This paper deals with the singular chemotaxis-Navier-Stokes system with indirect signal consumption n_(t)+u·▽v=△n-Х▽·(n/v▽u);v_(t)+u·▽v=△v-uw;w_(t)+u·▽w=△w-w+n;u_(t)+(u·▽)u=△u-▽P+...This paper deals with the singular chemotaxis-Navier-Stokes system with indirect signal consumption n_(t)+u·▽v=△n-Х▽·(n/v▽u);v_(t)+u·▽v=△v-uw;w_(t)+u·▽w=△w-w+n;u_(t)+(u·▽)u=△u-▽P+n▽Ф;▽·u=0,x∈Ω,t>0 in a bounded and smooth domainΩ⊂ℝ2 with no-flux/no-flux/no-flux/no-slip boundary conditions,whereΦ∈W2,∞(Ω).A recent literature[Dai F,Liu B.J Differential Equations,2023,369:115–155]has proved that for all reasonably regular initial data,the associated initial-boundary value problem possesses a global classical solution,but qualitative information on the behavior of solution has never been touched so far.In stark contrast to the positive effect of indirect signal consumption mechanism on the global solvability of system,the analysis of asymptotic behavior of solution to the system with indirect signal consumption is essentially complicated than that with direct signal consumption because the favorable coupled structure between cells and signal is broken down by the indirect signal consumption mechanism.The present study shows that the global classical solution exponentially stabilizes toward the corresponding spatially homogeneous equilibria under a smallness condition on the initial cell mass.In comparison to the previously known result concerning the uniform convergence of solution to the system with direct signal consumption,our result inter alia provides a more in-depth understanding on the asymptotic behavior of solution.展开更多
The dissolution of iron from the cathode and electrode/electrolyte interface(EEI)during long cycles significantly accelerates the aging process of LiFePO_(4)(LFP)/graphite batteries;there is a lack of systematic under...The dissolution of iron from the cathode and electrode/electrolyte interface(EEI)during long cycles significantly accelerates the aging process of LiFePO_(4)(LFP)/graphite batteries;there is a lack of systematic understanding of the spatial distribution of the EEI interface layer and the dissolve of Fe ions,especially in terms of the mechanism of the cathode-electrolyte interphase(CEI),solid electrolyte interphase(SEI),and iron dissolution.In this study,aged cells were subjected to continuous activation with constant current and multi-step segmented indirect activation(IA)and analyzed for capacity fade,impedance growth,and active Li^(+)mass loss at the EEI and nanoscale levels.The interaction between dissolved Fe^(2+)and the EEI in LFP/graphite pouch batteries was proposed and verified.The findings indicate that during IA process,the electric field facilitates the migration of solvated ions toward the electrodes,while simultaneously inhibiting the formation of organic species such as ROCO_(2)Li.The SEI primarily consists of a mixture of organic and inorganic small molecules,forming a continuous and uniform film on the electrode surface.This study demonstrates that IA favors the formation of a uniform EEI and offers constructive insights for advancing accelerated lifetime prediction strategies in lithium-ion batteries.展开更多
This paper deals with the problem of the absolute stability for general neutral type Lurie indirect control systems by Lyapunov method and linear matrix inequality （LMI） technique. Delay-dependent sufficient conditi...This paper deals with the problem of the absolute stability for general neutral type Lurie indirect control systems by Lyapunov method and linear matrix inequality （LMI） technique. Delay-dependent sufficient conditions for the absolute stability are derived and expressed as the feasibility problem of LMI, which can be easily solved by Matlab Toolbox. Finally, some examples are provide to demonstrate the effectiveness of proposed method.展开更多
This study was designed to evaluate the efficacy, tolerability, and sequential administration of abiraterone acetate （AA） and enzalutamide （Enz） for metastatic castration-resistant prostate cancer （mCRPC）. A lit...This study was designed to evaluate the efficacy, tolerability, and sequential administration of abiraterone acetate （AA） and enzalutamide （Enz） for metastatic castration-resistant prostate cancer （mCRPC）. A literature search was performed with PubMed, Embase, and Web of Science databases to identify relevant studies. Reviewed literature included published phase III trials of AA or Enz in mCRPC and studies regarding their sequential administration. Given the difference in control arms in AA （active comparator） and Enz （true placebo） randomized phase III studies, indirect comparisons between AA and Enz in mCRPC showed no statistically significant difference in overall survival in prechemotherapy and postchemotherapy settings （HR. 0.90, 95% CI, 0.73-1.11; HR： 0.85, 95% CI, 0.68-1.07）. Compared with AA, Enz may better outperform control arms in treating mCRPC both before and after chemotherapy regarding secondary endpoints based on indirect comparisons： time to prostate-specific antigen （PSA） progression （HR. 0.34, 95% CI, 0.28-0.42; HR： 0.40, 95% CI, 0.30-0.53）, radiographic progression-free survival （HR： 0.37, 95% CI, 0.28-0.48; HR： 0.61, 95% CI, 0.50-0.74）, and PSA response rate （OR： 18.29, 95% CI, 11.20-29.88; OR： 10.69, 95% CI, 3.92-29.20）. With regard to the effectiveness of Enz following AA or AA following Enz, recent retrospective case series reported overall survival and secondary endpoints for patients with mCRPC progression after chemotherapy. However, confirmatory head-to-head trials are necessary to determine the optimal sequencing of these agents.展开更多
