In this paper, we defined the concept of implicative and fuzzy implicative ideals of lattice implication algebras, and discussed the properties of them. And then, we pointed out the relations between implicative ideal...In this paper, we defined the concept of implicative and fuzzy implicative ideals of lattice implication algebras, and discussed the properties of them. And then, we pointed out the relations between implicative ideal and LI _ideal, implicative iedal and implicative filter, implicative ideal and fuzzy implicative ideal, fuzzy implicative ideal and fuzzy implicative filter, and fuzzy implicative ideal and fuzzy LI _ideal.展开更多
We prove that the adjoint semigroup of an implicative BCK algebra is an upper semilattice, and the adjoint semigroup of an implicative BCK algebra with condition(s) is a generalized Boolean algebra. Moreover we prov...We prove that the adjoint semigroup of an implicative BCK algebra is an upper semilattice, and the adjoint semigroup of an implicative BCK algebra with condition(s) is a generalized Boolean algebra. Moreover we prove the adjoint semigroup of a bounded implicative BCK algebra is a Boolean algebra.展开更多
Adjoint semigroups of BCI algebras were introduced by Huang [1] and some of its important properties were obtained. In this paper,some characterizations of positive implicative BCK algebras are given by discussing the...Adjoint semigroups of BCI algebras were introduced by Huang [1] and some of its important properties were obtained. In this paper,some characterizations of positive implicative BCK algebras are given by discussing the adjoint semigroups. Moreover,the semigroup differences between positive BCK algebras and implicative BCK algebras are discussed,and some semigroup characterizations of implicative BCK algebras are given.展开更多
In this paper, we use the notion of fuzzy point to study ideal and positive implicative ideal in BCK algebras, then we clarify the links between the fuzzy point approach, the classical fuzzy approach and the ordinary ...In this paper, we use the notion of fuzzy point to study ideal and positive implicative ideal in BCK algebras, then we clarify the links between the fuzzy point approach, the classical fuzzy approach and the ordinary case.展开更多
The concept of implicative pseudo valuations on hoops is introduced and some related properties are investigated. As an application of properties of pseudo valuations, we find the relationship between a pseudo valuati...The concept of implicative pseudo valuations on hoops is introduced and some related properties are investigated. As an application of properties of pseudo valuations, we find the relationship between a pseudo valuation and an implicative pseudo valuation and obtain some characterizations of implicative pseudo valuations. In particular, we show that a pseudo valuation on regular hoops is implicative if and only if it satisfies φ(x■x') = 0.This result will provide a more general algebraic foundation for pseudo valuations theory on algebraic structures based on substructure logic.展开更多
We introduce the notions of implicative ideals and fuzzy implicative ideals of a distributive implication groupoid. Some properties of these ideals will be investigated. In particular, the necessary and sufficient con...We introduce the notions of implicative ideals and fuzzy implicative ideals of a distributive implication groupoid. Some properties of these ideals will be investigated. In particular, the necessary and sufficient conditions for an ideal（fuzzy ideal） to be an implicative ideal（fuzzy implicative ideal） is given. By using the concept of level sets, we will characterize the fuzzy implicative ideals of a distributive implication groupoid. Finally, an extension property for fuzzy implicative ideals is given.展开更多
Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease i...Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the accumulation of misfoldedα-synuclein,forming insoluble Lewy bodies in the substantia nigra pars compacta,which contributes to neurodegeneration.Theseα-synuclein aggregates may act as autoantigens,leading to T-cell-mediated neuroinflammation and contributing to dopaminergic cell death.Our perspective explores the hypothesis that Parkinson's disease may have an autoimmune component,highlighting research that connects peripheral immune responses with neurodegeneration.T cells derived from Parkinson's disease patients appear to have the potential to initiate an autoimmune response againstα-synuclein and its modified peptides,possibly leading to the formation of neo-epitopes.Recent evidence associates Parkinson's disease with abnormal immune responses,as indicated by increased levels of immune cells,such as CD4^(+)and CD8^(+)T cells,observed in both patients and mouse models.The