Oncology Research Editorial Office Published:23 March 2026 The published article titled“MicroRNA 125a-5p Inhibits Cell Proliferation and Induces Apoptosis in Hepatitis B Virus-Related Hepatocellular Carcinoma by Down...Oncology Research Editorial Office Published:23 March 2026 The published article titled“MicroRNA 125a-5p Inhibits Cell Proliferation and Induces Apoptosis in Hepatitis B Virus-Related Hepatocellular Carcinoma by Downregulation of ErbB3”has been retracted from Oncology Research,Vol.27,No.4,2019,pp.449-458.DOI:10.3727/096504017X15016337254623 URL:https://www.techscience.com/or/v27n4/48558.展开更多
Diplodia tip blight,caused by Diplodia sapinea,is a global pine necrotic disease causing heavy economic losses to the pine industry.Chemical control,its main current management,easily induces pathogen resistance and e...Diplodia tip blight,caused by Diplodia sapinea,is a global pine necrotic disease causing heavy economic losses to the pine industry.Chemical control,its main current management,easily induces pathogen resistance and environmental pollution,which biological control avoids.This study investigated juniper essential oil’s efficacy against the disease on Mongolian Scots pine(Pinus sylvestris var.mongolica)and its induced resistance mechanisms via pot experiments,physiological assays(defense enzyme activities,resistant substances)and metabolomic sequencing(secondary metabolites).Results showed varied efficacy:three foliar sprays of 10μL mL^(-1) oil achieved the best control phenylalanine ammonia-lyase(PAL),polyphenol oxidase(82.9%).The 20μL mL^(-1) treatment significantly increased(PPO)activities,and contents of lignin,flavonoids and total phenolics.Metabolomic analysis showed 326 upregulated and 527 downregulated different metabolites in essential oilinduced and pathogen-inoculated pines,compared to 483 upregulated and 277 downregulated metabolites in noninduced but inoculated pines.The differentially expressed metabolites in treated pines were primarily enriched in pathways related to amino acid metabolism and plant secondary metabolite biosynthesis,with notably increased expression levels of ferulic acid,scopoletin,pipecolic acid,D-proline,and DL-arginine.Therefore,juniper essential oil protects against D.sapinea by inducing systemic acquired resistance in Mongolian Scots pine.In conclusion,juniper essential oil controls D.sapinea by inducing systemic acquired resistance(SAR)in Mongolian Scots pine,clarifying the molecular mechanism and supporting biological control of the disease.展开更多
Accurate phenological information is essential for measuring ecosystem dynamics and carbon uptake.Southwest China is one of the country's largest terrestrial carbon sink regions and plays a crucial role in carbon ...Accurate phenological information is essential for measuring ecosystem dynamics and carbon uptake.Southwest China is one of the country's largest terrestrial carbon sink regions and plays a crucial role in carbon peaking and neutrality.However,its complex terrain,fragile ecosystem,and variable climate challenge carbon sink stability.Vegetation phenology significantly impacts carbon absorption and release,making accurate phenological data essential for understanding carbon sequestration dynamics.The widespread distribution of evergreen forests and their weak seasonal variation in canopy introduce significant uncertainties in extracting phenology using traditional remote sensing information in this region.These limitations can lead to inaccurate assessments of carbon sink dynamics.Therefore,precise phenology extraction and analysis are vital for improving ecosystem dynamics and the carbon cycle in Southwest China.Firstly,we employed different ways to evaluate the ability of solar-induced chlorophyll fluorescence(SIF)and traditional remote sensing information to extract phenology.Secondly,based on SIF,we analyzed the spatial and temporal changes in the start of the growing season(SOS),the end of the growing season(EOS),and the length of the growing season(LOS)from 2001 to 2020.Finally,we systematically analyzed the response of SOS and EOS to five preseason climatic factors.The results showed that(1)SIF outperformed traditional remote sensing information in extracting phenology.(2)Vegetation phenology exhibited significant spatial heterogeneity.Moreover,SOS,EOS,and LOS showed trends of advancement,delay,and extension both overall and across all vegetation types.(3)Precipitation was the main factor influencing SOS,while surface downward solar radiation and mean temperature were the main factors affecting EOS,and the phenology of different vegetation types showed a great difference in response to preseason climate factors.These findings improve our understanding of vegetation phenology and its dynamics over Southwest China.展开更多
While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model...While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.展开更多
The innate immune system of the central nervous system(CNS),long viewed as primarily microgliadriven,is now increasingly recognized to include astrocytes as active participants in neuroimmune signaling.Chronic alcohol...The innate immune system of the central nervous system(CNS),long viewed as primarily microgliadriven,is now increasingly recognized to include astrocytes as active participants in neuroimmune signaling.Chronic alcohol exposure trigge rs oxidative stress,glial activation,and sustained inflammation,ultimately contributing to cognitive decline and neuronal injury.展开更多
Light element compounds under high pressure display intriguing properties and applications,owing to their diverse bonding patterns and crystalline structures.However,the system of ternary Be-C-O compounds under high p...Light element compounds under high pressure display intriguing properties and applications,owing to their diverse bonding patterns and crystalline structures.However,the system of ternary Be-C-O compounds under high pressure,as the lightest representative of the IIA-IVA-VIA family,remains largely unexplored.Using a machine-learning-accelerated crystal structure search and first-principles calculations,Be-C-O phase diagrams are investigated at pressures ranging from 0 to 100 GPa.Four ternary compounds are proposed to be stable at corresponding pressures:BeCO_(3),Be_(2)CO_(4),Be_(2)C_(4)O_(3),and BeC_(4)O_(2).Analyses of electronic structure and chemical bonding further reveal how the structural diversity of these compounds is induced.Remarkably,Be_(2)C_(4)O_(3) and BeC_(4)O_(2) are recoverable to ambient conditions and possess both high energy density and high hardness.The volumetric energy densities of Be_(2)C_(4)O_(3) and BeC_(4)O_(2) could approach 9.03 and 7.94 kJ/cm^(3),respectively.The Vickers hardnesses of Be_(2)C_(4)O_(3) and BeC_(4)O_(2) are found to be close to 39.58 and 51.57 GPa,respectively.These findings demonstrate the structural and functional diversity of Be-C-O compounds under high pressure,providing guidance for further exploration of the IIA-IVA-VIA compounds.展开更多
