To the Editor:Fibrous mediastinitis(FM)is a rare group of diseases characterized by excessive proliferation of fibrous tissue in the mediastinum,which can cause bronchial stenosis,superior vena cava(SVC)obstruction,an...To the Editor:Fibrous mediastinitis(FM)is a rare group of diseases characterized by excessive proliferation of fibrous tissue in the mediastinum,which can cause bronchial stenosis,superior vena cava(SVC)obstruction,and pulmonary artery(PA)and vein(PV)stenosis.Moreover,long-term obstruction of PAs and PVs may lead to pulmonary hypertension(PH),right heart failure(RHF),and death.[1]Although it is generally held that FM is an aberrant immunoproliferative response of the mediastinum to a triggering factor,such as infection of Mycobacterium tuberculosis and Histoplasma capsulatum,the exact etiology and pathogenesis of FM remain unclear;in particular,the genetic susceptibility of this fatal disease is unknown.展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.82070052 and U25A2001)the Tianjin high-level talent selection and training project in the health industry(No.TJSJMYXYC-D2-042)+1 种基金the Natural Science Foundation of Gansu Province of China(No.24JRRA1049)the Lanzhou Science and Technology Program of Gansu Province of China(No.LX-62000001-2022-090).
文摘To the Editor:Fibrous mediastinitis(FM)is a rare group of diseases characterized by excessive proliferation of fibrous tissue in the mediastinum,which can cause bronchial stenosis,superior vena cava(SVC)obstruction,and pulmonary artery(PA)and vein(PV)stenosis.Moreover,long-term obstruction of PAs and PVs may lead to pulmonary hypertension(PH),right heart failure(RHF),and death.[1]Although it is generally held that FM is an aberrant immunoproliferative response of the mediastinum to a triggering factor,such as infection of Mycobacterium tuberculosis and Histoplasma capsulatum,the exact etiology and pathogenesis of FM remain unclear;in particular,the genetic susceptibility of this fatal disease is unknown.