convergence of T cells filtration increasing major histocompatibility complex molecules,and the susceptibility of dopaminergic neurons supports the hypothesis that Parkinson's disease may exhibit autoimmune characteristics.Understanding the immune mechanisms involved in Parkinson's disease will be crucial for developing therapeutic strategies that target the autoimmune aspects of the disease.Novel approaches,including precision medicine based on major histocompatibility complex/human leukocyte antigen typing and early biomarker identification,could pave the way for immune-based treatments aimed at slowing or halting disease progression.This perspective explores the relationship between autoimmunity and Parkinson's disease,suggesting that further research could deepen understanding and offer new therapeutic avenues.In this paper,it is organized to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease.It investigates critical areas such as the autoimmune response observed in Parkinson's disease patients and the role of autoimmune mechanisms targetingα-synuclein in Parkinson's disease.The paper also examines the impact of CD4~+T cells,specifically Th1 and Th17,on neurons through in vitro and ex vivo studies.Additionally,it explores howα-synuclein influences glia-induced neuroinflammation in Parkinson's disease.The discussion extends to the clinical implications and therapeutic landscape,offering insights into potential treatments.Consequently,we aim to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease,incorporating both supportive and opposing views on its classification as an autoimmune disorder and exploring implications for clinical applications.展开更多
This editorial discusses recent advancements and ongoing challenges in diabetic retinopathy,as reviewed by Morya et al in their comprehensive analysis.In their review,Morya et al discussed the pathophysiology of diabe...This editorial discusses recent advancements and ongoing challenges in diabetic retinopathy,as reviewed by Morya et al in their comprehensive analysis.In their review,Morya et al discussed the pathophysiology of diabetic retinopathy and explored novel treatment modalities.This editorial highlights the importance of these advancements and emphasizes the need for continued research and innovation for the enhanced management of diabetic retinopathy.It also reflects upon the implications of the authors’review findings for clinical practice and future research directions,underscoring the potential of emerging therapies for improving patient outcomes and providing a deeper understanding of disease mechanisms.展开更多
This editorial offers insights from a minireview by Venkatesh et al,who explored pharmacological adjuvants for diabetic vitrectomy.Specifically,they synthesized current knowledge and evaluated the efficacy of various ...This editorial offers insights from a minireview by Venkatesh et al,who explored pharmacological adjuvants for diabetic vitrectomy.Specifically,they synthesized current knowledge and evaluated the efficacy of various adjunctive therapies in improving the outcomes of diabetic retinopathy and managing associated complications.Herein,we highlight the key roles of pharmacological adjuvants in optimizing surgical techniques,minimizing intraoperative challenges,and enhancing postoperative recovery.We further discuss the potential implications of this approach for clinical practice and future research directions in this evolving field.Overall,this editorial underscores the importance of incorporating pharmacological adjuvants into standard diabetic vitrectomy care to improve surgical outcomes and thus patients’quality of life.展开更多
Depression is a widespread and debilitating mental health disorder affecting millions globally.Chronotype has been increasingly recognized as a significant factor associated with depression.This review aims to compreh...Depression is a widespread and debilitating mental health disorder affecting millions globally.Chronotype has been increasingly recognized as a significant factor associated with depression.This review aims to comprehensively dissect the role of chronotype in depression,providing insights into the underlying mechanisms linking chronotype to depression,as well as the potential therapeutic implications.Converging evidence indicates that evening chronotype is notably associated with an elevated risk of depression,more severe symptoms,and a higher rate of suicidality,while morning chronotype may exert a protective effect.These findings highlight that chronotype plays a crucial role in the development,manifestation,and management of depression.Nevertheless,some methodological issues of the existing studies(e.g.,reliance on self-reported chronotype assessments)should be noted and discussed.Further investigations are warranted to elucidate the intricate mechanisms underlying the relationship between chronotype and depression,establish causal links,and optimize the clinical application of chronotype-based interventions for depression.展开更多