A novel control method for a general class of nonlinear systems using fuzzy logic systems （FLSs） is presertted. Indirect and direct methods are combined to design the adaptive fuzzy output feedback controller and a ...A novel control method for a general class of nonlinear systems using fuzzy logic systems （FLSs） is presertted. Indirect and direct methods are combined to design the adaptive fuzzy output feedback controller and a high-gain observer is used to estimate the derivatives of the system output. The closed-loop system is proven to be semiglobally uniformly ultimately bounded. In addition, it is shown that if the approximation accuracy of the fuzzy logic system is high enough and the observer gain is chosen sufficiently large, an arbitrarily small tracking error can be achieved. Simulation results verify the effectiveness of the newly designed scheme and the theoretical discussion.展开更多
The absolute stability of a class of indirect control systems was studied by applying the theory of Hermitian quadratic form and Jordan normal form. The algebraic formal criteria for the absolute stability are establi...The absolute stability of a class of indirect control systems was studied by applying the theory of Hermitian quadratic form and Jordan normal form. The algebraic formal criteria for the absolute stability are established, and these results are new and useful.展开更多
This paper considers the following quasilinear chemo-taxis system with indirect signal production and generalized logistic source{u_(t)=▽·(▽(u)▽u)-▽·(S(u)▽v)+μ(u-u^(Y)),x∈Ω,t>0 O=△v-v+w,x∈Ω,t&g...This paper considers the following quasilinear chemo-taxis system with indirect signal production and generalized logistic source{u_(t)=▽·(▽(u)▽u)-▽·(S(u)▽v)+μ(u-u^(Y)),x∈Ω,t>0 O=△v-v+w,x∈Ω,t>0 w_(t)=-δw+u,x∈Ω,t>0 under homogeneous Neumann boundary conditions in a smooth bounded domainΩ■R^(n)(n≥1),where the parametersμ,δ>0 andγ>1,the functions D(u)and S(u)are supposed to be smooth fulfilling D(u)≥C_(D)(u+1)^(-a)and S(u)≤C_(S)u(u+1)^(β-1)for all u≥0 with C D,α,β∈R and.It is proved that the corresponding initial-boundary value problem possesses a global bounded classical solution ifα+2β<γ-1.Moreover,ifμis suitably large,the asymptotic behavior and convergence rates are also been considered.展开更多
Primary and secondary networks are treated as a whole in indirect heating systems, and an advanced new temperature-flow regulation method is presented whose flow ratio is greater than 60% in a secondary network and 30...Primary and secondary networks are treated as a whole in indirect heating systems, and an advanced new temperature-flow regulation method is presented whose flow ratio is greater than 60% in a secondary network and 30% in a primary network when under a partial load. Through deducing and optimizing an exponential function flow regulation rule, the formulae of flow regulation and the supply and return water temperatures are obtained, and their relevant curves are plotted. After comparison, it is found that this control method has a huge energy conservation space, and it should therefore be generalized soon.展开更多
Automatic voltage regulators(AVR)are designed to manipulate a synchronous generator’s voltage level automatically.Proportional integral derivative(PID)controllers are typically used in AVR systems to regulate voltage...Automatic voltage regulators(AVR)are designed to manipulate a synchronous generator’s voltage level automatically.Proportional integral derivative(PID)controllers are typically used in AVR systems to regulate voltage.Although advanced PID tuning methods have been proposed,the actual voltage response differs from the theoretical predictions due to modeling errors and system uncertainties.This requires continuous fine tuning of the PID parameters.However,manual adjustment of these parameters can compromise the stability and robustness of the AVR system.This study focuses on the online self-tuning of PID controllers called indirect design approach-2(IDA-2)in AVR systems while preserving robustness.In particular,we indirectly tune the PID controller by shifting the frequency response.The new PID parameters depend on the frequency-shifting constant and the previously optimized PID parameters.Adjusting the frequency-shifting constant modifies all the PID parameters simultaneously,thereby improving the control performance and robustness.We evaluate the robustness of the proposed online PID tuning method by comparing the gain margins(GMs)and phase margins(PMs)with previously optimized PID parameters during parameter uncertainties.The proposed method is further evaluated in terms of disturbance rejection,measurement noise,and frequency response analysis during parameter uncertainty calculations against existing methods.Simulations show that the proposed method significantly improves the robustness of the controller in the AVR system.In summary,online self-tuning enables automated PID parameter adjustment in an AVR system,while maintaining stability and robustness.展开更多
In neutral point indirectly grounded systems, phase-to-ground fault is putting new demands on fault diagnosis technology. Information fusion is applied to detect the phase-to-ground fault, which integrates several sou...In neutral point indirectly grounded systems, phase-to-ground fault is putting new demands on fault diagnosis technology. Information fusion is applied to detect the phase-to-ground fault, which integrates several sources of information, including line current, line voltage, zero sequence current and voltage, and quintic harmonic wave component. This method is testified through the simulation of Matlab. Simulation results show that the precision and reliability of the detection has been greatly increased.展开更多
A form of iterative learning control (ILC) is used to update the set-point for the local controller. It is referred to as set-point-related (SPR) indirect ILC. SPR indirect ILC has shown excellent performance: as a su...A form of iterative learning control (ILC) is used to update the set-point for the local controller. It is referred to as set-point-related (SPR) indirect ILC. SPR indirect ILC has shown excellent performance: as a supervision module for the local controller, ILC can improve the tracking performance of the closed-loop system along the batch direction. In this study, an ILC-based P-type controller is proposed for multi-input multi-output (MIMO) linear batch processes, where a P-type controller is used to design the control signal directly and an ILC module is used to update the set-point for the P-type controller. Under the proposed ILC-based P-type controller, the closed-loop system can be transformed to a 2-dimensional (2D) Roesser s system. Based on the 2D system framework, a sufficient condition for asymptotic stability of the closed-loop system is derived in this paper. In terms of the average tracking error (ATE), the closed-loop control performance under the proposed algorithm can be improved from batch to batch, even though there are repetitive disturbances. A numerical example is used to validate the proposed results.展开更多