The generation of human induced pluripotent stem cell-derived motor neurons overcomes limited access to human tissues and offers an unprecedented approach to modeling motor neuron diseases such as dystonia and amyotro...The generation of human induced pluripotent stem cell-derived motor neurons overcomes limited access to human tissues and offers an unprecedented approach to modeling motor neuron diseases such as dystonia and amyotrophic lateral sclerosis.Motor neurons generated through different strategies may exhibit substantial differences in purity,maturation,characterization,and even neuronal identity,leading to variable outcomes in disease modeling and drug screening.However,very few comparative studies have been conducted to determine the similarities and differences among motor neurons prepared via different protocols.In this study,we prepared human induced pluripotent stem cell-derived motor neurons via lentiviral delivery of transcription factors and chemical induction and performed a systematic comparative analysis.We found that motor neurons generated by both approaches showed typical motor neuron morphology and robustly expressed motor neuron-specific markers,such as nuclear homeobox transcription factor 9 and choline acetyltransferase.The chemical induction protocol utilizes a combination of small molecules to induce motor neuron differentiation,offering a significantly faster maturation time of 35 days compared to 46 days with lentiviral delivery of transcription factors.Additionally,while lentiviral delivery of transcription factors are suitable for downstream biochemical analysis,chemical induction are more applicable for therapeutic approaches as they avoid the use of lentiviruses.Both approaches produce motor neurons with high purity(>95%)and yield.No significant differences were found between chemical induction and lentiviral delivery of transcription factors in terms of motor neuron markers and maturation markers.These robust methodologies offer researchers powerful tools for investigating motor neuron diseases and potential therapeutic strategies.展开更多
Microbially induced calcium carbonate precipitation(MICP)is an eco-friendly technology for soil improvement.Although numerous experiments have been conducted to solidify sand foundations using MICP,the mechanisms by w...Microbially induced calcium carbonate precipitation(MICP)is an eco-friendly technology for soil improvement.Although numerous experiments have been conducted to solidify sand foundations using MICP,the mechanisms by which grain interfacial morphologies influencethe MICP process remain unclear.This study utilized 3D-printed flowcells with different boundary morphologies to investigate the effects of interfacial morphologies on the MICP process.CaCO_(3)precipitation characteristics were investigated through microscopic observation and image quantificationanalysis.The results indicate that low flowvelocities near the interface promote bacterial accumulation due to reduced hydrodynamic shear forces.Rough interfaces,compared to smooth ones,enhance bacterial adsorption owing to the larger regions of low flowvelocity,increased surface area,and the formation of local eddies,which promote greater CaCO_(3)precipitation.Compared to the regions away from the interface,a higher abundance of small CaCO_(3)crystals is observed near the interface because of the high urease activity from bacteria and the reduced shear-induced entrainment due to the low flowvelocity.Besides,larger crystals also preferentially precipitate in proximity to interfaces as the low flowvelocity enhances crystal growth according to the particle attachment theory.The presence of rough interfaces further reduces flowvelocities,leading to the precipitation of larger and more densely packed CaCO_(3)crystals.Therefore,rough interfaces promote the microbially induced calcium carbonate precipitation.This work is expected to enhance the understanding of microbially induced calcium carbonate precipitation characteristics on solid surfaces such as soil grains and contribute to the optimization of MICP applications.展开更多
Acute eosinophilic pneumonia(AEP) is a pulmonary condition characterized by acute febrile illness and respiratory distress,with bilateral pulmonary infiltrates,particularly eosinophilic infiltration of the lungs.^([1]...Acute eosinophilic pneumonia(AEP) is a pulmonary condition characterized by acute febrile illness and respiratory distress,with bilateral pulmonary infiltrates,particularly eosinophilic infiltration of the lungs.^([1])Amiodarone,a widely applied antiarrhythmic agent,has been reported as a potential cause of drug-induced AEP.^([2]) Most reported cases of amiodarone-induced AEP typically occur following prolonged exposure for two months or more.展开更多
The loss of control over movement is one of the most devastating consequences of Parkinson’s disease(PD).The loss of control largely results from the gradual but inexorable destruction of dopamine-producing neurons i...The loss of control over movement is one of the most devastating consequences of Parkinson’s disease(PD).The loss of control largely results from the gradual but inexorable destruction of dopamine-producing neurons in the substantia nigra pars compacta.As dopamine levels fall,the ability to initiate,control,learn,and sustain actions declines.Treatment with the dopamine precursor levodopa can partly overcome motor impairments;however,years of use often leads to levodopa-induced dyskinesia(LID),a debilitating condition characterized by uncontrolled writhing and ballistic movements,making continued treatment difficult or impossible.While progress has been made towards unraveling the molecular and cellular processes driving the development of LID,far less is known about the changes in ongoing neuronal activity that contribute to LID expression.展开更多
Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells en...Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells encounter various obstacles,including limited tissue sources,invasive acquisition methods,cellular heterogeneity,purification challenges,cellular senescence,and diminished pluripotency and proliferation over successive passages.In this study,we used induced pluripotent stem cell-derived mesenchymal stem cells,known for their self-renewal capacity,multilineage differentiation potential,and immunomodulatory characteristics.We used induced pluripotent stem cell-derived mesenchymal stem cells in conjunction with acellular nerve allografts to address a 10 mm-long defect in a rat model of sciatic nerve injury.Our findings reveal that induced pluripotent stem cell-derived mesenchymal stem cells exhibit survival for up to 17 days in a rat model of peripheral nerve injury with acellular nerve allograft transplantation.Furthermore,the combination of acellular nerve allograft and induced pluripotent stem cell-derived mesenchymal stem cells significantly accelerates the regeneration of injured axons and improves behavioral function recovery in rats.Additionally,our in vivo and in vitro experiments indicate that induced pluripotent stem cell-derived mesenchymal stem cells play a pivotal role in promoting neovascularization.Collectively,our results suggest the potential of acellular nerve allografts with induced pluripotent stem cell-derived mesenchymal stem cells to augment nerve regeneration in rats,offering promising therapeutic strategies for clinical translation.展开更多
The metal‐reduction‐induced dechlorination coupling(MR-DC)strategy enables the first successful synthesis of an all‐inorganic crosslinked phosphazene network(aPN)from hexachlorocyclotriphosphazene(HCCP)under mild r...The metal‐reduction‐induced dechlorination coupling(MR-DC)strategy enables the first successful synthesis of an all‐inorganic crosslinked phosphazene network(aPN)from hexachlorocyclotriphosphazene(HCCP)under mild reaction conditions.Using Cu as a model,the resulting Cu-aPN(copper‐embedded all‐inorganic phosphazene network)retains the intrinsic N_(3)P_(3)backbone and exhibits an amorphous structure where Cu species are uniformly anchored at dense P/N coordination sites of the network.Time of flight secondary ion mass spectrometry(TOF‐SIMS)and X‐ray diffraction(XRD)reveal a gradual CuCl‐to‐CuO phase conversion during ammonia treatment,which effectively ensures the structural stability of the phosphazene framework.In 1 M KOH,Cu-aPN delivers an overpotential of 280 mV at 10 mA cm^(−2)and a Tafel slope of 48 mV dec^(−1),markedly outperforming Ga-aPN.In situ Raman and density functional theory(DFT)analyses indicate stronger Cu-P/N coordination coupling that lowers the*OH formation barrier(0.39 vs.0.88 eV for Ga).This MR-DC route furnishes a general and versatile pathway for constructing metal‐embedded all‐inorganic phosphazene frameworks with tunable coordination environments for advanced electrocatalytic applications.展开更多
BACKGROUND The discovery of induced pluripotent stem cells revolutionized regenerative medicine,providing a source for generating induced pluripotent stem cell-derived mesenchymal stem cells(iMSCs).AIM To evaluate and...BACKGROUND The discovery of induced pluripotent stem cells revolutionized regenerative medicine,providing a source for generating induced pluripotent stem cell-derived mesenchymal stem cells(iMSCs).AIM To evaluate and compare five iMSC differentiation protocols,assessing their efficiency,phenotypic characteristics,and functional properties relative to primary mesenchymal stem cells(MSCs).METHODS Five iMSC differentiation protocols were assessed:SB431542-based differentiation(iMSC1,iMSC3),an iMatrix-free method(iMSC2),growth factor supplementation(iMSC4),and embryoid body formation with retinoic acid(EB-iMSC).iMSC identity was confirmed according to the International Society for Cell&Gene Therapy 2006 criteria,requiring expression of surface markers(CD105,CD73,CD90)and absence of pluripotency markers.Functional assays were conducted to evaluate differentiation potential(osteogenic and adipogenic),proliferation,mitochondrial function,reactive oxygen species,senescence,and migration.RESULTS All iMSC types expressed MSC markers and lacked pluripotency markers.EBiMSC and iMSC2 showed enhanced osteogenesis(runt-related transcription factor 2;P≤0.01 and P≤0.0001,respectively),while adipogenic potential was reduced in iMSC2(Adipsin;P≤0.01)and EB-iMSC(Adipsin and peroxisome proliferatoractivated receptor gamma;P≤0.0001 and P≤0.01,respectively).Proliferation was comparable or superior to bone marrow MSCs,except in iMSC1,with iMSC4 showing the highest rate(MTT assay;P values ranged from 0.01 to 0.001).Despite reduced mitochondrial health in iMSC3 and iMSC4(P≤0.001),reactive oxygen species levels were lower in all iMSCs(P values ranged from 0.001 to 0.0001),and senescence was significantly reduced in all iMSCs with the exception of iMSC1(P values ranged from 0.01 to 0.0001).Migration was most reduced in iMSC4(P≤0.001 at 24 hours and P≤0.0001 at 48 hours).CONCLUSION While all protocols generated functional iMSCs,variations in differentiation,proliferation,and function emphasize the impact of protocol selection.These findings contribute to optimizing iMSC generation for research and clinical applications.展开更多
Microbially induced calcite precipitation(MICP)and Enzyme induced calcite precipitation(EICP)techniques were implemented to reinforce the large-scale calcareous sand in this study.Then a coupled numerical model to pre...Microbially induced calcite precipitation(MICP)and Enzyme induced calcite precipitation(EICP)techniques were implemented to reinforce the large-scale calcareous sand in this study.Then a coupled numerical model to predict the biochemical reactions and hydraulic characteristics of MICP and EICP reactions was proposed and verified by physical experiments.Results showed that:This model could describe the variations of bacteria,calcium,calcite,permeability over time reasonably.It is necessary to consider the influence of the calculation domain scale when simulating the convection-diffusionreaction in the multi-process of MICP and EICP reactions.The numerical and experimental values of calcite content are 0.841 g/cm^(3) and 0.861 g/cm^(3) for MICP-reinforced sand,0.263 g/cm^(3) and 0.227 g/cm^(3) for EICP-reinforced sand after 192 h of reaction.The reaction rate k_(rea) is an important parameter to control the calcite content.Accordingly,the permeability coefficient of MICP and EICP reinforced calcareous sand decreases by 32%and 18%.Due to the influence of substance transportation and calcite precipitation,the calcite shows a trend of decreasing firstly and then increasing with the enhancing of the initial permeability coefficient in biochemical reactions.The optimal injecting ratio q11:q12 in this study is 100:300 mL/min.The process for the application of MICP and EICP coupled numerical model is also recommended,which provides reference for engineering projects in ground improvement.展开更多
