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Role of liver transplantation in human immunodeficiency virus positive patients
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作者 Deepak Joshi Kosh Agarwal 《World Journal of Gastroenterology》 SCIE CAS 2015年第43期12311-12321,共11页
End-stage liver disease(ESLD) is a leading cause of morbidity and mortality amongst human immunodeficiency virus(HIV)-positive individuals. Chronic hepatitis B and hepatitis C virus(HCV) infection,drug-induced hepatot... End-stage liver disease(ESLD) is a leading cause of morbidity and mortality amongst human immunodeficiency virus(HIV)-positive individuals. Chronic hepatitis B and hepatitis C virus(HCV) infection,drug-induced hepatotoxicity related to combined antiretro-viral therapy,alcohol related liver disease and non-alcohol related fatty liver disease appear to be the leading causes. It is therefore,anticipated that more HIV-positive patients with ESLD will present as potential transplant candidates. HIV infection is no longer a contraindication to liver transplantation. Key transplantation outcomes such as rejection and infection rates as well as medium term graft and patient survival match those seen in the non-HIV infected patients in the absence of co-existing HCV infection. HIV disease does not seem to be negatively impacted by transplantation. However,HIV-HCV coinfection transplant outcomes remain suboptimal due to recurrence. In this article,we review the key challenges faced by this patient cohort in the pre- and posttransplant period. 展开更多
关键词 HEPATITIS B VIRUS HEPATITIS C VIRUS HUMAN immunode
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Proteinuria in paediatric patients with human immunodefi ciency virus infection 被引量:1
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作者 Vania Giacomet Paola Erba +3 位作者 Francesca Di Nello Sonia Coletto Alessandra Viganò Gian Vincenzo Zuccotti 《World Journal of Clinical Cases》 SCIE 2013年第1期13-18,共6页
In human immunodef iciency virus(HIV)-infected people kidney disease is as an important cause of morbidity and mortality. Clinical features of kidney damage in HIV-infected patients range from asymptomatic microalbumi... In human immunodef iciency virus(HIV)-infected people kidney disease is as an important cause of morbidity and mortality. Clinical features of kidney damage in HIV-infected patients range from asymptomatic microalbuminuria to nephrotic syndrome. The lack of specif ic clinical features despite the presence of heavy proteinuria may mask the renal involvement. Indeed, it is important in HIV patients to monitor renal function to early discover a possible kidney injury. After the introduction of antiretroviral therapy, mortality and morbidity associated to HIV-infection have shown a substantial reduction, although a variety of side effects for longterm use of highly active antiretroviral therapy, including renal toxicity, has emerged. Among more than 20 currently available antiretroviral agents, many of them can occasionally cause reversible or irreversible nephrotoxicity. At now, three antiretroviral agents, i.e., indinavir, atazanavir and tenofovir disoproxil fumarate have a well established association with direct nephrotoxicity. This review focuses on major causes of proteinuria and other pathological f indings related to kidney disease in HIV-infected children and adolescents. 展开更多
关键词 HUMAN immunodeFIciency virus-infection NEPHROPATHY PROTEINURIA ANTIRETROVIRAL therapy Children
