In the present paper,we give a systematic study of the discrete correspondence the-ory and topological correspondence theory of modal meet-implication logic and moda1 meet-semilattice logic,in the semantics provided i...In the present paper,we give a systematic study of the discrete correspondence the-ory and topological correspondence theory of modal meet-implication logic and moda1 meet-semilattice logic,in the semantics provided in[21].The special features of the present paper include the following three points:the first one is that the semantic structure used is based on a semilattice rather than an ordinary partial order,the second one is that the propositional vari-ables are interpreted as filters rather than upsets,and the nominals,which are the“first-order counterparts of propositional variables,are interpreted as principal filters rather than principal upsets;the third one is that in topological correspondence theory,the collection of admissi-ble valuations is not closed under taking disjunction,which makes the proof of the topological Ackermann 1emma different from existing settings.展开更多
Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and a...Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.展开更多
The conversion of subtropical red soils into farmland involves complex transformations of iron oxides.Investigating iron mineralogy can enhance understanding of magnetic minerals in relation to soil formation on farml...The conversion of subtropical red soils into farmland involves complex transformations of iron oxides.Investigating iron mineralogy can enhance understanding of magnetic minerals in relation to soil formation on farmland in subtropical regions.In this study,we investigated the properties of iron oxide and its environmental implications in the farmland of Meizhou city,Guangdong province.The results showed that farmland soils had higher magnetism than the red soils developed from the same metamorphic rock.The red soils displayed significantly higher concentrations of goethite and hematite than the farmland soils.The dominant factor influencing the magnetic changes in farmland and red soils was the concentration of fine-grained ferromagnetic minerals.Red soil magnetism is an indicator of soil weathering intensity,whereas farmland soil magnetism is closely related to human cultivation activities.In contrast to the red soils,the farmland soils lacked the pronounced transformation of ferromagnetic minerals into hematite and goethite.A vigorous oxidation process catalyzes the transformation of strong magnetic minerals into significant amounts of hematite and goethite,which promotes the reduced magnetism of red soils.The conversion of red soils into farmland soils initially increased the accumulation of ferromagnetic materials due to cultivation processes.However,long-term cultivation led to the gradual loss of fine-grained ferromagnetic minerals,while goethite and lepidocrocite became the dominant magnetic mineral types.展开更多
It is a common misconception that e-cigarettes are safer than tobacco smoking,given their adverse cardiopulmonary effects,habituation,and the fact that it is only a fashion based manifestation to sell and use them.The...It is a common misconception that e-cigarettes are safer than tobacco smoking,given their adverse cardiopulmonary effects,habituation,and the fact that it is only a fashion based manifestation to sell and use them.Therefore,the use of e cigarettes should not be encouraged as an alternative and pragmatic measure should be taken to profess this agenda.展开更多
Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working...Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working memory,and emotional regulation,is notably impaired in this condition.This review consolidates current insights into the role of PFC dysfunction in schizophrenia,with a focus on its implications for therapeutic strategies.The neuroanatomical and neurobiological foundations of PFC dysfunction are explored,emphasizing structural abnormalities,functional dysconnectivity,and microcircuit disruptions that contribute to cognitive deficits and impaired decision-making.Clinical implications are discussed,particularly the correlation between PFC dysfunction and the severity and progression of schizophrenia symptoms.Additionally,pharmacological and non-pharmacological approaches aimed at modulating PFC activity are reviewed as potential therapeutic options.In conclusion,a deeper understanding of PFC dysfunction is pivotal for developing targeted treatments,and ongoing research offers promising avenues for enhancing outcomes for individuals affected by this debilitating disorder.展开更多