It is demonstrated that if the vector sum of the external forces and the total external torque are functions of all the positions and the velocities of the particles, the internal forces will affect indirectly the lin...It is demonstrated that if the vector sum of the external forces and the total external torque are functions of all the positions and the velocities of the particles, the internal forces will affect indirectly the linear momentum and the angular momentum of a system of the particles through the and. In order to ensure that the internal forces have no effect on the and of the system, the external forces must be restricted to a linear function of and. Some examples which show that internal forces do affect the motion of the center of mass and the angular momentum of the system were discussed.展开更多
In this editorial,the authors of this paper comment on the article by Bokov et al published in the recent issue of World Journal of Orthopedics.We reviewed a general overview of oblique lumbar interbody fusions(OLIF)a...In this editorial,the authors of this paper comment on the article by Bokov et al published in the recent issue of World Journal of Orthopedics.We reviewed a general overview of oblique lumbar interbody fusions(OLIF)and lateral lumbar interbody fusions(LLIF),their indications and complications as an increasingly popular minimally invasive technique to address several lumbar pathologies.This editorial thoroughly discusses and reviews the literature regarding factors affecting outcomes of indirect decompression utilized through OLIF and LLIF procedures.Several parameters play a critical role in patient outcomes including restoration of disc height,foraminal height,central canal squared,and foraminal area.The indirect decompression allows for unbuckling of the ligamentum flavum which can significantly decompress the neural elements as well as aid in reduction of spondylolisthesis.However,the authors further highlight the limitations of indirect decompression and factors that may predict unsuccessful outcomes including bony foraminal stenosis,severe central canal stenosis,and osteoporosis.As a result,failure of indirect decompression can lead to persistent pain,radiculopathy and unsatisfied patients.Spinal surgeons may be left to reimage patients and consider additional procedures with direct decompression.展开更多
Immune modulation is crucial for male reproduction and fertility.Metals and metalloids(metals)have been extensively studied for their immunomodulatory effects.Whether metal exposure affects semen quality through immun...Immune modulation is crucial for male reproduction and fertility.Metals and metalloids(metals)have been extensively studied for their immunomodulatory effects.Whether metal exposure affects semen quality through immune modulation is unclear.In the present study,we explored the associations between exogenous metals within immune cells,immune cell proportions,and semen quality among 84 healthy men who repeatedly provided 266 semen samples over 90 days.We employed mass cytometry(CyTOF)technology to identify immune cells in semen and measured exogenous metals in these cells at the single-cell resolution.After adjusting for potential confounders,most detected metals in immune cells were inversely associated with the proportion of immune cells in semen samples(all p<0.05),indicating the adverse effects of exogenous metals on immune cells.The proportion of immune cells showed N-shaped,nonlinear associations with sperm concentration,total count,progressive motility,and total motility.Mediation analyses showed that the percentage of indirect effects of exogenous metals on sperm quality parameters via immune cells ranged from 15.11%to 54.29%.Overall,our findings unravel the indirect effects of exogenous metal exposure on male reproductive health via immune cells,contributing valuable insights into the complex interplay between environmental factors,immune cells,and human semen quality.展开更多
The objective of the present study is to investigate the efficiency of indirect adiabatic chiller-based cooling system efficiency dependence of outdoor air humidity. The system is located in historical building, in te...The objective of the present study is to investigate the efficiency of indirect adiabatic chiller-based cooling system efficiency dependence of outdoor air humidity. The system is located in historical building, in temperate climate of Latvia. The data about electricity consumption, water consumption, chiller operation stages, cooling average temperatures and outdoor air parameters have been acquired for the period of 2.5 month, during the cooling season. Using data collected by BACnet based BMS controllers and adiabatic chiller control system, we have analyzed operation efficiency of the chiller and its dependence of outdoor air humidity. Data range for the period from August 1st till October 13th, 2011 was taken for deeper analysis, which showed that in temperature range 22.0 ± 0.5 ℃ for the studied period of time chiller＇s COP is slightly dependent on the outdoor air moisture.展开更多
