOT）, were investigated by UV-vis, NMR, Zeta-potential, dynamic light scattering （DLS）, and transmission electron microscopy. The results revealed that host 3 can induce the molecular aggregation of anionic surfactant at concentration far lower than its original CAC, leading to the larger diameter, the narrower size distribution and the higher thermal stability of the induced aggregate towards the anionic surfactant possessing more hydrophobic tails.展开更多
Molecular ordering within the photoactive layer plays a crucial role in determining the device performance of organic solar cells(OSCs).However,the simultaneous molecular ordering processes of polymer donors and non-f...Molecular ordering within the photoactive layer plays a crucial role in determining the device performance of organic solar cells(OSCs).However,the simultaneous molecular ordering processes of polymer donors and non-fullerene acceptors(NFAs)during solution casting usually bring confinement effect,leading to insufficient structural order of photovoltaic components.Herein,the molecular packing of mINPOIC NFA is effectively formed through a heating induced aggregation strategy,with the aggregation of PBDB-T,which has a strong temperature dependence,is retarded by casting on a preheated substrate to reduce its interference toward m-INPOIC.A sequent thermal annealing treatment is then applied to promote the ordering of PBDB-T and achieve balanced aggregation of both donors and acceptors,resulting in the achievement of a maximum efficiency of 13.9% of PBDB-T:m-INPOIC binary OSCs.This work disentangles the interactions of donor polymer and NFA during the solution casting process and develops a rational strategy to enhance the molecular packing of NFAs to boost device performance.展开更多
A novel wate r-soluble red-emissive AIE fluorescence probe for cysteine(Cys) in situ was prepared and the performance of selectivity and sensitivity has been carefully investigated in this study.The probe was establis...A novel wate r-soluble red-emissive AIE fluorescence probe for cysteine(Cys) in situ was prepared and the performance of selectivity and sensitivity has been carefully investigated in this study.The probe was established on the electrostatic interaction of sulfonate functionalized tetraphenylethene(TPE) and polycation generated by the reaction between a polymer bearing dinitrobenzenesulfonate groups and Cys.From the experimental results,it was easy to distinguish Cys from glutathione(GSH) and homocysteine(Hcy) with a detection limit of 73 nmol/L.The assay system also possessed strong antiinterference ability against multitudinous amino acids.The Stokes shift was 142 nm and the emission ranged from 550 nm to 850 nm.In addition,double responses in fluorescence and ultraviolet-visible spectra also make the red-emissive assay ideal for sensitive detection and quantification of Cys for most purposes,especially in-situ monitoring of Cys in aqueous medium.展开更多
Carbon dots(CDs)are prepared through a simple one-step hydrothermal treatment of o-phenylendiamine(OPD)and show yellow photoluminescent(PL)emission under the ultraviolet excitation,which can be further enhanced by Cu2...Carbon dots(CDs)are prepared through a simple one-step hydrothermal treatment of o-phenylendiamine(OPD)and show yellow photoluminescent(PL)emission under the ultraviolet excitation,which can be further enhanced by Cu2+ions owing to Cu2+ions induced aggregation of OPD-CDs through the coordination of Cu2+with amino groups on the surface of OPD-CDs.The aggregation induced emission enhancement(AIEE)property enables it feasible to develop a simple,sensitive and selective method to detect environmental and intracellular copper(Ⅱ)ions.The limit of detection as lowas 0.28μmol/L(3σ/k)and a dynamic range from 0.5μmol/L to 40μmol/L make it veryeasy to detect the copper content inwater samples,such as river closure reservoir.Furthermore,fluorescence imaging of intracellular Cu2+suggests that the AIEE features of OPD-CDs specific to Cu2+ions can be also applied in biological systems.展开更多
Four derivatives of 9,10-bis[2-（2-alkoxynaphthalen-1-yl）vinyl]anthracene（BNAs） were designed,successfully synthesized and characterized by spectrofluorometer, powder wide-angle X-ray diffraction（PXRD） and differ...Four derivatives of 9,10-bis[2-（2-alkoxynaphthalen-1-yl）vinyl]anthracene（BNAs） were designed,successfully synthesized and characterized by spectrofluorometer, powder wide-angle X-ray diffraction（PXRD） and differential scanning calorimetry experiments（DSC）, etc. It was found that these compounds exhibited aggregation-induced emission phenomenon. Moreover, these target compounds displayed reversible color change from yellow to orange upon pressing and annealing process. Interestingly, all of BNAs obviously presented red-shifted piezofluorochromic（PFC） properties and behaved mainly length dependence of alkoxy group, in which, BNA displayed the largest PFC spectral shift（DlPFC= 26 nm）. The PXRD profiles demonstrated the transformation from crystalline to amorphous state upon grinding, and the mechanism of PFC behaviors was proposed. Thus, changing the length of alkoxyl chain could be an alternative way to tune their PFC behaviors.展开更多
In this paper,a decision-making problem with a q-rung orthopair fuzzy hypersoft environment is developed,and two operators of ordered weighted average and induced ordered weighted average are developed.Several fundame...In this paper,a decision-making problem with a q-rung orthopair fuzzy hypersoft environment is developed,and two operators of ordered weighted average and induced ordered weighted average are developed.Several fundamental features are also derived.The induced ordered weighted average operator is essential in a q-ROFH environment as the induced ordered aggregation operators are special cases of the existing aggregation operators that already exist in q-ROFH environments.The main function of these operators is to help decision-makers gain a complete understanding of uncertain facts.The proposed aggregation operator is applied to a decision-making problem,with the aim of selecting the most promising real estate project for investment.展开更多
