Immunoglobulin E(IgE)is a critical biomarker for diagnosing allergic and other immune diseases.However,traditional IgE detection methods are often time-consuming and require specialized operation.As an important bioma...Immunoglobulin E(IgE)is a critical biomarker for diagnosing allergic and other immune diseases.However,traditional IgE detection methods are often time-consuming and require specialized operation.As an important biomarker,researchers have used different strategies and explored various materials for designing IgE biosensors with highly sensitivity,specificity and cost-effectiveness.In this review,we comprehensively summarize recent advances in biosensing technologies for IgE detection,categorizing them into optical,electrochemical,and piezoelectric biosensors.It elaborates on the design principles,performance metrics,and comparative advantages of various platforms,such as surface plasmon resonance(SPR),fluorescence,electrochemical impedance spectroscopy(EIS),and quartz crystal microbalance(QCM).The integration of novel materials like aptamers and nanomaterials has significantly enhanced the performance of these biosensors.Biosensors present a promising alternative for rapid,sensitive,and efficient IgE detection,holding great potential for future clinical diagnostics and point-of-care testing applications.Future perspectives should highlight the discovery of novel materials,the application of artificial intelligence for aptamer development,and the synergy of optoelectronic sensing strategies to improve analytical performance for clinical diagnostics.展开更多
文摘Immunoglobulin E(IgE)is a critical biomarker for diagnosing allergic and other immune diseases.However,traditional IgE detection methods are often time-consuming and require specialized operation.As an important biomarker,researchers have used different strategies and explored various materials for designing IgE biosensors with highly sensitivity,specificity and cost-effectiveness.In this review,we comprehensively summarize recent advances in biosensing technologies for IgE detection,categorizing them into optical,electrochemical,and piezoelectric biosensors.It elaborates on the design principles,performance metrics,and comparative advantages of various platforms,such as surface plasmon resonance(SPR),fluorescence,electrochemical impedance spectroscopy(EIS),and quartz crystal microbalance(QCM).The integration of novel materials like aptamers and nanomaterials has significantly enhanced the performance of these biosensors.Biosensors present a promising alternative for rapid,sensitive,and efficient IgE detection,holding great potential for future clinical diagnostics and point-of-care testing applications.Future perspectives should highlight the discovery of novel materials,the application of artificial intelligence for aptamer development,and the synergy of optoelectronic sensing strategies to improve analytical performance for clinical diagnostics.
