Objective:To develop and bench-validate a fully passive,wireless implantable pressure monitoring system(WIPS)for on-demand assessment of intra-sac pressure in patients with endovascular aneurysm repair(EVAR)for abdomi...Objective:To develop and bench-validate a fully passive,wireless implantable pressure monitoring system(WIPS)for on-demand assessment of intra-sac pressure in patients with endovascular aneurysm repair(EVAR)for abdominal aortic aneurysms.Methods:WIPS includes a flexible 15 mm×145 mm implant integrating four pressure sensors(MS5839),an RFID tag(ST25DV04KC),and an ultra-low-power microcontroller(STM32L011).The device is powered wirelessly via 13.56 MHz RFID,enabling pressure measurements at configurable resolutions without need for batteries.Data is stored locally and retrieved via an external Reader(RD520).Benchtop tests evaluated power consumption,telemetry range,and sensor linearity in air,heated saline,and a biologically representative meat model.Uniform 1μm and 2μm Parylene C coatings were applied intentionally,as two predefined thickness conditions,to evaluate biocompatibility without compromising sensor performance.Results:Total power consumption remained below 4 mW across all oversampling ratios(OSRs).In free air,reliable telemetry was achieved up to 24 cm at 6 W Reader output.Heated mineral water reduced the optimal distance to 16 cm,and physiological saline limited it to 4 cm.In the Meat Model,a fixed 18 cm tissue path yielded 100%link reliability for OSR≤1024 at 5 W.Parylene C coatings did not alter pressure linearity or hysteresis.The strip is compatible with a 20 F delivery sheath,suggesting compatibility with standard EVAR catheters.Conclusions:WIPS combines low power consumption,deep-tissue wireless telemetry,and catheter-based deliverability,addressing longstanding limitations in implantable EVAR surveillance tools.These benchtop findings support feasibility for future in vivo testing in large animal models to validate long-term safety and clinical integration.展开更多
Biodegradable magnesium is a highly desired material for fracture fixation implants because of its good me-chanical properties and ability to completely dissolve in the body over time,eliminating the need for a second...Biodegradable magnesium is a highly desired material for fracture fixation implants because of its good me-chanical properties and ability to completely dissolve in the body over time,eliminating the need for a secondary surgery to remove the implant.Despite extensive research on these materials,there remains a dearth of infor-mation regarding critical factors that affect implant performance in clinical applications,such as the in vivo pH and mechanical loading conditions.We developed a measurement system with implantable strain,temperature,pH and motion sensors to characterize magnesium and titanium plates,fixating bilateral zygomatic arch osteotomies in three Swiss alpine sheep for eight weeks.pH 1-2 mm above titanium plates was 6.6±0.4,while for magnesium plates it was slightly elevated to 7.4±0.8.Strains on magnesium plates were higher than on titanium plates,possibly due to the lower Young’s modulus of magnesium.One magnesium plate experienced excessive loading,which led to plate failure within 31 h.This is,to our knowledge,the first in vivo strain,temperature,and pH data recorded for magnesium implants used for fracture fixation.These results provide insight into magnesium degradation and its influence on the in vivo environment,and may help to improve material and implant design for future clinical applications.展开更多
In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,...In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,implantable electrochemical microsensors have emerged as a prominent area of research.These microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for integration.They have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional performance.The development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated efforts.This review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for fabrication.Following this,we proceeded to explore the various implantation technologies employed for electrochemical microsensors.In addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease mechanisms.Lastly,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.展开更多
This article focuses on the potential impact of big data analysis to improve health, prevent and detect disease at an earlier stage, and personalize interventions. The role that big data analytics may have in interrog...This article focuses on the potential impact of big data analysis to improve health, prevent and detect disease at an earlier stage, and personalize interventions. The role that big data analytics may have in interrogating the patient electronic health record toward improved clinical decision support is discussed. Weexamine developments in pharmacogenetics that have increased our appreciation of the reasons why patients respond differently to chemotherapy. We also assess the expansion of online health communications and the way in which this data may be capitalized on in order to detect public health threats and control or contain epidemics. Finally, we describe how a new generation of wearable and implantable body sensors may improve wellbeing, streamline management of chronic diseases, and improve the quality of surgical implants.展开更多
Implantable sensors can provide access to accurate,continuous,and minimally invasive monitoring of physiological signals from internal organs and tissues,thereby facilitating timely diagnosis,closed-loop intervention,...Implantable sensors can provide access to accurate,continuous,and minimally invasive monitoring of physiological signals from internal organs and tissues,thereby facilitating timely diagnosis,closed-loop intervention,and advanced health management.Among the various types of implantable sensors,those capable of measuring physical parameters–such as temperature,force,and flow–are particularly important due to their ability to monitor physical conditions critical to nearly all organs and to provide insights into a wide range of health conditions.This review presents recent progress in four key types of implantable physical sensors:strain sensors,pressure sensors,temperature sensors,and flow sensors.It covers their engineering principles,design considerations,in vivo performances,and clinical relevance.The review also addresses critical challenges and future opportunities in the development of implantable physical sensors,such as flexibility and stretchability,biocompatibility,long-term stability,and the translation of these sensing technologies from bench to clinic.展开更多
Intraocular pressure(IOP)is a key clinical parameter in glaucoma management.However,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lac...Intraocular pressure(IOP)is a key clinical parameter in glaucoma management.However,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lacking,and IOP is typically measured only a few times a year.Here we report on a microscale implantable sensor that could provide convenient,accurate,ondemand IOP monitoring in the home environment.When excited by broadband near-infrared(NIR)light from a tungsten bulb,the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to IOP.NIR light is minimally absorbed by tissue and is not perceived visually.The sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm Hg.Sensors were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white rabbits.Implanted sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.展开更多
