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Engine Failure Prediction on Large-Scale CMAPSS Data Using Hybrid Feature Selection and Imbalance-Aware Learning
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作者 Ahmad Junaid Abid Iqbal +3 位作者 Abuzar Khan Ghassan Husnain Abdul-Rahim Ahmad Mohammed Al-Naeem 《Computers, Materials & Continua》 2026年第4期1485-1508,共24页
Most predictive maintenance studies have emphasized accuracy but provide very little focus on Interpretability or deployment readiness.This study improves on prior methods by developing a small yet robust system that ... Most predictive maintenance studies have emphasized accuracy but provide very little focus on Interpretability or deployment readiness.This study improves on prior methods by developing a small yet robust system that can predict when turbofan engines will fail.It uses the NASA CMAPSS dataset,which has over 200,000 engine cycles from260 engines.The process begins with systematic preprocessing,which includes imputation,outlier removal,scaling,and labelling of the remaining useful life.Dimensionality is reduced using a hybrid selection method that combines variance filtering,recursive elimination,and gradient-boosted importance scores,yielding a stable set of 10 informative sensors.To mitigate class imbalance,minority cases are oversampled,and class-weighted losses are applied during training.Benchmarking is carried out with logistic regression,gradient boosting,and a recurrent design that integrates gated recurrent units with long short-term memory networks.The Long Short-Term Memory–Gated Recurrent Unit(LSTM–GRU)hybrid achieved the strongest performance with an F1 score of 0.92,precision of 0.93,recall of 0.91,ReceiverOperating Characteristic–AreaUnder the Curve(ROC-AUC)of 0.97,andminority recall of 0.75.Interpretability testing using permutation importance and Shapley values indicates that sensors 13,15,and 11 are the most important indicators of engine wear.The proposed system combines imbalance handling,feature reduction,and Interpretability into a practical design suitable for real industrial settings. 展开更多
关键词 Predictive maintenance CMAPSS dataset feature selection class imbalance LSTM-GRUhybrid model INTERPRETABILITY industrial deployment
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Advances in Machine Learning for Explainable Intrusion Detection Using Imbalance Datasets in Cybersecurity with Harris Hawks Optimization
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作者 Amjad Rehman Tanzila Saba +2 位作者 Mona M.Jamjoom Shaha Al-Otaibi Muhammad I.Khan 《Computers, Materials & Continua》 2026年第1期1804-1818,共15页
Modern intrusion detection systems(MIDS)face persistent challenges in coping with the rapid evolution of cyber threats,high-volume network traffic,and imbalanced datasets.Traditional models often lack the robustness a... Modern intrusion detection systems(MIDS)face persistent challenges in coping with the rapid evolution of cyber threats,high-volume network traffic,and imbalanced datasets.Traditional models often lack the robustness and explainability required to detect novel and sophisticated attacks effectively.This study introduces an advanced,explainable machine learning framework for multi-class IDS using the KDD99 and IDS datasets,which reflects real-world network behavior through a blend of normal and diverse attack classes.The methodology begins with sophisticated data preprocessing,incorporating both RobustScaler and QuantileTransformer to address outliers and skewed feature distributions,ensuring standardized and model-ready inputs.Critical dimensionality reduction is achieved via the Harris Hawks Optimization(HHO)algorithm—a nature-inspired metaheuristic modeled on hawks’hunting strategies.HHO efficiently identifies the most informative features by optimizing a fitness function