It is a common misconception that e-cigarettes are safer than tobacco smoking,given their adverse cardiopulmonary effects,habituation,and the fact that it is only a fashion based manifestation to sell and use them.The...It is a common misconception that e-cigarettes are safer than tobacco smoking,given their adverse cardiopulmonary effects,habituation,and the fact that it is only a fashion based manifestation to sell and use them.Therefore,the use of e cigarettes should not be encouraged as an alternative and pragmatic measure should be taken to profess this agenda.展开更多
The conversion of subtropical red soils into farmland involves complex transformations of iron oxides.Investigating iron mineralogy can enhance understanding of magnetic minerals in relation to soil formation on farml...The conversion of subtropical red soils into farmland involves complex transformations of iron oxides.Investigating iron mineralogy can enhance understanding of magnetic minerals in relation to soil formation on farmland in subtropical regions.In this study,we investigated the properties of iron oxide and its environmental implications in the farmland of Meizhou city,Guangdong province.The results showed that farmland soils had higher magnetism than the red soils developed from the same metamorphic rock.The red soils displayed significantly higher concentrations of goethite and hematite than the farmland soils.The dominant factor influencing the magnetic changes in farmland and red soils was the concentration of fine-grained ferromagnetic minerals.Red soil magnetism is an indicator of soil weathering intensity,whereas farmland soil magnetism is closely related to human cultivation activities.In contrast to the red soils,the farmland soils lacked the pronounced transformation of ferromagnetic minerals into hematite and goethite.A vigorous oxidation process catalyzes the transformation of strong magnetic minerals into significant amounts of hematite and goethite,which promotes the reduced magnetism of red soils.The conversion of red soils into farmland soils initially increased the accumulation of ferromagnetic materials due to cultivation processes.However,long-term cultivation led to the gradual loss of fine-grained ferromagnetic minerals,while goethite and lepidocrocite became the dominant magnetic mineral types.展开更多
Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and a...Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.展开更多
BACKGROUND Lumbar disc extrusion,a common spinal disorder,is particularly uncommon in its severely displaced form,especially in young patients.This condition can pose diagnostic challenges due to its nonspecific prese...BACKGROUND Lumbar disc extrusion,a common spinal disorder,is particularly uncommon in its severely displaced form,especially in young patients.This condition can pose diagnostic challenges due to its nonspecific presentation.CASE SUMMARY A 36-year-old male patient presented with persistent low back pain and radiating leg pain lasting half a month,which had worsened over the previous four days.Lumbar magnetic resonance imaging scans showed an abnormal signal within the vertebral canal at the L3 level,suggesting either a disc cyst or an epidural hematoma.Based on these findings,the patient was provisionally diagnosed with either condition.Surgical exploration was conducted,revealing an extruded lumbar disc,which was subsequently excised.Following surgery,the patient's symptoms completely resolved.CONCLUSION High-grade lumbar disc extrusion in young patients is rare but should be considered in sedentary,physically inactive individuals presenting with lumbocrural pain and abnormal magnetic resonance imaging findings.Early and accurate diagnosis is crucial to avoid misdiagnosis,and prompt open surgery may be necessary in severe cases to alleviate symptoms.The case highlights the impotance of a thorough diagnostic workup and timely surgical intervention in managing such rare but potentially severe spinal disorders.展开更多
