The safety status of the coal mines is closely correlated with the operating status and its changes of the whole working system in the coal mines, and the safety system is the sub system of the whole production system...The safety status of the coal mines is closely correlated with the operating status and its changes of the whole working system in the coal mines, and the safety system is the sub system of the whole production system. In this paper, based on the analysis of the complicacy of the safety sub system and its affecting factors, the theory basis of the indexes system of the safety assessment was studied, including the establishing principles of the indexes system , the structure of the indexes system, the determining methods of the assessment indexes. The complete indexes system was established for the safety assessment of the coal mines in the paper.展开更多
Background:Cardiorespiratory fitness(CRF)is a powerful predictor of mortality and chronic disease risk,yet global patterns and determinants of CRF remain poorly defined,particularly in females and underrepresented pop...Background:Cardiorespiratory fitness(CRF)is a powerful predictor of mortality and chronic disease risk,yet global patterns and determinants of CRF remain poorly defined,particularly in females and underrepresented populations.We conducted a systematic review and quantitative synthesis of directly measured peak oxygen uptake(VO_(2peak))internationally and examined its association with human development and gender ine quality.Methods:Studies were eligible if VO_(2peak)was assessed via direct gas analysis during maximal exercise testing,and if the countries had scores for the Human Development Index(HDI)and Gender Inequality Index(GII).Studies were identified through MEDLINE/PubMed,Embase,CINAHL,and Web of Science.Risks of bias were assessed by an adaptation of the Newcastle-Ottawa Scale.Multivariable linear regression models examined associations between VO_(2peak),age,sex,exercise modality,HDI,GII,and study year.Results:Data included 95 studies from 24 countries with HDI and GII scores,comprising 119,435 adults(42%females)with VO_(2peak)assessed via direct gas analysis during maximal exercise testing.The risk of bias was low.VO_(2peak)was positively associated with HDI(β=14.1)and negatively associated with GII(β=-3.6).Slightly stronger associations were observed in females than males(HDI:β=18.9 vs.β=13.9,GII:β=-4.6vs.β=-3.6).Young females in middle-HDI countries had higher VO_(2peak)than those in low-HDI countries(31.2mL/kg/min vs.28.5 mL/kg/min),with limited additional gams in high-HDI contexts.VO_(2peak)decreased with higher gender inequality,with the largest disparities observed in young females between high-and low-GII countries(26.3 mL/kg/min vs.32.8 mL/kg/min).Conclusion:Global variation in CRF is tied to national levels of human development and gender equality.These findings support prioritizing structural and policy-level interventions that address social and gender disparities in physical activity access and health promotion.Studies from countries with lower HDI and information on ethnicity and socioeconomic status will bridge crucial gaps in understanding factors involved in global CRF levels.展开更多
BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an e...BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an evaluation index system for the mental health literacy of adolescent patients with mental disorders,providing a scientific,comprehensive,and reliable tool for the monitoring and intervention of mental health literacy of such patients.METHODS From December 2022 to June 2023,the evaluation index system for mental health literacy of adolescents with mental disorders was developed through literature reviews,semi-structured interviews,expert letter consultations,and the analytic hierarchy process.Based on this index system,a self-assessment questionnaire was compiled and administered to 305 adolescents with mental disorders to test the reliability and validity of the index system.RESULTS The final evaluation index system for mental health literacy of adolescents with mental disorders included 4 first-level indicators,10 second-level indicators,and 52 third-level indicators.The overall Cronbach’sαcoefficient of the index system was 0.957,with a partial reliability of 0.826 and a content validity index of 0.975.The cumulative variance contribution rate of 10 common factors was 66.491%.The correlation coefficients between each dimension and the total questionnaire ranged from 0.672 to 0.724,while the correlation coefficients in each dimension ranged from 0.389 to 0.705.CONCLUSION The evaluation index system for mental health literacy of adolescents with mental disorders,developed in this study,demonstrated notable reliability and validity,making it a valuable tool for evaluating mental health literacy in this population.展开更多
Gastric ulcer(GU)represents a clinically significant manifestation of peptic ulcer disease,driven by a complex interplay of microbial,environmental,and immuneinflammatory factors.A recent cross-sectional study by Shen...Gastric ulcer(GU)represents a clinically significant manifestation of peptic ulcer disease,driven by a complex interplay of microbial,environmental,and immuneinflammatory factors.A recent cross-sectional study by Shen et al systematically evaluated six complete blood count-derived inflammatory indices:Neutrophil-tolymphocyte ratio,monocyte-to-lymphocyte ratio,platelet-to-lymphocyte ratio,systemic immune-inflammation index,systemic inflammatory response index(SIRI),and aggregate index of systemic inflammation and demonstrated their positive associations with GU prevalence,identifying SIRI as the strongest predictor.This editorial contextualizes these findings within the broader literature,clarifies that these indices reflect systemic rather than GU-specific inflammation,highlights methodological strengths and major limitations,and proposes a conceptual clinical algorithm for integrating SIRI into GU risk assessment.Future multicenter studies incorporating Helicobacter pylori infection,non-steroidal antiinflammatory drug exposure,and prospective design are essential to validate and translate these findings into clinical practice.展开更多
This paper introduces a computationally efficient global sensitivity analysis method for quantifying the influence of uncertain clamp support conditions on the natural frequencies of aero-engine pipe systems.The dynam...This paper introduces a computationally efficient global sensitivity analysis method for quantifying the influence of uncertain clamp support conditions on the natural frequencies of aero-engine pipe systems.The dynamic model is based on a three-dimensional Timoshenko beam finite element formulation,with clamps represented as distributed spring elements possessing anisotropic stiffness.To overcome the prohibitive cost of traditional Monte Carlo simulation,the multiplicative dimensional reduction method(M-DRM)is integrated with variance decomposition theory.This approach approximates the high-dimensional frequency response function as a product of univariate components,enabling rapid computation of Sobol’sensitivity indices with a computational cost reduced by three orders of magnitude.Numerical case studies on a planar Z-shaped pipe and a spatial series-parallel configuration reveal that clamp position parameters dominate the system’s natural frequency characteristics.For critical clamps,Sobol’indices exceed 0.8 across multiple vibration modes,whereas stiffness parameters exhibit negligible influence.The proposed methodology provides a rigorous and efficient tool for identifying dominant uncertainty sources,guiding tolerance allocation in manufacturing,and informing robust support design for vibration-sensitive piping systems.展开更多