Heterogeneous structure exhibits superiority in improving mechanical properties,whereas their effects on fatigue damage properties have rarely been studied.In this work,we employed a high-throughput gradient heat trea...Heterogeneous structure exhibits superiority in improving mechanical properties,whereas their effects on fatigue damage properties have rarely been studied.In this work,we employed a high-throughput gradient heat treatment method(757−857℃)to rapidly acquire the solution microstructure of the Ti-6554 alloy with different recrystallization degrees(0%,40%and 100%),followed by the same aging treatment.The results showed that theβ-hetero structure exhibited a yield strength(σ_(YS))of 1403 MPa,an increase of 6.7%,and a remarkable improvement in uniform elongation(UE)of 109.7%,reaching 6.5%,compared to the homogeneous structure.Interestingly,introducing a heterogeneous structure not only overcame the traditional trade-off between strength and ductility but also enhanced fatigue crack propagation(FCP)performance.During FCP process,β-hetero structure,through hetero-deformation induced(HDI)strengthening effects,promoted the accumulation of geometric necessary dislocations(GNDs)within coarseα_(S) phase,enabling faster attainment of the critical shear stress of twinning and increasing twinning density.This facilitated stress relief,improved plastic deformation in the crack tip zone,and increased the critical fast fracture threshold from 30.4 to 36.0 MPa·m^(1/2)showing an enlarged steady state propagation region.This study provides valuable insights on tailoring fatigue damage tolerance through heterogeneous structure for titanium alloys.展开更多
The prognosis of drug-induced acute liver failure(ALF)is poor,with a survival rate of 27.1%without liver transplantation.Liver transplantation significantly improved survival rates to 66.2%.[1]The shortage of availabl...The prognosis of drug-induced acute liver failure(ALF)is poor,with a survival rate of 27.1%without liver transplantation.Liver transplantation significantly improved survival rates to 66.2%.[1]The shortage of available grafts can be addressed by living donor liver transplantation(LDLT),an effective and safe method that expands the donor pool,enhances timely transplantation,and improves patient survival.展开更多
Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells ...Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological recovery.However,the mechanism of CXCR4 upregulation in induced neural stem cells remains unclear.In this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 expression.However,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial activation.In agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury mice.Notably,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head injury.In conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neural stem cells on microglial activation via upregulation of CXCR4 and Crry,thereby promoting induced neural stem cell–mediated improvement of neuronal injury,cerebral edema,and neurological disorders following closed head injury.展开更多
0 INTRODUCTION.According to the China Earthquake Networks Center,an M6.8 earthquake struck Dingri County,Xizang Autonomous Region,China,on 7 January 2025 at 9:05 a.m.local time.The epicenter is located at 28.5°N,...0 INTRODUCTION.According to the China Earthquake Networks Center,an M6.8 earthquake struck Dingri County,Xizang Autonomous Region,China,on 7 January 2025 at 9:05 a.m.local time.The epicenter is located at 28.5°N,87.45°E,with a depth of~10 km.展开更多
Radiochemotherapy-induced oral mucositis(OM)is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy.Erosion and ulcers are the main features of OM that seriously affe...Radiochemotherapy-induced oral mucositis(OM)is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy.Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment.To date,differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties,which has increased the uncertainty of treatment effects.On the basis of current research evidence,this expert consensus outlines risk factors,clinical manifestations,clinical grading,ancillary examinations,diagnostic basis,prevention and treatment strategies and efficacy indicators for OM.In addition to strategies such as basic oral care,antiinflammatory and analgesic agents,anti-infective agents,pro-healing agents,and photobiotherapy recommended in previous guidelines,we also emphasize the role of traditional Chinese medicine in OM prevention and treatment.This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention,diagnosis,and treatment,standardizing clinical practice,reducing OM occurrence,promoting healing,and improving the quality of life of patients.展开更多
To investigate the wind⁃induced vibration re⁃sponse characteristics of multispan double⁃layer cable photo⁃voltaic(PV)support structures,wind tunnel tests using an aeroelastic model were carried out to obtain the wind⁃...To investigate the wind⁃induced vibration re⁃sponse characteristics of multispan double⁃layer cable photo⁃voltaic(PV)support structures,wind tunnel tests using an aeroelastic model were carried out to obtain the wind⁃induced vibration response data of a three⁃span four⁃row double⁃layer cable PV support system.The wind⁃induced vibration characteristics with different PV module tilt angles,wind speeds,and wind direction angles were analyzed.The results showed that the double⁃layer cable large⁃span flexible PV support can effectively control the wind⁃induced vibration response and prevent the occur⁃rence of flutter under strong wind conditions.The maxi⁃mum value of the wind⁃induced vibration displacement of the flexible PV support system occurs in the windward first row.The upstream module has a significant shading effect on the downstream module,with a maximum effect of 23%.The most unfavorable wind direction angles of the structure are 0°and 180°.The change of the wind direction angle in the range of 0°to 30°has little effect on the wind vi⁃bration response.The change in the tilt angle of the PV modules has a greater impact on the wind vibration in the downwind direction and a smaller impact in the upwind di⁃rection.Special attention should be paid to the structural wind⁃resistant design of such systems in the upwind side span.展开更多
文摘Oncology Research Editorial Office Published:23 March 2026 The published article titled“MicroRNA 125a-5p Inhibits Cell Proliferation and Induces Apoptosis in Hepatitis B Virus-Related Hepatocellular Carcinoma by Downregulation of ErbB3”has been retracted from Oncology Research,Vol.27,No.4,2019,pp.449-458.DOI:10.3727/096504017X15016337254623 URL:https://www.techscience.com/or/v27n4/48558.