Marx scientifically summarized the experience and lessons of the Paris Commune,deeply exposed the root causes of bourgeois corruption,and emphasized the purity and advancement of the construction of proletarian politi...Marx scientifically summarized the experience and lessons of the Paris Commune,deeply exposed the root causes of bourgeois corruption,and emphasized the purity and advancement of the construction of proletarian political parties and political power.The dictatorship of the proletariat puts forward the ideas of cheap government that eradicate corruption,realizes that the people are the masters of the country,implements democratic supervision of elections,simplifies the construction of institutions,lowers governance costs,and achieves higher efficiency.A deep understanding of the theoretical characteristics of Marx’s thoughts on integrity,democracy,and honor,and a profound clarification of the practical significance of Marx’s ideology on clean governance,combined with practical practice,will help promote the construction of a new system of anti-corruption and incorruption in our country,and will benefit our contemporary services.The construction of a type-oriented government system is conducive to deepening the construction of China’s national legal system.展开更多
Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working...Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working memory,and emotional regulation,is notably impaired in this condition.This review consolidates current insights into the role of PFC dysfunction in schizophrenia,with a focus on its implications for therapeutic strategies.The neuroanatomical and neurobiological foundations of PFC dysfunction are explored,emphasizing structural abnormalities,functional dysconnectivity,and microcircuit disruptions that contribute to cognitive deficits and impaired decision-making.Clinical implications are discussed,particularly the correlation between PFC dysfunction and the severity and progression of schizophrenia symptoms.Additionally,pharmacological and non-pharmacological approaches aimed at modulating PFC activity are reviewed as potential therapeutic options.In conclusion,a deeper understanding of PFC dysfunction is pivotal for developing targeted treatments,and ongoing research offers promising avenues for enhancing outcomes for individuals affected by this debilitating disorder.展开更多
To the editor,We read with great interest the recent study by Wu et al.1 in the Journal of the National Cancer Center,which utilized a nationwide cohort of over two million Chinese adults to reveal a significant,nonli...To the editor,We read with great interest the recent study by Wu et al.1 in the Journal of the National Cancer Center,which utilized a nationwide cohort of over two million Chinese adults to reveal a significant,nonlinear association between long-term ozone(O_(3))exposure and lung cancer incidence.By extending the health implications of O_(3)beyond cardiopulmonary effects to oncogenesis,the study offers timely evidence amid rising ground-level ozone concentrations and limited regulatory oversight.展开更多
Hepatitis B virus remains a major cause of cirrhosis and hepatocellular carcinoma,with genetic polymorphisms and mutations influencing immune responses and disease progression.Nguyen et al present novel findings on sp...Hepatitis B virus remains a major cause of cirrhosis and hepatocellular carcinoma,with genetic polymorphisms and mutations influencing immune responses and disease progression.Nguyen et al present novel findings on specific human leukocyte antigen(HLA)alleles,including rs2856718 of HLA-DQ and rs3077 and rs9277535 of HLA-DP,which may predispose individuals to cirrhosis and liver cancer,based on multi-clustering analysis.Here,we discuss the feasibility of this approach and identify key areas for further investigation,aiming to offer insights for advancing clinical practice and research in liver disease and related cancers.展开更多
文摘In this paper, we defined the concept of implicative and fuzzy implicative ideals of lattice implication algebras, and discussed the properties of them. And then, we pointed out the relations between implicative ideal and LI _ideal, implicative iedal and implicative filter, implicative ideal and fuzzy implicative ideal, fuzzy implicative ideal and fuzzy implicative filter, and fuzzy implicative ideal and fuzzy LI _ideal.
文摘We prove that the adjoint semigroup of an implicative BCK algebra is an upper semilattice, and the adjoint semigroup of an implicative BCK algebra with condition(s) is a generalized Boolean algebra. Moreover we prove the adjoint semigroup of a bounded implicative BCK algebra is a Boolean algebra.
文摘Adjoint semigroups of BCI algebras were introduced by Huang [1] and some of its important properties were obtained. In this paper,some characterizations of positive implicative BCK algebras are given by discussing the adjoint semigroups. Moreover,the semigroup differences between positive BCK algebras and implicative BCK algebras are discussed,and some semigroup characterizations of implicative BCK algebras are given.
文摘In this paper, we use the notion of fuzzy point to study ideal and positive implicative ideal in BCK algebras, then we clarify the links between the fuzzy point approach, the classical fuzzy approach and the ordinary case.
