This editorial delves into the potential of systemic immune indicators(SIIs)as early predictors of renal damage in children with newly diagnosed type 1 diabetes mellitus.By exploring the recent study published by Cao ...This editorial delves into the potential of systemic immune indicators(SIIs)as early predictors of renal damage in children with newly diagnosed type 1 diabetes mellitus.By exploring the recent study published by Cao et al,this article aims to highlight the importance of early detection and intervention.This study compre-hensively analyzes various SIIs,examining their correlation with renal compli-cations in newly diagnosed type 1 diabetic children.The findings reveal a sig-nificant association between immune system dysregulation and the onset of renal damage,suggesting that certain immune indicators can be early markers for predicting renal complications.This editorial emphasizes the clinical implications and applications of utilizing SIIs for early detection in pediatric diabetes care.It underscores the importance of innovative diagnostic approaches and illustrates real-world applications and outcomes.Additionally,it addresses the challenges and considerations in adopting these indicators and outlines future research directions to enhance diabetes management in children.展开更多
Objective:To analyze the therapeutic efficacy of Yinzhihuang granules in treating neonatal jaundice.Methods:A total of 62 neonates with jaundice,admitted from September 2021 to September 2023,were randomly divided int...Objective:To analyze the therapeutic efficacy of Yinzhihuang granules in treating neonatal jaundice.Methods:A total of 62 neonates with jaundice,admitted from September 2021 to September 2023,were randomly divided into two groups.The observation group received Yinzhihuang granules,while the control group received conventional blue light therapy.The overall efficacy rate and other indicators were compared.Results:The observation group showed a higher overall efficacy rate and superior clinical indicators compared to the control group(P<0.05).Before treatment,there was no significant difference between the two groups in bilirubin,liver function,or immune function indicators(P>0.05).After one week of treatment,the observation group had lower bilirubin and liver function indicators and higher immune function indicators than the control group(P<0.05).Conclusion:Yinzhihuang granules can improve the efficacy of neonatal jaundice treatment,accelerate recovery,reduce bilirubin levels,protect liver function,and enhance immune function in neonates.展开更多
This experiment was conducted to investigate the effects of live yeast and yeast cell wall polysaccharides on growth performance,rumen function and plasma lipopolysaccharides(LPS) content and immunity parameters of be...This experiment was conducted to investigate the effects of live yeast and yeast cell wall polysaccharides on growth performance,rumen function and plasma lipopolysaccharides(LPS) content and immunity parameters of beef cattle.Forty Qinchuan cattle were randomly assigned to one of four treatments with 10 replicates in each treatment.The dietary treatments were: control diet(CTR),CTR supplemented with 1 g live yeast(2×10^10 live cell g^-1 per cattle per day(YST1),CTR supplemented with 2 g live yeast per cattle per day(YST2) and CTR supplemented with 20 g of yeast cell wall polysaccharides(30.0%≤β-glucan≤35.0%,and 28.0%≤mannanoligosaccharide≤32.0%) per cattle per day(YCW).The average daily gain was higher(P=0.023) and feed conversion ratio was lower(P=0.042) for the YST2 than the CTR.The digestibility of neutral detergent fiber(P=0.039) and acid detergent fiber(P=0.016) were higher in yeast supplemented groups.The acetic acid:propionic acid of the YST2 was lower compared with the CTR(P=0.033).Plasma LPS(P=0.032),acute phase protein haptoglobin(P=0.033),plasma amyloid A(P=0.015) and histamine(P=0.038) were lower in the YST2 compared with the CTR.The copies of fibrolytic microbial populations such as Fibrobacter succinogenes S85,Ruminococcus albus 7 and Ruminococcus flavefaciens FD-1 of the YST2 were higher(P<0.001),while the copies of typical lactate producing bacteria Streptococcus bovis JB1 was lower(P<0.001) compared with the CTR.Little differences were observed between the CTR,YST1 and YCW in growth performance,ruminal fermentation characteristics,microbial populations,immunity indices and total tract nutrient digestibility.It is concluded that the YST2 could promote fibrolytic microbial populations,decrease starch-utilizing bacteria,reduce LPS production in the rumen and LPS absorption into plasma and decrease inflammatory parameters,which can lead to an improvement in growth performance in beef cattle.展开更多