Marx scientifically summarized the experience and lessons of the Paris Commune,deeply exposed the root causes of bourgeois corruption,and emphasized the purity and advancement of the construction of proletarian politi...Marx scientifically summarized the experience and lessons of the Paris Commune,deeply exposed the root causes of bourgeois corruption,and emphasized the purity and advancement of the construction of proletarian political parties and political power.The dictatorship of the proletariat puts forward the ideas of cheap government that eradicate corruption,realizes that the people are the masters of the country,implements democratic supervision of elections,simplifies the construction of institutions,lowers governance costs,and achieves higher efficiency.A deep understanding of the theoretical characteristics of Marx’s thoughts on integrity,democracy,and honor,and a profound clarification of the practical significance of Marx’s ideology on clean governance,combined with practical practice,will help promote the construction of a new system of anti-corruption and incorruption in our country,and will benefit our contemporary services.The construction of a type-oriented government system is conducive to deepening the construction of China’s national legal system.展开更多
Anopheles(An.)stephensi is one of the dominant malaria vectors in India,Bangladesh,Pakistan,Iran,Iraq and some other Asian countries[1].It plays a crucial role in transmitting Plasmodium falciparum and Plasmodium viva...Anopheles(An.)stephensi is one of the dominant malaria vectors in India,Bangladesh,Pakistan,Iran,Iraq and some other Asian countries[1].It plays a crucial role in transmitting Plasmodium falciparum and Plasmodium vivax in India along with its rural counterpart,An.culicifacies.This mosquito species has adapted well to urban and peri-urban environments,making it a significant public health concern in the country.The presence of An.stephensi in urban areas contrasts with other malaria vectors that predominantly inhabit rural regions,thus complicating traditional malaria control strategies.It is well-adapted to human-made environments,breeding in various containers including tanks,cisterns,and barrels used for water storage.展开更多
Teacher professional identity is a comprehensive reflection of teachers’role perception,emotional experiences,and behavioral tendencies towards their profession.It serves as an intrinsic driving force for teachers’p...Teacher professional identity is a comprehensive reflection of teachers’role perception,emotional experiences,and behavioral tendencies towards their profession.It serves as an intrinsic driving force for teachers’professional development and is also a crucial issue in teacher education research.From a global perspective,this study systematically reviews and examines relevant research on the professional identity of international Chinese language teachers(ICLTs).A comparative analysis is conducted between Chinese and foreign scholars’research in terms of theoretical foundations,research subjects,research content,and research methodologies.This comprehensive overview of the current research landscape in this field,along with a summary of existing achievements and identified problems,facilitates the transformation of fragmented research findings on ICLTs’professional identity into a systematic understanding and reveals research gaps.Building upon this foundation,the study proposes future research prospects for the professional identity of ICLTs from aspects such as the construction of a cross-cultural perspective-based teacher professional identity system,the transformation of teacher professional identity in the context of digital transformation,and case studies on ICLTs’professional identity.The aim is to promote high-quality development in both theory and practice of international Chinese language education.展开更多
Rapid technological advancements are driving embodied intelligent robots from laboratories to real-life applications to serve as a key force reshaping the future way of life.Like many other revolutionary technologies,...Rapid technological advancements are driving embodied intelligent robots from laboratories to real-life applications to serve as a key force reshaping the future way of life.Like many other revolutionary technologies,while sparking utopian visions of the future,the development of embodied intelligence has aroused concerns about safety risks, emotional ethics, and socio-cultural implications.展开更多
Introduction Small cell lung cancer(SCLC)is a highly aggressive malignancy with limited treatment options.Despite advances in immunotherapy,response rates remain low,and the efficacy of current molecular subtyping1,2 ...Introduction Small cell lung cancer(SCLC)is a highly aggressive malignancy with limited treatment options.Despite advances in immunotherapy,response rates remain low,and the efficacy of current molecular subtyping1,2 is insufficient to predict therapeutic outcomes3,4.A recently identified vulnerability in SCLC involves the dysregulation of nuclear-cytoplasmic transport,particularly through exportin 1(XPO1)5-7.展开更多
