A recent study by Li et al.[1]was published in Nature and proposed the crucial roles of lactylation in regulating innate immunity.Alanyl-tRNA synthetase 1(AARS1)and AARS2,the intracellular L-lactate sensors,were demon...A recent study by Li et al.[1]was published in Nature and proposed the crucial roles of lactylation in regulating innate immunity.Alanyl-tRNA synthetase 1(AARS1)and AARS2,the intracellular L-lactate sensors,were demonstrated to directly conjugate L-lactate to a lysine residue of substrate proteins.AARS2interacts with cGAS and mediates its lactylation,dampening cGAS-mediated innate antiviral response.展开更多
基金supported by the National Natural Science Foundation of China(32270975,32070907,U24A20371,and T2321005)the National Key R&D Program of China(2023YFA1800200 and 2022YFA1105200)+3 种基金the National Science Fund for Distinguished Young Scholars(32125016)Suzhou Medical College basic frontier innovation cross project(YXY2303027)Suzhou Innovation and Entrepreneurship Leading Talent Program(ZXL2022505)the Priority Acadamic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘A recent study by Li et al.[1]was published in Nature and proposed the crucial roles of lactylation in regulating innate immunity.Alanyl-tRNA synthetase 1(AARS1)and AARS2,the intracellular L-lactate sensors,were demonstrated to directly conjugate L-lactate to a lysine residue of substrate proteins.AARS2interacts with cGAS and mediates its lactylation,dampening cGAS-mediated innate antiviral response.