The effect of a storage system on drying time and estimation of drying parameters of cocoa beans using an indirect solar dryer with a sensible heat energy storage system (stones which act as both absorber and heat sto...The effect of a storage system on drying time and estimation of drying parameters of cocoa beans using an indirect solar dryer with a sensible heat energy storage system (stones which act as both absorber and heat storage media) is the main subject of this article. This dryer, which uses stones as storage material and is made of wood and plywood, was used to dry a quantity of 5 kg of fermented cocoa beans. The drying parameters for the drying curves and the drying efficiency of cocoa beans were established and studied. The drying curves were modelled from semi-empirical models. The results showed that the moisture of cocoa beans decreased from 60% to 7% in wet basis. With a solar collector and drying efficiency of 40% and 34%, respectively. And this with a maximum average difference temperature between the drying air and the ambient temperature of 13.25˚C day or night. The best concordances are obtained with R2 values of 0.9983, 0.9843, 0.9813 and 0.9837 respectively from the models of Hii, Jena and Das, Demir et al. and Alibas.展开更多
BACKGROUND Diabetic retinopathy(DR)is a major cause of visual impairment and blindness.However,the current DR biomarkers are insufficient for accurately predicting its onset.AIM To identify a novel marker for predicti...BACKGROUND Diabetic retinopathy(DR)is a major cause of visual impairment and blindness.However,the current DR biomarkers are insufficient for accurately predicting its onset.AIM To identify a novel marker for predicting the risk of developing DR in patients with type 2 diabetes mellitus(T2DM).METHODS We conducted a cross-sectional study involving 6993 hospitalized T2DM patients between 2013 and 2020.Patients were divided into two groups:The DR group and the non-DR group.Data were analyzed using univariate,correlation,multivariate,subgroup,and receiver operating characteristic curve analyses.RESULTS Total bilirubin,indirect bilirubin(IBIL),and direct bilirubin were negatively correlated with the risk of developing DR(P<0.001).Moreover,these three factors were all positively correlated with clinical indicators related to DR,including the estimated glomerular filtration rate,the albumin/creatinine ratio,and the 1,25-dihydroxyvitamin D3 level(P<0.001).After adjusting for multiple variables,greater IBIL levels remained independently associated with a lower risk of developing DR(odds ratio=0.500;95%confidence interval:0.363-0.686;P<0.001).The optimal IBIL cutoff point for predicting the risk of DR in male patients with elevated diastolic blood pressure was 0.655μmol/dL(area under the curve=0.662).CONCLUSION These findings suggest that IBIL could be a valuable biomarker for predicting DR risk,offering a noninvasive,cost-effective,and readily available clinical tool for the early identification of high-risk patients.Future multicenter and longitudinal studies are warranted to validate these findings and further explore the biological mechanisms underlying the protective role of IBIL in DR.展开更多
Hierarchical porous structure,which include macropores,minor pores,and micropores in scaffolds,are essential in the multiple biological functions of bone repair and regeneration.In this study,patientcustomized calcium...Hierarchical porous structure,which include macropores,minor pores,and micropores in scaffolds,are essential in the multiple biological functions of bone repair and regeneration.In this study,patientcustomized calcium-deficient hydroxyapatite(CDHA)scaffolds with three-level hierarchical porous structure were fabricated by indirect 3D printing technology and particulate leaching method.The sacrificial template scaffolds were fabricated using a photo-curing 3D printer,which provided a prerequisite for the integral structure and interconnected macropores of CDHA scaffolds.Additionally,20 wt%pore former was incorporated into the slurry to enhance the content of smaller pores within the CDHA-2 scaffolds,and then the CDHA-2 scaffolds were sintered to remove the sacrificial template scaffolds and pore former.The obtained CDHA-2 scaffolds exhibited interconnected macropores(300-400μm),minor pores(∼10-100μm),and micropores(<10μm)distributed throughout the scaffolds,which could promote bone tissue ingrowth,increase surface roughness,and enhance protein adsorption of scaffolds.In vitro studies identified that CDHA-2 scaffolds had nanocrystal grains,high specific surface area,and outstanding protein adsorption capacity,which could provide a microenvironment for cell adhesion,spreading,and proliferation.In addition,the murine intramuscular implantation experiment suggested that CDHA-2 scaffolds exhibited excellent osteoinductivity and were superior to traditional BCP ceramics under conditions without the addition of live cells and exogenous growth factors.The rabbit calvarial defect repair results indicated that CDHA-2 scaffolds could enhance in situ bone regeneration.In conclusion,these findings demonstrated that the hierarchical porous structure of CDHA scaffolds was a pivotal factor in modulating osteoinductivity and bone regeneration,and CDHA-2 scaffolds were potential candidates for bone regeneration.展开更多
Interdependencies between critical infrastructures and the economy amplify the effects of damage caused by disasters.The growing interest in impacts beyond physical damage and community resilience has spurred a surge ...Interdependencies between critical infrastructures and the economy amplify the effects of damage caused by disasters.The growing interest in impacts beyond physical damage and community resilience has spurred a surge in literature on economic modeling methodologies for estimating indirect economic impacts of disasters and the recovery of economic activity over time.In this review,we present a framework for categorizing modeling approaches that assess indirect economic impacts across natural hazards and anthropogenic disasters such as cyber attacks.We first conduct a comparative analysis of macroeconomic models,focusing on the approaches capturing sectoral interdependencies.These include the Leontief Input-Output(I/O)model,the Inoperability Input-Output Model(IIM),the Dynamic Inoperability Input-Output Model(DIIM),the Adaptive Regional