基金Supported by a grant of National Natural Science Foundation of China（11571281）
文摘The concept of implicative pseudo valuations on hoops is introduced and some related properties are investigated. As an application of properties of pseudo valuations, we find the relationship between a pseudo valuation and an implicative pseudo valuation and obtain some characterizations of implicative pseudo valuations. In particular, we show that a pseudo valuation on regular hoops is implicative if and only if it satisfies φ(x■x') = 0.This result will provide a more general algebraic foundation for pseudo valuations theory on algebraic structures based on substructure logic.
文摘We introduce the notions of implicative ideals and fuzzy implicative ideals of a distributive implication groupoid. Some properties of these ideals will be investigated. In particular, the necessary and sufficient conditions for an ideal（fuzzy ideal） to be an implicative ideal（fuzzy implicative ideal） is given. By using the concept of level sets, we will characterize the fuzzy implicative ideals of a distributive implication groupoid. Finally, an extension property for fuzzy implicative ideals is given.
基金supported by the National Research Foundation of South Korea(2023R1A2C2004516,RS-2023-00219399 to SPY,and 2022R1I1A1A01063513 to MGJ)。
文摘Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the accumulation of misfoldedα-synuclein,forming insoluble Lewy bodies in the substantia nigra pars compacta,which contributes to neurodegeneration.Theseα-synuclein aggregates may act as autoantigens,leading to T-cell-mediated neuroinflammation and contributing to dopaminergic cell death.Our perspective explores the hypothesis that Parkinson's disease may have an autoimmune component,highlighting research that connects peripheral immune responses with neurodegeneration.T cells derived from Parkinson's disease patients appear to have the potential to initiate an autoimmune response againstα-synuclein and its modified peptides,possibly leading to the formation of neo-epitopes.Recent evidence associates Parkinson's disease with abnormal immune responses,as indicated by increased levels of immune cells,such as CD4^(+)and CD8^(+)T cells,observed in both patients and mouse models.The convergence of T cells filtration increasing major histocompatibility complex molecules,and the susceptibility of dopaminergic neurons supports the hypothesis that Parkinson's disease may exhibit autoimmune characteristics.Understanding the immune mechanisms involved in Parkinson's disease will be crucial for developing therapeutic strategies that target the autoimmune aspects of the disease.Novel approaches,including precision medicine based on major histocompatibility complex/human leukocyte antigen typing and early biomarker identification,could pave the way for immune-based treatments aimed at slowing or halting disease progression.This perspective explores the relationship between autoimmunity and Parkinson's disease,suggesting that further research could deepen understanding and offer new therapeutic avenues.In this paper,it is organized to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease.It investigates critical areas such as the autoimmune response observed in Parkinson's disease patients and the role of autoimmune mechanisms targetingα-synuclein in Parkinson's disease.The paper also examines the impact of CD4~+T cells,specifically Th1 and Th17,on neurons through in vitro and ex vivo studies.Additionally,it explores howα-synuclein influences glia-induced neuroinflammation in Parkinson's disease.The discussion extends to the clinical implications and therapeutic landscape,offering insights into potential treatments.Consequently,we aim to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease,incorporating both supportive and opposing views on its classification as an autoimmune disorder and exploring implications for clinical applications.
文摘This editorial discusses recent advancements and ongoing challenges in diabetic retinopathy,as reviewed by Morya et al in their comprehensive analysis.In their review,Morya et al discussed the pathophysiology of diabetic retinopathy and explored novel treatment modalities.This editorial highlights the importance of these advancements and emphasizes the need for continued research and innovation for the enhanced management of diabetic retinopathy.It also reflects upon the implications of the authors’review findings for clinical practice and future research directions,underscoring the potential of emerging therapies for improving patient outcomes and providing a deeper understanding of disease mechanisms.