基金supported by the National Key R&D Program of China(2022YFD1401005).
文摘Diplodia tip blight,caused by Diplodia sapinea,is a global pine necrotic disease causing heavy economic losses to the pine industry.Chemical control,its main current management,easily induces pathogen resistance and environmental pollution,which biological control avoids.This study investigated juniper essential oil’s efficacy against the disease on Mongolian Scots pine(Pinus sylvestris var.mongolica)and its induced resistance mechanisms via pot experiments,physiological assays(defense enzyme activities,resistant substances)and metabolomic sequencing(secondary metabolites).Results showed varied efficacy:three foliar sprays of 10μL mL^(-1) oil achieved the best control phenylalanine ammonia-lyase(PAL),polyphenol oxidase(82.9%).The 20μL mL^(-1) treatment significantly increased(PPO)activities,and contents of lignin,flavonoids and total phenolics.Metabolomic analysis showed 326 upregulated and 527 downregulated different metabolites in essential oilinduced and pathogen-inoculated pines,compared to 483 upregulated and 277 downregulated metabolites in noninduced but inoculated pines.The differentially expressed metabolites in treated pines were primarily enriched in pathways related to amino acid metabolism and plant secondary metabolite biosynthesis,with notably increased expression levels of ferulic acid,scopoletin,pipecolic acid,D-proline,and DL-arginine.Therefore,juniper essential oil protects against D.sapinea by inducing systemic acquired resistance in Mongolian Scots pine.In conclusion,juniper essential oil controls D.sapinea by inducing systemic acquired resistance(SAR)in Mongolian Scots pine,clarifying the molecular mechanism and supporting biological control of the disease.
基金supported by the National Natural Science Foundation of China[Grant NO.42401465 and 42401464]Yunnan Fundamental Research Projects[Grant NO.202501AT070343,202401AU070169 and 202401CF070161]+1 种基金Natural Science Fund of Kunming University of Science and Technology(KKZ3202421125)Yunnan Provincial Talent Project“High-level Talent Training Support Plan”[YNWR-QNBJ-2020-031]。
文摘Accurate phenological information is essential for measuring ecosystem dynamics and carbon uptake.Southwest China is one of the country's largest terrestrial carbon sink regions and plays a crucial role in carbon peaking and neutrality.However,its complex terrain,fragile ecosystem,and variable climate challenge carbon sink stability.Vegetation phenology significantly impacts carbon absorption and release,making accurate phenological data essential for understanding carbon sequestration dynamics.The widespread distribution of evergreen forests and their weak seasonal variation in canopy introduce significant uncertainties in extracting phenology using traditional remote sensing information in this region.These limitations can lead to inaccurate assessments of carbon sink dynamics.Therefore,precise phenology extraction and analysis are vital for improving ecosystem dynamics and the carbon cycle in Southwest China.Firstly,we employed different ways to evaluate the ability of solar-induced chlorophyll fluorescence(SIF)and traditional remote sensing information to extract phenology.Secondly,based on SIF,we analyzed the spatial and temporal changes in the start of the growing season(SOS),the end of the growing season(EOS),and the length of the growing season(LOS)from 2001 to 2020.Finally,we systematically analyzed the response of SOS and EOS to five preseason climatic factors.The results showed that(1)SIF outperformed traditional remote sensing information in extracting phenology.(2)Vegetation phenology exhibited significant spatial heterogeneity.Moreover,SOS,EOS,and LOS showed trends of advancement,delay,and extension both overall and across all vegetation types.(3)Precipitation was the main factor influencing SOS,while surface downward solar radiation and mean temperature were the main factors affecting EOS,and the phenology of different vegetation types showed a great difference in response to preseason climate factors.These findings improve our understanding of vegetation phenology and its dynamics over Southwest China.
基金funded by Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20671)the Major Project of Inner Mongolia Science and Technology(Grant No.2021ZD0034)the Creative Groups of Natural Science Foundation of Hubei Province,China(Grant No.2021CFA030).
文摘While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.
基金supported by startup funding from UNMC to Dr.PPpartially by the National Institute on Alcohol Abuse and Alcoholism (AA031444 and P50AA030407-5126,Pilot Core grant) to Dr.SS
文摘The innate immune system of the central nervous system(CNS),long viewed as primarily microgliadriven,is now increasingly recognized to include astrocytes as active participants in neuroimmune signaling.Chronic alcohol exposure trigge rs oxidative stress,glial activation,and sustained inflammation,ultimately contributing to cognitive decline and neuronal injury.
基金supported by the National Key R&D Program of China(Grant Nos.2018YFA0703404 and 2017YFA0403704)the National Natural Science Foundation of China(Grant Nos.11774121 and 91745203)the Program for Changjiang Scholars and Innovative Research Team in University(Grant No.IRT_15R23).
文摘Light element compounds under high pressure display intriguing properties and applications,owing to their diverse bonding patterns and crystalline structures.However,the system of ternary Be-C-O compounds under high pressure,as the lightest representative of the IIA-IVA-VIA family,remains largely unexplored.Using a machine-learning-accelerated crystal structure search and first-principles calculations,Be-C-O phase diagrams are investigated at pressures ranging from 0 to 100 GPa.Four ternary compounds are proposed to be stable at corresponding pressures:BeCO_(3),Be_(2)CO_(4),Be_(2)C_(4)O_(3),and BeC_(4)O_(2).Analyses of electronic structure and chemical bonding further reveal how the structural diversity of these compounds is induced.Remarkably,Be_(2)C_(4)O_(3) and BeC_(4)O_(2) are recoverable to ambient conditions and possess both high energy density and high hardness.The volumetric energy densities of Be_(2)C_(4)O_(3) and BeC_(4)O_(2) could approach 9.03 and 7.94 kJ/cm^(3),respectively.The Vickers hardnesses of Be_(2)C_(4)O_(3) and BeC_(4)O_(2) are found to be close to 39.58 and 51.57 GPa,respectively.These findings demonstrate the structural and functional diversity of Be-C-O compounds under high pressure,providing guidance for further exploration of the IIA-IVA-VIA compounds.