based on classification performance.Following feature selection,the SMOTE is applied to the training data to resolve class imbalance by synthetically augmenting underrepresented attack types.The stacked architecture is then employed,combining the strengths of XGBoost,SVM,and RF as base learners.This layered approach improves prediction robustness and generalization by balancing bias and variance across diverse classifiers.The model was evaluated using standard classification metrics:precision,recall,F1-score,and overall accuracy.The best overall performance was recorded with an accuracy of 99.44%for UNSW-NB15,demonstrating the model’s effectiveness.After balancing,the model demonstrated a clear improvement in detecting the attacks.We tested the model on four datasets to show the effectiveness of the proposed approach and performed the ablation study to check the effect of each parameter.Also,the proposed model is computationaly efficient.To support transparency and trust in decision-making,explainable AI(XAI)techniques are incorporated that provides both global and local insight into feature contributions,and offers intuitive visualizations for individual predictions.This makes it suitable for practical deployment in cybersecurity environments that demand both precision and accountability. 展开更多
关键词 Intrusion detection XAI machine learning ensemble method CYBERSECURITY imbalance data
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TDP-43 loss-of-function triggers mitochondrial dysfunction and metabolic imbalance
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作者 Miriam Ceron-Codorniu Anna Fernandez-Bernal +1 位作者 Reinald Pamplona Manuel Portero-Otin 《Neural Regeneration Research》 2026年第8期3512-3514,共3页
Neurodegenerative diseases are chronic,age-related disorders characterized by a relentless,irreversible,and selective loss of neurons in motor,sensory,or cognitive systems(Gao et al.,2019).Despite their heterogeneity,... Neurodegenerative diseases are chronic,age-related disorders characterized by a relentless,irreversible,and selective loss of neurons in motor,sensory,or cognitive systems(Gao et al.,2019).Despite their heterogeneity,a common pathological feature across many of these diseases is the accumulation of aggregate-prone proteins.Particularly,the cytoplasmic aggregation in neurons of the Transactive response DNA-binding protein 43(TDP-43). 展开更多
关键词 neurodegenerative diseases tdp chronic disorders metabolic imbalance mitochondrial dysfunction protein aggregation age related disorders cytoplasmic aggregation
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Noninvasive Radar Sensing Augmented with Machine Learning for Reliable Detection of Motor Imbalance
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作者 Faten S.Alamri Adil Ali Saleem +2 位作者 Muhammad I.Khan Hafeez Ur Rehman Siddiqui Amjad Rehman 《Computer Modeling in Engineering & Sciences》 2026年第1期698-726,共29页
Motor imbalance is a critical failure mode in rotating machinery,potentially causing severe equipment damage if undetected.Traditional vibration-based diagnostic methods rely on direct sensor contact,leading to instal... Motor imbalance is a critical failure mode in rotating machinery,potentially causing severe equipment damage if undetected.Traditional vibration-based diagnostic methods rely on direct sensor contact,leading to installation challenges and measurement artifacts that can compromise accuracy.This study presents a novel radar-based framework for non-contact motor imbalance detection using 24 GHz continuous-wave radar.A dataset of 1802 experimental trials was sourced,covering four imbalance levels(0,10,20,30 g)across varying motor speeds(500–1500 rpm)and load torques(0–3 Nm).Dual-channel in-phase and quadrature radar signals were captured at 10,000 samples per second for 30-s intervals,preserving