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Clinical characteristics of acute adrenal insuffi ciency in emergency patients: an analysis of data in Lhasa, Xizang Autonomous Region of China
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作者 Guiying Dong Jianbo Yu +6 位作者 Lobsang Chodron Tenzin Chodron Peiliang Gao Xueying Fu Jihong Zhu Zhenzhong Yang Lobsang Cering 《World Journal of Emergency Medicine》 2025年第5期481-485,共5页
BACKGROUND:The nonspecifi c clinical presentation of adrenal insuffi ciency(AI)frequently leads to misdiagnosis,often as psychiatric or gastrointestinal disorders.AI is classifi ed anatomically as primary AI(PAI),seco... BACKGROUND:The nonspecifi c clinical presentation of adrenal insuffi ciency(AI)frequently leads to misdiagnosis,often as psychiatric or gastrointestinal disorders.AI is classifi ed anatomically as primary AI(PAI),secondary AI(SAI),or tertiary AI(TAI).Without timely recognition,progression to adrenal crisis(AC)can result in life-threatening outcomes.This study aimed to systematically analyze the clinical features,etiologies,and outcomes of AI in Lhasa’s emergency population to improve diagnostic accuracy and optimize clinical management.METHODS:A retrospective analysis of emergency department admissions from January 2020 to August 2024 at People’s Hospital of Xizang Autonomous Region was conducted.AI diagnoses were identifi ed via International Classifi cation of Diseases,Tenth Revision,Clinical Modifi cation(ICD-10-CM)codes from electronic health records(EHR).Patients were grouped into incipient AC(IAC)or AC cohorts based on hemodynamic status.Demographic profi les,etiologies,clinical presentations,and laboratory results were analyzed.RESULTS:Forty-three AI patients were identifi ed.The population-standardized admission rate for AI increased from 9 to 16 per million person-years,with PAI cases doubling during this period.Adrenal tuberculosis(58.1%)and adrenal hematoma(18.6%)were the leading etiologies.Compared to the IAC group,the AC group demonstrated lower systolic blood pressure(SBP)(P=0.001)and diastolic blood pressure(DBP)(P<0.001);higher neutrophil count(P=0.048),eosinophil count(P=0.044),CRP(P=0.004),blood urea nitrogen(BUN)(P=0.007);lower sodium(P<0.001)and glucose levels(P=0.001).The hospital stay was longer in the AC group(20 d vs.14 d;P<0.001).CONCLUSION:AI incidence is rising in high-altitude regions,with adrenal tuberculosis remaining the most common cause.AC is associated with increased inflammatory responses,hemodynamic instability,and metabolic disturbances.Targeted interventions are required to improve outcomes. 展开更多
关键词 Adrenal insuffi ciency Adrenal crisis EMERGENCY
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Comparative Analysis of Golden Gate and ClassicalCloning Techniques in E.coli:A Study in Molecular Cloning Efficiency
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作者 Ziyao Liu 《Asia Pacific Journal of Clinical Medical Research》 2025年第2期29-38,共10页
Molecular cloning remains a cornerstone technique in genetic engineering and synthetic biology.In this study,we conducted a systematic comparative analysis between the classical cloning method and the Golden Gate asse... Molecular cloning remains a cornerstone technique in genetic engineering and synthetic biology.In this study,we conducted a systematic comparative analysis between the classical cloning method and the Golden Gate assembly technique,utilizing Escherichia coli as the model organism.Through polymerase chain reaction(PCR)amplification,restriction enzyme digestion,ligation,transformation,and Sanger sequencing,we assessed the operational