Rodents are popular biological models for physiological and behavioral research in neuroscience and rats are better models than mice due to their higher genome similarity to human and more accessible surgical procedur...Rodents are popular biological models for physiological and behavioral research in neuroscience and rats are better models than mice due to their higher genome similarity to human and more accessible surgical procedures.However,rat brain is larger than mice brain and it needs powerful imaging tools to implement better penetration against the scattering of the thicker brain tissue.Three-photon fluorescence microscopy(3PFM)combined with near-infrared(NIR)excitation has great potentials for brain circuits imaging beause of its abilities of anti scattering,deep-tissue imaging,and high signal-to-noise ratio(SNR).In this work,a type of AIE lumninogen with red fuorescence was synthesized and encapsulated with Pluronic F-127 to make up form nano-particles(NPs).Bright DCDPP-2TPA NPs were employed for in trino three-photon fuorescent laser scanning microscopy of blood vessels in rats brain under 1550 nm femtosecond laser exci-tation.A fine three-dimensional(3D)reconstruction up to the deepness of 600 pm was achieved and the blood flow velocity of a selected vessel was measured in vrito as well.Our 3PFM deep brain imaging method simultaneously recorded the morphology and function of the brain blood vessels in vivo in the rat model.Using this angiography combined with the arsenal of rodent's brain disease,models can accelerate the neuroscience research and clinical diagnosis of brain disease in the future.展开更多
A new chiral bromobinaphthol-pyrene compound was developed to achieve a green circularly polarized luminescence(CPL)from its excimer with a dissymmetry factor(|glum|)value of 4.3×10^-3 and a high quantum yieldΦF...A new chiral bromobinaphthol-pyrene compound was developed to achieve a green circularly polarized luminescence(CPL)from its excimer with a dissymmetry factor(|glum|)value of 4.3×10^-3 and a high quantum yieldΦF,solid up to 55.9%,while no CPL signals could be observed for the blue luminescence from unimolecule.Meanwhile,reversal CPL signals can be observed from both concentrated solution and solid.展开更多
In this paper,a novel“turn-on”chemosensor for detecting temperature and Fe3+has been designed.This nanosensor is based on the aggregation-induced emission enhancement(AIEE)properties of fluorescent carbon dots(CDs)....In this paper,a novel“turn-on”chemosensor for detecting temperature and Fe3+has been designed.This nanosensor is based on the aggregation-induced emission enhancement(AIEE)properties of fluorescent carbon dots(CDs).The CDs prepared by a facile hydrothermal route show blue emission(λ_(em)=505 nm)with a quantum yield of 4.7%.The resultant CDs are modified by glutathione(GSH)on the surface through the carbodiimide-activated coupling reaction.The as-prepared GSH-CDs show good dispersion,high fluorescence and AIEE phenomenon.Resultant GSH-CDs would be aggregated by Fe^(3+)ions in aqueous solution which results in enhanced fluorescence.Therefore,such GSH-CDs would be excellent candidates as fluorescent probes for the label-free detection of Fe^(3+)ions with a limit of detection of 0.1μM.Moreover,the PL intensity of GSH-CDs increases progressively with increasing temperature and they could be used in optical thermometry over a wide temperature range(25–80°C)with small temperature resolution(∼0.5℃).Using MC3T3-E1 cells as the model,the resultant nanosensor is demonstrated to monitor temperature and Fe^(3+)ions in cells.Thus,resultant GSH-CDs could be used as a“turnon”sensor for highly sensitive and selective detection of temperature and Fe3+ions in aqueous solution and biosystems.展开更多
Aggregation-induced emission(AIE)is a fascinating luminescence phenomenon that provides new ideas for developing new fluorescent devices.However,research on photofunctional complexes with AIE properties is still in it...Aggregation-induced emission(AIE)is a fascinating luminescence phenomenon that provides new ideas for developing new fluorescent devices.However,research on photofunctional complexes with AIE properties is still in its infancy,mainly because the motion of the AIE molecules that can move freely will be greatly restricted after immobilization in the complex.Therefore,extending the AIE properties of organic molecules to their constructed complexes has been difficult.展开更多
Organometallic iridium(Ⅲ)complexes with AIE properties have received much attention for their potential in the photoelectric and biomedical fields;however,the development of such materials remains challenging due to ...Organometallic iridium(Ⅲ)complexes with AIE properties have received much attention for their potential in the photoelectric and biomedical fields;however,the development of such materials remains challenging due to the lack of a precise design strategy.Herein,a family of cationic iridium(Ⅲ)complexes with pyridine-azole ancillary ligands,in which 1-(2,4-difluorophenyl)-1H-pyrazole is a cyclometalated ligand,have been strategically synthesized.展开更多
In this study,three-photon absorbing cyclometalated iridium(Ⅲ)complexes(Ir-H,Ir-8C,and Ir-O)were rationally designed and synthesized through fine-tuning of an auxiliary ligand.The long alkoxy chains in Ir-8C and Ir-O...In this study,three-photon absorbing cyclometalated iridium(Ⅲ)complexes(Ir-H,Ir-8C,and Ir-O)were rationally designed and synthesized through fine-tuning of an auxiliary ligand.The long alkoxy chains in Ir-8C and Ir-O allow maintaining the intramolecular mobility upon aggregation,resulting in the absence of emission in aggregated states.In comparison with Ir-8C and Ir-O,Ir-H exhibited excellent aggregation-induced emission properties in dimethyl sulfoxide/water(DMSO/H_(2)O)solution.The three-photon absorption cross section reached 300×10^(−92) cm^(6) s^(2) photon−2 in the aggregated state.Furthermore,the singlet oxygen(^(1)O_(2))quantum yield of Ir-H could be increased to 0.87 through the synergistic effect of the strong spin–orbit coupling effect of the iridium center and the aggregation-induced intersystem crossing.Ir-H effectively induced cancer cell death both ex vivo and in vivo,with potential application in multiphoton imaging-guided photodynamic therapy.展开更多