both amplitude and phase information for analysis.A multi-domain feature extraction methodology captured imbalance signatures in time,frequency,and complex signal domains.From 65 initial features,statistical analysis using Kruskal–Wallis tests identified significant descriptors,and recursive feature elimination with Random Forest reduced the feature set to 20 dimensions,achieving 69%dimensionality reduction without loss of performance.Six machine learning algorithms,Random Forest,Extra Trees Classifier,Extreme Gradient Boosting,Categorical Boosting,Support Vector Machine with radial basis function kernel,and k-Nearest Neighbors were evaluated with grid-search hyperparameter optimization and five-fold cross-validation.The Extra Trees Classifier achieved the best performance with 98.52%test accuracy,98%cross-validation accuracy,and minimal variance,maintaining per-class precision and recall above 97%.Its superior performance is attributed to its randomized split selection and full bootstrapping strategy,which reduce variance and overfitting while effectively capturing the nonlinear feature interactions and non-normal distributions present in the dataset.The model’s average inference time of 70 ms enables near real-time deployment.Comparative analysis demonstrates that the radar-based framework matches or exceeds traditional contact-based methods while eliminating their inherent limitations,providing a robust,scalable,and noninvasive solution for industrial motor condition monitoring,particularly in hazardous or space-constrained environments. 展开更多
关键词 Condition monitoring imbalance detection industrial applications machine learning motor fault diagnosis non-contact sensing radar sensing vibration monitoring
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Resilient Class-Incremental Learning:On the Interplay of Drifting,Unlabeled and Imbalanced Data Streams
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作者 Jin Li Kleanthis Malialis Marios M.Polycarpou 《Artificial Intelligence Science and Engineering》 2026年第1期49-65,共17页
In today's connected world,the generation of massive streaming data across diverse domains has become commonplace.In the presence of concept drift,class imbalance,label scarcity,and new class emergence,these chall... In today's connected world,the generation of massive streaming data across diverse domains has become commonplace.In the presence of concept drift,class imbalance,label scarcity,and new class emergence,these challenges jointly degrade representation stability,bias learning toward outdated distributions,and reduce the resilience and reliability of detection in dynamic environments.This paper proposes a streaming classincremental learning(SCIL)framework to address these issues.The SCIL framework integrates an autoencoder(AE)with a multi-layer perceptron for multi-class prediction,employs a dual-loss strategy(classification and reconstruction)for prediction and new class detection,uses corrected pseudo-labels for online training,manages classes with queues,and applies oversampling to handle imbalance.The rationale behind the method's structure is elucidated through ablation studies,and a comprehensive experimental evaluation is performed using both real-world and synthetic datasets that feature class imbalance,incremental classes,and concept drifts.Our results demonstrate that SCIL outperforms strong baselines and state-of-the-art methods.In line with our commitment to Open Science,we make our code and datasets available to the community. 展开更多
关键词 concept drift data stream mining class-incremental learning class imbalance
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Initial serum electrolyte imbalances and mortality in patients with traumatic brain injury:a retrospective study 被引量:2