Ecosystems along the eastern margin of the Qinghai-Tibet Plateau(EQTP)are highly fragile and extremely sensitive to climate change and human disturbances.To quantitatively assess climate-induced ecosystem responses,th...Ecosystems along the eastern margin of the Qinghai-Tibet Plateau(EQTP)are highly fragile and extremely sensitive to climate change and human disturbances.To quantitatively assess climate-induced ecosystem responses,this study proposes a Climate-Induced Productivity Index(CIPI)based on the Super Slack-Based Measure(Super-SBM)model using remote sensing data from 2001 to 2020.The results reveal persistently low CIPI values(0.47-0.53)across major ecosystem types,indicating widespread vulnerability to climatic variability.Among these ecosystems,forests exhibit the highest CIPI(0.55),followed by shrublands(0.54),croplands(0.53),grasslands(0.51),and barelands(0.43).The Theil index analysis further demonstrates significant intra-group disparities,suggesting that extreme climatic events amplify CIPI heterogeneity.Moreover,the dominant environmental drivers differ among ecosystem types:the Palmer Drought Severity Index(PDSI)primarily constrains grassland productivity,solar radiation(SRAD)strongly influences shrub and cropland systems,whereas subsurface factors exert greater control in forested regions.This study provides a quantitative framework for evaluating climate-ecosystem interactions and offers a scientific basis for long-term ecological monitoring and security planning across the EQTP.展开更多
This paper presents an image encryption scheme for underwater optical wireless communication(UOWC)systems based on dynamically generated hyperchaotic S-boxes,aiming to enhance both data security and transmission perfo...This paper presents an image encryption scheme for underwater optical wireless communication(UOWC)systems based on dynamically generated hyperchaotic S-boxes,aiming to enhance both data security and transmission performance in underwater environments.The proposed encryption approach provides strong confusion and diffusion properties and is evaluated over five Jerlov water types with different optical attenuation characteristics.Security analysis demonstrates that the encrypted images achieve information entropy values close to the ideal value of 8(7.9925–7.9993),with very low correlation coefficients in horizontal,vertical,and diagonal directions,as well as the system achieves high values in key metrics such as the Unified Average Changing Intensity(UACI)and Number of Pixel Change Rate(NPCR),ranging from 33.42 to 33.47 and from 99.58%to 99.62%,respectively,both near their theoretical optima.In addition to improving confidentiality,the hyperchaotic encryption process decorrelates pixel intensities and redistributes image spectral content,which enhances robustness against underwater absorption and scattering effects.As a result,improved transmission performance is observed;for example,in Jerlov type I(JI)water,the effective transmission distance is extended from16mfor plain images to 24mfor encrypted images,while the Peak Signal to Noise Ratio(PSNR)at 24 m increases from 9.25 to 20.13 dB after decryption and enhancement.These results confirmthat the proposed scheme provides a dual benefit of secure and reliable image transmission in UOWC systems.展开更多
Amyotrophic lateral sclerosis is characterized by the progressive loss of motor neurons.Early-stage axonal dysfunction,rather than central nervous system injury,plays a key role in the disease process.However,the mole...Amyotrophic lateral sclerosis is characterized by the progressive loss of motor neurons.Early-stage axonal dysfunction,rather than central nervous system injury,plays a key role in the disease process.However,the molecular mechanisms underlying this dysfunction remain unclear.To investigate the relationship between peripheral immune dysregulation and axonal dysfunction in amyotrophic lateral sclerosis,we recruited 372 patients within the first 12 months of sporadic amyotrophic lateral sclerosis onset between January 2018 and May 2024.We collected peripheral immune markers at baseline,including total leukocytes,lymphocytes,monocytes,neutrophils,basophils,eosinophils,and platelets.We also calculated four derived ratios:neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,lymphocyte-to-monocyte ratio,and systemic immune inflammation index.Multivariate analysis,adjusted for confounding factors,revealed that higher counts of total leukocytes and neutrophils,as well as higher neutrophil-related ratios,including the neutrophil to lymphocyte ratio and the systemic immune inflammation index,were significantly correlated with higher compound muscle action potential scores.Stratified analyses revealed that these associations varied by age and sex.Furthermore,mediation analysis demonstrated that axonal dysfunction plays a significant role in the relationship between immune markers and disease progression.These findings emphasize the critical role that peripheral immune dysregulation plays in amyotrophic lateral sclerosis progression by mediating peripheral nerve injury,particularly in the early stages of the disease.This study highlights the importance of the peripheral nervous system in the early stages of amyotrophic lateral sclerosis and provides new insights into disease mechanisms and potential therapeutic targets.展开更多
The pot-culture method combined with chemical and statistical analyses was used to get basic data for determination of the food-security indexes related to combined pollution of Cr and phenol in soil-rice systems.Regr...The pot-culture method combined with chemical and statistical analyses was used to get basic data for determination of the food-security indexes related to combined pollution of Cr and phenol in soil-rice systems.Regression analyses according to the experimental result indicated that the critical concentrations of Cr andphenol in brown rice were 0.37 and 0.33 mg kg-1, respectively, under the condition of Cr-phenol combined pollution.展开更多
Aiming at the characteristics of multi-stage and(extremely)small samples of the identification problem of key effectiveness indexes of weapon equipment system-of-systems(WESoS),a Bayesian intelligent identification an...Aiming at the characteristics of multi-stage and(extremely)small samples of the identification problem of key effectiveness indexes of weapon equipment system-of-systems(WESoS),a Bayesian intelligent identification and inference model for system effectiveness assessment indexes based on dynamic grey incidence is proposed.The method uses multi-layer Bayesian techniques,makes full use of historical statistics and empirical information,and determines the Bayesian estima-tion of the incidence degree of indexes,which effectively solves the difficulties of small sample size of effectiveness indexes and difficulty in obtaining incidence rules between indexes.Sec-ondly,The method quantifies the incidence relationship between evaluation indexes and combat effectiveness based on Bayesian posterior grey incidence,and then identifies key system effec-tiveness evaluation indexes.Finally,the proposed method is applied to a case of screening key effectiveness indexes of a missile defensive system,and the analysis results show that the proposed method can fuse multi-moment information and extract multi-stage key indexes,and has good data extraction capability in the case of small samples.展开更多
