Both animals and plants employ nucleotide-binding leucinerich repeat receptors(NLRs)to perceive pathogens and activate immunity.Typical plant NLRs are categorized into three major groups:Toll and interleukin-1 recepto...Both animals and plants employ nucleotide-binding leucinerich repeat receptors(NLRs)to perceive pathogens and activate immunity.Typical plant NLRs are categorized into three major groups:Toll and interleukin-1 receptor(TIR)type NLRs(TNLs),coiled-coil(CC)type NLRs(CNLs),and RPW8-like CC domain containing NLRs(RNLs)[1,2].Notably,full-length TNLs are absent in monocots,but TIR-only or atypical TIR-containing proteins can be found in monocots[2].Plant TNLs or TIR-only proteins were shown to possess NADase(nicotinamide adenine dinucleotide hydrolase)activity[3,4].Upon sensing pathogen effectors,TNLs such as recognition of XopQ1(ROQ1)from Nicotiana benthamiana and recognition of Peronospora parasitica 1(RPP1)from Arabidopsis can tetramerize,enabling the NADase activity of their TIR domains[5,6].展开更多
文摘Both animals and plants employ nucleotide-binding leucinerich repeat receptors(NLRs)to perceive pathogens and activate immunity.Typical plant NLRs are categorized into three major groups:Toll and interleukin-1 receptor(TIR)type NLRs(TNLs),coiled-coil(CC)type NLRs(CNLs),and RPW8-like CC domain containing NLRs(RNLs)[1,2].Notably,full-length TNLs are absent in monocots,but TIR-only or atypical TIR-containing proteins can be found in monocots[2].Plant TNLs or TIR-only proteins were shown to possess NADase(nicotinamide adenine dinucleotide hydrolase)activity[3,4].Upon sensing pathogen effectors,TNLs such as recognition of XopQ1(ROQ1)from Nicotiana benthamiana and recognition of Peronospora parasitica 1(RPP1)from Arabidopsis can tetramerize,enabling the NADase activity of their TIR domains[5,6].