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作者 Ahammed Mekkodathil Ayman El-Menyar +5 位作者 Talat Chughtai Ahmed Abdel-Aziz Bahey Ahmed Labib Shehatta Ali Ayyad Abdulnasser Alyafai Hassan Al-Thani 《World Journal of Emergency Medicine》 2025年第4期331-339,共9页
BACKGROUND:Electrolyte imbalance is common following traumatic brain injury(TBI)and can significantly impact patient outcomes.We aimed to explore the occurrence,patterns,and consequences of electrolyte imbalance in ad... BACKGROUND:Electrolyte imbalance is common following traumatic brain injury(TBI)and can significantly impact patient outcomes.We aimed to explore the occurrence,patterns,and consequences of electrolyte imbalance in adult patients with TBI.METHODS:A retrospective study was conducted from 2016 to 2021 at a level 1 trauma center among hospitalized TBI patients.On admission,the levels of serum electrolytes,including sodium,potassium,calcium,magnesium,and phosphate,were analyzed.Demographics,injury characteristics,and interventions were assessed.The primary outcome was the in-hospital mortality.Multivariate logistic regression analysis was performed to identify independent predictors of mortality in TBI patients.RESULTS:A total of 922 TBI patients were included in the analysis,of whom 902(98%)had electrolyte imbalance.The mean age of patients with electrolyte imbalance was 32.0±15.0 years.Most patients were males(94%).The most common electrolyte abnormalities were hypocalcemia,hypophosphatemia,and hypokalemia.The overall in-hospital mortality rate was 22%in the entire cohort.In multivariate logistic analysis,the predictors of mortality included age(odds ratio[OR]=1.029,95%confidence intervals[CI]:1.013-1.046,P<0.001),low GCS(OR=0.883,95%CI:0.816-0.956,P=0.002),high Injury Severity Score(ISS)scale(OR=1.051,95%CI:1.026-1.078,P<0.001),hypernatremia(OR=2.175,95%CI:1.196-3.955,P=0.011),hyperkalemia(OR=4.862,95%CI:1.222-19.347;P=0.025),low serum bicarbonate levels(OR=0.926,95%CI:0.868-0.988,P=0.020),high serum lactate levels(OR=1.128,95%CI:1.022-1.244,P=0.017),high glucose levels(OR=1.072,95%CI:1.014-1.133,P=0.015),a longer activated partial thromboplastin time(OR=1.054,95%CI:1.024-1.084,P<0.001)and higer international normalized ratio(INR)(OR=3.825,95%CI:1.592-9.188,P=0.003).CONCLUSION:Electrolyte imbalance is common in TBI patients,with the significant prevalence of hypocalcemia,hypophosphatemia,and hypokalemia.However,hypernatremia and hyperkalemia were associated with the risk of mortality,emphasizing the need for further research to comprehend electrolyte dynamics in TBI patients. 展开更多
关键词 Electrolyte imbalance Traumatic brain injury MORTALITY
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Oversampling for class-imbalanced learning in credit risk assessment based on CVAE-WGAN-gp model
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作者 Kaiming Wang Qing Yang 《中国科学技术大学学报》 北大核心 2025年第7期37-48,36,I0001,I0002,共15页
Credit risk assessment is a crucial task in bank risk management.By making lending decisions based on credit risk assessment results,banks can reduce the probability of non-performing loans.However,class imbalance in ... Credit risk assessment is a crucial task in bank risk management.By making lending decisions based on credit risk assessment results,banks can reduce the probability of non-performing loans.However,class imbalance in bank credit default datasets limits the predictive performance of traditional machine learning and deep learning models.To address this issue,this study employs the conditional variational autoencoder-Wasserstein generative adversarial network with gradient penalty(CVAE-WGAN-gp)model for oversampling,generating samples similar to the original default customer data to enhance model prediction performance.To evaluate the quality of the data generated by the CVAE-WGAN-gp model,we selected several bank loan datasets for experimentation.The experimental results demonstrate that using the CVAE-WGAN-gp model for oversampling can significantly improve the predictive performance in credit risk assessment problems. 展开更多