The global aging crisis has increased the prevalence of skeletal disorders,necessitating innovative therapeutic strategies.This review employs the brain-bone axis(BBA)framework to examine the role of the sympathetic n...The global aging crisis has increased the prevalence of skeletal disorders,necessitating innovative therapeutic strategies.This review employs the brain-bone axis(BBA)framework to examine the role of the sympathetic nervous system(SNS)in bone metabolism.The research systematically elucidates the molecular mechanisms by which the SNS mediates signaling pathways through neurofibers and neurotransmitters,such as norepinephrine,dopamine,neuropeptide Y,and leptin,regulating interactions between bone-related cells to maintain skeletal homeostasis.It also identifies the pathological associations between the dysregulation of these pathways and the progression of bone-related conditions,such as osteoporosis,osteoarthritis,and intervertebral disc degeneration.By integrating current evidence,we identify novel therapeutic targets within the BBA and propose neuro-centric intervention strategies to mitigate skeletal diseases.This review deepens the understanding of neuro-skeletal interactions and lays a foundation for innovative treatments for bone-related pathologies.展开更多
Interval-valued pre-aggregation functions are a hot topic in the research of aggregation functions and have received considerable attention in recent years.As a special class of interval-valued pre-aggregation functio...Interval-valued pre-aggregation functions are a hot topic in the research of aggregation functions and have received considerable attention in recent years.As a special class of interval-valued pre-aggregation functions,(light)interval-valued pre-t-norms were initially proposed by Wang and Hu,but their properties were not further discussed by the authors.The main purpose of this paper is to study in depth the properties and generation of(light)intervalvalued pre-t-norms.Firstly,several properties of(light)interval-valued pre-t-norms and their relationship with(light)pre-t-norms are presented.Then,two different generation methods for(light)interval-valued pre-t-norms are introduced.Finally,it demonstrates a specific application of(light)interval-valued pre-t-norms in constructing interval-valued directional monotonic fuzzy implications,namely,using the(light)interval-valued pre-t-norm IT,interval-valued fuzzy negations IN,and(light)interval-valued pre-t-conorm IS to construct interval-valued QL-directional monotonic operations.展开更多
This multidisciplinary study integrates structural and cave mapping,3D geological modeling,and Geographical Information System(GIS)analysis to provide constraints of the hydrogeological model for the central Lefka Ori...This multidisciplinary study integrates structural and cave mapping,3D geological modeling,and Geographical Information System(GIS)analysis to provide constraints of the hydrogeological model for the central Lefka Ori Massif.Through 44 km of linear mapping,we discovered the new mid-Miocene Pachnes Thrust(PT)which plays a key role in the central Lefka Ori Massif structural framework.展开更多
The relationship between heaven and humanity is one of the fundamental philosophical foundations of ecological ethics in ancient Chinese Confucian thought.As a master of Confucian philosophy of mind,Wang Yangming inte...The relationship between heaven and humanity is one of the fundamental philosophical foundations of ecological ethics in ancient Chinese Confucian thought.As a master of Confucian philosophy of mind,Wang Yangming integrated the traditional Confucian discourse on the relationship between heaven and humanity into the principles of the philosophy of mind.Building on the traditional doctrine of benevolence centered on moral concern,he further developed an ecological view of‘benevolence as the unity of heaven and earth’.In his work Inquiry on the Great Learning,Wang Yangming systematically elaborated on this notion,emphasizing the philosophical expression of the relationship between humans and nature within an ethical framework and outlining the new implications of traditional Confucian ecological thought.This paper aims to analyze Wang Yangming’s ecological view of‘benevolence as the unity of heaven and earth’by examining the ecological ideas in his Inquiry on the Great Learning.On this basis,it seeks to refine the valuable achievements of traditional Chinese ecological civilization thought and strengthen the theoretical foundation of contemporary ecological ideas with Chinese characteristics.展开更多
Although the late Quaternary slip rate of the Northern Margin Fault of the Huaizhuo Basin(NFHB)was studied approximately 30 years ago using thermoluminescence and geomorphic methods,the underlying uncertainty cannot b...Although the late Quaternary slip rate of the Northern Margin Fault of the Huaizhuo Basin(NFHB)was studied approximately 30 years ago using thermoluminescence and geomorphic methods,the underlying uncertainty cannot be neglected,considering the limitations resulting from age and displacement measurements.Accordingly,we attempted to re-estimate the late Quaternary slip rate of the NFHB using high-precision remote sensing image interpretation,large-scale geological and geomorphic mapping,paleoseismic analysis,and Quaternary geochronology testing.The results,based on stratigraphic dislocation and age constraint in the trenches,show that the present deformation