Input-Output(ARIO)model,and the Computable General Equilibrium(CGE)model and its extensions.We evaluate their applicability to disaster scenarios based on input data availability,the compatibility of model assumptions,and output capabilities.We also reveal the functional relationships of input data and output metrics across economic modeling approaches for inter-sectoral impacts.Furthermore,we examine how the damage mechanisms posed by different types of disasters translate into model inputs and impact modeling processes.This synthesis provides guidance for researchers and practitioners in selecting and configuring models based on specific disaster scenarios.It also identifies the gaps in the literature,including the need for a deeper understanding of model performance reliability,key drivers of economic outcomes in different disaster contexts,and the disparities in modeling approach applications across various hazard types.展开更多
文摘This paper deals with the singular chemotaxis-Navier-Stokes system with indirect signal consumption n_(t)+u·▽v=△n-Х▽·(n/v▽u);v_(t)+u·▽v=△v-uw;w_(t)+u·▽w=△w-w+n;u_(t)+(u·▽)u=△u-▽P+n▽Ф;▽·u=0,x∈Ω,t>0 in a bounded and smooth domainΩ⊂ℝ2 with no-flux/no-flux/no-flux/no-slip boundary conditions,whereΦ∈W2,∞(Ω).A recent literature[Dai F,Liu B.J Differential Equations,2023,369:115–155]has proved that for all reasonably regular initial data,the associated initial-boundary value problem possesses a global classical solution,but qualitative information on the behavior of solution has never been touched so far.In stark contrast to the positive effect of indirect signal consumption mechanism on the global solvability of system,the analysis of asymptotic behavior of solution to the system with indirect signal consumption is essentially complicated than that with direct signal consumption because the favorable coupled structure between cells and signal is broken down by the indirect signal consumption mechanism.The present study shows that the global classical solution exponentially stabilizes toward the corresponding spatially homogeneous equilibria under a smallness condition on the initial cell mass.In comparison to the previously known result concerning the uniform convergence of solution to the system with direct signal consumption,our result inter alia provides a more in-depth understanding on the asymptotic behavior of solution.
基金supported by the National Key R&D Program of China(2021YFB2401800)the support from Beijing Nova Program(20230484241)+2 种基金the support from the China Postdoctoral Science Foundation(2024M754084)the Postdoctoral Fellowship Program of CPSF(GZB20230931)the support from Initial Energy Science&Technology Co.,Ltd(IEST)。
文摘The dissolution of iron from the cathode and electrode/electrolyte interface(EEI)during long cycles significantly accelerates the aging process of LiFePO_(4)(LFP)/graphite batteries;there is a lack of systematic understanding of the spatial distribution of the EEI interface layer and the dissolve of Fe ions,especially in terms of the mechanism of the cathode-electrolyte interphase(CEI),solid electrolyte interphase(SEI),and iron dissolution.In this study,aged cells were subjected to continuous activation with constant current and multi-step segmented indirect activation(IA)and analyzed for capacity fade,impedance growth,and active Li^(+)mass loss at the EEI and nanoscale levels.The interaction between dissolved Fe^(2+)and the EEI in LFP/graphite pouch batteries was proposed and verified.The findings indicate that during IA process,the electric field facilitates the migration of solvated ions toward the electrodes,while simultaneously inhibiting the formation of organic species such as ROCO_(2)Li.The SEI primarily consists of a mixture of organic and inorganic small molecules,forming a continuous and uniform film on the electrode surface.This study demonstrates that IA favors the formation of a uniform EEI and offers constructive insights for advancing accelerated lifetime prediction strategies in lithium-ion batteries.
文摘This paper deals with the problem of the absolute stability for general neutral type Lurie indirect control systems by Lyapunov method and linear matrix inequality （LMI） technique. Delay-dependent sufficient conditions for the absolute stability are derived and expressed as the feasibility problem of LMI, which can be easily solved by Matlab Toolbox. Finally, some examples are provide to demonstrate the effectiveness of proposed method.
文摘This study was designed to evaluate the efficacy, tolerability, and sequential administration of abiraterone acetate （AA） and enzalutamide （Enz） for metastatic castration-resistant prostate cancer （mCRPC）. A literature search was performed with PubMed, Embase, and Web of Science databases to identify relevant studies. Reviewed literature included published phase III trials of AA or Enz in mCRPC and studies regarding their sequential administration. Given the difference in control arms in AA （active comparator） and Enz （true placebo） randomized phase III studies, indirect comparisons between AA and Enz in mCRPC showed no statistically significant difference in overall survival in prechemotherapy and postchemotherapy settings （HR. 0.90, 95% CI, 0.73-1.11; HR： 0.85, 95% CI, 0.68-1.07）. Compared with AA, Enz may better outperform control arms in treating mCRPC both before and after chemotherapy regarding secondary endpoints based on indirect comparisons： time to prostate-specific antigen （PSA） progression （HR. 0.34, 95% CI, 0.28-0.42; HR： 0.40, 95% CI, 0.30-0.53）, radiographic progression-free survival （HR： 0.37, 95% CI, 0.28-0.48; HR： 0.61, 95% CI, 0.50-0.74）, and PSA response rate （OR： 18.29, 95% CI, 11.20-29.88; OR： 10.69, 95% CI, 3.92-29.20）. With regard to the effectiveness of Enz following AA or AA following Enz, recent retrospective case series reported overall survival and secondary endpoints for patients with mCRPC progression after chemotherapy. However, confirmatory head-to-head trials are necessary to determine the optimal sequencing of these agents.