关键词 credit risk assessment class imbalance OVERSAMPLING conditional variational autoencoder(CVAE) generative adversarial network(GAN)
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Single-Phase Grounding Fault Identification in Distribution Networks with Distributed Generation Considering Class Imbalance across Different Network Topologies
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作者 Lei Han Wanyu Ye +4 位作者 Chunfang Liu Shihua Huang Chun Chen Luxin Zhan Siyuan Liang 《Energy Engineering》 2025年第12期4947-4969,共23页
In contemporary medium-voltage distribution networks heavily penetrated by distributed energy resources(DERs),the harmonic components injected by power-electronic interfacing converters,together with the inherently in... In contemporary medium-voltage distribution networks heavily penetrated by distributed energy resources(DERs),the harmonic components injected by power-electronic interfacing converters,together with the inherently intermittent output of renewable generation,distort the zero-sequence current and continuously reshape its frequency spectrum.As a result,single-line-to-ground(SLG)faults exhibit a pronounced,strongly non-stationary behaviour that varies with operating point,load mix and DER dispatch.Under such circumstances the performance of traditional rule-based algorithms—or methods that rely solely on steady-state frequency-domain indicators—degrades sharply,and they no longer satisfy the accuracy and universality required by practical protection systems.To overcome these shortcomings,the present study develops an SLG-fault identification scheme that transforms the zero-sequence currentwaveforminto two-dimensional image representations and processes themwith a convolutional neural network(CNN).First,the causes of sample-distribution imbalance are analysed in detail by considering different neutralgrounding configurations,fault-inception mechanisms and the statistical probability of fault occurrence on each phase.Building on these insights,a discriminator network incorporating a Convolutional Block Attention Module(CBAM)is designed to autonomously extract multi-layer spatial-spectral features,while Gradient-weighted Class Activation Mapping(Grad-CAM)is employed to visualise the contribution of every salient image region,thereby enhancing interpretability.A comprehensive simulation platform is subsequently established for a DER-rich distribution system encompassing several representative topologies,feeder lengths and DER penetration levels.Large numbers of realistic SLG-fault scenarios are generated—including noise and measurement uncertainty—and are used to train,validate and test the proposed model.Extensive simulation campaigns,corroborated by field measurements from an actual utility network,demonstrate that the proposed approach attains an SLG-fault identification accuracy approaching 100 percent and maintains robust performance under severe noise conditions,confirming its suitability for real-world engineering applications. 展开更多
关键词 Distribution network single-phase grounding fault distribution generation class imbalance sample CNN
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Innovative Machine Learning Approaches for Drinking Water Quality Classification:Addressing Data Imbalances with Custom SMOTE Sampling Strategy
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作者 Borislava Toleva Ivan Ivanov Kalina Kitova 《Journal of Environmental & Earth Sciences》 2025年第3期262-273,共12页