基金National Institute of Health(NIH)National Institute of Neurological Disorders and Stroke(NINDS),Nos.NS112910,NS133252(to BD)Department of Defense(DoD)Peer Reviewed Medical Research Program(PRMRP)Discovery Award,No.W81XWH2010186(to BD).
文摘The generation of human induced pluripotent stem cell-derived motor neurons overcomes limited access to human tissues and offers an unprecedented approach to modeling motor neuron diseases such as dystonia and amyotrophic lateral sclerosis.Motor neurons generated through different strategies may exhibit substantial differences in purity,maturation,characterization,and even neuronal identity,leading to variable outcomes in disease modeling and drug screening.However,very few comparative studies have been conducted to determine the similarities and differences among motor neurons prepared via different protocols.In this study,we prepared human induced pluripotent stem cell-derived motor neurons via lentiviral delivery of transcription factors and chemical induction and performed a systematic comparative analysis.We found that motor neurons generated by both approaches showed typical motor neuron morphology and robustly expressed motor neuron-specific markers,such as nuclear homeobox transcription factor 9 and choline acetyltransferase.The chemical induction protocol utilizes a combination of small molecules to induce motor neuron differentiation,offering a significantly faster maturation time of 35 days compared to 46 days with lentiviral delivery of transcription factors.Additionally,while lentiviral delivery of transcription factors are suitable for downstream biochemical analysis,chemical induction are more applicable for therapeutic approaches as they avoid the use of lentiviruses.Both approaches produce motor neurons with high purity(>95%)and yield.No significant differences were found between chemical induction and lentiviral delivery of transcription factors in terms of motor neuron markers and maturation markers.These robust methodologies offer researchers powerful tools for investigating motor neuron diseases and potential therapeutic strategies.
基金supported by the National Key Research and Development Program of China(Grant No.2023YFC3707900)National Natural Science Foundation of China(Grant No.42230710,42525201)Key task project for joint research and development of the Yangtze River Delta Science and Technology Innovation Community(Grant No.2022CSJGG1200).
文摘Microbially induced calcium carbonate precipitation(MICP)is an eco-friendly technology for soil improvement.Although numerous experiments have been conducted to solidify sand foundations using MICP,the mechanisms by which grain interfacial morphologies influencethe MICP process remain unclear.This study utilized 3D-printed flowcells with different boundary morphologies to investigate the effects of interfacial morphologies on the MICP process.CaCO_(3)precipitation characteristics were investigated through microscopic observation and image quantificationanalysis.The results indicate that low flowvelocities near the interface promote bacterial accumulation due to reduced hydrodynamic shear forces.Rough interfaces,compared to smooth ones,enhance bacterial adsorption owing to the larger regions of low flowvelocity,increased surface area,and the formation of local eddies,which promote greater CaCO_(3)precipitation.Compared to the regions away from the interface,a higher abundance of small CaCO_(3)crystals is observed near the interface because of the high urease activity from bacteria and the reduced shear-induced entrainment due to the low flowvelocity.Besides,larger crystals also preferentially precipitate in proximity to interfaces as the low flowvelocity enhances crystal growth according to the particle attachment theory.The presence of rough interfaces further reduces flowvelocities,leading to the precipitation of larger and more densely packed CaCO_(3)crystals.Therefore,rough interfaces promote the microbially induced calcium carbonate precipitation.This work is expected to enhance the understanding of microbially induced calcium carbonate precipitation characteristics on solid surfaces such as soil grains and contribute to the optimization of MICP applications.
基金supported by the Anhui Provincial Health and Medical Research Project (AHWJ2023A30277)。
文摘Acute eosinophilic pneumonia(AEP) is a pulmonary condition characterized by acute febrile illness and respiratory distress,with bilateral pulmonary infiltrates,particularly eosinophilic infiltration of the lungs.^([1])Amiodarone,a widely applied antiarrhythmic agent,has been reported as a potential cause of drug-induced AEP.^([2]) Most reported cases of amiodarone-induced AEP typically occur following prolonged exposure for two months or more.
基金supported by Arizona Biomedical Research Commission[ADHS18-198846]the National Institute of Health NINDS[R56-NS109608 and R01-NS122805]Davies,Robert and Peyton,Parkinson’s Disease Research Fund to TF.
文摘The loss of control over movement is one of the most devastating consequences of Parkinson’s disease(PD).The loss of control largely results from the gradual but inexorable destruction of dopamine-producing neurons in the substantia nigra pars compacta.As dopamine levels fall,the ability to initiate,control,learn,and sustain actions declines.Treatment with the dopamine precursor levodopa can partly overcome motor impairments;however,years of use often leads to levodopa-induced dyskinesia(LID),a debilitating condition characterized by uncontrolled writhing and ballistic movements,making continued treatment difficult or impossible.While progress has been made towards unraveling the molecular and cellular processes driving the development of LID,far less is known about the changes in ongoing neuronal activity that contribute to LID expression.