Background Over one million soldiers were treated for battle- or training-fatigue during World War I1. Of all ground combat troops, 37% were discharged for psychiatric reasons due to fatigue. The neuroendocrinological...Background Over one million soldiers were treated for battle- or training-fatigue during World War I1. Of all ground combat troops, 37% were discharged for psychiatric reasons due to fatigue. The neuroendocrinological and immunological systems played important roles in the work-related fatigue of military personnel. The aim of this study was to investigate the characteristics of fatigue associated with military operations, and we observed changes in the regulatory functions of the neuroendocrinological and immunological systems that may provide theoretical support for improving the combat effectiveness of armies. Methods A total of 240 soldiers from the Field Artillery regiment were selected as subjects. Researchers and subjects received training before participating in the study. Data of the subjects＇ medical histories, physical examinations, scores on a fatigue assessment scale, and assessments of pituitary-adrenal hormones （adrenal cortical hormone （ACTH）, cortical hormone （F）, and 24-hour urine-free cortisol （UFC））, pituitary-gonadal hormones （luteinizing hormone （LH）, follicle-stimulating hormone （FSH）, testosterone, estradiol （E2）, and prolactin （PRL））, pituitary-thyroid hormones （thyroid-stimulating hormone （TSH）, thyroxine （TT4）, triiodothyronine （TT3）, free thyroxine （FT4）, and free triiodothyronine （FT3））, and cellular immune parameters （CD3~, CD4~, CD8~, CD4~/CD8＋, B, and NK cells） were investigated before and after large-scale and high-intensity field exercises. Data were statistically analyzed with Student＇s t test using SPSS software （version 13.0）, and P values 〈0.05 were deemed to be significant. Results After the high-intensity military training, the scores on the fatigue scale reflected significant increases of feeling of unpleasantness among soldiers. Additionally, the symptom checklist showed notable increases in somatization scores and significant decreases in psychoticism scores. After intensive military work, levels of plasma ACTH, F, and UFC of soldiers were decreased （P 〈0.01）. The level of testosterone decreased significantly after the maneuver （（23.51_＋6.49） versus （18.89_＋5.89） nmol/L; P 〈0.001）, whereas the thyroid function （＇1-1-3, FT4, and FT3） was markedly increased after the maneuver （P 〈0.01）. The number of CD3~, CD4~, CD4~/CD8~ cells, and B lymphocytes were decreased （P 〈0.05）, and NK cells were increased （P 〈0.001） after the maneuver. Conclusions Following high-intensity military operations, the psychological tolerance of soldiers was depressed. And the hypoadrenocorticism （the functional decreases of hypothalamic-pituitary-gonadal and abnormal pituitary-thyroid axis） contributed to the increased levels of fatigue. Hypoimmunity may increase the susceptibility to diseases after high-intensity military operations.展开更多
文摘This editorial delves into the potential of systemic immune indicators(SIIs)as early predictors of renal damage in children with newly diagnosed type 1 diabetes mellitus.By exploring the recent study published by Cao et al,this article aims to highlight the importance of early detection and intervention.This study compre-hensively analyzes various SIIs,examining their correlation with renal compli-cations in newly diagnosed type 1 diabetic children.The findings reveal a sig-nificant association between immune system dysregulation and the onset of renal damage,suggesting that certain immune indicators can be early markers for predicting renal complications.This editorial emphasizes the clinical implications and applications of utilizing SIIs for early detection in pediatric diabetes care.It underscores the importance of innovative diagnostic approaches and illustrates real-world applications and outcomes.Additionally,it addresses the challenges and considerations in adopting these indicators and outlines future research directions to enhance diabetes management in children.
基金2023 Innovation Fund Project for College Teachers of Gansu Provincial Department of Education(Project No.2023B-004)The Foundation of the First Hospital of Lanzhou University(Grant No.Idyyyn 2021-92)。
文摘Objective:To analyze the therapeutic efficacy of Yinzhihuang granules in treating neonatal jaundice.Methods:A total of 62 neonates with jaundice,admitted from September 2021 to September 2023,were randomly divided into two groups.The observation group received Yinzhihuang granules,while the control group received conventional blue light therapy.The overall efficacy rate and other indicators were compared.Results:The observation group showed a higher overall efficacy rate and superior clinical indicators compared to the control group(P<0.05).Before treatment,there was no significant difference between the two groups in bilirubin,liver function,or immune function indicators(P>0.05).After one week of treatment,the observation group had lower bilirubin and liver function indicators and higher immune function indicators than the control group(P<0.05).Conclusion:Yinzhihuang granules can improve the efficacy of neonatal jaundice treatment,accelerate recovery,reduce bilirubin levels,protect liver function,and enhance immune function in neonates.