efficiency and cloning fidelity of both strategies.Our results demonstrated that Golden Gate assembly,leveraging type IIS restriction enzymes and simultaneous ligation,significantly enhanced cloning efficiency and precision,particularly for seamless multi-fragment assembly.In contrast,the classical cloning approach maintained certain advantages in simplicity and robustness for specific experimental conditions.Challenges encountered during transformation and sequencing highlighted the critical impact of technical accuracy on experimental outcomes.This study underscores the importance of selecting appropriate cloning methodologies tailored to experimental objectives and laboratory capabilities,providing a foundation for optimized molecular cloning workflows in future synthetic biology and biotechnology applications. 展开更多
关键词 Golden Gate Assembly Classical Cloning Escherichia Coli Molecular Cloning DNA Assembly Recombinant DNA Technology Transformation Effi ciency Synthetic Biology
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血常规衍生炎症指标联合TyG对类风湿性关节炎患者动脉粥样硬化的预测价值
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作者 欧洪菊 赵晓姬 +3 位作者 马燕 王军文 刘春兰 刘兴国 《转化医学杂志》 2026年第1期89-94,共6页
目的探讨血常规衍生炎症指标联合三酰甘油葡萄糖乘积指数(TyG)对类风湿性关节炎患者动脉粥样硬化的预测价值。方法选取2019年2月至2024年2月于江油市人民医院接受治疗的类风湿性关节炎患者208例,根据是否发生动脉粥样硬化分为动脉粥样... 目的探讨血常规衍生炎症指标联合三酰甘油葡萄糖乘积指数(TyG)对类风湿性关节炎患者动脉粥样硬化的预测价值。方法选取2019年2月至2024年2月于江油市人民医院接受治疗的类风湿性关节炎患者208例,根据是否发生动脉粥样硬化分为动脉粥样硬化组(68例)和非动脉粥样硬化组(140例)。比较两组一般资料和血常规衍生炎症指标[中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、单核细胞与淋巴细胞比值(MLR)、系统性免疫炎症指数(SII)]、TyG;采用多因素Logistic回归分析类风湿性关节炎患者发生动脉粥样硬化的影响因素;采用ROC曲线分析NLR、PLR、MLR、SII及TyG对类风湿性关节炎患者动脉粥样硬化的预测价值。结果两组年龄、性别、身体质量指数、类风湿性关节炎病程、类风湿性关节炎严重程度、受教育程度、吸烟、饮酒比例比较,差异无统计学意义(P>0.05)。动脉粥样硬化组NLR、PLR、MLR、SII及TyG高于非动脉粥样硬化组(P<0.05)。多因素Logistic回归分析显示,高NLR、PLR、MLR、SII及TyG水平是类风湿性关节炎患者发生动脉粥样硬化的独立危险因素(OR=2.535,95%CI:1.412~4.549,P=0.002;OR=1.020,95%CI:1.009~1.031,P<0.001;OR=1.742,95%CI:1.159~2.619,P=0.008;OR=1.112,95%CI:1.046~1.181,P=0.001;OR=1.232,95%CI:1.030~1.474,P=0.023)。ROC曲线分析显示,NLR、PLR、MLR、SII及TyG联合预测类风湿性关节炎患者发生动脉粥样硬化的AUC为0.836,优于各指标单独预测(Z=4.266、4.063、4.399、3.936、5.055,P<0.05)。结论NLR、PLR、MLR、SII和TyG对类风湿性关节炎患者动脉粥样硬化具有一定的预测价值,且各指标联合测定可提升预测价值。 展开更多
关键词 类风湿性关节炎 动脉粥样硬化 中性粒细胞与淋巴细胞比值 三酰甘油葡萄糖乘积指数 预测价值
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华式变电站结构特点及试验的研究
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作者 魏秀秀 王显磊 孔得永 《中国标准化》 2026年第2期174-177,共4页
华式变电站作为一种灵活、可靠和新型的紧凑型预装式变电站,随着新能源的快速发展,逐渐发展应用起来。本篇通过对华式变电站结构组成,高压室、变压器本体、低压室、箱体、联锁、接地和不间断电源的一一解析,以及对华式变电站特点的介绍... 华式变电站作为一种灵活、可靠和新型的紧凑型预装式变电站,随着新能源的快速发展,逐渐发展应用起来。本篇通过对华式变电站结构组成,高压室、变压器本体、低压室、箱体、联锁、接地和不间断电源的一一解析,以及对华式变电站特点的介绍,结合华式变电站与欧式变电站型式试验预装式变电站声级的验证和温升试验的差异分析,详尽介绍了华式变电站这种新型预装式变电站的结构特点,为了解、学习和研究华式变电站提供了理论基础。 展开更多
关键词 华式变电站 变压器 新能源 能源效率
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Risk factors and predictive model of adrenocortical insuffi ciency in patients with traumatic brain injury 被引量:11
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作者 Gui-long Feng Miao-miao Zheng +6 位作者 Shi-hong Yao Yin-qi Li Shao-jun Zhang Wei-jing Wen Kai Fan Jia-li Zhang Xiao Zhang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2021年第3期179-184,共6页