Based on the daily reanalysis data of NCEP / NCAR and by using the method of phase space reconstruction, the point conditional probability density of the subtropical high ridge index are determined and then used, toge...Based on the daily reanalysis data of NCEP / NCAR and by using the method of phase space reconstruction, the point conditional probability density of the subtropical high ridge index are determined and then used, together with their power spectra, to seek the correlation between them and individual monsoon-affecting factors and their power spectra. Through diagnosis, six indexes are discovered that have the most important effects on the subtropical high index. The results of the diagnosis indicate that the technique can identify the factors which are dynamically correlated. It can offer the basis in determining and choosing dynamic conceptual factors.展开更多
In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in...In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in Hainan Province,it has been found that the quality of vocational education generally depends on the talent training program and professional construction at the macro level.At the meso level,the teacher level and teaching environment are critical,while at the micro level,the evaluation of talent training quality cannot be underestimated.Strategies for quality improvement in vocational education are proposed from the perspectives of talent training programs,major construction,teacher development,teaching environment,and talent training quality,all under the lens of digital transformation.展开更多
BACKGROUND The diagnosis of gastric carcinoma(GC)is essential for improving clinical outcomes.However,the biomarkers currently used for GC screening are not ideal.AIM To explore the diagnostic implications of the neut...BACKGROUND The diagnosis of gastric carcinoma(GC)is essential for improving clinical outcomes.However,the biomarkers currently used for GC screening are not ideal.AIM To explore the diagnostic implications of the neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and systemic immune-inflammatory index(SII)for GC.METHODS The baseline data of 133 patients with GC and 134 patients with precancerous gastric conditions admitted between January 2022 and December 2023 were retrospectively analyzed.The information on peripheral blood platelet,neutrophil,and lymphocyte counts in each patient was collected,and the NLR,PLR,and SII levels of both groups were calculated.Additionally,multivariate logistic regression analysis was conducted,and the diagnostic implications of NLR,PLR,and SII in differentiating patients with precancerous gastric conditions,compared with those with GC,were analyzed through receiver operating characteristic(ROC)curves.RESULTS The data indicated that NLR,PLR,and SII had abnormally increased levels in the patients with GC.Gender and body mass index were risk factors for the occurrence of GC.ROC data revealed that the areas under the curve of three patients with precancerous gastric conditions,who were differentiated from those with GC,were 0.824,0.787,and 0.842,respectively.CONCLUSION NLR,PLR,and SII are all abnormally expressed in GC and have diagnostic implications,especially when used as joint indicators,in distinguishing patients with precancerous gastric conditions from those with GC.展开更多
BACKGROUND Gastric cancer(GC)is the fifth most common cancer and the third leading cause of cancer-related deaths in China.Many patients with GC frequently experience symptoms related to the disease,including anorexia...BACKGROUND Gastric cancer(GC)is the fifth most common cancer and the third leading cause of cancer-related deaths in China.Many patients with GC frequently experience symptoms related to the disease,including anorexia,nausea,vomiting,and other discomforts,and often suffer from malnutrition,which in turn negatively affects perioperative safety,prognosis,and the effectiveness of adjuvant therapeutic measures.Consequently,some nutritional indicators such as nutritional risk index(NRI),prognostic nutritional index(PNI),and systemic immune-inflammatorynutritional index(SIINI)can be used as predictors of the prognosis of GC patients.AIM To examine the prognostic significance of PNI,NRI,and SIINI in postoperative patients with GC.METHODS A retrospective analysis was conducted on the clinical data of patients with GC who underwent surgical treatment at the Guangxi Medical University Cancer Hospital between January 2010 and December 2018.The area under the receiver operating characteristic(ROC)curve was assessed using ROC curve analysis,and the optimal cutoff values for NRI,PNI,and SIINI were identified using the You-Review-HTMLden index.Survival analysis was performed using the Kaplan-Meier method.In addition,univariate and multivariate analyses were conducted using the Cox proportional hazards regression model.RESULTS This study included a total of 803 patients.ROC curves were used to evaluate the prognostic ability of NRI,PNI,and SIINI.The results revealed that SIINI had superior predictive accuracy.Survival analysis indicated that patients with GC in the low SIINI group had a significantly better survival rate than those in the high SIINI group(P<0.05).Univariate analysis identified NRI[hazard ratio(HR)=0.68,95%confidence interval(CI):0.52-0.89,P=0.05],PNI(HR=0.60,95%CI:0.46-0.79,P<0.001),and SIINI(HR=2.10,95%CI:1.64-2.69,P<0.001)as prognostic risk factors for patients with GC.However,multifactorial analysis indicated that SIINI was an independent risk factor for the prognosis of patients with GC(HR=1.65,95%CI:1.26-2.16,P<0.001).CONCLUSION Analysis of clinical retrospective data revealed that SIINI is a valuable indicator for predicting the prognosis of patients with GC.Compared with NRI and PNI,SIINI may offer greater application for prognostic assessment.展开更多
The recurrence of atrial fibrillation(AF)in patients after successful radiofrequency catheter ablation(RFCA)appears to be an unresolved clinical issue and needs to be clearly elucidated.There are many factors associat...The recurrence of atrial fibrillation(AF)in patients after successful radiofrequency catheter ablation(RFCA)appears to be an unresolved clinical issue and needs to be clearly elucidated.There are many factors associated with AF recurrence,such as duration of AF,male sex,concomitant heart failure,hemodynamic parameters,chronic obstructive pulmonary disease,hypertension,obstructive sleep apnea,hyperthyroidism,smoking and obesity.However,the inflammatory changes are strongly associated with electrical and structural cardiac remodeling,cardiac damage,myocardial fibrotic changes,microvascular dysfunction and altered reparative response.In this context,biomarkers reflecting the different stages of AF pathogenesis deserve thorough investigation.The authors of the retrospective study revealed that one-year recurrence rate of non-valvular AF in the high systemic immune inflammation(SII)index group was significantly increased compared to that of the low SII index group and provided additional predictive value to the APPLE.Furthermore,the authors suggest that this biomarker may help physicians to optimize the selection of AF patients and to develop a personalized treatment approach.In conclusion,the SII index may serve as a valuable indicator of recurrent AF in patients after RFCA and may be a biomarker with plausible predictive value for poor clinical outcomes.展开更多