Traditional fluorescent emitters cannot eff ectively utilize triplet excitons owing to the spin statistical limitation, thus their electrochemiluminescence(ECL) efficiency(Φ_(ECL)) is relatively low. Improving the ut...Traditional fluorescent emitters cannot eff ectively utilize triplet excitons owing to the spin statistical limitation, thus their electrochemiluminescence(ECL) efficiency(Φ_(ECL)) is relatively low. Improving the utilization efficiency of triplet excitons is of great significance for developing efficient luminescent materials. Here we designed a hot exciton molecule(NZ2TPA) containing highly efficient chromophore naphthothiadiazole as an electron acceptor and triphenylamine(TPA) with aggregation induced emission(AIE) property as the strong electron donor to synthesize an ECL nanoemitter-NZ2TPA nanoparticles(NT NPs). The hybridized local and charge-transfer(HLCT) excited state of NZ2TPA achieved a high exciton utilization through the reverse intersystem crossing from higher triplet states( h RISC). The combination of HLCT and AIE characteristics endowed NT NPs with superior ΦECLover other nanoemitters, which provided an excellent material for the design of highly sensitive ECL biosensors. Using alkaline phosphatase(ALP) as an analyte model, a “signal-on” ECL biosensing approach was constructed by combining the quenching of manganese dioxide nanosheets(MnO_(2)NSs) on ECL emission of NT NPs and the reduction of MnO_(2)by ascorbic acid produced from ALP-catalyzed dephosphorylation, which showed a detectable range of 0.004-400 U/L with a detection limit of 0.57 mU/L. The excellent performance demonstrated the immense potential of organic nanomaterials through combining HLCT and AIE properties to improve ΦECL.展开更多
Macrocyclic hosts play a crucial role in supramolecular chemistry and the development of supramolecular functional materials.Their well-defined cavities and diverse host-vip interactions endow macrocycles with excel...Macrocyclic hosts play a crucial role in supramolecular chemistry and the development of supramolecular functional materials.Their well-defined cavities and diverse host-vip interactions endow macrocycles with excellent stimuli responsiveness,facilitating efficient assembly construction.However,the limited availability of functional groups in conventional macrocycles restricts their ability to meet the demand for fabricating materials with multiple functionalities.To address this limitation,several research groups have introduced tetraphenylethylene(TPE),a well-known building block renowned for its remarkable aggregation-induced emission(AIE)effect,into the macrocycle framework.Herein,this paper summarizes the combination strategies and synergistic approaches that achieve multi-functionality by integrating TPE and macrocyclic architectures.The emission characteristics of TPE-embedded macrocycles are elucidated,and it is anticipated that more AIE-type macrocycles with innovative backbones and broad applications will emerge.展开更多
Parathyroid hormone (PTH) is an important factor in maintaining blood calcium levels in the human body. Therefore, monitoring PTH levels is essential for assessing the various diseases progression and managing overall...Parathyroid hormone (PTH) is an important factor in maintaining blood calcium levels in the human body. Therefore, monitoring PTH levels is essential for assessing the various diseases progression and managing overall health. In this study, a fluorescence and optical sensor based on an aggregation-induced emissive liquid crystal photopolymer (AIE-LC-Poly) film was established for the qualitative and quantitative detection of PTH. The specific interaction between PTH and anti-PTH on the substrate surface was utilized, and variations in orientation and aggregation state of the fluorescent LCs were evaluated by both optic and fluorescent means. The detection limit for PTH using optical image was above 10 µg/mL, while fluorescence detection achieved a much lower limit of 1 ng/mL. Additionally, the photopolymer further amplified the detection signals by strengthening the AIE effect of the fluorescent LCs in initiate state, and enhancing the disturbance of LCs ordered orientation upon PTH addition. Ultimately, the detection limits for PTH were reduced to 0.01 µg/mL for optical detection and 50 pg/mL for fluorescence detection. The quantitative and sensitive AIE-LC-Poly biosensing technology presented here sets the stage to develop LC-based sensor for biomedical applications without labeling.展开更多
The aggregation process plays a significant role in regulating the aggregate structures from molecules toward macroscopic photophysical properties.Pyrene(Py),as the simplest dimer candidate,serves as a suitable model ...The aggregation process plays a significant role in regulating the aggregate structures from molecules toward macroscopic photophysical properties.Pyrene(Py),as the simplest dimer candidate,serves as a suitable model for studying the aggregation.Herein,a series of Py-based aggregation-induced emission(AIE)materials have been investigated by clarifying the comprehensive roles of oxygen,substituents,molecular motion,and packing during aggregation,initially realizing the aim of controlling aggregate structures.With a largely planar and conjugated conformation,Py shows anomalous AIE characteristics due to the oxygen quenching at the molecular level but turn-on fluorescence in the aggregate state because of the oxygen isolation.Although introducing substituents induces molecular motion and similarly weakened luminescence in the molecular state,the impact of substituents on the aggregate-state photophysical properties enormously differs,exhibiting from weak blue,strong cyan,and strong green to weak yellow emissions,due to variable aggregate structures.Interestingly,the natural alicycle-substituted Py-dehydroabietylamine(Py-DAA)exhibits both mechanochromism and acidichromism,which can be synergistically applied in dynamic encryption-decryption.This work not only elucidates the unique AIE property of Py for the first time but also clarifies the bridging role of aggregation between single-molecular and aggregate states,achieving preliminary control over the aggregate structures.展开更多