BACKGROUND:Neuroendocrine dysfunction after traumatic brain injury(TBI)has received increased attention due to its impact on the recovery of neural function.The purpose of this study is to investigate the incidence an... BACKGROUND:Neuroendocrine dysfunction after traumatic brain injury(TBI)has received increased attention due to its impact on the recovery of neural function.The purpose of this study is to investigate the incidence and risk factors of adrenocortical insuffi ciency(AI)after TBI to reveal independent predictors and build a prediction model of AI after TBI.METHODS:Enrolled patients were grouped into the AI and non-AI groups.Fourteen preset impact factors were recorded.Patients were regrouped according to each impact factor as a categorical variable.Univariate and multiple logistic regression analyses were performed to screen the related independent risk factors of AI after TBI and develop the predictive model.RESULTS:A total of 108 patients were recruited,of whom 34(31.5%)patients had AI.Nine factors(age,Glasgow Coma Scale[GCS]score on admission,mean arterial pressure[MAP],urinary volume,serum sodium level,cerebral hernia,frontal lobe contusion,diff use axonal injury[DAI],and skull base fracture)were probably related to AI after TBI.Three factors(urinary volume[X4],serum sodium level[X5],and DAI[X8])were independent variables,based on which a prediction model was developed(logit P=-3.552+2.583X4+2.235X5+2.269X8).CONCLUSIONS:The incidence of AI after TBI is high.Factors such as age,GCS score,MAP,urinary volume,serum sodium level,cerebral hernia,frontal lobe contusion,DAI,and skull base fracture are probably related to AI after TBI.Urinary volume,serum sodium level,and DAI are the independent predictors of AI after TBI. 展开更多
关键词 Adrenocortical insuffi ciency Risk factor PREDICTOR Traumatic brain injury
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Effect of sedation on short-term and long-term outcomes of critically ill patients with acute respiratory insufficiency 被引量:7
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作者 Xue-zhong Xing Yong Gao +6 位作者 Hai-jun Wang Shi-ning Qu Chu-lin Huang Hao Zhang Hao Wang Qing-ling Xiao Ke-lin Sun 《World Journal of Emergency Medicine》 CAS 2015年第2期147-152,共6页
BACKGROUND: The present study aimed to determine the short-term and long-term outcomes of critically ill patients with acute respiratory insuffi ciency who had received sedation or no sedation.METHODS: The data of 91 ... BACKGROUND: The present study aimed to determine the short-term and long-term outcomes of critically ill patients with acute respiratory insuffi ciency who had received sedation or no sedation.METHODS: The data of 91 patients who had received mechanical ventilation in the first 24 hours between November 2008 and October 2009 were retrospectively analyzed. These patients were divided into two groups: a sedation group(n=28) and a non-sedation group(n=63). The patients were also grouped in two groups: deep sedation group and daily interruption and /or light sedation group.RESULTS: Overall, the 91 patients who had received ventilation ≥48 hours were analyzed. Multivariate analysis demonstrated two independent risk factors for in-hospital death: sequential organ failure assessment score(P=0.019, RR 1.355, 95%CI 1.051–1.747, B=0.304, SE=0.130, Wald=50483) and sedation(P=0.041, RR 5.015, 95%CI 1.072–23.459, B=1.612, SE=0.787, Wald=4.195). Compared with the patients who had received no sedation, those who had received sedation had a longer duration of ventilation, a longer stay in intensive care unit and hospital, and an increased in-hospital mortality rate. The Kaplan-Meier method showed that patients who had received sedation had a lower 60-month survival rate than those who had received no sedation(76.7% vs. 88.9%, Log-rank test=3.630, P=0.057). Compared with the patients who had received deep sedation, those who had received daily interruption or light sedation