This paper intends to analyze the six types of English imperative sentences proposed by Chen (1984) from a perspective of causal-chain windowing. It comes to the conclusions that Talmy's causal-chain windowing app...This paper intends to analyze the six types of English imperative sentences proposed by Chen (1984) from a perspective of causal-chain windowing. It comes to the conclusions that Talmy's causal-chain windowing approach as well as the cognitive underpinnings of causal windowing and gapping is proved to be applicable in English imperative structures, and that generally speaking, the final portion of an imperative sentence is always windowed while the intermediate portions gapped.展开更多
With the marked globalization of cultural transmission and wide opening of the Chinese market, Chinese movie & TV industry faces unprecedented opportunities and challenges as well. What we face is not only the eno...With the marked globalization of cultural transmission and wide opening of the Chinese market, Chinese movie & TV industry faces unprecedented opportunities and challenges as well. What we face is not only the enormous impact of the economic form of film industry; what is more, in the field of culture, we will also face the enormous impact of"cultural imperialism". This paper focuses on the"cultural imperialism"existed in global especially American films. To counter the cultural empirical globalization of American films growing in great intensity, this paper discusses the theory of"culture rebounds"presented earliest in France. Moreover, under the influence of the theory especially in Chinese film circles, it makes research and analysis to deal with the present situation.展开更多
BACKGROUND Differential diagnosis among atypical hyperplasia(AH)(including reparative hyperplasia and intestinal metaplasia),low-grade dysplasia(LGD),high-grade dysplasia(HGD),and adenocarcinoma(AC)in gastric mucosal ...BACKGROUND Differential diagnosis among atypical hyperplasia(AH)(including reparative hyperplasia and intestinal metaplasia),low-grade dysplasia(LGD),high-grade dysplasia(HGD),and adenocarcinoma(AC)in gastric mucosal biopsies is challenging due to histomorphological overlaps,variability in pathological diagnosis consistency,and limited reproducibility.AIM To evaluate the diagnostic utility of P53,Ki67,P504S,and IMP3 in gastric cancer and its precancerous lesions,focusing on their effectiveness in distinguishing AH,LGD,HGD,and AC.METHODS From January 2018 to September 2020,a total of 185 gastric mucosal biopsy specimens were analyzed according to the pathological diagnostic criteria outlined in the World Health Organization Classification of Digestive System Tumors(2019).The specimens were categorized into four groups:AH,LGD,HGD,and AC.Immunohistochemistry was employed to assess the expression status of P53,Ki67,P504S,and IMP3.Intergroup comparisons were performed using theχ^(2)test or Fisher's exact probability test to compare the differences in immunohistochemical markers across the distinct lesion groups.RESULTS The expression rate of P504S was highest in the LGD group(53.3%,16/30),while IMP3 expression was highest in the AC group(41.9%,26/62),followed by the HGD group(33.3%).Significant differences in P504S and IMP3 expression levels were observed among the four lesion groups(P<0.001).Pairwise comparisons revealed statistically significant differences in P504S expression between the AH group and the LGD,HGD,and AC groups(P<0.001),as well as significant variations in IMP3 expression between the AH group and the HGD and AC groups,and between the LGD group and the HGD and AC groups(P<0.001).Additionally,significant correlations were found between P504S and the polarity expression pattern of Ki67,and between IMP3 and the mutation expression pattern of P53(P<0.001).The combined detection of P504S with Ki67 and IMP3 with P53 increased the diagnostic sensitivity for LGD and HGD/AC,respectively.CONCLUSION P504S is highly expressed in LGD and is associated with the Ki67“polarity”expression pattern.IMP3 is highly expressed in HGD/AC and is correlated with the P53 mutation expression pattern.The combined detection of P504S with Ki67 and IMP3 with P53 increased the diagnostic sensitivity for LGD and HGD/AC,respectively.The rational use of P504S,Ki67,IMP3,and p53 can help distinguish gastric cancer and precancerous lesions,improving the early cancer diagnosis rate.展开更多
