Background:Lung cancer remains the primary cause of mortality worldwide.Methylation modifications of eukaryotic messenger RNA(mRNA),recognized as one of the most prevalent chemical alterations,significantly impact the...Background:Lung cancer remains the primary cause of mortality worldwide.Methylation modifications of eukaryotic messenger RNA(mRNA),recognized as one of the most prevalent chemical alterations,significantly impact the stability,splicing,and translation of mRNA.Methyltransferase-like 21A(METTL21A)functions as a non-histone methyltransferase.The role of methylation-related compounds in the development of cancer has garnered increasing interest in recent years.Methods:The expression levels of METTL21A were assessed in 86 lung cancer samples and 78 adjacent non-cancerous tissues from Taizhou Hospital.Gene expression data were sourced from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases.Multi-omics studies were conducted to examine the biological role of METTL21A within lung cancer.We thoroughly explored the potential functions and prognostic implications of METTL21A in this context.Results:An elevated expression of METTL21A was observed in lung cancer tissues.Furthermore,high levels of METTL21A expression correlate with various factors,including age,sex,race,tumor protein P53(TP53)mutations,cancer type,metastasis,and the pathological stage of lung cancer patients,indicating a relationship with poor prognosis.Additionally,METTL21A may affect lung cancer patient outcomes through distinct patterns of immune cell infiltration.Conclusion:METTL21A emerges as a promising candidate prognostic biomarker linked to immune invasion in lung cancer.展开更多
基金supported by the Shenzhen Municipal Government of China(No.JCYJ20180507184647104)the Natural Science Foundation of Guangdong Province(Nos.2021A1515011426,2023A1515012585)。
文摘Background:Lung cancer remains the primary cause of mortality worldwide.Methylation modifications of eukaryotic messenger RNA(mRNA),recognized as one of the most prevalent chemical alterations,significantly impact the stability,splicing,and translation of mRNA.Methyltransferase-like 21A(METTL21A)functions as a non-histone methyltransferase.The role of methylation-related compounds in the development of cancer has garnered increasing interest in recent years.Methods:The expression levels of METTL21A were assessed in 86 lung cancer samples and 78 adjacent non-cancerous tissues from Taizhou Hospital.Gene expression data were sourced from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases.Multi-omics studies were conducted to examine the biological role of METTL21A within lung cancer.We thoroughly explored the potential functions and prognostic implications of METTL21A in this context.Results:An elevated expression of METTL21A was observed in lung cancer tissues.Furthermore,high levels of METTL21A expression correlate with various factors,including age,sex,race,tumor protein P53(TP53)mutations,cancer type,metastasis,and the pathological stage of lung cancer patients,indicating a relationship with poor prognosis.Additionally,METTL21A may affect lung cancer patient outcomes through distinct patterns of immune cell infiltration.Conclusion:METTL21A emerges as a promising candidate prognostic biomarker linked to immune invasion in lung cancer.