基金the financial support from the National Key R&D Program of China (2017YFD0502005)the support of the Faculty of Veterinary and Agricultural Sciences Start-up Fund, The University of Melbourne, Australia
文摘This experiment was conducted to investigate the effects of live yeast and yeast cell wall polysaccharides on growth performance,rumen function and plasma lipopolysaccharides(LPS) content and immunity parameters of beef cattle.Forty Qinchuan cattle were randomly assigned to one of four treatments with 10 replicates in each treatment.The dietary treatments were: control diet(CTR),CTR supplemented with 1 g live yeast(2×10^10 live cell g^-1 per cattle per day(YST1),CTR supplemented with 2 g live yeast per cattle per day(YST2) and CTR supplemented with 20 g of yeast cell wall polysaccharides(30.0%≤β-glucan≤35.0%,and 28.0%≤mannanoligosaccharide≤32.0%) per cattle per day(YCW).The average daily gain was higher(P=0.023) and feed conversion ratio was lower(P=0.042) for the YST2 than the CTR.The digestibility of neutral detergent fiber(P=0.039) and acid detergent fiber(P=0.016) were higher in yeast supplemented groups.The acetic acid:propionic acid of the YST2 was lower compared with the CTR(P=0.033).Plasma LPS(P=0.032),acute phase protein haptoglobin(P=0.033),plasma amyloid A(P=0.015) and histamine(P=0.038) were lower in the YST2 compared with the CTR.The copies of fibrolytic microbial populations such as Fibrobacter succinogenes S85,Ruminococcus albus 7 and Ruminococcus flavefaciens FD-1 of the YST2 were higher(P<0.001),while the copies of typical lactate producing bacteria Streptococcus bovis JB1 was lower(P<0.001) compared with the CTR.Little differences were observed between the CTR,YST1 and YCW in growth performance,ruminal fermentation characteristics,microbial populations,immunity indices and total tract nutrient digestibility.It is concluded that the YST2 could promote fibrolytic microbial populations,decrease starch-utilizing bacteria,reduce LPS production in the rumen and LPS absorption into plasma and decrease inflammatory parameters,which can lead to an improvement in growth performance in beef cattle.
文摘Background Over one million soldiers were treated for battle- or training-fatigue during World War I1. Of all ground combat troops, 37% were discharged for psychiatric reasons due to fatigue. The neuroendocrinological and immunological systems played important roles in the work-related fatigue of military personnel. The aim of this study was to investigate the characteristics of fatigue associated with military operations, and we observed changes in the regulatory functions of the neuroendocrinological and immunological systems that may provide theoretical support for improving the combat effectiveness of armies. Methods A total of 240 soldiers from the Field Artillery regiment were selected as subjects. Researchers and subjects received training before participating in the study. Data of the subjects＇ medical histories, physical examinations, scores on a fatigue assessment scale, and assessments of pituitary-adrenal hormones （adrenal cortical hormone （ACTH）, cortical hormone （F）, and 24-hour urine-free cortisol （UFC））, pituitary-gonadal hormones （luteinizing hormone （LH）, follicle-stimulating hormone （FSH）, testosterone, estradiol （E2）, and prolactin （PRL））, pituitary-thyroid hormones （thyroid-stimulating hormone （TSH）, thyroxine （TT4）, triiodothyronine （TT3）, free thyroxine （FT4）, and free triiodothyronine （FT3））, and cellular immune parameters （CD3~, CD4~, CD8~, CD4~/CD8＋, B, and NK cells） were investigated before and after large-scale and high-intensity field exercises. Data were statistically analyzed with Student＇s t test using SPSS software （version 13.0）, and P values 〈0.05 were deemed to be significant. Results After the high-intensity military training, the scores on the fatigue scale reflected significant increases of feeling of unpleasantness among soldiers. Additionally, the symptom checklist showed notable increases in somatization scores and significant decreases in psychoticism scores. After intensive military work, levels of plasma ACTH, F, and UFC of soldiers were decreased （P 〈0.01）. The level of testosterone decreased significantly after the maneuver （（23.51_＋6.49） versus （18.89_＋5.89） nmol/L; P 〈0.001）, whereas the thyroid function （＇1-1-3, FT4, and FT3） was markedly increased after the maneuver （P 〈0.01）. The number of CD3~, CD4~, CD4~/CD8~ cells, and B lymphocytes were decreased （P 〈0.05）, and NK cells were increased （P 〈0.001） after the maneuver. Conclusions Following high-intensity military operations, the psychological tolerance of soldiers was depressed. And the hypoadrenocorticism （the functional decreases of hypothalamic-pituitary-gonadal and abnormal pituitary-thyroid axis） contributed to the increased levels of fatigue. Hypoimmunity may increase the susceptibility to diseases after high-intensity military operations.