In 2001,Tang's team discovered a unique type of luminogens with substantial enhanced fluorescence upon aggregation and introduced the concept of"aggregation-induced emission(AlE)".Unlike conventional flu...In 2001,Tang's team discovered a unique type of luminogens with substantial enhanced fluorescence upon aggregation and introduced the concept of"aggregation-induced emission(AlE)".Unlike conventional fluorescent materials,AlE luminogens(AlEgens)emit weak or no fluorescence in solution but become highly fluorescent in aggregated or solid states,due to a mechanism known as restriction of intramolecular motions(RIM).Initially considered a purely inorganic chemical phenomenon,AIE was later applied in biomedicine to improve the sensitivity of immunoassays.Subsequently,AlE has been extensively explored in various biomedical applications,especially in cell imaging.Early studies achieved nonspecific cell imaging using nontargeted AlEgens,and later,specific cellular imaging was realized through the design of targeted AlEgens.These advancements have enabled the visualization of various biomacromolecules and intracellular organelles,providing valuable insights into cellular microenvironments and statuses.Neurological disorders affect over 3 billion people worldwide,highlighting the urgent need for advanced diagnostic and therapeutic tools.AlEgens offer promising opportunities for imaging the central nervous system(CNS),including nerve cells,neural tissues,and blood vessels.This review focuses on the application of AlEgens in CNS imaging,exploring their roles in the diagnosis of various neurological diseases.We will discuss the evolution and conclude with an outlook on the future challenges and opportunities for AlEgens in clinical diagnostics and therapeutics of CNS disorders.展开更多
AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emissi...AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emission(AIE)molecules have been developed and have evoked massive ICD in cells.However,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to elicit ICD.AIEgen-based nanomicelles,which maintain a stable micellar structure,can prevent defects of AIE molecules in photodynamic therapy(PDT)applications.Therefore,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.展开更多
Comprehensive Summary Currently,solid-state fluorescent carbonized polymer dots(CPDs)have attracted attention increasingly due to their applications for optoelectronic display.However,designing CPDs possessing solid-s...Comprehensive Summary Currently,solid-state fluorescent carbonized polymer dots(CPDs)have attracted attention increasingly due to their applications for optoelectronic display.However,designing CPDs possessing solid-state fluorescence and clarifying the fluorescence mechanism remain challenging.Herein,we initially synthesized a novel type of polythiophene derivatives CPDs,poly-4,4’-(thiophene-3,4-diyl)dibenzoic acid carbonized polymer dots(PDBA-CPDs)with solid-state fluorescence.Subsequently,the structural and optical characterization revealed that the solid-state fluorescence originated from the aggregation induced emission of the CPDs.In brief,in aggregation state,the remaining polymer structure groups on the surface of the CPDs overlapped and weakened the non-radiative transition,enhancing solid-state fluorescence emission.Thirdly,three polythiophene-derived CPDs were designed to further demonstrate the aggregation induced solid-state fluorescence mechanism.Finally,owing to their unique properties of solid-state fluorescence,the white LEDs(light emitting diodes)were fabricated with high color rendering index(CRI)of 82.7 and CIE coordinates of(0.37,0.39)using commercial 460 nm chip.展开更多
The development of novel photosensitizers(PSs)with aggregation-induced emission(AIE)properties has emerged as a crucial advancement in the field of photodynamic therapy(PDT).However,the versatile applications of AIE P...The development of novel photosensitizers(PSs)with aggregation-induced emission(AIE)properties has emerged as a crucial advancement in the field of photodynamic therapy(PDT).However,the versatile applications of AIE PSs are limited by low encapsulation efficiency and inadequate target tissue permeability.Biomimetic technology stands out as a promising strategy to overcome these challenges,aiming to enhance AIE PSs tumor penetration efficacy,and their association with antitumor immune responses.In this review,recent advancements in biomimetic AIE PSs for PDT and immunotherapy are summarized.We start with introducing strategies involving biomimetic AIE PSs based on cell membranes and extracellular vesicles for the combined application of PDT and immunotherapy.We then discuss the preparation of biomimetic AIE PSs nanoparticles.Finally,we briefly outline the challenges and prospects associated with biomimetic AIE PSs.展开更多
基金973 Programme (No. 2011CB932502)NNSFC (Nos. 91227107, 21432004, and 21272125) for financial support
文摘A β cyclodextrin derivative bearing seven cationic arms and its singly charged analogue, i.e., per-6- deoxy-f-（1-methylimidazol-3-ium-3-yl）-β-cyclodextrin （3） and mono-fi-deoxy-6-（1-methylimidazol- 3-ium-3-yl）-β-cyclodextrin （4） were synthesized and fully characterized. Their induced aggregation behaviours towards two anionic surfactant, that is, sodium dodecyl sulfonate （SDS） and dioctyl sodium sulfosuccinate （Aerosol OT, AOT）, were investigated by UV-vis, NMR, Zeta-potential, dynamic light scattering （DLS）, and transmission electron microscopy. The results revealed that host 3 can induce the molecular aggregation of anionic surfactant at concentration far lower than its original CAC, leading to the larger diameter, the narrower size distribution and the higher thermal stability of the induced aggregate towards the anionic surfactant possessing more hydrophobic tails.