基金This project was supported by the National Natural Science Foundation of China (90405011).
文摘A novel control method for a general class of nonlinear systems using fuzzy logic systems （FLSs） is presertted. Indirect and direct methods are combined to design the adaptive fuzzy output feedback controller and a high-gain observer is used to estimate the derivatives of the system output. The closed-loop system is proven to be semiglobally uniformly ultimately bounded. In addition, it is shown that if the approximation accuracy of the fuzzy logic system is high enough and the observer gain is chosen sufficiently large, an arbitrarily small tracking error can be achieved. Simulation results verify the effectiveness of the newly designed scheme and the theoretical discussion.
文摘The absolute stability of a class of indirect control systems was studied by applying the theory of Hermitian quadratic form and Jordan normal form. The algebraic formal criteria for the absolute stability are established, and these results are new and useful.
基金Supported by Program for New Century Excellent Talents in Universities of China （NCET-05-0607）, National Natural Science Foundation of China （60774010）, and Project for Fundamental Research of Natural Sciences in Universities of Jiangsu Province （07KJB510114）
基金Supported by the Science and Technology Research Project of Chongqing Education Commission(KJQN202000618)。
文摘This paper considers the following quasilinear chemo-taxis system with indirect signal production and generalized logistic source{u_(t)=▽·(▽(u)▽u)-▽·(S(u)▽v)+μ(u-u^(Y)),x∈Ω,t>0 O=△v-v+w,x∈Ω,t>0 w_(t)=-δw+u,x∈Ω,t>0 under homogeneous Neumann boundary conditions in a smooth bounded domainΩ■R^(n)(n≥1),where the parametersμ,δ>0 andγ>1,the functions D(u)and S(u)are supposed to be smooth fulfilling D(u)≥C_(D)(u+1)^(-a)and S(u)≤C_(S)u(u+1)^(β-1)for all u≥0 with C D,α,β∈R and.It is proved that the corresponding initial-boundary value problem possesses a global bounded classical solution ifα+2β<γ-1.Moreover,ifμis suitably large,the asymptotic behavior and convergence rates are also been considered.
文摘Primary and secondary networks are treated as a whole in indirect heating systems, and an advanced new temperature-flow regulation method is presented whose flow ratio is greater than 60% in a secondary network and 30% in a primary network when under a partial load. Through deducing and optimizing an exponential function flow regulation rule, the formulae of flow regulation and the supply and return water temperatures are obtained, and their relevant curves are plotted. After comparison, it is found that this control method has a huge energy conservation space, and it should therefore be generalized soon.
基金the Malaysian Ministry of Higher Education(MOHE)for their support through the Fundamental Research Grant Scheme(FRGS/1/2021/ICT02/UMP/03/3)(UMPSA Reference:RDU 210117)。
文摘Automatic voltage regulators(AVR)are designed to manipulate a synchronous generator’s voltage level automatically.Proportional integral derivative(PID)controllers are typically used in AVR systems to regulate voltage.Although advanced PID tuning methods have been proposed,the actual voltage response differs from the theoretical predictions due to modeling errors and system uncertainties.This requires continuous fine tuning of the PID parameters.However,manual adjustment of these parameters can compromise the stability and robustness of the AVR system.This study focuses on the online self-tuning of PID controllers called indirect design approach-2(IDA-2)in AVR systems while preserving robustness.In particular,we indirectly tune the PID controller by shifting the frequency response.The new PID parameters depend on the frequency-shifting constant and the previously optimized PID parameters.Adjusting the frequency-shifting constant modifies all the PID parameters simultaneously,thereby improving the control performance and robustness.We evaluate the robustness of the proposed online PID tuning method by comparing the gain margins(GMs)and phase margins(PMs)with previously optimized PID parameters during parameter uncertainties.The proposed method is further evaluated in terms of disturbance rejection,measurement noise,and frequency response analysis during parameter uncertainty calculations against existing methods.Simulations show that the proposed method significantly improves the robustness of the controller in the AVR system.In summary,online self-tuning enables automated PID parameter adjustment in an AVR system,while maintaining stability and robustness.
文摘In neutral point indirectly grounded systems, phase-to-ground fault is putting new demands on fault diagnosis technology. Information fusion is applied to detect the phase-to-ground fault, which integrates several sources of information, including line current, line voltage, zero sequence current and voltage, and quintic harmonic wave component. This method is testified through the simulation of Matlab. Simulation results show that the precision and reliability of the detection has been greatly increased.