基金supported by the National Natural Science Foundation of China,No.32171356(to YW)Self-Support Research Projects of Shihezi University,No.ZZZC2021105(to WJ)+1 种基金Capital Medical University Natural Science Cultivation Fund,No.PYZ23044(to FQM)Beijing Municipal Natural Science Foundation,No.7244410(to JHD)。
文摘Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells encounter various obstacles,including limited tissue sources,invasive acquisition methods,cellular heterogeneity,purification challenges,cellular senescence,and diminished pluripotency and proliferation over successive passages.In this study,we used induced pluripotent stem cell-derived mesenchymal stem cells,known for their self-renewal capacity,multilineage differentiation potential,and immunomodulatory characteristics.We used induced pluripotent stem cell-derived mesenchymal stem cells in conjunction with acellular nerve allografts to address a 10 mm-long defect in a rat model of sciatic nerve injury.Our findings reveal that induced pluripotent stem cell-derived mesenchymal stem cells exhibit survival for up to 17 days in a rat model of peripheral nerve injury with acellular nerve allograft transplantation.Furthermore,the combination of acellular nerve allograft and induced pluripotent stem cell-derived mesenchymal stem cells significantly accelerates the regeneration of injured axons and improves behavioral function recovery in rats.Additionally,our in vivo and in vitro experiments indicate that induced pluripotent stem cell-derived mesenchymal stem cells play a pivotal role in promoting neovascularization.Collectively,our results suggest the potential of acellular nerve allografts with induced pluripotent stem cell-derived mesenchymal stem cells to augment nerve regeneration in rats,offering promising therapeutic strategies for clinical translation.
基金financially supported by the National Natural Science Foundation of China(Grant 22205173)the Innovation Capability Support Program of Shaanxi(Grant 2024CX‐GXPT‐12)。
文摘The metal‐reduction‐induced dechlorination coupling(MR-DC)strategy enables the first successful synthesis of an all‐inorganic crosslinked phosphazene network(aPN)from hexachlorocyclotriphosphazene(HCCP)under mild reaction conditions.Using Cu as a model,the resulting Cu-aPN(copper‐embedded all‐inorganic phosphazene network)retains the intrinsic N_(3)P_(3)backbone and exhibits an amorphous structure where Cu species are uniformly anchored at dense P/N coordination sites of the network.Time of flight secondary ion mass spectrometry(TOF‐SIMS)and X‐ray diffraction(XRD)reveal a gradual CuCl‐to‐CuO phase conversion during ammonia treatment,which effectively ensures the structural stability of the phosphazene framework.In 1 M KOH,Cu-aPN delivers an overpotential of 280 mV at 10 mA cm^(−2)and a Tafel slope of 48 mV dec^(−1),markedly outperforming Ga-aPN.In situ Raman and density functional theory(DFT)analyses indicate stronger Cu-P/N coordination coupling that lowers the*OH formation barrier(0.39 vs.0.88 eV for Ga).This MR-DC route furnishes a general and versatile pathway for constructing metal‐embedded all‐inorganic phosphazene frameworks with tunable coordination environments for advanced electrocatalytic applications.
文摘BACKGROUND The discovery of induced pluripotent stem cells revolutionized regenerative medicine,providing a source for generating induced pluripotent stem cell-derived mesenchymal stem cells(iMSCs).AIM To evaluate and compare five iMSC differentiation protocols,assessing their efficiency,phenotypic characteristics,and functional properties relative to primary mesenchymal stem cells(MSCs).METHODS Five iMSC differentiation protocols were assessed:SB431542-based differentiation(iMSC1,iMSC3),an iMatrix-free method(iMSC2),growth factor supplementation(iMSC4),and embryoid body formation with retinoic acid(EB-iMSC).iMSC identity was confirmed according to the International Society for Cell&Gene Therapy 2006 criteria,requiring expression of surface markers(CD105,CD73,CD90)and absence of pluripotency markers.Functional assays were conducted to evaluate differentiation potential(osteogenic and adipogenic),proliferation,mitochondrial function,reactive oxygen species,senescence,and migration.RESULTS All iMSC types expressed MSC markers and lacked pluripotency markers.EBiMSC and iMSC2 showed enhanced osteogenesis(runt-related transcription factor 2;P≤0.01 and P≤0.0001,respectively),while adipogenic potential was reduced in iMSC2(Adipsin;P≤0.01)and EB-iMSC(Adipsin and peroxisome proliferatoractivated receptor gamma;P≤0.0001 and P≤0.01,respectively).Proliferation was comparable or superior to bone marrow MSCs,except in iMSC1,with iMSC4 showing the highest rate(MTT assay;P values ranged from 0.01 to 0.001).Despite reduced mitochondrial health in iMSC3 and iMSC4(P≤0.001),reactive oxygen species levels were lower in all iMSCs(P values ranged from 0.001 to 0.0001),and senescence was significantly reduced in all iMSCs with the exception of iMSC1(P values ranged from 0.01 to 0.0001).Migration was most reduced in iMSC4(P≤0.001 at 24 hours and P≤0.0001 at 48 hours).CONCLUSION While all protocols generated functional iMSCs,variations in differentiation,proliferation,and function emphasize the impact of protocol selection.These findings contribute to optimizing iMSC generation for research and clinical applications.
基金supports from the National Key R&D Program of China(Grant No.2023YFB4203301)National Natural Science Foundation of China(Grant No.52238008)Postdoctoral Fellowship Program of CPSF(Grant No.GZC20241516).
文摘Microbially induced calcite precipitation(MICP)and Enzyme induced calcite precipitation(EICP)techniques were implemented to reinforce the large-scale calcareous sand in this study.Then a coupled numerical model to predict the biochemical reactions and hydraulic characteristics of MICP and EICP reactions was proposed and verified by physical experiments.Results showed that:This model could describe the variations of bacteria,calcium,calcite,permeability over time reasonably.It is necessary to consider the influence of the calculation domain scale when simulating the convection-diffusionreaction in the multi-process of MICP and EICP reactions.The numerical and experimental values of calcite content are 0.841 g/cm^(3) and 0.861 g/cm^(3) for MICP-reinforced sand,0.263 g/cm^(3) and 0.227 g/cm^(3) for EICP-reinforced sand after 192 h of reaction.The reaction rate k_(rea) is an important parameter to control the calcite content.Accordingly,the permeability coefficient of MICP and EICP reinforced calcareous sand decreases by 32%and 18%.Due to the influence of substance transportation and calcite precipitation,the calcite shows a trend of decreasing firstly and then increasing with the enhancing of the initial permeability coefficient in biochemical reactions.The optimal injecting ratio q11:q12 in this study is 100:300 mL/min.The process for the application of MICP and EICP coupled numerical model is also recommended,which provides reference for engineering projects in ground improvement.