文摘This editorial offers insights from a minireview by Venkatesh et al,who explored pharmacological adjuvants for diabetic vitrectomy.Specifically,they synthesized current knowledge and evaluated the efficacy of various adjunctive therapies in improving the outcomes of diabetic retinopathy and managing associated complications.Herein,we highlight the key roles of pharmacological adjuvants in optimizing surgical techniques,minimizing intraoperative challenges,and enhancing postoperative recovery.We further discuss the potential implications of this approach for clinical practice and future research directions in this evolving field.Overall,this editorial underscores the importance of incorporating pharmacological adjuvants into standard diabetic vitrectomy care to improve surgical outcomes and thus patients’quality of life.
基金Supported by the Science and Technology Projects in Guangzhou,China,No.2025A03J4256 and No.2025A03J4239.
文摘Depression is a widespread and debilitating mental health disorder affecting millions globally.Chronotype has been increasingly recognized as a significant factor associated with depression.This review aims to comprehensively dissect the role of chronotype in depression,providing insights into the underlying mechanisms linking chronotype to depression,as well as the potential therapeutic implications.Converging evidence indicates that evening chronotype is notably associated with an elevated risk of depression,more severe symptoms,and a higher rate of suicidality,while morning chronotype may exert a protective effect.These findings highlight that chronotype plays a crucial role in the development,manifestation,and management of depression.Nevertheless,some methodological issues of the existing studies(e.g.,reliance on self-reported chronotype assessments)should be noted and discussed.Further investigations are warranted to elucidate the intricate mechanisms underlying the relationship between chronotype and depression,establish causal links,and optimize the clinical application of chronotype-based interventions for depression.
文摘It is a common misconception that e-cigarettes are safer than tobacco smoking,given their adverse cardiopulmonary effects,habituation,and the fact that it is only a fashion based manifestation to sell and use them.Therefore,the use of e cigarettes should not be encouraged as an alternative and pragmatic measure should be taken to profess this agenda.
基金Technology Program of Jiaying University,No.2024KJZ01Open Funding of Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas,No.2023JYKF08National Natural Science Foundation of China,No.42277442。
文摘The conversion of subtropical red soils into farmland involves complex transformations of iron oxides.Investigating iron mineralogy can enhance understanding of magnetic minerals in relation to soil formation on farmland in subtropical regions.In this study,we investigated the properties of iron oxide and its environmental implications in the farmland of Meizhou city,Guangdong province.The results showed that farmland soils had higher magnetism than the red soils developed from the same metamorphic rock.The red soils displayed significantly higher concentrations of goethite and hematite than the farmland soils.The dominant factor influencing the magnetic changes in farmland and red soils was the concentration of fine-grained ferromagnetic minerals.Red soil magnetism is an indicator of soil weathering intensity,whereas farmland soil magnetism is closely related to human cultivation activities.In contrast to the red soils,the farmland soils lacked the pronounced transformation of ferromagnetic minerals into hematite and goethite.A vigorous oxidation process catalyzes the transformation of strong magnetic minerals into significant amounts of hematite and goethite,which promotes the reduced magnetism of red soils.The conversion of red soils into farmland soils initially increased the accumulation of ferromagnetic materials due to cultivation processes.However,long-term cultivation led to the gradual loss of fine-grained ferromagnetic minerals,while goethite and lepidocrocite became the dominant magnetic mineral types.
基金supported by the Natural Science Foundation of Sichuan Province,China(2024NSFSC1272)the Innovation Team Development Funds for Sichuan Mutton Goat&Sheep,China(SCCXTD-2024-14)Scientific and Technological Innovation Team for Qinghai-Tibetan Plateau Research in Southwest Minzu University,China(2024CXTD08)。
文摘Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.