基金supported by National Natural Science Foundation of China (No. 60874116)Natural Science Foundation of Hebei Province (No. F2009000857)
文摘A form of iterative learning control (ILC) is used to update the set-point for the local controller. It is referred to as set-point-related (SPR) indirect ILC. SPR indirect ILC has shown excellent performance: as a supervision module for the local controller, ILC can improve the tracking performance of the closed-loop system along the batch direction. In this study, an ILC-based P-type controller is proposed for multi-input multi-output (MIMO) linear batch processes, where a P-type controller is used to design the control signal directly and an ILC module is used to update the set-point for the P-type controller. Under the proposed ILC-based P-type controller, the closed-loop system can be transformed to a 2-dimensional (2D) Roesser s system. Based on the 2D system framework, a sufficient condition for asymptotic stability of the closed-loop system is derived in this paper. In terms of the average tracking error (ATE), the closed-loop control performance under the proposed algorithm can be improved from batch to batch, even though there are repetitive disturbances. A numerical example is used to validate the proposed results.
文摘It is demonstrated that if the vector sum of the external forces and the total external torque are functions of all the positions and the velocities of the particles, the internal forces will affect indirectly the linear momentum and the angular momentum of a system of the particles through the and. In order to ensure that the internal forces have no effect on the and of the system, the external forces must be restricted to a linear function of and. Some examples which show that internal forces do affect the motion of the center of mass and the angular momentum of the system were discussed.
文摘In this editorial,the authors of this paper comment on the article by Bokov et al published in the recent issue of World Journal of Orthopedics.We reviewed a general overview of oblique lumbar interbody fusions(OLIF)and lateral lumbar interbody fusions(LLIF),their indications and complications as an increasingly popular minimally invasive technique to address several lumbar pathologies.This editorial thoroughly discusses and reviews the literature regarding factors affecting outcomes of indirect decompression utilized through OLIF and LLIF procedures.Several parameters play a critical role in patient outcomes including restoration of disc height,foraminal height,central canal squared,and foraminal area.The indirect decompression allows for unbuckling of the ligamentum flavum which can significantly decompress the neural elements as well as aid in reduction of spondylolisthesis.However,the authors further highlight the limitations of indirect decompression and factors that may predict unsuccessful outcomes including bony foraminal stenosis,severe central canal stenosis,and osteoporosis.As a result,failure of indirect decompression can lead to persistent pain,radiculopathy and unsatisfied patients.Spinal surgeons may be left to reimage patients and consider additional procedures with direct decompression.
基金financially supported by the National Natural Science Foundation of China(42025704,22206033,82473581,22193052).
文摘Immune modulation is crucial for male reproduction and fertility.Metals and metalloids(metals)have been extensively studied for their immunomodulatory effects.Whether metal exposure affects semen quality through immune modulation is unclear.In the present study,we explored the associations between exogenous metals within immune cells,immune cell proportions,and semen quality among 84 healthy men who repeatedly provided 266 semen samples over 90 days.We employed mass cytometry(CyTOF)technology to identify immune cells in semen and measured exogenous metals in these cells at the single-cell resolution.After adjusting for potential confounders,most detected metals in immune cells were inversely associated with the proportion of immune cells in semen samples(all p<0.05),indicating the adverse effects of exogenous metals on immune cells.The proportion of immune cells showed N-shaped,nonlinear associations with sperm concentration,total count,progressive motility,and total motility.Mediation analyses showed that the percentage of indirect effects of exogenous metals on sperm quality parameters via immune cells ranged from 15.11%to 54.29%.Overall,our findings unravel the indirect effects of exogenous metal exposure on male reproductive health via immune cells,contributing valuable insights into the complex interplay between environmental factors,immune cells,and human semen quality.
文摘The objective of the present study is to investigate the efficiency of indirect adiabatic chiller-based cooling system efficiency dependence of outdoor air humidity. The system is located in historical building, in temperate climate of Latvia. The data about electricity consumption, water consumption, chiller operation stages, cooling average temperatures and outdoor air parameters have been acquired for the period of 2.5 month, during the cooling season. Using data collected by BACnet based BMS controllers and adiabatic chiller control system, we have analyzed operation efficiency of the chiller and its dependence of outdoor air humidity. Data range for the period from August 1st till October 13th, 2011 was taken for deeper analysis, which showed that in temperature range 22.0 ± 0.5 ℃ for the studied period of time chiller＇s COP is slightly dependent on the outdoor air moisture.
文摘The effect of a storage system on drying time and estimation of drying parameters of cocoa beans using an indirect solar dryer with a sensible heat energy storage system (stones which act as both absorber and heat storage media) is the main subject of this article. This dryer, which uses stones as storage material and is made of wood and plywood, was used to dry a quantity of 5 kg of fermented cocoa beans. The drying parameters for the drying curves and the drying efficiency of cocoa beans were established and studied. The drying curves were modelled from semi-empirical models. The results showed that the moisture of cocoa beans decreased from 60% to 7% in wet basis. With a solar collector and drying efficiency of 40% and 34%, respectively. And this with a maximum average difference temperature between the drying air and the ambient temperature of 13.25˚C day or night. The best concordances are obtained with R2 values of 0.9983, 0.9843, 0.9813 and 0.9837 respectively from the models of Hii, Jena and Das, Demir et al. and Alibas.
