To the Editor:Neoadjuvant chemotherapy(NAC)significantly improves the prognosis for patients with breast cancer with internal mammary lymph node(IMN)involvement,[1]but the locoregional treatment of IMNs including IMN ...To the Editor:Neoadjuvant chemotherapy(NAC)significantly improves the prognosis for patients with breast cancer with internal mammary lymph node(IMN)involvement,[1]but the locoregional treatment of IMNs including IMN dissection(IMND)and IMN boost irradiation(IMNB)has long been debated,[2]owing to the difficulty in surgical approaches and cardiopulmonary side effects caused by high-dose radiation.[3]To date,the surgical dissection of IMNs is rarely performed;thus,the data regarding survival outcome of IMND is quite limited.In terms of radiotherapy(RT),there is marked discrepancy in radiation dose to IMNs in patients with metastatic IMN following NAC.[4]In this study,we report our institutional experience in the locoregional treatment of metastatic IMN and its impact on prognosis in patients who have undergone NAC.展开更多
基金National Natural Science Foundation of China(No.82273399)Natural Science Foundation of Guangdong Province(No.2022A1515012229)National Natural Science Foundation of China(No.82372742)
文摘To the Editor:Neoadjuvant chemotherapy(NAC)significantly improves the prognosis for patients with breast cancer with internal mammary lymph node(IMN)involvement,[1]but the locoregional treatment of IMNs including IMN dissection(IMND)and IMN boost irradiation(IMNB)has long been debated,[2]owing to the difficulty in surgical approaches and cardiopulmonary side effects caused by high-dose radiation.[3]To date,the surgical dissection of IMNs is rarely performed;thus,the data regarding survival outcome of IMND is quite limited.In terms of radiotherapy(RT),there is marked discrepancy in radiation dose to IMNs in patients with metastatic IMN following NAC.[4]In this study,we report our institutional experience in the locoregional treatment of metastatic IMN and its impact on prognosis in patients who have undergone NAC.