文摘BACKGROUND Lumbar disc extrusion,a common spinal disorder,is particularly uncommon in its severely displaced form,especially in young patients.This condition can pose diagnostic challenges due to its nonspecific presentation.CASE SUMMARY A 36-year-old male patient presented with persistent low back pain and radiating leg pain lasting half a month,which had worsened over the previous four days.Lumbar magnetic resonance imaging scans showed an abnormal signal within the vertebral canal at the L3 level,suggesting either a disc cyst or an epidural hematoma.Based on these findings,the patient was provisionally diagnosed with either condition.Surgical exploration was conducted,revealing an extruded lumbar disc,which was subsequently excised.Following surgery,the patient's symptoms completely resolved.CONCLUSION High-grade lumbar disc extrusion in young patients is rare but should be considered in sedentary,physically inactive individuals presenting with lumbocrural pain and abnormal magnetic resonance imaging findings.Early and accurate diagnosis is crucial to avoid misdiagnosis,and prompt open surgery may be necessary in severe cases to alleviate symptoms.The case highlights the impotance of a thorough diagnostic workup and timely surgical intervention in managing such rare but potentially severe spinal disorders.
基金Chongqing Social Science Planning Project“Research on the Practical Path of Leading and Cultivating Youth Responsibility and Commitment with the Spirit of Struggle”(2021YBCS24)。
文摘Marx scientifically summarized the experience and lessons of the Paris Commune,deeply exposed the root causes of bourgeois corruption,and emphasized the purity and advancement of the construction of proletarian political parties and political power.The dictatorship of the proletariat puts forward the ideas of cheap government that eradicate corruption,realizes that the people are the masters of the country,implements democratic supervision of elections,simplifies the construction of institutions,lowers governance costs,and achieves higher efficiency.A deep understanding of the theoretical characteristics of Marx’s thoughts on integrity,democracy,and honor,and a profound clarification of the practical significance of Marx’s ideology on clean governance,combined with practical practice,will help promote the construction of a new system of anti-corruption and incorruption in our country,and will benefit our contemporary services.The construction of a type-oriented government system is conducive to deepening the construction of China’s national legal system.
文摘Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working memory,and emotional regulation,is notably impaired in this condition.This review consolidates current insights into the role of PFC dysfunction in schizophrenia,with a focus on its implications for therapeutic strategies.The neuroanatomical and neurobiological foundations of PFC dysfunction are explored,emphasizing structural abnormalities,functional dysconnectivity,and microcircuit disruptions that contribute to cognitive deficits and impaired decision-making.Clinical implications are discussed,particularly the correlation between PFC dysfunction and the severity and progression of schizophrenia symptoms.Additionally,pharmacological and non-pharmacological approaches aimed at modulating PFC activity are reviewed as potential therapeutic options.In conclusion,a deeper understanding of PFC dysfunction is pivotal for developing targeted treatments,and ongoing research offers promising avenues for enhancing outcomes for individuals affected by this debilitating disorder.
文摘To the editor,We read with great interest the recent study by Wu et al.1 in the Journal of the National Cancer Center,which utilized a nationwide cohort of over two million Chinese adults to reveal a significant,nonlinear association between long-term ozone(O_(3))exposure and lung cancer incidence.By extending the health implications of O_(3)beyond cardiopulmonary effects to oncogenesis,the study offers timely evidence amid rising ground-level ozone concentrations and limited regulatory oversight.
基金Supported by National Natural Science Foundation of China,No.32270768,No.82273970,No.32070726,and No.82370715National Key R&D Program of China,No.2023YFC2507904the Innovation Group Project of Hubei Province,No.2023AFA026.
文摘Hepatitis B virus remains a major cause of cirrhosis and hepatocellular carcinoma,with genetic polymorphisms and mutations influencing immune responses and disease progression.Nguyen et al present novel findings on specific human leukocyte antigen(HLA)alleles,including rs2856718 of HLA-DQ and rs3077 and rs9277535 of HLA-DP,which may predispose individuals to cirrhosis and liver cancer,based on multi-clustering analysis.Here,we discuss the feasibility of this approach and identify key areas for further investigation,aiming to offer insights for advancing clinical practice and research in liver disease and related cancers.