Due to the mining,smelting,sewage irriga-tion,agricultural runoff,and development ofrural enterprises,combined pollution of Cd andZn in soil-rice systems has frequently oc-curred.This problem was studied by using thep...Due to the mining,smelting,sewage irriga-tion,agricultural runoff,and development ofrural enterprises,combined pollution of Cd andZn in soil-rice systems has frequently oc-curred.This problem was studied by using thepot-culture imitative method combined withhemical analysis and mathematical models.展开更多
In the context of post-stimulation shale gas wells,the terms“shut-in”and“flowback”refer to two critical phases that occur after hydraulic fracturing(fracking)has been completed.These stages play a crucial role in ...In the context of post-stimulation shale gas wells,the terms“shut-in”and“flowback”refer to two critical phases that occur after hydraulic fracturing(fracking)has been completed.These stages play a crucial role in determining both the well’s initial production performance and its long-term hydrocarbon recovery.By establishing a comprehensive big data analysis platform,the flowback dynamics of over 1000 shale gas wells were analyzed in this work,leading to the development of an index system for evaluating flowback production capacity.Additionally,a shut-in chart was created for wells with different types of post-stimulation fracture networks,providing a structured approach to optimizing production strategies.A dynamic analysis method for flowback was also developed,using daily pressure drop and artificial fracture conductivity as key indicators.This method offers a systematic and effective approach to managing the shut-in and flowback processes for gas wells.Field trials demonstrated significant improvements:the probability of sand production was reduced,gas breakthrough time was extended,artificial fracture conductivity was enhanced,and the average estimated ultimate recovery(EUR)per well increased.展开更多
To identify the root causes of heavy metal contamination in soils as well as prevent and control such contamination from its sources,this study explored the accumulation patterns and ecological risks of heavy metals l...To identify the root causes of heavy metal contamination in soils as well as prevent and control such contamination from its sources,this study explored the accumulation patterns and ecological risks of heavy metals like Cd and Pb in solid waste in mining areas and across the water body,sediment,soil and agricultural product ecosystem surrounding the mining areas.Focusing on the residual solid waste samples in lead-zinc deposits in a certain area of Guizhou Province,along with samples of topsoils,irrigation water,river sediments,and crops from surrounding areas.This study analyzed the distributions of eight heavy metals,i.e.,Cd,As,Cr,Hg,Pb,Zn,Cu,and Ni,in the samples through field surveys and sample tests.Furthermore,this study assessed the contamination levels and ecological risks of heavy metals in soils,sediments,and agricultural products using methods such as the single-factor index,Nemerow composite index,and potential ecological risk assessment.The results indicate that heavy metals in the solid waste samples all exhibited concentrations exceeding their risk screening values,with 60%greater than their risk intervention values.The soils and sediments demonstrate slight and moderate comprehensive ecological risks of heavy metals.The single-factor potential ecological risks of heavy metals in both the soil and sediment samples decreased in the order of Hg,Cd,Pb,As,Cu,Zn,Cr,and Ni,suggesting the same sources of heavy metals in the soils and sediments.Most of the agricultural product samples exhibited over-limit concentrations of heavy metals dominated by Cd,Pb,Ni,and Cr,excluding Hg and As.The agricultural product assessment using the Nemerow composite index reveals that 35%of the agricultural product samples reached the heavy metal contamination level,implying that the agricultural products from farmland around the solid waste dumps have been contaminated with heavy metals.The eight heavy metals in the soil,sediment,and agricultural product samples manifested high coefficients of variation(CVs),indicating pronounced spatial variability.This suggests that their concentrations in soils,sediments,and agricultural products are significantly influenced by human mining activities.Additionally,the agricultural products exhibit strong transport and accumulation capacities for Cd,Cu,and Zn.展开更多
[Objective] The aim was to establish the water quality evaluation index system for freshwater aquaculture pond.[Method] The expert survey,DELPHI,field research and other methods were used.Based on the analysis of fact...[Objective] The aim was to establish the water quality evaluation index system for freshwater aquaculture pond.[Method] The expert survey,DELPHI,field research and other methods were used.Based on the analysis of factors influencing water quality of freshwater aquaculture pond,and the importance degree of 14 factors influencing water quality of freshwater aquaculture pond was ordered.Then,five factors were selected as index to establish the water quality evaluation index system of freshwater aquaculture with the determination for thresholds of these factors.[Result] The importance degree of water quality of freshwater aquaculture pond showed an order of Dissolved oxygenpHPhytoplankton biomassSecchi depthTotal NitrogenZooplankton biomassWater temperatureBiochemical Oxygen DemandWater colorSalinityTotal hardness;according to the value of importance degree,the dissolved oxygen,pH,secchi depth,phytoplankton biomass and total nitrogen these five factors were selected as the index system of water quality evaluation of pond.The level of water quality of freshwater aquaculture pond was divided into five,and the tolerance range of fish to each index was obtained by expert observation.[Conclusion] This study had provided a scientific basis for water quality evaluation system of freshwater aquaculture pond.展开更多
文摘The safety status of the coal mines is closely correlated with the operating status and its changes of the whole working system in the coal mines, and the safety system is the sub system of the whole production system. In this paper, based on the analysis of the complicacy of the safety sub system and its affecting factors, the theory basis of the indexes system of the safety assessment was studied, including the establishing principles of the indexes system , the structure of the indexes system, the determining methods of the assessment indexes. The complete indexes system was established for the safety assessment of the coal mines in the paper.