of the NFHB has been dominated by the extension,with a vertical slip rate~0.04-0.11 mm/a.We estimate a vertical slip rate of~0.06 mm/a,with an R^(2) value of~0.91,which is much lower than the~0.5 mm/a result estimated previously.There are three possible reasons for this discrepancy.The first is the limitation resulting from dating and displacement measurements in earlier studies;the second is the slip decomposition caused by multiple branches of the NFHB,which leads to the low slip rate observed at a single fault;and third possible explanation is that the fault may be locked at present with a low slip rate,which means that the earthquake hazard of the NFHB cannot be ignored,and more in-depth research,such as geodetic and intensive observations of earthquake precursors,is urgently needed.This discovery poses a new challenge for the active study of the NFHB and the northeast corner of the Ordos Plateau in the North China Block.展开更多
In this paper, we defined the concept of implicative and fuzzy implicative ideals of lattice implication algebras, and discussed the properties of them. And then, we pointed out the relations between implicative ideal...In this paper, we defined the concept of implicative and fuzzy implicative ideals of lattice implication algebras, and discussed the properties of them. And then, we pointed out the relations between implicative ideal and LI _ideal, implicative iedal and implicative filter, implicative ideal and fuzzy implicative ideal, fuzzy implicative ideal and fuzzy implicative filter, and fuzzy implicative ideal and fuzzy LI _ideal.展开更多
Zircon U-Pb ages, Hf isotope data and whole-rock major and trace element data for the Middle to Late Ordovician gabbros and granites in the Erguna Massif, NE China were presented in this paper. The petrogenesis of the...Zircon U-Pb ages, Hf isotope data and whole-rock major and trace element data for the Middle to Late Ordovician gabbros and granites in the Erguna Massif, NE China were presented in this paper. The petrogenesis of these rocks and the Early Paleozoic tectonic evolution of the massif were discussed. Zircons from the granites and gabbros are of magmatic origin based on their cathodoluminescence（CL） images. The 206Pb/238 U ages obtained from 20 spots on zircons from the granites range from 446±9 to 464±10 Ma, yielding a weighted mean age of 455±10 Ma; and 16 spots on zircons from the gabbros range from 465±10 to 466±7 Ma, yielding a weighted mean age of 465±2 Ma. Chemically, the Late Ordovician granites in the Erguna Massif are weakly peraluminous and similar to A-type granites. The granites and gabbros are all enriched in light rare earth elements and large ion lithophile elements（e.g., Rb, K）, and depleted in heavy rare earth elements and high field strength elements（e.g., Nb, Ta, and Ti）; they all exhibit marked negative Eu anomalies. Their zircon εHf（t） values range mainly from ＋1.86 to ＋6.21（for the granites） and ＋1.39 to ＋3.89（for the gabbros）, except for one spot with a value of-0.27（for a gabbro）. The TDM1 ages for the gabbros and TDM2 ages for the granites vary from 928 to 1 091 Ma and from 1 287 to 1 675 Ma, respectively. It is concluded that the primary magma of the granites could have been derived by partial melting of Mesoproterozoic newly accreted crustal material, whereas the primary magma of the gabbros originated by partial melting of a depleted mantle wedge that had been metasomatized by fluids derived from a subducted slab. These Middle-Late Ordovician granites and gabbros constitute a typical bimodal igneous rock association, implying an extensional environment that was probably related to the post-collisional development of the Erguna and Xing＇an massifs in the early Early Paleozoic.展开更多
In this paper, we discuss some propertie s of lattice implication algebra and difine the transitivity of implication in a set, we show the transitivity of implication and the substitution Theorem hold i n filters. S...In this paper, we discuss some propertie s of lattice implication algebra and difine the transitivity of implication in a set, we show the transitivity of implication and the substitution Theorem hold i n filters. So every filter of lattice implication algebra satisfies the Syllogis m and substitution Theorem of propositional logic.展开更多
Eighty-four pollen samples were obtained for 80 taxa, of which, 13 species and one variety are from sect. Brachycalyx Sweet, 58 species and two varieties from sect. Tsutsusi Sweet, and six species from subgen. Pentant...Eighty-four pollen samples were obtained for 80 taxa, of which, 13 species and one variety are from sect. Brachycalyx Sweet, 58 species and two varieties from sect. Tsutsusi Sweet, and six species from subgen. Pentanthera （G. Don） Pojarkova, respectively. Pollen morphology of all samples was observed using LM and SEM. Pollen grains are revealed to be spheroidal and tetrahedral with tricolporate apertures. Pollen sizes of subgen. Tsutsusi （Sweet） Pojarkova range from 37.67 μm to 61.06μm, and the exine sculptures are more or less compactly granulated. Pollen sizes are significantly different between sect. Brachycalyx and sect. Tsutsusi of subgen. Tsutsusi. Rhododendron tashiroi Maxim. of sect. Tsusiopsis Sleumer shows a close affinity to sect. Brachycalyx. Pollen size and exine are consistent with general morphology in differentiating species in sect. Tsutsusi. Rhododendron huadingense B. Y. Ding ＆ Y. Y. Fang, once placed as a member of sect. Brachycalyx, should be considered as a species in subgen. Pentanthera.展开更多