showed a decreased in-hospital mortality rate(57.1% vs. 9.5%, P=0.008). The 60-month survival of the patients who had received deep sedation was signifi cantly lower than that of those who had daily interruption or light sedation(38.1% vs. 90.5%, Log-rank test=6.783, P=0.009).CONCLUSIONS: Sedation was associated with in-hospital death. The patients who had received sedation had a longer duration of ventilation, a longer stay in intensive care unit and in hospital, and an increased in-hospital mortality rate compared with the patients who did not receive sedation. Compared with daily interruption or light sedation, deep sedation increased the in-hospital mortality and decreased the 60-month survival for patients who had received sedation. 展开更多
关键词 SEDATION Respiratory insuffi ciency PROGNOSIS Critical illness
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Measuring effi ciency of listed tourism companies in China
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作者 SUN Yuan-yuan 《Ecological Economy》 2015年第1期72-80,共9页
This study seeks to evaluate the comparative productivity of 32 listed tourism companies which are the main suppliers of China tourism, using the popular methodology known as the data envelopment analysis(DEA). This s... This study seeks to evaluate the comparative productivity of 32 listed tourism companies which are the main suppliers of China tourism, using the popular methodology known as the data envelopment analysis(DEA). This study analyzes the productivity of listed tourism companies from business and region aspects based on the calculation of Malmquist index. The results show that(1) the overall productivity is non-effi cient(0.954);(2) the productivity of accommodation and catering is biggest, which shows the tourism develops quickly with supports from technology;(3) the productivity in western China is highest, where the economy and tourism attraction are better than other regions; and(4) the effi ciency differences among the listed tourism companies are not signifi cant, and they attribute to the scale effi-ciency, that is the input of the fi nance, resource, talents and policy. 展开更多
关键词 LISTED TOURISM COMPANIES OPERATIONAL effi ciency MALMQUIST index DEA China
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Smart Nutrient Deficiency Prediction System for Groundnut Leaf
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作者 Janani Malaisamy JebakumarRethnaraj 《Intelligent Automation & Soft Computing》 SCIE 2023年第5期1845-1862,共18页
Prediction of the nutrient deficiency range and control of it through application of an appropriate amount of fertiliser at all growth stages is critical to achieving a qualitative and quantitative yield.Distributing f... Prediction of the nutrient deficiency range and control of it through application of an appropriate amount of fertiliser at all growth stages is critical to achieving a qualitative and quantitative yield.Distributing fertiliser in optimum amounts will protect the environment’s condition and human health risks.Early identification also prevents the disease’s occurrence in groundnut crops.A convo-lutional neural network is a computer vision algorithm that can be replaced in the place of human experts and laboratory methods to predict groundnut crop nitro-gen nutrient deficiency through image features.Since chlorophyll and nitrogen are proportionate to one another,the Smart Nutrient Deficiency Prediction System(SNDP)is proposed to detect and categorise the chlorophyll concentration range via which nitrogen concentration can be