RNA contains diverse post-transcriptional modifications,and its catabolic breakdown yields numerous modified nucleosides requiring correct processing,but the mechanisms remain unknown.Here,we demonstrate that three RN...RNA contains diverse post-transcriptional modifications,and its catabolic breakdown yields numerous modified nucleosides requiring correct processing,but the mechanisms remain unknown.Here,we demonstrate that three RNA-derived modified adenosines,N6-methyladenosine(m6A),N6,N6-dimethyladenosine(m6,6A),and N6-isopentenyladenosine(i6A),are sequentially metabolized into inosine monophosphate(IMP)to mitigate their intrinsic cytotoxicity.展开更多
China’s annual import expo continues to generate new opportunities Amid lingering challenges brought on by the COVID-19 pandemic,the Fourth China International Import Expo (CIIE),held in Shanghai from November 5 to 1...China’s annual import expo continues to generate new opportunities Amid lingering challenges brought on by the COVID-19 pandemic,the Fourth China International Import Expo (CIIE),held in Shanghai from November 5 to 10,still managed to attract global participants and saw the enduring enthusiasm of domestic buyers and traders.展开更多
There's a chink in the Caesar's armor:the salad has become too popular;and some chefs don't find it ap-peallng anymore.Once a hallmark of fine-dining es-tablishments where it was often prepared tableside,t...There's a chink in the Caesar's armor:the salad has become too popular;and some chefs don't find it ap-peallng anymore.Once a hallmark of fine-dining es-tablishments where it was often prepared tableside,the iconic mix of greens has become so wildly popular in the past 20 years that no restaura nt could open without one on the menu.展开更多
In order to address the output feedback issue for linear discrete-time systems, this work suggests a brand-new adaptive dynamic programming(ADP) technique based on the internal model principle(IMP). The proposed metho...In order to address the output feedback issue for linear discrete-time systems, this work suggests a brand-new adaptive dynamic programming(ADP) technique based on the internal model principle(IMP). The proposed method, termed as IMP-ADP, does not require complete state feedback-merely the measurement of input and output data. More specifically, based on the IMP, the output control problem can first be converted into a stabilization problem. We then design an observer to reproduce the full state of the system by measuring the inputs and outputs. Moreover, this technique includes both a policy iteration algorithm and a value iteration algorithm to determine the optimal feedback gain without using a dynamic system model. It is important that with this concept one does not need to solve the regulator equation. Finally, this control method was tested on an inverter system of grid-connected LCLs to demonstrate that the proposed method provides the desired performance in terms of both tracking and disturbance rejection.展开更多
为进一步挖掘控制水稻抗倒伏的基因,以524份水稻种质资源为材料,采用GWAS(genome-wide association analysis)鉴定与抗倒伏性状显著关联的位点qRLG7,通过基因表达水平分析和候选基因关联分析确定调控水稻抗倒伏性的候选基因,在分析候选...为进一步挖掘控制水稻抗倒伏的基因,以524份水稻种质资源为材料,采用GWAS(genome-wide association analysis)鉴定与抗倒伏性状显著关联的位点qRLG7,通过基因表达水平分析和候选基因关联分析确定调控水稻抗倒伏性的候选基因,在分析候选基因的表达特征和启动子区自然变异基础上利用CRISPR-Cas9技术构建2个候选基因的突变体家系,考察转基因材料的抗倒伏性状。结果显示,编码肌醇-1-单磷酸酶的2个串联排列基因LOC_Os07g37220和LOC_Os07g37230在离茎秆基部5 cm节间中的表达量显著高于其余候选基因,而且这2个候选基因的表达量在极端抗倒伏和易倒伏2组材料中存在极显著差异;通过候选基因关联分析发现这2个基因启动子区的SNP与离基部5 cm茎秆直径(CD5)的表型值显著关联,且基于显著关联SNP的2种单倍型的CD5表型值存在显著差异,这2个候选基因的2种单倍型启动子活性检测结果也表明2种单倍型之间存在极显著差异;2个基因的功能缺失突变体植株在基部节间抗折力、茎秆厚度、茎秆直径以及株高和穗质量等性状方面与野生型对照存在显著差异。结果表明,候选基因LOC_Os07g37220和LOC_Os07g37230具有一定的抗倒伏功能。展开更多
文摘This paper intends to analyze the six types of English imperative sentences proposed by Chen (1984) from a perspective of causal-chain windowing. It comes to the conclusions that Talmy's causal-chain windowing approach as well as the cognitive underpinnings of causal windowing and gapping is proved to be applicable in English imperative structures, and that generally speaking, the final portion of an imperative sentence is always windowed while the intermediate portions gapped.
文摘With the marked globalization of cultural transmission and wide opening of the Chinese market, Chinese movie & TV industry faces unprecedented opportunities and challenges as well. What we face is not only the enormous impact of the economic form of film industry; what is more, in the field of culture, we will also face the enormous impact of"cultural imperialism". This paper focuses on the"cultural imperialism"existed in global especially American films. To counter the cultural empirical globalization of American films growing in great intensity, this paper discusses the theory of"culture rebounds"presented earliest in France. Moreover, under the influence of the theory especially in Chinese film circles, it makes research and analysis to deal with the present situation.