This study demonstrates the complexity and importance of water quality as a measure of the health and sustainability of ecosystems that directly influence biodiversity,human health,and the world economy.The predictabi... This study demonstrates the complexity and importance of water quality as a measure of the health and sustainability of ecosystems that directly influence biodiversity,human health,and the world economy.The predictability of water quality thus plays a crucial role in managing our ecosystems to make informed decisions and,hence,proper environmental management.This study addresses these challenges by proposing an effective machine learning methodology applied to the“Water Quality”public dataset.The methodology has modeled the dataset suitable for providing prediction classification analysis with high values of the evaluating parameters such as accuracy,sensitivity,and specificity.The proposed methodology is based on two novel approaches:(a)the SMOTE method to deal with unbalanced data and(b)the skillfully involved classical machine learning models.This paper uses Random Forests,Decision Trees,XGBoost,and Support Vector Machines because they can handle large datasets,train models for handling skewed datasets,and provide high accuracy in water quality classification.A key contribution of this work is the use of custom sampling strategies within the SMOTE approach,which significantly enhanced performance metrics and improved class imbalance handling.The results demonstrate significant improvements in predictive performance,achieving the highest reported metrics:accuracy(98.92%vs.96.06%),sensitivity(98.3%vs.71.26%),and F1 score(98.37%vs.79.74%)using the XGBoost model.These improvements underscore the effectiveness of our custom SMOTE sampling strategies in addressing class imbalance.The findings contribute to environmental management by enabling ecology specialists to develop more accurate strategies for monitoring,assessing,and managing drinking water quality,ensuring better ecosystem and public health outcomes. 展开更多
关键词 Data Modeling Class imbalance SMOTE Machine Learning Classification Model Estimation Water Quality Dataset
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Increase in global per capita cropland imbalance across countries from 1985 to 2022:A threat to achieving Sustainable Development Goals
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作者 Tingting Zhao Xiao Zhang +3 位作者 Wendi Liu Jinqing Wang Zhehua Li Liangyun Liu 《Geography and Sustainability》 2025年第2期253-264,共12页
Sustainable Development Goal 2(SDG 2,zero hunger)highlights that global hunger and food insecurity have worsened since 2015,driven in part by growing imbalance.Addressing the challenge of achieving SDG 2 in the face o... Sustainable Development Goal 2(SDG 2,zero hunger)highlights that global hunger and food insecurity have worsened since 2015,driven in part by growing imbalance.Addressing the challenge of achieving SDG 2 in the face of rapid global population growth requires sustained attention to global and national cropland changes.Accurately quantifying the correlation between population and cropland area(i.e.,SDG 2.4.1 per capita cropland)and analyzing the trends of global cropland imbalance are essential for a comprehensive understanding of SDG 2.In this study,we utilized a new global 30 m land-cover dynamic dataset(GLC_FCS30D)to analyze cropland dynamics,quantify per capita cropland and its changes across various countries and levels of development.Our results indicate that the global cropland area expanded by 0.944 million km^(2)from 1985 to 2022,with an average expansion rate of 2.42×10^(4)km^(2)/yr.However,the global per capita cropland area decreased from 0.347 ha in 1985 to 0.217 ha in 2022,mainly due to a higher population increase of nearly 65%in the same period.In the context of globalization,cropland expansion and per capita cropland exhibited spatial imbalances globally,particularly in developing countries.Developing countries saw an increase in total cropland area by 7.09%but a significant decrease in per capita cropland area by 37.38%.From a temporal perspective,the global imbalance has been steadily increasing with the Gini index rising from 0.895 in 1985 to 0.909 in 2022.Consequently,this study reveals an increasing imbalance of global per capita cropland across various countries,which threatens the attainment of the targets of SDG 2. 展开更多