known.The model’sfirst part is to per-form preprocessing using Groundnut Leaf Image Preprocessing(GLIP).Then,in the second part,feature extraction using a convolution process with Non-negative ReLU(CNNR)is done,and then,in the third part,the extracted features areflat-tened and given to the dense layer(DL)layer.Next,the Maximum Margin clas-sifier(MMC)is deployed and takes the input from DL for the classification process tofind CCR.The dataset used in this work has no visible symptoms of a deficiency with three categories:low level(LL),beginning stage of low level(BSLL),and appropriate level(AL).This model could help to predict nitrogen deficiency before perceivable symptoms.The performance of the implemented model is analysed and compared with ImageNet pre-trained models.The result shows that the CNNR-MMC model obtained the highest training and validation accuracy of 99%and 95%,respectively,compared to existing pre-trained models. 展开更多
关键词 CNN CHLOROPHYLL groundnut crop deep learning nitrogen deficiency
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Input-output Efficiency of Elements of Urban Construction Land in Beijing: Empirical Analysis Based on Panel Data of Jurisdiction
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作者 GU Yuekun 《Journal of Landscape Research》 2020年第2期49-53,56,共6页
Based on the Data Envelopment Analysis method,and by using CCR and BCC model,Super Efficiency model and Malmquist model guided by input efficiency,the input-output efficiency of elements of urban construction land in ... Based on the Data Envelopment Analysis method,and by using CCR and BCC model,Super Efficiency model and Malmquist model guided by input efficiency,the input-output efficiency of elements of urban construction land in different jurisdictions of Beijing from 2005 to 2015 was studied.The results showed that there were obvious differences between input-output efficiency of elements of urban construction land in different jurisdictions of Beijing,among which the efficiency of the core area of capital,Yanqing District,Fangshan District and Huairou District was relatively high,while the efficiency of Daxing District,Fengtai District and Miyun District was relatively low.There was no obvious correlation between efficiency differentiation and location factors,which is mainly caused by whether the land use in each jurisdiction has scale effect,whether the technology is improved,whether the input is redundant and whether the output is insufficient.For the jurisdiction of inefficient land use,we should strengthen the consciousness of intensive land use,improve the technical level,appropriately reduce the redundancy of input elements,and pay attention to the output of social and ecological benefits. 展开更多
关键词 Data Envelopment Analysis Urban construction LAND Input and OUTPUT Effi ciency
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Artificial Intelligence for Maximizing Agricultural Input Use Efficiency: Exploring Nutrient, Water and Weed Management Strategies
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作者 Sumit Sow Shivani Ranjan +8 位作者 Mahmoud F.Seleiman Hiba M.Alkharabsheh Mukesh Kumar Navnit Kumar Smruti Ranjan Padhan Dhirendra Kumar Roy Dibyajyoti Nath Harun Gitari Daniel O.Wasonga 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第7期1569-1598,共30页