基金NJP holds a Future Leader Award from the Novo Nordisk Foundation and European Foundation for the Study of Diabetes(NNF/EFSD NNF21SA0072747)a grant from the Diabetes Wellness Network Sverige(PG21-6524)+5 种基金supported by the Swedish Research Council(2015-00165)the European Research Council(ERC-2023-Ad G 101142093)a Wallenberg Scholars Award from the Knut and Alice Wallenberg Foundation(KAW 2023.0312)the Swedish Research Council for Sport Science(P2023-0093)The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research center at the Faculty of Health and Medical Sciences,University of Copenhagen,Denmark partially funded by an unrestricted donation from the Novo Nordisk Foundation(NNF18CC0034900,NNF23SA0084103)supported by a postdoctoral fellowship from the Strategic Research Program in Diabetes at Karolinska Institutet。
文摘Background:Cardiorespiratory fitness(CRF)is a powerful predictor of mortality and chronic disease risk,yet global patterns and determinants of CRF remain poorly defined,particularly in females and underrepresented populations.We conducted a systematic review and quantitative synthesis of directly measured peak oxygen uptake(VO_(2peak))internationally and examined its association with human development and gender ine quality.Methods:Studies were eligible if VO_(2peak)was assessed via direct gas analysis during maximal exercise testing,and if the countries had scores for the Human Development Index(HDI)and Gender Inequality Index(GII).Studies were identified through MEDLINE/PubMed,Embase,CINAHL,and Web of Science.Risks of bias were assessed by an adaptation of the Newcastle-Ottawa Scale.Multivariable linear regression models examined associations between VO_(2peak),age,sex,exercise modality,HDI,GII,and study year.Results:Data included 95 studies from 24 countries with HDI and GII scores,comprising 119,435 adults(42%females)with VO_(2peak)assessed via direct gas analysis during maximal exercise testing.The risk of bias was low.VO_(2peak)was positively associated with HDI(β=14.1)and negatively associated with GII(β=-3.6).Slightly stronger associations were observed in females than males(HDI:β=18.9 vs.β=13.9,GII:β=-4.6vs.β=-3.6).Young females in middle-HDI countries had higher VO_(2peak)than those in low-HDI countries(31.2mL/kg/min vs.28.5 mL/kg/min),with limited additional gams in high-HDI contexts.VO_(2peak)decreased with higher gender inequality,with the largest disparities observed in young females between high-and low-GII countries(26.3 mL/kg/min vs.32.8 mL/kg/min).Conclusion:Global variation in CRF is tied to national levels of human development and gender equality.These findings support prioritizing structural and policy-level interventions that address social and gender disparities in physical activity access and health promotion.Studies from countries with lower HDI and information on ethnicity and socioeconomic status will bridge crucial gaps in understanding factors involved in global CRF levels.
基金Supported by Inter Disciplinary Direction Cultivation Project of Hunan University of Chinese Medicine,No.2025JC01032025 Hunan Province Science and Technology Innovation Plan Project,No.2025RC9012+2 种基金2022"Unveiling and Leading"Project of Discipline Construction at Hunan University of Chinese Medicine,No.22JBZ044Changsha Municipal Natural Science Foundation,No.kq2402174Hunan Provincial Science Popularization Fund Project,No.2025ZK4223.
文摘BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an evaluation index system for the mental health literacy of adolescent patients with mental disorders,providing a scientific,comprehensive,and reliable tool for the monitoring and intervention of mental health literacy of such patients.METHODS From December 2022 to June 2023,the evaluation index system for mental health literacy of adolescents with mental disorders was developed through literature reviews,semi-structured interviews,expert letter consultations,and the analytic hierarchy process.Based on this index system,a self-assessment questionnaire was compiled and administered to 305 adolescents with mental disorders to test the reliability and validity of the index system.RESULTS The final evaluation index system for mental health literacy of adolescents with mental disorders included 4 first-level indicators,10 second-level indicators,and 52 third-level indicators.The overall Cronbach’sαcoefficient of the index system was 0.957,with a partial reliability of 0.826 and a content validity index of 0.975.The cumulative variance contribution rate of 10 common factors was 66.491%.The correlation coefficients between each dimension and the total questionnaire ranged from 0.672 to 0.724,while the correlation coefficients in each dimension ranged from 0.389 to 0.705.CONCLUSION The evaluation index system for mental health literacy of adolescents with mental disorders,developed in this study,demonstrated notable reliability and validity,making it a valuable tool for evaluating mental health literacy in this population.
基金Supported by the National Natural Science Foundation of China,No.82170406 and No.81970238.
文摘Gastric ulcer(GU)represents a clinically significant manifestation of peptic ulcer disease,driven by a complex interplay of microbial,environmental,and immuneinflammatory factors.A recent cross-sectional study by Shen et al systematically evaluated six complete blood count-derived inflammatory indices:Neutrophil-tolymphocyte ratio,monocyte-to-lymphocyte ratio,platelet-to-lymphocyte ratio,systemic immune-inflammation index,systemic inflammatory response index(SIRI),and aggregate index of systemic inflammation and demonstrated their positive associations with GU prevalence,identifying SIRI as the strongest predictor.This editorial contextualizes these findings within the broader literature,clarifies that these indices reflect systemic rather than GU-specific inflammation,highlights methodological strengths and major limitations,and proposes a conceptual clinical algorithm for integrating SIRI into GU risk assessment.Future multicenter studies incorporating Helicobacter pylori infection,non-steroidal antiinflammatory drug exposure,and prospective design are essential to validate and translate these findings into clinical practice.