基金Supported by The Science and Technology Research Project of Anyang,No.2022C01SF074。
文摘BACKGROUND Differential diagnosis among atypical hyperplasia(AH)(including reparative hyperplasia and intestinal metaplasia),low-grade dysplasia(LGD),high-grade dysplasia(HGD),and adenocarcinoma(AC)in gastric mucosal biopsies is challenging due to histomorphological overlaps,variability in pathological diagnosis consistency,and limited reproducibility.AIM To evaluate the diagnostic utility of P53,Ki67,P504S,and IMP3 in gastric cancer and its precancerous lesions,focusing on their effectiveness in distinguishing AH,LGD,HGD,and AC.METHODS From January 2018 to September 2020,a total of 185 gastric mucosal biopsy specimens were analyzed according to the pathological diagnostic criteria outlined in the World Health Organization Classification of Digestive System Tumors(2019).The specimens were categorized into four groups:AH,LGD,HGD,and AC.Immunohistochemistry was employed to assess the expression status of P53,Ki67,P504S,and IMP3.Intergroup comparisons were performed using theχ^(2)test or Fisher's exact probability test to compare the differences in immunohistochemical markers across the distinct lesion groups.RESULTS The expression rate of P504S was highest in the LGD group(53.3%,16/30),while IMP3 expression was highest in the AC group(41.9%,26/62),followed by the HGD group(33.3%).Significant differences in P504S and IMP3 expression levels were observed among the four lesion groups(P<0.001).Pairwise comparisons revealed statistically significant differences in P504S expression between the AH group and the LGD,HGD,and AC groups(P<0.001),as well as significant variations in IMP3 expression between the AH group and the HGD and AC groups,and between the LGD group and the HGD and AC groups(P<0.001).Additionally,significant correlations were found between P504S and the polarity expression pattern of Ki67,and between IMP3 and the mutation expression pattern of P53(P<0.001).The combined detection of P504S with Ki67 and IMP3 with P53 increased the diagnostic sensitivity for LGD and HGD/AC,respectively.CONCLUSION P504S is highly expressed in LGD and is associated with the Ki67“polarity”expression pattern.IMP3 is highly expressed in HGD/AC and is correlated with the P53 mutation expression pattern.The combined detection of P504S with Ki67 and IMP3 with P53 increased the diagnostic sensitivity for LGD and HGD/AC,respectively.The rational use of P504S,Ki67,IMP3,and p53 can help distinguish gastric cancer and precancerous lesions,improving the early cancer diagnosis rate.
文摘RNA contains diverse post-transcriptional modifications,and its catabolic breakdown yields numerous modified nucleosides requiring correct processing,but the mechanisms remain unknown.Here,we demonstrate that three RNA-derived modified adenosines,N6-methyladenosine(m6A),N6,N6-dimethyladenosine(m6,6A),and N6-isopentenyladenosine(i6A),are sequentially metabolized into inosine monophosphate(IMP)to mitigate their intrinsic cytotoxicity.
文摘China’s annual import expo continues to generate new opportunities Amid lingering challenges brought on by the COVID-19 pandemic,the Fourth China International Import Expo (CIIE),held in Shanghai from November 5 to 10,still managed to attract global participants and saw the enduring enthusiasm of domestic buyers and traders.
文摘There's a chink in the Caesar's armor:the salad has become too popular;and some chefs don't find it ap-peallng anymore.Once a hallmark of fine-dining es-tablishments where it was often prepared tableside,the iconic mix of greens has become so wildly popular in the past 20 years that no restaura nt could open without one on the menu.
基金supported by the National Science Fund for Distinguished Young Scholars (62225303)the Fundamental Research Funds for the Central Universities (buctrc202201)+1 种基金China Scholarship Council,and High Performance Computing PlatformCollege of Information Science and Technology,Beijing University of Chemical Technology。
文摘In order to address the output feedback issue for linear discrete-time systems, this work suggests a brand-new adaptive dynamic programming(ADP) technique based on the internal model principle(IMP). The proposed method, termed as IMP-ADP, does not require complete state feedback-merely the measurement of input and output data. More specifically, based on the IMP, the output control problem can first be converted into a stabilization problem. We then design an observer to reproduce the full state of the system by measuring the inputs and outputs. Moreover, this technique includes both a policy iteration algorithm and a value iteration algorithm to determine the optimal feedback gain without using a dynamic system model. It is important that with this concept one does not need to solve the regulator equation. Finally, this control method was tested on an inverter system of grid-connected LCLs to demonstrate that the proposed method provides the desired performance in terms of both tracking and disturbance rejection.
文摘为进一步挖掘控制水稻抗倒伏的基因,以524份水稻种质资源为材料,采用GWAS(genome-wide association analysis)鉴定与抗倒伏性状显著关联的位点qRLG7,通过基因表达水平分析和候选基因关联分析确定调控水稻抗倒伏性的候选基因,在分析候选基因的表达特征和启动子区自然变异基础上利用CRISPR-Cas9技术构建2个候选基因的突变体家系,考察转基因材料的抗倒伏性状。结果显示,编码肌醇-1-单磷酸酶的2个串联排列基因LOC_Os07g37220和LOC_Os07g37230在离茎秆基部5 cm节间中的表达量显著高于其余候选基因,而且这2个候选基因的表达量在极端抗倒伏和易倒伏2组材料中存在极显著差异;通过候选基因关联分析发现这2个基因启动子区的SNP与离基部5 cm茎秆直径(CD5)的表型值显著关联,且基于显著关联SNP的2种单倍型的CD5表型值存在显著差异,这2个候选基因的2种单倍型启动子活性检测结果也表明2种单倍型之间存在极显著差异;2个基因的功能缺失突变体植株在基部节间抗折力、茎秆厚度、茎秆直径以及株高和穗质量等性状方面与野生型对照存在显著差异。结果表明,候选基因LOC_Os07g37220和LOC_Os07g37230具有一定的抗倒伏功能。