基金supported by the Chinese Ministry of Education of Humanities and Social Science Project(23YJC72040003)the Key Project of Chinese Ministry of Education(22JJD720021)supported by the Natural Science Foundation of Shandong Province,China(project number:ZR2023QF021)。
文摘In the present paper,we give a systematic study of the discrete correspondence the-ory and topological correspondence theory of modal meet-implication logic and moda1 meet-semilattice logic,in the semantics provided in[21].The special features of the present paper include the following three points:the first one is that the semantic structure used is based on a semilattice rather than an ordinary partial order,the second one is that the propositional vari-ables are interpreted as filters rather than upsets,and the nominals,which are the“first-order counterparts of propositional variables,are interpreted as principal filters rather than principal upsets;the third one is that in topological correspondence theory,the collection of admissi-ble valuations is not closed under taking disjunction,which makes the proof of the topological Ackermann 1emma different from existing settings.
基金supported by the Natural Science Foundation of Sichuan Province,China(2024NSFSC1272)the Innovation Team Development Funds for Sichuan Mutton Goat&Sheep,China(SCCXTD-2024-14)Scientific and Technological Innovation Team for Qinghai-Tibetan Plateau Research in Southwest Minzu University,China(2024CXTD08)。
文摘Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.
基金Technology Program of Jiaying University,No.2024KJZ01Open Funding of Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas,No.2023JYKF08National Natural Science Foundation of China,No.42277442。
文摘The conversion of subtropical red soils into farmland involves complex transformations of iron oxides.Investigating iron mineralogy can enhance understanding of magnetic minerals in relation to soil formation on farmland in subtropical regions.In this study,we investigated the properties of iron oxide and its environmental implications in the farmland of Meizhou city,Guangdong province.The results showed that farmland soils had higher magnetism than the red soils developed from the same metamorphic rock.The red soils displayed significantly higher concentrations of goethite and hematite than the farmland soils.The dominant factor influencing the magnetic changes in farmland and red soils was the concentration of fine-grained ferromagnetic minerals.Red soil magnetism is an indicator of soil weathering intensity,whereas farmland soil magnetism is closely related to human cultivation activities.In contrast to the red soils,the farmland soils lacked the pronounced transformation of ferromagnetic minerals into hematite and goethite.A vigorous oxidation process catalyzes the transformation of strong magnetic minerals into significant amounts of hematite and goethite,which promotes the reduced magnetism of red soils.The conversion of red soils into farmland soils initially increased the accumulation of ferromagnetic materials due to cultivation processes.However,long-term cultivation led to the gradual loss of fine-grained ferromagnetic minerals,while goethite and lepidocrocite became the dominant magnetic mineral types.
文摘It is a common misconception that e-cigarettes are safer than tobacco smoking,given their adverse cardiopulmonary effects,habituation,and the fact that it is only a fashion based manifestation to sell and use them.Therefore,the use of e cigarettes should not be encouraged as an alternative and pragmatic measure should be taken to profess this agenda.
文摘Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working memory,and emotional regulation,is notably impaired in this condition.This review consolidates current insights into the role of PFC dysfunction in schizophrenia,with a focus on its implications for therapeutic strategies.The neuroanatomical and neurobiological foundations of PFC dysfunction are explored,emphasizing structural abnormalities,functional dysconnectivity,and microcircuit disruptions that contribute to cognitive deficits and impaired decision-making.Clinical implications are discussed,particularly the correlation between PFC dysfunction and the severity and progression of schizophrenia symptoms.Additionally,pharmacological and non-pharmacological approaches aimed at modulating PFC activity are reviewed as potential therapeutic options.In conclusion,a deeper understanding of PFC dysfunction is pivotal for developing targeted treatments,and ongoing research offers promising avenues for enhancing outcomes for individuals affected by this debilitating disorder.