基金funded by the Major Projects of Aero-Engines and Gas Turbines grant number J2019-I-0008-0008.
文摘This paper introduces a computationally efficient global sensitivity analysis method for quantifying the influence of uncertain clamp support conditions on the natural frequencies of aero-engine pipe systems.The dynamic model is based on a three-dimensional Timoshenko beam finite element formulation,with clamps represented as distributed spring elements possessing anisotropic stiffness.To overcome the prohibitive cost of traditional Monte Carlo simulation,the multiplicative dimensional reduction method(M-DRM)is integrated with variance decomposition theory.This approach approximates the high-dimensional frequency response function as a product of univariate components,enabling rapid computation of Sobol’sensitivity indices with a computational cost reduced by three orders of magnitude.Numerical case studies on a planar Z-shaped pipe and a spatial series-parallel configuration reveal that clamp position parameters dominate the system’s natural frequency characteristics.For critical clamps,Sobol’indices exceed 0.8 across multiple vibration modes,whereas stiffness parameters exhibit negligible influence.The proposed methodology provides a rigorous and efficient tool for identifying dominant uncertainty sources,guiding tolerance allocation in manufacturing,and informing robust support design for vibration-sensitive piping systems.
基金National Key R&D Program of China,No.2022YFF1302401National Natural Science Foundation of China,No.42271007。
文摘Ecosystems along the eastern margin of the Qinghai-Tibet Plateau(EQTP)are highly fragile and extremely sensitive to climate change and human disturbances.To quantitatively assess climate-induced ecosystem responses,this study proposes a Climate-Induced Productivity Index(CIPI)based on the Super Slack-Based Measure(Super-SBM)model using remote sensing data from 2001 to 2020.The results reveal persistently low CIPI values(0.47-0.53)across major ecosystem types,indicating widespread vulnerability to climatic variability.Among these ecosystems,forests exhibit the highest CIPI(0.55),followed by shrublands(0.54),croplands(0.53),grasslands(0.51),and barelands(0.43).The Theil index analysis further demonstrates significant intra-group disparities,suggesting that extreme climatic events amplify CIPI heterogeneity.Moreover,the dominant environmental drivers differ among ecosystem types:the Palmer Drought Severity Index(PDSI)primarily constrains grassland productivity,solar radiation(SRAD)strongly influences shrub and cropland systems,whereas subsurface factors exert greater control in forested regions.This study provides a quantitative framework for evaluating climate-ecosystem interactions and offers a scientific basis for long-term ecological monitoring and security planning across the EQTP.
基金funded by Prince Sattam bin Abdulaziz University,grant number PSAU/2025/01/34620.
文摘This paper presents an image encryption scheme for underwater optical wireless communication(UOWC)systems based on dynamically generated hyperchaotic S-boxes,aiming to enhance both data security and transmission performance in underwater environments.The proposed encryption approach provides strong confusion and diffusion properties and is evaluated over five Jerlov water types with different optical attenuation characteristics.Security analysis demonstrates that the encrypted images achieve information entropy values close to the ideal value of 8(7.9925–7.9993),with very low correlation coefficients in horizontal,vertical,and diagonal directions,as well as the system achieves high values in key metrics such as the Unified Average Changing Intensity(UACI)and Number of Pixel Change Rate(NPCR),ranging from 33.42 to 33.47 and from 99.58%to 99.62%,respectively,both near their theoretical optima.In addition to improving confidentiality,the hyperchaotic encryption process decorrelates pixel intensities and redistributes image spectral content,which enhances robustness against underwater absorption and scattering effects.As a result,improved transmission performance is observed;for example,in Jerlov type I(JI)water,the effective transmission distance is extended from16mfor plain images to 24mfor encrypted images,while the Peak Signal to Noise Ratio(PSNR)at 24 m increases from 9.25 to 20.13 dB after decryption and enhancement.These results confirmthat the proposed scheme provides a dual benefit of secure and reliable image transmission in UOWC systems.
基金Natural Science Foundation of Beijing,No.7244428(to WZ)Peking University Medicine Sailing Program for Young Scholars’Scientific and Technological Innovation,No.BMU2023YFJHPY034(to WZ)+1 种基金the National Natural Science Foundation of China,Nos.81873784(to DF),82071426(to DF)Clinical Cohort Construction Program of Peking University Third Hospital,Nos.BYSYDL2019002(to DF)and BYSYZD2021004(to DF).
文摘Amyotrophic lateral sclerosis is characterized by the progressive loss of motor neurons.Early-stage axonal dysfunction,rather than central nervous system injury,plays a key role in the disease process.However,the molecular mechanisms underlying this dysfunction remain unclear.To investigate the relationship between peripheral immune dysregulation and axonal dysfunction in amyotrophic lateral sclerosis,we recruited 372 patients within the first 12 months of sporadic amyotrophic lateral sclerosis onset between January 2018 and May 2024.We collected peripheral immune markers at baseline,including total leukocytes,lymphocytes,monocytes,neutrophils,basophils,eosinophils,and platelets.We also calculated four derived ratios:neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,lymphocyte-to-monocyte ratio,and systemic immune inflammation index.Multivariate analysis,adjusted for confounding factors,revealed that higher counts of total leukocytes and neutrophils,as well as higher neutrophil-related ratios,including the neutrophil to lymphocyte ratio and the systemic immune inflammation index,were significantly correlated with higher compound muscle action potential scores.Stratified analyses revealed that these associations varied by age and sex.Furthermore,mediation analysis demonstrated that axonal dysfunction plays a significant role in the relationship between immune markers and disease progression.These findings emphasize the critical role that peripheral immune dysregulation plays in amyotrophic lateral sclerosis progression by mediating peripheral nerve injury,particularly in the early stages of the disease.This study highlights the importance of the peripheral nervous system in the early stages of amyotrophic lateral sclerosis and provides new insights into disease mechanisms and potential therapeutic targets.