基金supported by the Natural Science Foundation of Hubei Province(Grant No.2018CFA055)of Chinathe National Natural Science Foundation of China(Grant No.21774097)the ACAP fellowship supported by the Australian government through the Australian Renewable Energy Agency(ARENA)。
文摘Molecular ordering within the photoactive layer plays a crucial role in determining the device performance of organic solar cells(OSCs).However,the simultaneous molecular ordering processes of polymer donors and non-fullerene acceptors(NFAs)during solution casting usually bring confinement effect,leading to insufficient structural order of photovoltaic components.Herein,the molecular packing of mINPOIC NFA is effectively formed through a heating induced aggregation strategy,with the aggregation of PBDB-T,which has a strong temperature dependence,is retarded by casting on a preheated substrate to reduce its interference toward m-INPOIC.A sequent thermal annealing treatment is then applied to promote the ordering of PBDB-T and achieve balanced aggregation of both donors and acceptors,resulting in the achievement of a maximum efficiency of 13.9% of PBDB-T:m-INPOIC binary OSCs.This work disentangles the interactions of donor polymer and NFA during the solution casting process and develops a rational strategy to enhance the molecular packing of NFAs to boost device performance.
基金financial support from the National Key Research and Development Program of China (No. 2017YFA0701303)the National Natural Science Foundation of China (Nos.51873097 and 21674058)。
文摘A novel wate r-soluble red-emissive AIE fluorescence probe for cysteine(Cys) in situ was prepared and the performance of selectivity and sensitivity has been carefully investigated in this study.The probe was established on the electrostatic interaction of sulfonate functionalized tetraphenylethene(TPE) and polycation generated by the reaction between a polymer bearing dinitrobenzenesulfonate groups and Cys.From the experimental results,it was easy to distinguish Cys from glutathione(GSH) and homocysteine(Hcy) with a detection limit of 73 nmol/L.The assay system also possessed strong antiinterference ability against multitudinous amino acids.The Stokes shift was 142 nm and the emission ranged from 550 nm to 850 nm.In addition,double responses in fluorescence and ultraviolet-visible spectra also make the red-emissive assay ideal for sensitive detection and quantification of Cys for most purposes,especially in-situ monitoring of Cys in aqueous medium.
基金financially supported by the National Natural Science Foundation of China(NSFC,No.21535006)
文摘Carbon dots(CDs)are prepared through a simple one-step hydrothermal treatment of o-phenylendiamine(OPD)and show yellow photoluminescent(PL)emission under the ultraviolet excitation,which can be further enhanced by Cu2+ions owing to Cu2+ions induced aggregation of OPD-CDs through the coordination of Cu2+with amino groups on the surface of OPD-CDs.The aggregation induced emission enhancement(AIEE)property enables it feasible to develop a simple,sensitive and selective method to detect environmental and intracellular copper(Ⅱ)ions.The limit of detection as lowas 0.28μmol/L(3σ/k)and a dynamic range from 0.5μmol/L to 40μmol/L make it veryeasy to detect the copper content inwater samples,such as river closure reservoir.Furthermore,fluorescence imaging of intracellular Cu2+suggests that the AIEE features of OPD-CDs specific to Cu2+ions can be also applied in biological systems.
基金financial support from the National Natural Science Foundation of China(No.21576194)
文摘Four derivatives of 9,10-bis[2-（2-alkoxynaphthalen-1-yl）vinyl]anthracene（BNAs） were designed,successfully synthesized and characterized by spectrofluorometer, powder wide-angle X-ray diffraction（PXRD） and differential scanning calorimetry experiments（DSC）, etc. It was found that these compounds exhibited aggregation-induced emission phenomenon. Moreover, these target compounds displayed reversible color change from yellow to orange upon pressing and annealing process. Interestingly, all of BNAs obviously presented red-shifted piezofluorochromic（PFC） properties and behaved mainly length dependence of alkoxy group, in which, BNA displayed the largest PFC spectral shift（DlPFC= 26 nm）. The PXRD profiles demonstrated the transformation from crystalline to amorphous state upon grinding, and the mechanism of PFC behaviors was proposed. Thus, changing the length of alkoxyl chain could be an alternative way to tune their PFC behaviors.
文摘In this paper,a decision-making problem with a q-rung orthopair fuzzy hypersoft environment is developed,and two operators of ordered weighted average and induced ordered weighted average are developed.Several fundamental features are also derived.The induced ordered weighted average operator is essential in a q-ROFH environment as the induced ordered aggregation operators are special cases of the existing aggregation operators that already exist in q-ROFH environments.The main function of these operators is to help decision-makers gain a complete understanding of uncertain facts.The proposed aggregation operator is applied to a decision-making problem,with the aim of selecting the most promising real estate project for investment.
