An efficient asymmetric[4+2]cyclization of hydroxyphenyl indolinone with azlactone for the synthesis of spirooxindoleδ-lactone has been developed,which realized the first asymmetric reaction of hydroxyphenyl indolino...An efficient asymmetric[4+2]cyclization of hydroxyphenyl indolinone with azlactone for the synthesis of spirooxindoleδ-lactone has been developed,which realized the first asymmetric reaction of hydroxyphenyl indolinone.A series of intricate structures with congested vicinal quaternary chiral centers were provided in good yields with excellent enantioselectivities via the in situ generated o-QM from hydroxyphenyl indolinone.展开更多
Two new indole alkaloids. wuchuyuamide I and II were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth and their structures were elucidated on the basis of spectral data.
Indolinonic aminoxyls can effectively scavenge various radicals by directly coupling with them or by imitating superoxide dismutase. To better understand the radical-coupling reactions, DFT method B3LYP/6-31G(d,p) wa...Indolinonic aminoxyls can effectively scavenge various radicals by directly coupling with them or by imitating superoxide dismutase. To better understand the radical-coupling reactions, DFT method B3LYP/6-31G(d,p) was employed to calculate variations of free energy for the coupling reactions and other physico-chemical parameters. The radical-coupling activity difference between aminoxyls was elucidated to a large extent in terms of electronic properties of substituents.展开更多
基金We thank the Qingdao Marine Science and Technology Center(No.2022QNLM030003-2)the Fundamental Research Funds for the Central Universities,Taishan Scholar Program of Shandong Province(No.tsqn201909056)National Natural Science Foundation of China(No.22171251)for financial support.
文摘An efficient asymmetric[4+2]cyclization of hydroxyphenyl indolinone with azlactone for the synthesis of spirooxindoleδ-lactone has been developed,which realized the first asymmetric reaction of hydroxyphenyl indolinone.A series of intricate structures with congested vicinal quaternary chiral centers were provided in good yields with excellent enantioselectivities via the in situ generated o-QM from hydroxyphenyl indolinone.
文摘Two new indole alkaloids. wuchuyuamide I and II were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth and their structures were elucidated on the basis of spectral data.
基金This study was supported by the National Natural Science Foundation of China (Grant No. 30100035).
文摘Indolinonic aminoxyls can effectively scavenge various radicals by directly coupling with them or by imitating superoxide dismutase. To better understand the radical-coupling reactions, DFT method B3LYP/6-31G(d,p) was employed to calculate variations of free energy for the coupling reactions and other physico-chemical parameters. The radical-coupling activity difference between aminoxyls was elucidated to a large extent in terms of electronic properties of substituents.