文摘The pot-culture method combined with chemical and statistical analyses was used to get basic data for determination of the food-security indexes related to combined pollution of Cr and phenol in soil-rice systems.Regression analyses according to the experimental result indicated that the critical concentrations of Cr andphenol in brown rice were 0.37 and 0.33 mg kg-1, respectively, under the condition of Cr-phenol combined pollution.
基金supported by the National Natural Science Foundation of China(72271124,72071111).
文摘Aiming at the characteristics of multi-stage and(extremely)small samples of the identification problem of key effectiveness indexes of weapon equipment system-of-systems(WESoS),a Bayesian intelligent identification and inference model for system effectiveness assessment indexes based on dynamic grey incidence is proposed.The method uses multi-layer Bayesian techniques,makes full use of historical statistics and empirical information,and determines the Bayesian estima-tion of the incidence degree of indexes,which effectively solves the difficulties of small sample size of effectiveness indexes and difficulty in obtaining incidence rules between indexes.Sec-ondly,The method quantifies the incidence relationship between evaluation indexes and combat effectiveness based on Bayesian posterior grey incidence,and then identifies key system effec-tiveness evaluation indexes.Finally,the proposed method is applied to a case of screening key effectiveness indexes of a missile defensive system,and the analysis results show that the proposed method can fuse multi-moment information and extract multi-stage key indexes,and has good data extraction capability in the case of small samples.
基金Research Foundation for Tropical and Marine Meteorology (200609)Natural Science Foundation of China (40375019)Key and Open Laboratory on Tropical Monsoon, China Meteorological Administration
文摘Based on the daily reanalysis data of NCEP / NCAR and by using the method of phase space reconstruction, the point conditional probability density of the subtropical high ridge index are determined and then used, together with their power spectra, to seek the correlation between them and individual monsoon-affecting factors and their power spectra. Through diagnosis, six indexes are discovered that have the most important effects on the subtropical high index. The results of the diagnosis indicate that the technique can identify the factors which are dynamically correlated. It can offer the basis in determining and choosing dynamic conceptual factors.
文摘In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in Hainan Province,it has been found that the quality of vocational education generally depends on the talent training program and professional construction at the macro level.At the meso level,the teacher level and teaching environment are critical,while at the micro level,the evaluation of talent training quality cannot be underestimated.Strategies for quality improvement in vocational education are proposed from the perspectives of talent training programs,major construction,teacher development,teaching environment,and talent training quality,all under the lens of digital transformation.
文摘BACKGROUND The diagnosis of gastric carcinoma(GC)is essential for improving clinical outcomes.However,the biomarkers currently used for GC screening are not ideal.AIM To explore the diagnostic implications of the neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and systemic immune-inflammatory index(SII)for GC.METHODS The baseline data of 133 patients with GC and 134 patients with precancerous gastric conditions admitted between January 2022 and December 2023 were retrospectively analyzed.The information on peripheral blood platelet,neutrophil,and lymphocyte counts in each patient was collected,and the NLR,PLR,and SII levels of both groups were calculated.Additionally,multivariate logistic regression analysis was conducted,and the diagnostic implications of NLR,PLR,and SII in differentiating patients with precancerous gastric conditions,compared with those with GC,were analyzed through receiver operating characteristic(ROC)curves.RESULTS The data indicated that NLR,PLR,and SII had abnormally increased levels in the patients with GC.Gender and body mass index were risk factors for the occurrence of GC.ROC data revealed that the areas under the curve of three patients with precancerous gastric conditions,who were differentiated from those with GC,were 0.824,0.787,and 0.842,respectively.CONCLUSION NLR,PLR,and SII are all abnormally expressed in GC and have diagnostic implications,especially when used as joint indicators,in distinguishing patients with precancerous gastric conditions from those with GC.
基金Supported by the Scientific Research Project of Hospital Pharmacy of Guangxi Pharmaceutical Association in 2022,No.GXYXH1-202202.
文摘BACKGROUND Gastric cancer(GC)is the fifth most common cancer and the third leading cause of cancer-related deaths in China.Many patients with GC frequently experience symptoms related to the disease,including anorexia,nausea,vomiting,and other discomforts,and often suffer from malnutrition,which in turn negatively affects perioperative safety,prognosis,and the effectiveness of adjuvant therapeutic measures.Consequently,some nutritional indicators such as nutritional risk index(NRI),prognostic nutritional index(PNI),and systemic immune-inflammatorynutritional index(SIINI)can be used as predictors of the prognosis of GC patients.AIM To examine the prognostic significance of PNI,NRI,and SIINI in postoperative patients with GC.METHODS A retrospective analysis was conducted on the clinical data of patients with GC who underwent surgical treatment at the Guangxi Medical University Cancer Hospital between January 2010 and December 2018.The area under the receiver operating characteristic(ROC)curve was assessed using ROC curve analysis,and the optimal cutoff values for NRI,PNI,and SIINI were identified using the You-Review-HTMLden index.Survival analysis was performed using the Kaplan-Meier method.In addition,univariate and multivariate analyses were conducted using the Cox proportional hazards regression model.RESULTS This study included a total of 803 patients.ROC curves were used to evaluate the prognostic ability of NRI,PNI,and SIINI.The results revealed that SIINI had superior predictive accuracy.Survival analysis indicated that patients with GC in the low SIINI group had a significantly better survival rate than those in the high SIINI group(P<0.05).Univariate analysis identified NRI[hazard ratio(HR)=0.68,95%confidence interval(CI):0.52-0.89,P=0.05],PNI(HR=0.60,95%CI:0.46-0.79,P<0.001),and SIINI(HR=2.10,95%CI:1.64-2.69,P<0.001)as prognostic risk factors for patients with GC.However,multifactorial analysis indicated that SIINI was an independent risk factor for the prognosis of patients with GC(HR=1.65,95%CI:1.26-2.16,P<0.001).CONCLUSION Analysis of clinical retrospective data revealed that SIINI is a valuable indicator for predicting the prognosis of patients with GC.Compared with NRI and PNI,SIINI may offer greater application for prognostic assessment.
