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Multi-omics decodes exercise-induced geroprotection:betaine unlocks aging delay via TBK1 inhibition
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作者 Yang Li Liang Guo Ru Wang 《Science China(Life Sciences)》 2025年第11期3419-3421,共3页
Exercise is widely recognized for its extensive health benefits,ranging from cardiovascular protection to improved metabolic function and immune regulation.However,exercise-induced physiological adaptations are highly... Exercise is widely recognized for its extensive health benefits,ranging from cardiovascular protection to improved metabolic function and immune regulation.However,exercise-induced physiological adaptations are highly dependent on duration and frequency(Sanford et al.,2020).While acute exercise(AE)rapidly activates metabolic and immune responses(Mo Tr PAC Study Group et al.,2024),long-term exercise(LE)brings profound and systemic benefits,such as enhanced immunity,tissue regeneration,improved neuroplasticity,and cognitive function,optimized skeletal muscle metabolism and insulin sensitivity,and alleviation of chronic inflammation(De Miguel et al.,2021). 展开更多
关键词 metabolic immune responses mo tr pac study group BETAINE metabolic function enhanced immunitytissue aging delay multi omics acute exercise exercise induced geroprotection
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