基金Chongqing Social Science Planning Project“Research on the Practical Path of Leading and Cultivating Youth Responsibility and Commitment with the Spirit of Struggle”(2021YBCS24)。
文摘Marx scientifically summarized the experience and lessons of the Paris Commune,deeply exposed the root causes of bourgeois corruption,and emphasized the purity and advancement of the construction of proletarian political parties and political power.The dictatorship of the proletariat puts forward the ideas of cheap government that eradicate corruption,realizes that the people are the masters of the country,implements democratic supervision of elections,simplifies the construction of institutions,lowers governance costs,and achieves higher efficiency.A deep understanding of the theoretical characteristics of Marx’s thoughts on integrity,democracy,and honor,and a profound clarification of the practical significance of Marx’s ideology on clean governance,combined with practical practice,will help promote the construction of a new system of anti-corruption and incorruption in our country,and will benefit our contemporary services.The construction of a type-oriented government system is conducive to deepening the construction of China’s national legal system.
文摘Anopheles(An.)stephensi is one of the dominant malaria vectors in India,Bangladesh,Pakistan,Iran,Iraq and some other Asian countries[1].It plays a crucial role in transmitting Plasmodium falciparum and Plasmodium vivax in India along with its rural counterpart,An.culicifacies.This mosquito species has adapted well to urban and peri-urban environments,making it a significant public health concern in the country.The presence of An.stephensi in urban areas contrasts with other malaria vectors that predominantly inhabit rural regions,thus complicating traditional malaria control strategies.It is well-adapted to human-made environments,breeding in various containers including tanks,cisterns,and barrels used for water storage.
文摘Teacher professional identity is a comprehensive reflection of teachers’role perception,emotional experiences,and behavioral tendencies towards their profession.It serves as an intrinsic driving force for teachers’professional development and is also a crucial issue in teacher education research.From a global perspective,this study systematically reviews and examines relevant research on the professional identity of international Chinese language teachers(ICLTs).A comparative analysis is conducted between Chinese and foreign scholars’research in terms of theoretical foundations,research subjects,research content,and research methodologies.This comprehensive overview of the current research landscape in this field,along with a summary of existing achievements and identified problems,facilitates the transformation of fragmented research findings on ICLTs’professional identity into a systematic understanding and reveals research gaps.Building upon this foundation,the study proposes future research prospects for the professional identity of ICLTs from aspects such as the construction of a cross-cultural perspective-based teacher professional identity system,the transformation of teacher professional identity in the context of digital transformation,and case studies on ICLTs’professional identity.The aim is to promote high-quality development in both theory and practice of international Chinese language education.
文摘Rapid technological advancements are driving embodied intelligent robots from laboratories to real-life applications to serve as a key force reshaping the future way of life.Like many other revolutionary technologies,while sparking utopian visions of the future,the development of embodied intelligence has aroused concerns about safety risks, emotional ethics, and socio-cultural implications.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82172635,82272686,and 82203628)Natural Science Foundation of Tianjin(Grant No.23JCZDJC00200)Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-010A).
文摘Introduction Small cell lung cancer(SCLC)is a highly aggressive malignancy with limited treatment options.Despite advances in immunotherapy,response rates remain low,and the efficacy of current molecular subtyping1,2 is insufficient to predict therapeutic outcomes3,4.A recently identified vulnerability in SCLC involves the dysregulation of nuclear-cytoplasmic transport,particularly through exportin 1(XPO1)5-7.
基金funded by Shaoxing University’s enterprise important horizontal topic(No.2024USXH287)the Graduate research project of Shaoxing University(Nos.Y20240280)。
文摘The global aging crisis has increased the prevalence of skeletal disorders,necessitating innovative therapeutic strategies.This review employs the brain-bone axis(BBA)framework to examine the role of the sympathetic nervous system(SNS)in bone metabolism.The research systematically elucidates the molecular mechanisms by which the SNS mediates signaling pathways through neurofibers and neurotransmitters,such as norepinephrine,dopamine,neuropeptide Y,and leptin,regulating interactions between bone-related cells to maintain skeletal homeostasis.It also identifies the pathological associations between the dysregulation of these pathways and the progression of bone-related conditions,such as osteoporosis,osteoarthritis,and intervertebral disc degeneration.By integrating current evidence,we identify novel therapeutic targets within the BBA and propose neuro-centric intervention strategies to mitigate skeletal diseases.This review deepens the understanding of neuro-skeletal interactions and lays a foundation for innovative treatments for bone-related pathologies.