基金supported by the Zhejiang Provincial Natural Science Foundation of China(LR17F050001 and LY17C090005)the National Natural Science Foundation of China(61735016 and 91632105)National Basic Research Program of China(973 Program,2013CB834701 and 2013CB834704).
文摘Rodents are popular biological models for physiological and behavioral research in neuroscience and rats are better models than mice due to their higher genome similarity to human and more accessible surgical procedures.However,rat brain is larger than mice brain and it needs powerful imaging tools to implement better penetration against the scattering of the thicker brain tissue.Three-photon fluorescence microscopy(3PFM)combined with near-infrared(NIR)excitation has great potentials for brain circuits imaging beause of its abilities of anti scattering,deep-tissue imaging,and high signal-to-noise ratio(SNR).In this work,a type of AIE lumninogen with red fuorescence was synthesized and encapsulated with Pluronic F-127 to make up form nano-particles(NPs).Bright DCDPP-2TPA NPs were employed for in trino three-photon fuorescent laser scanning microscopy of blood vessels in rats brain under 1550 nm femtosecond laser exci-tation.A fine three-dimensional(3D)reconstruction up to the deepness of 600 pm was achieved and the blood flow velocity of a selected vessel was measured in vrito as well.Our 3PFM deep brain imaging method simultaneously recorded the morphology and function of the brain blood vessels in vivo in the rat model.Using this angiography combined with the arsenal of rodent's brain disease,models can accelerate the neuroscience research and clinical diagnosis of brain disease in the future.
基金the National Natural Science Foundation of China(NSFC,Nos.21788102,21722603 and 21871083)Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX03)+2 种基金‘Shu Guang’Project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation(No.19SG26)the Innovation Program of Shanghai Municipal Education Commission(No.2017-01-07-00-02-E00010)the Fundamental Research Funds for the Central Universities。
文摘A new chiral bromobinaphthol-pyrene compound was developed to achieve a green circularly polarized luminescence(CPL)from its excimer with a dissymmetry factor(|glum|)value of 4.3×10^-3 and a high quantum yieldΦF,solid up to 55.9%,while no CPL signals could be observed for the blue luminescence from unimolecule.Meanwhile,reversal CPL signals can be observed from both concentrated solution and solid.
基金supported by the National Natural Science Foundation of China(no.51503085 and 51432006)the Ministry of Science and Technology of China for the International Science Linkages Program(no.2011DFG52970)+3 种基金the Natural Science Foundation of Jiangsu Province,China(no.BK20140157)the Changjiang Innovation Research Team(IRT14R23)the Programme of Introducing Talents of Discipline to Universities(111 Project B13025)the Fundamental Research Funds for the Central Universities(JUSRP11418).
文摘In this paper,a novel“turn-on”chemosensor for detecting temperature and Fe3+has been designed.This nanosensor is based on the aggregation-induced emission enhancement(AIEE)properties of fluorescent carbon dots(CDs).The CDs prepared by a facile hydrothermal route show blue emission(λ_(em)=505 nm)with a quantum yield of 4.7%.The resultant CDs are modified by glutathione(GSH)on the surface through the carbodiimide-activated coupling reaction.The as-prepared GSH-CDs show good dispersion,high fluorescence and AIEE phenomenon.Resultant GSH-CDs would be aggregated by Fe^(3+)ions in aqueous solution which results in enhanced fluorescence.Therefore,such GSH-CDs would be excellent candidates as fluorescent probes for the label-free detection of Fe^(3+)ions with a limit of detection of 0.1μM.Moreover,the PL intensity of GSH-CDs increases progressively with increasing temperature and they could be used in optical thermometry over a wide temperature range(25–80°C)with small temperature resolution(∼0.5℃).Using MC3T3-E1 cells as the model,the resultant nanosensor is demonstrated to monitor temperature and Fe^(3+)ions in cells.Thus,resultant GSH-CDs could be used as a“turnon”sensor for highly sensitive and selective detection of temperature and Fe3+ions in aqueous solution and biosystems.
基金supported by the National Natural Science Foundation of China(Project No.22061047)The Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province(No.YNWR-QNBJ-2019-088)the Yunnan University’s Research Innovation Fund for Graduate Students(No.2021Z107).
文摘Aggregation-induced emission(AIE)is a fascinating luminescence phenomenon that provides new ideas for developing new fluorescent devices.However,research on photofunctional complexes with AIE properties is still in its infancy,mainly because the motion of the AIE molecules that can move freely will be greatly restricted after immobilization in the complex.Therefore,extending the AIE properties of organic molecules to their constructed complexes has been difficult.
基金support from the National Natural Science Foundation of China(22175033 and 51902124)the Technology Development Plan of Jilin Science and Technology Department(20230101046JC).
文摘Organometallic iridium(Ⅲ)complexes with AIE properties have received much attention for their potential in the photoelectric and biomedical fields;however,the development of such materials remains challenging due to the lack of a precise design strategy.Herein,a family of cationic iridium(Ⅲ)complexes with pyridine-azole ancillary ligands,in which 1-(2,4-difluorophenyl)-1H-pyrazole is a cyclometalated ligand,have been strategically synthesized.
基金supported by grants for the National Natural Science Foundation of China(21871003 and 22001005)the Doctor Start-up Fund(S020118002/026 and S020118002/073)the Natural Science Foundation of Anhui Province of China(1908085MB30,2008085QB52 and 2108085MB49).