Agriculture plays a crucial role in the economy,and there is an increasing global emphasis on automating agri-cultural processes.With the tremendous increase in population,the demand for food and employment has also i... Agriculture plays a crucial role in the economy,and there is an increasing global emphasis on automating agri-cultural processes.With the tremendous increase in population,the demand for food and employment has also increased significantly.Agricultural methods traditionally used to meet these requirements are no longer ade-quate,requiring solutions to issues such as excessive herbicide use and the use of chemical fertilizers.Integration of technologies such as the Internet of Things,wireless communication,machine learning,artificial intelligence(AI),and deep learning shows promise in addressing these challenges.However,there is a lack of comprehensive documentation on the application and potential of AI in improving agricultural input efficiency.To address this gap,a desk research approach was used by utilizing peer-reviewed electronic databases like PubMed,Scopus,Goo-gle Scholar,Web of Science,and Science Direct for relevant articles.Out of 327 initially identified articles,180 were deemed pertinent,focusing primarily on AI’s potential in enhancing yield through better management of nutrients,water,and weeds.Taking into account researchfindings worldwide,we found that AI technologies could assist farmers by providing recommendations on the optimal nutrients to enhance soil quality and deter-mine the best time for irrigation or herbicide application.The present status of AI-driven automation in agricul-ture holds significant promise for optimizing agricultural input utilization and reducing resource waste,particularly in the context of three pillars of crop management,i.e.,nutrient,irrigation,and weed management. 展开更多
关键词 Agriculture artificial intelligence crop management NUTRIENT IRRIGATION weed management resource use efficiency
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一种农杆菌介导的糜子高效遗传转化方法
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作者 夏启玉 降彦苗 +5 位作者 刘亚男 李海权 程汝宏 郭安平 刘国庆 赵辉 《热带作物学报》 北大核心 2025年第1期44-50,共7页
糜子(Panicum miliaceum L.)是我国传统的粮食作物,截至目前,针对糜子遗传转化方法的研究仍较少,本研究旨在建立农杆菌介导的糜子高效遗传转化方法。以糜子品种冀黍5号的成熟种子为外植体,在CIM和MSD诱导培养基上分别诱导糜子的胚性愈伤... 糜子(Panicum miliaceum L.)是我国传统的粮食作物,截至目前,针对糜子遗传转化方法的研究仍较少,本研究旨在建立农杆菌介导的糜子高效遗传转化方法。以糜子品种冀黍5号的成熟种子为外植体,在CIM和MSD诱导培养基上分别诱导糜子的胚性愈伤,以其作为转化受体材料,用含植物表达载体的农杆菌侵染60min并共培养6d,转接至含0.025g/L潮霉素的筛选培养基上筛选出抗性愈伤,接着在含0.015g/L潮霉素的分化培养基上分化,最后在含0.015g/L潮霉素的生根培养基上生根成苗,用载体特异性引物对再生植株进行PCR检测,鉴定其是否为阳性转基因植株。根据多个批次的转化实验统计糜子的抗性再生植株的筛选效率和转化效率。结果表明:CIM和MSD诱导培养基均能诱导出糜子胚性愈伤,但CIM培养基诱导的糜子胚性愈伤效果更好;糜子胚性愈伤在被农杆菌侵染及与农杆菌共培养后,经在含潮霉素的培养基上筛选、分化和生根后获得多株抗性再生糜子植株,3次试验获得的糜子抗性再生植株的PCR鉴定阳性率为100%,平均转化效率为30%以上。本研究成功建立了农杆菌介导的糜子遗传转化方法,操作简单,转化效率高,成本低廉,且转化不受季节限制,能规模化开展,为糜子的遗传改良提供有效的技术手段。 展开更多
关键词 糜子 农杆菌 遗传转化 转化效率
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基于“阴火理论”探析肠道菌群与郁证性干眼的相关性 被引量:1
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作者 许洁 李萍 刘昳 《中国中医眼科杂志》 2025年第6期540-544,563,共6页
本文以脾胃学说为基础,从“阴火理论”探析肠道菌群与郁证性干眼的相关性。干眼是一种常见的眼表病症,病情缠绵难愈,严重影响患者的日常生活,继而危害患者的身心健康。根据临床研究发现,干眼患者多伴有焦虑症或抑郁状态,其中肝郁脾虚型... 本文以脾胃学说为基础,从“阴火理论”探析肠道菌群与郁证性干眼的相关性。干眼是一种常见的眼表病症,病情缠绵难愈,严重影响患者的日常生活,继而危害患者的身心健康。根据临床研究发现,干眼患者多伴有焦虑症或抑郁状态,其中肝郁脾虚型最为多见。而郁证性干眼是指伴焦虑或抑郁状态的干眼,以肝郁脾虚型干眼为主。本文将干眼与郁证相结合,运用“阴火理论”探析现代郁证性干眼的疾病机理。现代研究表明肠道菌群是肝郁脾虚证候生理学基础的内涵。将“阴火理论”作为肠道菌群与郁证性干眼联系的桥梁,完善基于“阴火理论”探析肠道菌群在郁证性干眼中的相关性,利用“阴火理论”从养血健脾以散阴火、疏肝解郁以散郁火对郁证性干眼患者因人施治,进一步完善脾胃学说在干眼诊治方面的应用。 展开更多
关键词 郁证性干眼 肝郁脾虚型干眼 阴火理论 肠道菌群
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基于正交试验的井下气液分离器结构优化设计
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作者 练章华 安南 +2 位作者 赵朝阳 于浩 孙辉 《石油机械》 北大核心 2025年第9期96-103,共8页