基金Supported by Natural Science Foundation of Shaanxi Province,No.2024JC-YBQN-0828 and No.2024JC-YBMS-765Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University,No.XJTU1AF-CRF-2022-036National Innovation Center for Advanced Medical Devices,No.NMED2023AGP-013.
文摘BACKGROUND Diabetic retinopathy(DR)is a major cause of visual impairment and blindness.However,the current DR biomarkers are insufficient for accurately predicting its onset.AIM To identify a novel marker for predicting the risk of developing DR in patients with type 2 diabetes mellitus(T2DM).METHODS We conducted a cross-sectional study involving 6993 hospitalized T2DM patients between 2013 and 2020.Patients were divided into two groups:The DR group and the non-DR group.Data were analyzed using univariate,correlation,multivariate,subgroup,and receiver operating characteristic curve analyses.RESULTS Total bilirubin,indirect bilirubin(IBIL),and direct bilirubin were negatively correlated with the risk of developing DR(P<0.001).Moreover,these three factors were all positively correlated with clinical indicators related to DR,including the estimated glomerular filtration rate,the albumin/creatinine ratio,and the 1,25-dihydroxyvitamin D3 level(P<0.001).After adjusting for multiple variables,greater IBIL levels remained independently associated with a lower risk of developing DR(odds ratio=0.500;95%confidence interval:0.363-0.686;P<0.001).The optimal IBIL cutoff point for predicting the risk of DR in male patients with elevated diastolic blood pressure was 0.655μmol/dL(area under the curve=0.662).CONCLUSION These findings suggest that IBIL could be a valuable biomarker for predicting DR risk,offering a noninvasive,cost-effective,and readily available clinical tool for the early identification of high-risk patients.Future multicenter and longitudinal studies are warranted to validate these findings and further explore the biological mechanisms underlying the protective role of IBIL in DR.
基金supported by the National Key Research and Development Program of China(No.2019YFA0110600)the Science and Technology Support Program of Sichuan Province(No.2019YJ0161).
文摘Hierarchical porous structure,which include macropores,minor pores,and micropores in scaffolds,are essential in the multiple biological functions of bone repair and regeneration.In this study,patientcustomized calcium-deficient hydroxyapatite(CDHA)scaffolds with three-level hierarchical porous structure were fabricated by indirect 3D printing technology and particulate leaching method.The sacrificial template scaffolds were fabricated using a photo-curing 3D printer,which provided a prerequisite for the integral structure and interconnected macropores of CDHA scaffolds.Additionally,20 wt%pore former was incorporated into the slurry to enhance the content of smaller pores within the CDHA-2 scaffolds,and then the CDHA-2 scaffolds were sintered to remove the sacrificial template scaffolds and pore former.The obtained CDHA-2 scaffolds exhibited interconnected macropores(300-400μm),minor pores(∼10-100μm),and micropores(<10μm)distributed throughout the scaffolds,which could promote bone tissue ingrowth,increase surface roughness,and enhance protein adsorption of scaffolds.In vitro studies identified that CDHA-2 scaffolds had nanocrystal grains,high specific surface area,and outstanding protein adsorption capacity,which could provide a microenvironment for cell adhesion,spreading,and proliferation.In addition,the murine intramuscular implantation experiment suggested that CDHA-2 scaffolds exhibited excellent osteoinductivity and were superior to traditional BCP ceramics under conditions without the addition of live cells and exogenous growth factors.The rabbit calvarial defect repair results indicated that CDHA-2 scaffolds could enhance in situ bone regeneration.In conclusion,these findings demonstrated that the hierarchical porous structure of CDHA scaffolds was a pivotal factor in modulating osteoinductivity and bone regeneration,and CDHA-2 scaffolds were potential candidates for bone regeneration.
基金supported by the Stanford Graduate Fellowship,the Center for Urban Science and Progress at New York Universitythe National Science Foundation under award number CMMI-2053014.The views and opinions expressed in this paper are those of the authors alone.
文摘Interdependencies between critical infrastructures and the economy amplify the effects of damage caused by disasters.The growing interest in impacts beyond physical damage and community resilience has spurred a surge in literature on economic modeling methodologies for estimating indirect economic impacts of disasters and the recovery of economic activity over time.In this review,we present a framework for categorizing modeling approaches that assess indirect economic impacts across natural hazards and anthropogenic disasters such as cyber attacks.We first conduct a comparative analysis of macroeconomic models,focusing on the approaches capturing sectoral interdependencies.These include the Leontief Input-Output(I/O)model,the Inoperability Input-Output Model(IIM),the Dynamic Inoperability Input-Output Model(DIIM),the Adaptive Regional Input-Output(ARIO)model,and the Computable General Equilibrium(CGE)model and its extensions.We evaluate their applicability to disaster scenarios based on input data availability,the compatibility of model assumptions,and output capabilities.We also reveal the functional relationships of input data and output metrics across economic modeling approaches for inter-sectoral impacts.Furthermore,we examine how the damage mechanisms posed by different types of disasters translate into model inputs and impact modeling processes.This synthesis provides guidance for researchers and practitioners in selecting and configuring models based on specific disaster scenarios.It also identifies the gaps in the literature,including the need for a deeper understanding of model performance reliability,key drivers of economic outcomes in different disaster contexts,and the disparities in modeling approach applications across various hazard types.