关键词 Sustainable Development Goals GLC_FCS30D Cropland changes Population imbalance
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Distribution and imbalance of basic research funding in environmental chemistry in China
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作者 Weiyi Wang Qian Liu +1 位作者 Guibin Jiang Qiankun Zhuang 《Journal of Environmental Sciences》 2025年第9期267-277,共11页
This study investigates the distribution and imbalances of research funding in the field of Environmental Chemistry,utilizing application and funding data fromthe National Natural Science Foundation of China(NSFC)over... This study investigates the distribution and imbalances of research funding in the field of Environmental Chemistry,utilizing application and funding data fromthe National Natural Science Foundation of China(NSFC)over the past decade.The findings reveal significant regional disparities,with Eastern regions receiving over 70%of the national funding,while the Northeast accounts for only 4%to 6.5%.Additionally,the analysis shows notable differences in funding allocation among various research institutions,with a substantial portion of funds concentrated in a few leading institutions,leading to inequities across different types and levels of organizations.The impact of applicant gender on funding disparities is relatively minor;although female applicants have a slightly lower funding rate,the concentration of funds is marginally higher among females.Furthermore,the study highlights that key projects and talent-oriented initiatives,due to their significant funding concentration,exacerbate the existing imbalances.Overall,this research provides valuable insights for optimizing funding policies and advocates for a more equitable distribution of resources in Environmental Chemistry research,addressing the identified disparities. 展开更多
关键词 Scientific fund National natural science foundation of China Environmental chemistry POLICY Regional imbalance
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Handling class imbalance of radio frequency interference in deep learning-based fast radio burst search pipelines using a deep convolutional generative adversarial network
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作者 Wenlong Du Yanling Liu Maozheng Chen 《Astronomical Techniques and Instruments》 2025年第1期10-15,共6页
This paper addresses the performance degradation issue in a fast radio burst search pipeline based on deep learning.This issue is caused by the class imbalance of the radio frequency interference samples in the traini... This paper addresses the performance degradation issue in a fast radio burst search pipeline based on deep learning.This issue is caused by the class imbalance of the radio frequency interference samples in the training dataset,and one solution is applied to improve the distribution of the training data by augmenting minority class samples using a deep convolutional generative adversarial network.Experi.mental results demonstrate that retraining the deep learning model with the newly generated dataset leads to a new fast radio burst classifier,which effectively reduces false positives caused by periodic wide-band impulsive radio frequency interference,thereby enhancing the performance of the search pipeline. 展开更多
关键词 Fast radio burst Deep convolutional generative adversarial network Class imbalance Radio frequency interference Deep learning
