Near Field Communication(NFC)and Radio Frequency Identification(RFID)technologies offer wireless data transmission and energy supply for flexible wearable and implantable sensing systems.By eliminating bulky batteries...Near Field Communication(NFC)and Radio Frequency Identification(RFID)technologies offer wireless data transmission and energy supply for flexible wearable and implantable sensing systems.By eliminating bulky batteries or external wiring,these technologies significantly advance personalized medicine through wearable and implantable systems with reduced size,increased flexibility,and improved mechanical adaptability to the human body.This multidisciplinary research area encompasses the fundamental mechanisms of antenna theory,simulation&design,micro/nano-fabrication,and their biomedical applications.This review provides an overview of emerging wireless,personalized/decentralized biomedical devices focusing on NFC/RFID antennas design mechanisms,flexible NFC/RFID-based physical,chemical,and biosensors,as well as drug delivery implants.Moreover,challenges and future directions regarding flexible NFC/RFID-based systems are provided.Advancing this field will require collaborative efforts from researchers in antenna design,materials science,biology,and medical care,driving the development of NFC/RFID in biomedical applications.展开更多
The need for long-term treatments of chronic diseases has motivated the widespread development of long-acting parenteral formulations(LAPFs)with the aim of improving drug pharmacokinetics and therapeutic efficacy.LAPF...The need for long-term treatments of chronic diseases has motivated the widespread development of long-acting parenteral formulations(LAPFs)with the aim of improving drug pharmacokinetics and therapeutic efficacy.LAPFs have been proven to extend the half-life of therapeutics,as well as to improve patient adherence;consequently,this enhances the outcome of therapy positively.Over past decades,considerable progress has been made in designing effective LAPFs in both preclinical and clinical settings.Here we review the latest advances of LAPFs in preclinical and clinical stages,focusing on the strategies and underlying mechanisms for achieving long acting.Existing strategies are classified into manipulation of in vivo clearance and manipulation of drug release from delivery systems,respectively.And the current challenges and prospects of each strategy are discussed.In addition,we also briefly discuss the design principles of LAPFs and provide future perspectives of the rational design of more effective LAPFs for their further clinical translation.展开更多
基金the financial support from the National Natural Science Foundation of China(62235008)Natural Science Foundation for Excellent Young Scholars(62322108)+3 种基金National Key R&D Program of China under Grant(2021YFB3601200)Natural Science Foundation for Young Scholars(62201286,62301283,22405131)the Program of Jiangsu Specially-Appointed Professor,Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB587)Nanjing U35 Program,Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(NY222099).
文摘Near Field Communication(NFC)and Radio Frequency Identification(RFID)technologies offer wireless data transmission and energy supply for flexible wearable and implantable sensing systems.By eliminating bulky batteries or external wiring,these technologies significantly advance personalized medicine through wearable and implantable systems with reduced size,increased flexibility,and improved mechanical adaptability to the human body.This multidisciplinary research area encompasses the fundamental mechanisms of antenna theory,simulation&design,micro/nano-fabrication,and their biomedical applications.This review provides an overview of emerging wireless,personalized/decentralized biomedical devices focusing on NFC/RFID antennas design mechanisms,flexible NFC/RFID-based physical,chemical,and biosensors,as well as drug delivery implants.Moreover,challenges and future directions regarding flexible NFC/RFID-based systems are provided.Advancing this field will require collaborative efforts from researchers in antenna design,materials science,biology,and medical care,driving the development of NFC/RFID in biomedical applications.
基金supported by the National Natural Science Foundation of China(No.81603041)
文摘The need for long-term treatments of chronic diseases has motivated the widespread development of long-acting parenteral formulations(LAPFs)with the aim of improving drug pharmacokinetics and therapeutic efficacy.LAPFs have been proven to extend the half-life of therapeutics,as well as to improve patient adherence;consequently,this enhances the outcome of therapy positively.Over past decades,considerable progress has been made in designing effective LAPFs in both preclinical and clinical settings.Here we review the latest advances of LAPFs in preclinical and clinical stages,focusing on the strategies and underlying mechanisms for achieving long acting.Existing strategies are classified into manipulation of in vivo clearance and manipulation of drug release from delivery systems,respectively.And the current challenges and prospects of each strategy are discussed.In addition,we also briefly discuss the design principles of LAPFs and provide future perspectives of the rational design of more effective LAPFs for their further clinical translation.