基金Project(2021YFB3700801)supported by the National Key Research and Development Program of ChinaProject(2023JJ30683)supported by the Natural Science Foundation of Hunan Province,ChinaProject supported by the State Key Laboratory of Powder Metallurgy(Central South University),China。
文摘Heterogeneous structure exhibits superiority in improving mechanical properties,whereas their effects on fatigue damage properties have rarely been studied.In this work,we employed a high-throughput gradient heat treatment method(757−857℃)to rapidly acquire the solution microstructure of the Ti-6554 alloy with different recrystallization degrees(0%,40%and 100%),followed by the same aging treatment.The results showed that theβ-hetero structure exhibited a yield strength(σ_(YS))of 1403 MPa,an increase of 6.7%,and a remarkable improvement in uniform elongation(UE)of 109.7%,reaching 6.5%,compared to the homogeneous structure.Interestingly,introducing a heterogeneous structure not only overcame the traditional trade-off between strength and ductility but also enhanced fatigue crack propagation(FCP)performance.During FCP process,β-hetero structure,through hetero-deformation induced(HDI)strengthening effects,promoted the accumulation of geometric necessary dislocations(GNDs)within coarseα_(S) phase,enabling faster attainment of the critical shear stress of twinning and increasing twinning density.This facilitated stress relief,improved plastic deformation in the crack tip zone,and increased the critical fast fracture threshold from 30.4 to 36.0 MPa·m^(1/2)showing an enlarged steady state propagation region.This study provides valuable insights on tailoring fatigue damage tolerance through heterogeneous structure for titanium alloys.
基金approved by the Ethics Committee of the Second Affiliated Hospital,Zhejiang University School of Medicine(2024-0690).
文摘The prognosis of drug-induced acute liver failure(ALF)is poor,with a survival rate of 27.1%without liver transplantation.Liver transplantation significantly improved survival rates to 66.2%.[1]The shortage of available grafts can be addressed by living donor liver transplantation(LDLT),an effective and safe method that expands the donor pool,enhances timely transplantation,and improves patient survival.
基金supported by the National Natural Science Foundation of China,Nos.82271397(to MG),82001293(to MG),82171355(to RX),81971295(to RX),and 81671189(to RX)。
文摘Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological recovery.However,the mechanism of CXCR4 upregulation in induced neural stem cells remains unclear.In this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 expression.However,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial activation.In agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury mice.Notably,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head injury.In conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neural stem cells on microglial activation via upregulation of CXCR4 and Crry,thereby promoting induced neural stem cell–mediated improvement of neuronal injury,cerebral edema,and neurological disorders following closed head injury.
基金funded by the National Key R&D Program of China(No.2020YFC150071)partly supported by the Shaanxi Province Geoscience Big Data and Geohazard Prevention Innovation Team(2022)and the Research Funds for the Interdisciplinary Projects,CHU(No.300104240914)。
文摘0 INTRODUCTION.According to the China Earthquake Networks Center,an M6.8 earthquake struck Dingri County,Xizang Autonomous Region,China,on 7 January 2025 at 9:05 a.m.local time.The epicenter is located at 28.5°N,87.45°E,with a depth of~10 km.
基金supported by the National Natural Science Foundation of China(U23A20445)the Science and Technology Program of Guangzhou(202206080009)。
文摘Radiochemotherapy-induced oral mucositis(OM)is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy.Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment.To date,differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties,which has increased the uncertainty of treatment effects.On the basis of current research evidence,this expert consensus outlines risk factors,clinical manifestations,clinical grading,ancillary examinations,diagnostic basis,prevention and treatment strategies and efficacy indicators for OM.In addition to strategies such as basic oral care,antiinflammatory and analgesic agents,anti-infective agents,pro-healing agents,and photobiotherapy recommended in previous guidelines,we also emphasize the role of traditional Chinese medicine in OM prevention and treatment.This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention,diagnosis,and treatment,standardizing clinical practice,reducing OM occurrence,promoting healing,and improving the quality of life of patients.
基金The National Natural Science Foundation of China(No.52338011).
文摘To investigate the wind⁃induced vibration re⁃sponse characteristics of multispan double⁃layer cable photo⁃voltaic(PV)support structures,wind tunnel tests using an aeroelastic model were carried out to obtain the wind⁃induced vibration response data of a three⁃span four⁃row double⁃layer cable PV support system.The wind⁃induced vibration characteristics with different PV module tilt angles,wind speeds,and wind direction angles were analyzed.The results showed that the double⁃layer cable large⁃span flexible PV support can effectively control the wind⁃induced vibration response and prevent the occur⁃rence of flutter under strong wind conditions.The maxi⁃mum value of the wind⁃induced vibration displacement of the flexible PV support system occurs in the windward first row.The upstream module has a significant shading effect on the downstream module,with a maximum effect of 23%.The most unfavorable wind direction angles of the structure are 0°and 180°.The change of the wind direction angle in the range of 0°to 30°has little effect on the wind vi⁃bration response.The change in the tilt angle of the PV modules has a greater impact on the wind vibration in the downwind direction and a smaller impact in the upwind di⁃rection.Special attention should be paid to the structural wind⁃resistant design of such systems in the upwind side span.