文摘The recurrence of atrial fibrillation(AF)in patients after successful radiofrequency catheter ablation(RFCA)appears to be an unresolved clinical issue and needs to be clearly elucidated.There are many factors associated with AF recurrence,such as duration of AF,male sex,concomitant heart failure,hemodynamic parameters,chronic obstructive pulmonary disease,hypertension,obstructive sleep apnea,hyperthyroidism,smoking and obesity.However,the inflammatory changes are strongly associated with electrical and structural cardiac remodeling,cardiac damage,myocardial fibrotic changes,microvascular dysfunction and altered reparative response.In this context,biomarkers reflecting the different stages of AF pathogenesis deserve thorough investigation.The authors of the retrospective study revealed that one-year recurrence rate of non-valvular AF in the high systemic immune inflammation(SII)index group was significantly increased compared to that of the low SII index group and provided additional predictive value to the APPLE.Furthermore,the authors suggest that this biomarker may help physicians to optimize the selection of AF patients and to develop a personalized treatment approach.In conclusion,the SII index may serve as a valuable indicator of recurrent AF in patients after RFCA and may be a biomarker with plausible predictive value for poor clinical outcomes.
文摘Due to the mining,smelting,sewage irriga-tion,agricultural runoff,and development ofrural enterprises,combined pollution of Cd andZn in soil-rice systems has frequently oc-curred.This problem was studied by using thepot-culture imitative method combined withhemical analysis and mathematical models.
基金PetroChina Research Applied Science and Technology Project,“Shale Gas Scale Increase Production and Exploration andDevelopment Technology-Research and Application of Key Technology of Deep Shale Gas Scale Production”(No.2023ZZ21YJ01).
文摘In the context of post-stimulation shale gas wells,the terms“shut-in”and“flowback”refer to two critical phases that occur after hydraulic fracturing(fracking)has been completed.These stages play a crucial role in determining both the well’s initial production performance and its long-term hydrocarbon recovery.By establishing a comprehensive big data analysis platform,the flowback dynamics of over 1000 shale gas wells were analyzed in this work,leading to the development of an index system for evaluating flowback production capacity.Additionally,a shut-in chart was created for wells with different types of post-stimulation fracture networks,providing a structured approach to optimizing production strategies.A dynamic analysis method for flowback was also developed,using daily pressure drop and artificial fracture conductivity as key indicators.This method offers a systematic and effective approach to managing the shut-in and flowback processes for gas wells.Field trials demonstrated significant improvements:the probability of sand production was reduced,gas breakthrough time was extended,artificial fracture conductivity was enhanced,and the average estimated ultimate recovery(EUR)per well increased.
文摘To identify the root causes of heavy metal contamination in soils as well as prevent and control such contamination from its sources,this study explored the accumulation patterns and ecological risks of heavy metals like Cd and Pb in solid waste in mining areas and across the water body,sediment,soil and agricultural product ecosystem surrounding the mining areas.Focusing on the residual solid waste samples in lead-zinc deposits in a certain area of Guizhou Province,along with samples of topsoils,irrigation water,river sediments,and crops from surrounding areas.This study analyzed the distributions of eight heavy metals,i.e.,Cd,As,Cr,Hg,Pb,Zn,Cu,and Ni,in the samples through field surveys and sample tests.Furthermore,this study assessed the contamination levels and ecological risks of heavy metals in soils,sediments,and agricultural products using methods such as the single-factor index,Nemerow composite index,and potential ecological risk assessment.The results indicate that heavy metals in the solid waste samples all exhibited concentrations exceeding their risk screening values,with 60%greater than their risk intervention values.The soils and sediments demonstrate slight and moderate comprehensive ecological risks of heavy metals.The single-factor potential ecological risks of heavy metals in both the soil and sediment samples decreased in the order of Hg,Cd,Pb,As,Cu,Zn,Cr,and Ni,suggesting the same sources of heavy metals in the soils and sediments.Most of the agricultural product samples exhibited over-limit concentrations of heavy metals dominated by Cd,Pb,Ni,and Cr,excluding Hg and As.The agricultural product assessment using the Nemerow composite index reveals that 35%of the agricultural product samples reached the heavy metal contamination level,implying that the agricultural products from farmland around the solid waste dumps have been contaminated with heavy metals.The eight heavy metals in the soil,sediment,and agricultural product samples manifested high coefficients of variation(CVs),indicating pronounced spatial variability.This suggests that their concentrations in soils,sediments,and agricultural products are significantly influenced by human mining activities.Additionally,the agricultural products exhibit strong transport and accumulation capacities for Cd,Cu,and Zn.
基金Supported by National Natural Science Foundation of China (40801227)Foundation of Key Laboratory of Aquatic Genetic Resources and Aquacul-tural Ecology,Ministry of Agriculture (KFT2006-7)~~
文摘[Objective] The aim was to establish the water quality evaluation index system for freshwater aquaculture pond.[Method] The expert survey,DELPHI,field research and other methods were used.Based on the analysis of factors influencing water quality of freshwater aquaculture pond,and the importance degree of 14 factors influencing water quality of freshwater aquaculture pond was ordered.Then,five factors were selected as index to establish the water quality evaluation index system of freshwater aquaculture with the determination for thresholds of these factors.[Result] The importance degree of water quality of freshwater aquaculture pond showed an order of Dissolved oxygenpHPhytoplankton biomassSecchi depthTotal NitrogenZooplankton biomassWater temperatureBiochemical Oxygen DemandWater colorSalinityTotal hardness;according to the value of importance degree,the dissolved oxygen,pH,secchi depth,phytoplankton biomass and total nitrogen these five factors were selected as the index system of water quality evaluation of pond.The level of water quality of freshwater aquaculture pond was divided into five,and the tolerance range of fish to each index was obtained by expert observation.[Conclusion] This study had provided a scientific basis for water quality evaluation system of freshwater aquaculture pond.