基金the National Natural Science Foundation of China(Grant No.12171294)。
文摘Interval-valued pre-aggregation functions are a hot topic in the research of aggregation functions and have received considerable attention in recent years.As a special class of interval-valued pre-aggregation functions,(light)interval-valued pre-t-norms were initially proposed by Wang and Hu,but their properties were not further discussed by the authors.The main purpose of this paper is to study in depth the properties and generation of(light)intervalvalued pre-t-norms.Firstly,several properties of(light)interval-valued pre-t-norms and their relationship with(light)pre-t-norms are presented.Then,two different generation methods for(light)interval-valued pre-t-norms are introduced.Finally,it demonstrates a specific application of(light)interval-valued pre-t-norms in constructing interval-valued directional monotonic fuzzy implications,namely,using the(light)interval-valued pre-t-norm IT,interval-valued fuzzy negations IN,and(light)interval-valued pre-t-conorm IS to construct interval-valued QL-directional monotonic operations.
基金funded by IUGS and UNESCO through the IGCP-715 initiativethe collection of rock samples and topographical data.Special recognition goes to the Sternes Cave Expeditions(2018–2023)the Gourgouthakas Expedition(2022)and the Lion Expeditions(2013–2015)for their substantial contributions.
文摘This multidisciplinary study integrates structural and cave mapping,3D geological modeling,and Geographical Information System(GIS)analysis to provide constraints of the hydrogeological model for the central Lefka Ori Massif.Through 44 km of linear mapping,we discovered the new mid-Miocene Pachnes Thrust(PT)which plays a key role in the central Lefka Ori Massif structural framework.
文摘The relationship between heaven and humanity is one of the fundamental philosophical foundations of ecological ethics in ancient Chinese Confucian thought.As a master of Confucian philosophy of mind,Wang Yangming integrated the traditional Confucian discourse on the relationship between heaven and humanity into the principles of the philosophy of mind.Building on the traditional doctrine of benevolence centered on moral concern,he further developed an ecological view of‘benevolence as the unity of heaven and earth’.In his work Inquiry on the Great Learning,Wang Yangming systematically elaborated on this notion,emphasizing the philosophical expression of the relationship between humans and nature within an ethical framework and outlining the new implications of traditional Confucian ecological thought.This paper aims to analyze Wang Yangming’s ecological view of‘benevolence as the unity of heaven and earth’by examining the ecological ideas in his Inquiry on the Great Learning.On this basis,it seeks to refine the valuable achievements of traditional Chinese ecological civilization thought and strengthen the theoretical foundation of contemporary ecological ideas with Chinese characteristics.
基金The research and development project of Beijing Disaster Prevention Technology Co.,Ltd.(FZKJYF202201)funded this work.
文摘Although the late Quaternary slip rate of the Northern Margin Fault of the Huaizhuo Basin(NFHB)was studied approximately 30 years ago using thermoluminescence and geomorphic methods,the underlying uncertainty cannot be neglected,considering the limitations resulting from age and displacement measurements.Accordingly,we attempted to re-estimate the late Quaternary slip rate of the NFHB using high-precision remote sensing image interpretation,large-scale geological and geomorphic mapping,paleoseismic analysis,and Quaternary geochronology testing.The results,based on stratigraphic dislocation and age constraint in the trenches,show that the present deformation of the NFHB has been dominated by the extension,with a vertical slip rate~0.04-0.11 mm/a.We estimate a vertical slip rate of~0.06 mm/a,with an R^(2) value of~0.91,which is much lower than the~0.5 mm/a result estimated previously.There are three possible reasons for this discrepancy.The first is the limitation resulting from dating and displacement measurements in earlier studies;the second is the slip decomposition caused by multiple branches of the NFHB,which leads to the low slip rate observed at a single fault;and third possible explanation is that the fault may be locked at present with a low slip rate,which means that the earthquake hazard of the NFHB cannot be ignored,and more in-depth research,such as geodetic and intensive observations of earthquake precursors,is urgently needed.This discovery poses a new challenge for the active study of the NFHB and the northeast corner of the Ordos Plateau in the North China Block.