文摘Objective:To develop and bench-validate a fully passive,wireless implantable pressure monitoring system(WIPS)for on-demand assessment of intra-sac pressure in patients with endovascular aneurysm repair(EVAR)for abdominal aortic aneurysms.Methods:WIPS includes a flexible 15 mm×145 mm implant integrating four pressure sensors(MS5839),an RFID tag(ST25DV04KC),and an ultra-low-power microcontroller(STM32L011).The device is powered wirelessly via 13.56 MHz RFID,enabling pressure measurements at configurable resolutions without need for batteries.Data is stored locally and retrieved via an external Reader(RD520).Benchtop tests evaluated power consumption,telemetry range,and sensor linearity in air,heated saline,and a biologically representative meat model.Uniform 1μm and 2μm Parylene C coatings were applied intentionally,as two predefined thickness conditions,to evaluate biocompatibility without compromising sensor performance.Results:Total power consumption remained below 4 mW across all oversampling ratios(OSRs).In free air,reliable telemetry was achieved up to 24 cm at 6 W Reader output.Heated mineral water reduced the optimal distance to 16 cm,and physiological saline limited it to 4 cm.In the Meat Model,a fixed 18 cm tissue path yielded 100%link reliability for OSR≤1024 at 5 W.Parylene C coatings did not alter pressure linearity or hysteresis.The strip is compatible with a 20 F delivery sheath,suggesting compatibility with standard EVAR catheters.Conclusions:WIPS combines low power consumption,deep-tissue wireless telemetry,and catheter-based deliverability,addressing longstanding limitations in implantable EVAR surveillance tools.These benchtop findings support feasibility for future in vivo testing in large animal models to validate long-term safety and clinical integration.
基金supported by the Swiss National Science Foundation via an SNF Sinergia Grant(grant number CRSII5-180367).
文摘Biodegradable magnesium is a highly desired material for fracture fixation implants because of its good me-chanical properties and ability to completely dissolve in the body over time,eliminating the need for a secondary surgery to remove the implant.Despite extensive research on these materials,there remains a dearth of infor-mation regarding critical factors that affect implant performance in clinical applications,such as the in vivo pH and mechanical loading conditions.We developed a measurement system with implantable strain,temperature,pH and motion sensors to characterize magnesium and titanium plates,fixating bilateral zygomatic arch osteotomies in three Swiss alpine sheep for eight weeks.pH 1-2 mm above titanium plates was 6.6±0.4,while for magnesium plates it was slightly elevated to 7.4±0.8.Strains on magnesium plates were higher than on titanium plates,possibly due to the lower Young’s modulus of magnesium.One magnesium plate experienced excessive loading,which led to plate failure within 31 h.This is,to our knowledge,the first in vivo strain,temperature,and pH data recorded for magnesium implants used for fracture fixation.These results provide insight into magnesium degradation and its influence on the in vivo environment,and may help to improve material and implant design for future clinical applications.
基金the Fundamental Research Funds for the Central Universities,National Natural Science Foundation of China(No.82302345).
文摘In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,implantable electrochemical microsensors have emerged as a prominent area of research.These microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for integration.They have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional performance.The development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated efforts.This review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for fabrication.Following this,we proceeded to explore the various implantation technologies employed for electrochemical microsensors.In addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease mechanisms.Lastly,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.
文摘This article focuses on the potential impact of big data analysis to improve health, prevent and detect disease at an earlier stage, and personalize interventions. The role that big data analytics may have in interrogating the patient electronic health record toward improved clinical decision support is discussed. Weexamine developments in pharmacogenetics that have increased our appreciation of the reasons why patients respond differently to chemotherapy. We also assess the expansion of online health communications and the way in which this data may be capitalized on in order to detect public health threats and control or contain epidemics. Finally, we describe how a new generation of wearable and implantable body sensors may improve wellbeing, streamline management of chronic diseases, and improve the quality of surgical implants.
基金funding by the National Institutes of Health Center for Autonomic Nerve Recording and Stimulation Systems under award number 1U41NS129514.
文摘Implantable sensors can provide access to accurate,continuous,and minimally invasive monitoring of physiological signals from internal organs and tissues,thereby facilitating timely diagnosis,closed-loop intervention,and advanced health management.Among the various types of implantable sensors,those capable of measuring physical parameters–such as temperature,force,and flow–are particularly important due to their ability to monitor physical conditions critical to nearly all organs and to provide insights into a wide range of health conditions.This review presents recent progress in four key types of implantable physical sensors:strain sensors,pressure sensors,temperature sensors,and flow sensors.It covers their engineering principles,design considerations,in vivo performances,and clinical relevance.The review also addresses critical challenges and future opportunities in the development of implantable physical sensors,such as flexibility and stretchability,biocompatibility,long-term stability,and the translation of these sensing technologies from bench to clinic.
基金The project was funded by the National Institute of Health(NIH)EY024582the Basic Science Research Program through the National Research Foundation of Korea(NRF)under the Ministry of Education(NRF-2013R1A6A3A03026384).
文摘Intraocular pressure(IOP)is a key clinical parameter in glaucoma management.However,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lacking,and IOP is typically measured only a few times a year.Here we report on a microscale implantable sensor that could provide convenient,accurate,ondemand IOP monitoring in the home environment.When excited by broadband near-infrared(NIR)light from a tungsten bulb,the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to IOP.NIR light is minimally absorbed by tissue and is not perceived visually.The sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm Hg.Sensors were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white rabbits.Implanted sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.