文摘In this study,three-photon absorbing cyclometalated iridium(Ⅲ)complexes(Ir-H,Ir-8C,and Ir-O)were rationally designed and synthesized through fine-tuning of an auxiliary ligand.The long alkoxy chains in Ir-8C and Ir-O allow maintaining the intramolecular mobility upon aggregation,resulting in the absence of emission in aggregated states.In comparison with Ir-8C and Ir-O,Ir-H exhibited excellent aggregation-induced emission properties in dimethyl sulfoxide/water(DMSO/H_(2)O)solution.The three-photon absorption cross section reached 300×10^(−92) cm^(6) s^(2) photon−2 in the aggregated state.Furthermore,the singlet oxygen(^(1)O_(2))quantum yield of Ir-H could be increased to 0.87 through the synergistic effect of the strong spin–orbit coupling effect of the iridium center and the aggregation-induced intersystem crossing.Ir-H effectively induced cancer cell death both ex vivo and in vivo,with potential application in multiphoton imaging-guided photodynamic therapy.
基金funded by by National Natural Science Foundation of China (21890741,21827812)。
文摘Traditional fluorescent emitters cannot eff ectively utilize triplet excitons owing to the spin statistical limitation, thus their electrochemiluminescence(ECL) efficiency(Φ_(ECL)) is relatively low. Improving the utilization efficiency of triplet excitons is of great significance for developing efficient luminescent materials. Here we designed a hot exciton molecule(NZ2TPA) containing highly efficient chromophore naphthothiadiazole as an electron acceptor and triphenylamine(TPA) with aggregation induced emission(AIE) property as the strong electron donor to synthesize an ECL nanoemitter-NZ2TPA nanoparticles(NT NPs). The hybridized local and charge-transfer(HLCT) excited state of NZ2TPA achieved a high exciton utilization through the reverse intersystem crossing from higher triplet states( h RISC). The combination of HLCT and AIE characteristics endowed NT NPs with superior ΦECLover other nanoemitters, which provided an excellent material for the design of highly sensitive ECL biosensors. Using alkaline phosphatase(ALP) as an analyte model, a “signal-on” ECL biosensing approach was constructed by combining the quenching of manganese dioxide nanosheets(MnO_(2)NSs) on ECL emission of NT NPs and the reduction of MnO_(2)by ascorbic acid produced from ALP-catalyzed dephosphorylation, which showed a detectable range of 0.004-400 U/L with a detection limit of 0.57 mU/L. The excellent performance demonstrated the immense potential of organic nanomaterials through combining HLCT and AIE properties to improve ΦECL.
基金the National Natural Science Foundation of China(No.22271154)the Science Fund for Distinguished Young Scholars of Jiangsu Province(No.BK20240078).
文摘Macrocyclic hosts play a crucial role in supramolecular chemistry and the development of supramolecular functional materials.Their well-defined cavities and diverse host-vip interactions endow macrocycles with excellent stimuli responsiveness,facilitating efficient assembly construction.However,the limited availability of functional groups in conventional macrocycles restricts their ability to meet the demand for fabricating materials with multiple functionalities.To address this limitation,several research groups have introduced tetraphenylethylene(TPE),a well-known building block renowned for its remarkable aggregation-induced emission(AIE)effect,into the macrocycle framework.Herein,this paper summarizes the combination strategies and synergistic approaches that achieve multi-functionality by integrating TPE and macrocyclic architectures.The emission characteristics of TPE-embedded macrocycles are elucidated,and it is anticipated that more AIE-type macrocycles with innovative backbones and broad applications will emerge.
基金supported by the National Natural Science Foundation of China(No.51973007).
文摘Parathyroid hormone (PTH) is an important factor in maintaining blood calcium levels in the human body. Therefore, monitoring PTH levels is essential for assessing the various diseases progression and managing overall health. In this study, a fluorescence and optical sensor based on an aggregation-induced emissive liquid crystal photopolymer (AIE-LC-Poly) film was established for the qualitative and quantitative detection of PTH. The specific interaction between PTH and anti-PTH on the substrate surface was utilized, and variations in orientation and aggregation state of the fluorescent LCs were evaluated by both optic and fluorescent means. The detection limit for PTH using optical image was above 10 µg/mL, while fluorescence detection achieved a much lower limit of 1 ng/mL. Additionally, the photopolymer further amplified the detection signals by strengthening the AIE effect of the fluorescent LCs in initiate state, and enhancing the disturbance of LCs ordered orientation upon PTH addition. Ultimately, the detection limits for PTH were reduced to 0.01 µg/mL for optical detection and 50 pg/mL for fluorescence detection. The quantitative and sensitive AIE-LC-Poly biosensing technology presented here sets the stage to develop LC-based sensor for biomedical applications without labeling.
基金supported by the National Natural Science Foundation of China(21601087)the Natural Science Foundation of Jiangsu Province(BK20231296)+3 种基金the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates,Guangzhou 510640,China(South China University of Technology[2023B1212060003])the Shenzhen Key Laboratory of Functional Aggregate Materials(ZDSYS20211021111400001)the Science Technology Innovation Commission of Shenzhen Municipality(KQTD20210811090142053)the Key Research and Development Project of Yunnan Province(202303AC100010).