文摘In this paper, we defined the concept of implicative and fuzzy implicative ideals of lattice implication algebras, and discussed the properties of them. And then, we pointed out the relations between implicative ideal and LI _ideal, implicative iedal and implicative filter, implicative ideal and fuzzy implicative ideal, fuzzy implicative ideal and fuzzy implicative filter, and fuzzy implicative ideal and fuzzy LI _ideal.
基金financially supported by the National Key Basic Research Program of China (Nos. 2013CB429802 and 2013CB429803)the National Natural Science Foundation of China (No. 41272077)by the Opening Foundation of the State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan (No. GPMR201104)
文摘Zircon U-Pb ages, Hf isotope data and whole-rock major and trace element data for the Middle to Late Ordovician gabbros and granites in the Erguna Massif, NE China were presented in this paper. The petrogenesis of these rocks and the Early Paleozoic tectonic evolution of the massif were discussed. Zircons from the granites and gabbros are of magmatic origin based on their cathodoluminescence（CL） images. The 206Pb/238 U ages obtained from 20 spots on zircons from the granites range from 446±9 to 464±10 Ma, yielding a weighted mean age of 455±10 Ma; and 16 spots on zircons from the gabbros range from 465±10 to 466±7 Ma, yielding a weighted mean age of 465±2 Ma. Chemically, the Late Ordovician granites in the Erguna Massif are weakly peraluminous and similar to A-type granites. The granites and gabbros are all enriched in light rare earth elements and large ion lithophile elements（e.g., Rb, K）, and depleted in heavy rare earth elements and high field strength elements（e.g., Nb, Ta, and Ti）; they all exhibit marked negative Eu anomalies. Their zircon εHf（t） values range mainly from ＋1.86 to ＋6.21（for the granites） and ＋1.39 to ＋3.89（for the gabbros）, except for one spot with a value of-0.27（for a gabbro）. The TDM1 ages for the gabbros and TDM2 ages for the granites vary from 928 to 1 091 Ma and from 1 287 to 1 675 Ma, respectively. It is concluded that the primary magma of the granites could have been derived by partial melting of Mesoproterozoic newly accreted crustal material, whereas the primary magma of the gabbros originated by partial melting of a depleted mantle wedge that had been metasomatized by fluids derived from a subducted slab. These Middle-Late Ordovician granites and gabbros constitute a typical bimodal igneous rock association, implying an extensional environment that was probably related to the post-collisional development of the Erguna and Xing＇an massifs in the early Early Paleozoic.
文摘In this paper, we discuss some propertie s of lattice implication algebra and difine the transitivity of implication in a set, we show the transitivity of implication and the substitution Theorem hold i n filters. So every filter of lattice implication algebra satisfies the Syllogis m and substitution Theorem of propositional logic.
基金supported by the National Natural Science Foundation of China (Grant No.30370106)
文摘Eighty-four pollen samples were obtained for 80 taxa, of which, 13 species and one variety are from sect. Brachycalyx Sweet, 58 species and two varieties from sect. Tsutsusi Sweet, and six species from subgen. Pentanthera （G. Don） Pojarkova, respectively. Pollen morphology of all samples was observed using LM and SEM. Pollen grains are revealed to be spheroidal and tetrahedral with tricolporate apertures. Pollen sizes of subgen. Tsutsusi （Sweet） Pojarkova range from 37.67 μm to 61.06μm, and the exine sculptures are more or less compactly granulated. Pollen sizes are significantly different between sect. Brachycalyx and sect. Tsutsusi of subgen. Tsutsusi. Rhododendron tashiroi Maxim. of sect. Tsusiopsis Sleumer shows a close affinity to sect. Brachycalyx. Pollen size and exine are consistent with general morphology in differentiating species in sect. Tsutsusi. Rhododendron huadingense B. Y. Ding ＆ Y. Y. Fang, once placed as a member of sect. Brachycalyx, should be considered as a species in subgen. Pentanthera.