针对高含气井(30%~50%)开采过程中井下螺旋式气液分离器分离效率低的问题,基于气液两相流动理论,采用数值模拟方法建立了常规井下气液分离器有限元模型。根据某油田实际高含气工况,开展了不同叶轮参数(螺距、外径、圈数)下分离器液相体... 针对高含气井(30%~50%)开采过程中井下螺旋式气液分离器分离效率低的问题,基于气液两相流动理论,采用数值模拟方法建立了常规井下气液分离器有限元模型。根据某油田实际高含气工况,开展了不同叶轮参数(螺距、外径、圈数)下分离器液相体积分数分布、气液两相压力和速度、分离效率敏感性分析,并依据叶轮参数正交试验优化结果,提出了新型双级井下气液分离器。研究结果表明:对于常规井下气液分离器,增大叶轮外径,分离效率呈现上升趋势;增大叶轮螺距和叶轮圈数,分离器分离效率先升高后降低。新型双级井下气液分离器总长为1 252 mm,结构采用双级叶轮组合方式,上叶轮为螺旋增压轮,螺距为158.22 mm,圈数为2.25,外径为99.06 mm;下叶轮为螺旋分离轮,采用4叶轮设计,螺距为178.22 mm,圈数为2.75,外径为89.06 mm;过渡分离轮外径采用渐变设计。优化后的分离效率由78.5%提高至86.2%,提升了9.8%。研究方法和结果可为高含气井井下气液分离器的参数优化和设计提供参考。 展开更多
关键词 高含气井 气液分离器 数值模拟 敏感性分析 分离效率 正交试验
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非环境政策工具对制造业企业绿色转型的影响——基于“营改增”政策试点的准自然实验
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作者 张谛 徐翘楚 杨晗硕 《南开经济研究》 北大核心 2025年第6期229-248,共20页
加快制造业企业绿色转型是实现我国经济高质量发展的关键环节。本文基于全国税收调查数据,首次在全规模企业层面测度碳排放,并利用连续型双重差分模型研究了营改增政策作为非环境政策工具对制造业企业碳排放强度的影响。研究发现,营改... 加快制造业企业绿色转型是实现我国经济高质量发展的关键环节。本文基于全国税收调查数据,首次在全规模企业层面测度碳排放,并利用连续型双重差分模型研究了营改增政策作为非环境政策工具对制造业企业碳排放强度的影响。研究发现,营改增政策显著降低了制造业企业的碳排放强度,其影响通过两条机制传导:一方面,通过增值税抵扣机制释放企业现金流、促进绿色技术投入与清洁能源使用,从而提升能源使用效率;另一方面,通过完善抵扣链条推动企业间的专业化分工,形成规模效应,间接降低碳排放水平。进一步分析发现,该政策的绿色效应依赖于地方环境规制的强度,并在国有企业及高污染企业中更为显著。本文为识别非环境政策的绿色溢出效应提供了理论分析框架与经验证据,丰富了绿色转型的政策工具视角。 展开更多
关键词 “营改增”政策 企业碳排放强度 能源使用效率 专业化分工
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多目标协同视角下东北地区农户耕地经营规模与耕地利用效率的关系 被引量:2
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作者 宁嘉晨 张平宇 +2 位作者 杨奇峰 马佐澎 初楠臣 《地理科学》 北大核心 2025年第4期744-755,共12页
基于经济效益、社会效益、生态效益的多目标协同视角,以2010—2021年东北地区的地级行政区为样本单元,测算农户耕地经营规模和耕地利用效率,分析其演变特征和区域差异;进而通过回归分析探索东北地区农户耕地经营规模与耕地利用效率的关... 基于经济效益、社会效益、生态效益的多目标协同视角,以2010—2021年东北地区的地级行政区为样本单元,测算农户耕地经营规模和耕地利用效率,分析其演变特征和区域差异;进而通过回归分析探索东北地区农户耕地经营规模与耕地利用效率的关系,计算现阶段东北地区农户耕地经营的适度规模。结果表明:(1)2010—2021年东北地区的农户耕地经营规模和耕地利用效率均有所上升,其中黑龙江省的农户耕地经营规模较大、耕地利用效率较高,辽宁省的农户耕地经营规模较小,吉林省和蒙东地区的耕地利用效率较低。(2)在此期间,东北地区农户耕地经营规模和耕地利用效率的区域差异扩大、离散性增强,规模较小和效率较低的地区仍占据较大比例,农户耕地经营规模的两极分化现象逐渐明显,耕地利用效率的两极分化得到缓解。(3)东北地区农户耕地经营规模与耕地利用效率之间具有显著的倒“U”型关系,当农户耕地经营规模处于较低水平时,其增长对耕地利用效率具有促进作用;然而在达到一定程度后,农户耕地经营规模对耕地利用效率的影响由正变负。(4)现阶段东北地区农户耕地经营适度规模,在不考虑区域之间相互联系的前提下为11.61~11.95 hm^(2),考虑区域之间的相互联系则为10.04~10.10 hm^(2)。 展开更多
关键词 农户耕地经营规模 耕地利用效率 倒“U”型关系 东北地区
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基于毫米波大规模MIMO的共享型阵列混合波束成形算法
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作者 李光远 付辉 +3 位作者 张凯 韩芳 徐顺清 孟溪 《高技术通讯》 北大核心 2025年第2期175-182,共8页
考虑到毫米波大规模多输入输出(multiple input multiple output,MIMO)系统中传统的全数字波束成形算法能耗较高、成本较大且模拟预编码算法性能较差,提出了一种共享型阵列的混合波束成形算法。首先通过信道矩阵的奇异值分解,提取它们... 考虑到毫米波大规模多输入输出(multiple input multiple output,MIMO)系统中传统的全数字波束成形算法能耗较高、成本较大且模拟预编码算法性能较差,提出了一种共享型阵列的混合波束成形算法。首先通过信道矩阵的奇异值分解,提取它们的相位信息作为模拟预编码和模拟合成矩阵,然后将得到的模拟预编码和模拟合成矩阵与信道矩阵一起作为等效信道矩阵,再次进行奇异值分解,即可得到相应的数字预编码矩阵和数字合成矩阵。仿真结果表明,本文所提混合波束成形算法,当射频链路数与数据流数配置相等时,其频谱效率和能效都要明显优于传统的混合波束成形算法,且在工程上易于实现。 展开更多
关键词 大规模多输入输出 毫米波 波束成形 频谱效率
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热敏灸结合补中益气汤治疗过敏性鼻炎肺脾气虚证的临床疗效观察 被引量:1
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作者 徐海燕 张琳 +2 位作者 徐敏 朱道成 许巍 《中华养生保健》 2025年第6期19-22,共4页
目的与常规西药对比,观察热敏灸结合补中益气汤治疗过敏性鼻炎肺脾气虚证患者的临床疗效。方法选择2022年10月—2023年10月江西中医药大学附属医院热敏灸科门诊收治的过敏性鼻炎患者60例作为研究对象,采用随机数表法将所有患者分为试验... 目的与常规西药对比,观察热敏灸结合补中益气汤治疗过敏性鼻炎肺脾气虚证患者的临床疗效。方法选择2022年10月—2023年10月江西中医药大学附属医院热敏灸科门诊收治的过敏性鼻炎患者60例作为研究对象,采用随机数表法将所有患者分为试验组与对照组,各30例。试验组采用热敏灸结合补中益气汤治疗,对照组采用常规抗过敏药氯雷他定治疗。两组均治疗1次/d,5次/周,10次为1疗程,治疗2个疗程后分别评估鼻症状总分(TNSS)、鼻炎伴随症状总分(TNNSS)、鼻-结膜炎生存质量量表(RQLQ)及临床疗效。结果干预前,两组的年龄、性别、TNSS评分、RQLQ评分以及TNNSS评分比较,差异无统计学意义(P>0.05)。干预后,试验组在改善患者TNSS评分、TNNSS评分、RQLQ评分方面优于对照组,差异有统计学意义(P<0.05)。试验组总有效率高于对照组,差异有统计学意义(P<0.05)。结论热敏灸结合补中益气汤治疗过敏性鼻炎肺脾气虚证患者,比常规抗过敏药氯雷他定治疗临床效果更佳。 展开更多
关键词 热敏灸 补中气益汤 过敏性鼻炎 肺脾气虚证 疗效
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