文摘The aggregation process plays a significant role in regulating the aggregate structures from molecules toward macroscopic photophysical properties.Pyrene(Py),as the simplest dimer candidate,serves as a suitable model for studying the aggregation.Herein,a series of Py-based aggregation-induced emission(AIE)materials have been investigated by clarifying the comprehensive roles of oxygen,substituents,molecular motion,and packing during aggregation,initially realizing the aim of controlling aggregate structures.With a largely planar and conjugated conformation,Py shows anomalous AIE characteristics due to the oxygen quenching at the molecular level but turn-on fluorescence in the aggregate state because of the oxygen isolation.Although introducing substituents induces molecular motion and similarly weakened luminescence in the molecular state,the impact of substituents on the aggregate-state photophysical properties enormously differs,exhibiting from weak blue,strong cyan,and strong green to weak yellow emissions,due to variable aggregate structures.Interestingly,the natural alicycle-substituted Py-dehydroabietylamine(Py-DAA)exhibits both mechanochromism and acidichromism,which can be synergistically applied in dynamic encryption-decryption.This work not only elucidates the unique AIE property of Py for the first time but also clarifies the bridging role of aggregation between single-molecular and aggregate states,achieving preliminary control over the aggregate structures.
基金supported by the Natural Science Foundation of the Sichuan Provincial Department of Science and Technology(no.2025ZNSFSC0738)Department of Chengdu Science and Technology(no.2024-YF05-01250-SN)+2 种基金Popularized Application Project of Sichuan Provincial Health Commission(no.chuan-gan-yan2023-214)National Natural Science Foundation of China(no.81603018)Tianfu Jincheng Laboratory,City of Future Medicine(no.TFJC-2024-JB003).
文摘In 2001,Tang's team discovered a unique type of luminogens with substantial enhanced fluorescence upon aggregation and introduced the concept of"aggregation-induced emission(AlE)".Unlike conventional fluorescent materials,AlE luminogens(AlEgens)emit weak or no fluorescence in solution but become highly fluorescent in aggregated or solid states,due to a mechanism known as restriction of intramolecular motions(RIM).Initially considered a purely inorganic chemical phenomenon,AIE was later applied in biomedicine to improve the sensitivity of immunoassays.Subsequently,AlE has been extensively explored in various biomedical applications,especially in cell imaging.Early studies achieved nonspecific cell imaging using nontargeted AlEgens,and later,specific cellular imaging was realized through the design of targeted AlEgens.These advancements have enabled the visualization of various biomacromolecules and intracellular organelles,providing valuable insights into cellular microenvironments and statuses.Neurological disorders affect over 3 billion people worldwide,highlighting the urgent need for advanced diagnostic and therapeutic tools.AlEgens offer promising opportunities for imaging the central nervous system(CNS),including nerve cells,neural tissues,and blood vessels.This review focuses on the application of AlEgens in CNS imaging,exploring their roles in the diagnosis of various neurological diseases.We will discuss the evolution and conclude with an outlook on the future challenges and opportunities for AlEgens in clinical diagnostics and therapeutics of CNS disorders.
基金supported by the National Natural Science Foundation of China(Nos.52173137 and 51873163).
文摘AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emission(AIE)molecules have been developed and have evoked massive ICD in cells.However,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to elicit ICD.AIEgen-based nanomicelles,which maintain a stable micellar structure,can prevent defects of AIE molecules in photodynamic therapy(PDT)applications.Therefore,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.
基金the National Natural Science Foundation of China(Grant Nos.52272052,51972315,21873110,and 61720106014).
文摘Comprehensive Summary Currently,solid-state fluorescent carbonized polymer dots(CPDs)have attracted attention increasingly due to their applications for optoelectronic display.However,designing CPDs possessing solid-state fluorescence and clarifying the fluorescence mechanism remain challenging.Herein,we initially synthesized a novel type of polythiophene derivatives CPDs,poly-4,4’-(thiophene-3,4-diyl)dibenzoic acid carbonized polymer dots(PDBA-CPDs)with solid-state fluorescence.Subsequently,the structural and optical characterization revealed that the solid-state fluorescence originated from the aggregation induced emission of the CPDs.In brief,in aggregation state,the remaining polymer structure groups on the surface of the CPDs overlapped and weakened the non-radiative transition,enhancing solid-state fluorescence emission.Thirdly,three polythiophene-derived CPDs were designed to further demonstrate the aggregation induced solid-state fluorescence mechanism.Finally,owing to their unique properties of solid-state fluorescence,the white LEDs(light emitting diodes)were fabricated with high color rendering index(CRI)of 82.7 and CIE coordinates of(0.37,0.39)using commercial 460 nm chip.
基金Ministry of Education Academic Research Fund Tier 1,Grant/Award Number:A-0009304-00-00Sichuan Science and Technology Program,Grant/Award Number:2022NSFSC1269。
文摘The development of novel photosensitizers(PSs)with aggregation-induced emission(AIE)properties has emerged as a crucial advancement in the field of photodynamic therapy(PDT).However,the versatile applications of AIE PSs are limited by low encapsulation efficiency and inadequate target tissue permeability.Biomimetic technology stands out as a promising strategy to overcome these challenges,aiming to enhance AIE PSs tumor penetration efficacy,and their association with antitumor immune responses.In this review,recent advancements in biomimetic AIE PSs for PDT and immunotherapy are summarized.We start with introducing strategies involving biomimetic AIE PSs based on cell membranes and extracellular vesicles for the combined application of PDT and immunotherapy.We then discuss the preparation of biomimetic AIE PSs nanoparticles.Finally,we briefly outline the challenges and prospects associated with biomimetic AIE PSs.