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全身骨骼三维建模成像系统检测脊柱矢状位失衡与膝关节参数的相关性 被引量:1
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作者 周峰 符鹏飞 +3 位作者 钱宇帆 许平成 郭炯炯 张磊 《中国组织工程研究》 北大核心 2026年第3期596-603,共8页
背景:随着人们生活方式的变化和年龄增长,脊柱矢状位失衡成为一种常见的骨科问题,对膝关节和骨盆的功能产生显著影响。了解脊柱矢状位失衡的影响及其代偿机制,对于改善慢性疼痛的临床管理至关重要。目的:使用全身骨骼三维建模成像系统... 背景:随着人们生活方式的变化和年龄增长,脊柱矢状位失衡成为一种常见的骨科问题,对膝关节和骨盆的功能产生显著影响。了解脊柱矢状位失衡的影响及其代偿机制,对于改善慢性疼痛的临床管理至关重要。目的:使用全身骨骼三维建模成像系统评估脊柱-骨盆-下肢矢状位排列模式,分析脊柱矢状位失衡与膝关节参数的相关性,并探讨其代偿机制。方法:纳入2021-01-01/2023-12-31就诊于苏州大学附属第一医院骨科门诊的71例慢性下腰痛或髌股关节痛患者,采用全身骨骼三维建模成像系统进行放射学测量,确定骨盆倾斜角、骨盆入射角、腰椎前凸角、脊柱矢状轴、整体倾斜角、髋-膝-踝角、屈膝角股骨远端外侧角、胫骨近端内侧角。根据SRS-Schwab脊柱畸形分类按骨盆入射角与腰椎前凸角差值(PI-LL)将患者分为正常组(PI-LL<10°)、代偿组(PI-LL为10°-20°)和失代偿组(PI-LL>20°),检测各组间放射学参数的差异。对比各组患者美国膝关节协会评分和Oswestry功能障碍指数的差异。根据临床症状将患者分为慢性下腰痛组和无慢性下腰痛组、髌股关节痛组和无髌股关节痛组,分析放射学参数差异与临床症状的关系。结果与结论:①PI-LL<20°时,股骨远端外侧角和胫骨近端内侧角趋于稳定;当PI-LL>20°时,其与股骨远端外侧角和胫骨近端内侧角呈线性相关,随着PI-LL增大,股骨远端外侧角值增大、胫骨近端内侧角值减小;②与正常组相比,代偿组骨盆倾斜角明显增大(P<0.01),髋-膝-踝角和屈膝角无明显差异,失代偿组的骨盆倾斜角显著增大(P<0.01),髋-膝-踝角和屈膝角显著减小(P<0.01);与代偿组相比,失代偿组髋-膝-踝角显著减小(P<0.05),而骨盆倾斜角和屈膝角无明显差异;③与无髌股关节痛组相比,髌股关节痛患者腰椎前凸角、股骨远端外侧角、胫骨近端内侧角显著减小(P<0.05),PI-LL显著增大(P<0.05);④慢性下腰痛患者放射学参数与无慢性下腰痛患者均有显著差异(P<0.05);⑤与正常组相比,代偿组和失代偿组的美国膝关节协会评分显著下降、Oswestry功能障碍指数显著升高(P<0.05);与代偿组相比,失代偿组美国膝关节协会评分显著下降、Oswestry功能障碍指数显著升高(P<0.05);⑥PI-LL随着年龄增加而变大,女性PI-LL相比男性较高;⑦提示脊柱与下肢在疾病进展和临床症状中具有重要作用;髌股关节痛和慢性下腰痛与脊柱-骨盆-下肢排列稳定有关;此外,高龄和女性患者的脊柱矢状位失衡较为严重。 展开更多
关键词 全身骨骼三维建模成像系统 膝关节参数 脊柱矢状位失衡 慢性下腰痛 髌股关节痛
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东北黑土地保护成效、土壤酸化问题及其对策建议
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作者 戴慧敏 方运霆 +3 位作者 刘凯 房娜娜 陈超群 梁帅 《水土保持学报》 北大核心 2026年第2期114-120,共7页
[目的]为评估黑土地保护工程实施效果及土壤酸化问题。[方法]通过对黑土区农田近40 a来土壤pH时空变化特征,以及辽宁省昌图县、吉林省四平市和黑龙江省海伦市的定位监测,分析实施黑土地保护工程以来土壤pH及养分变化特征。[结果]近40 a... [目的]为评估黑土地保护工程实施效果及土壤酸化问题。[方法]通过对黑土区农田近40 a来土壤pH时空变化特征,以及辽宁省昌图县、吉林省四平市和黑龙江省海伦市的定位监测,分析实施黑土地保护工程以来土壤pH及养分变化特征。[结果]近40 a来,东北黑土区农田土壤有机质质量分数先下降后上升,总体呈下降特征,酸化和碱化两极分化的发展趋势显著,其中55.76%的土壤pH出现下降,下降区pH平均降低0.87个单位,局部酸化趋势明显。自2005年起,昌图地区、四平地区及海伦地区监测显示,实施黑土地保护工程后,土壤有机质及大量养分元素质量分数均显著提升,反映出黑土地保护成效显著。监测显示,昌图地区和海伦地区土壤pH分别下降0.38和0.66个单位,酸化趋势突出,酸化会引发钙、镁等养分失衡。[结论]黑土地土壤酸化趋势的研究成果及提出的防治对策,可为黑土地可持续利用提供科学依据。 展开更多
关键词 黑土地 土壤酸化 养分失衡 可持续利用 保护对策
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“脾受病则意舍不清”理论视域下探析线粒体稳态失衡在糖尿病认知功能障碍中的核心作用
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作者 王钰 范丹枫 +1 位作者 战丽彬 岳晓青 《世界科学技术-中医药现代化》 北大核心 2026年第2期388-393,共6页
糖尿病认知功能障碍(DACD)是糖尿病的重要并发症之一,严重影响患者的生活质量,但其病因尚不明确,且缺乏有效的防治方法。现代医学认为线粒体稳态失衡是DACD发病的核心机制之一,而线粒体功能与中医脾的运化功能关系密切。本文通过探析中... 糖尿病认知功能障碍(DACD)是糖尿病的重要并发症之一,严重影响患者的生活质量,但其病因尚不明确,且缺乏有效的防治方法。现代医学认为线粒体稳态失衡是DACD发病的核心机制之一,而线粒体功能与中医脾的运化功能关系密切。本文通过探析中医脾与线粒体能量代谢和信号传导功能间的关系,发现线粒体功能正常是脾气健运的重要微观体现,并认为“脾失运化,意舍不清”是DACD的主要发病机制。在“脾受病则意舍不清”理论指导下,探索“脾藏意”现代物质基础与相关调控机制,旨在为DACD等代谢性疾病的综合防治提供新思路,同时丰富中医脾藏象理论的科学内涵。 展开更多
关键词 “脾” “意” 线粒体稳态失衡 糖尿病认知功能障碍
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从“调枢机、和阴阳”论治失眠的临床应用举隅
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作者 岳双冰 张广路 +4 位作者 卓超林 田欢 张庭基 李一明 金宇 《深圳中西医结合杂志》 2026年第1期51-54,共4页
李一明教授基于“少阳为枢”的理论提出“枢机不利、阴阳失和”是情志相关失眠的核心病机,确立“调枢机、和阴阳”的治疗大法,临床以小柴胡汤为底方,通过精准辨证与灵活化裁显著改善患者睡眠质量。本文作者系统总结李教授运用“小柴胡... 李一明教授基于“少阳为枢”的理论提出“枢机不利、阴阳失和”是情志相关失眠的核心病机,确立“调枢机、和阴阳”的治疗大法,临床以小柴胡汤为底方,通过精准辨证与灵活化裁显著改善患者睡眠质量。本文作者系统总结李教授运用“小柴胡汤加味安眠方”治疗失眠的学术思想与临证经验,结合典型医案,对“疏少阳、调气机、安神志”的诊疗体系进行分析,为中医治疗失眠提供重要参考。 展开更多
关键词 失眠 情志病 枢机不利 小柴胡汤 临床经验
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夏热冬冷地区地源热泵系统冷热不平衡特性及优化运行策略研究
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作者 饶大骞 闫亚蕾 +4 位作者 王合安 高斌 高文龙 朱波 赵亚洲 《可再生能源》 北大核心 2026年第3期319-328,共10页
为了揭示夏热冬冷地区地源热泵系统冷热不平衡特性,文章通过数值模拟获得系统运行10 a的性能参数,采用多目标优化遗传算法,综合系统能效、地温场热平衡指数以及源侧/末端负荷不平衡率进行全局寻优,获得了系统最优运行工况。结果表明,在... 为了揭示夏热冬冷地区地源热泵系统冷热不平衡特性,文章通过数值模拟获得系统运行10 a的性能参数,采用多目标优化遗传算法,综合系统能效、地温场热平衡指数以及源侧/末端负荷不平衡率进行全局寻优,获得了系统最优运行工况。结果表明,在单个制冷或制热季内,地埋管换热器冷、热堆积相对严重,其换热性能随着运行时间增加逐渐衰减,且源侧/末端负荷不平衡率较大。通过优化调控,复合地源热泵系统能效显著提高,地埋管群地下热失衡的状况得到显著改善。复合地源热泵系统各设备通过自适应地切换启停,源侧/末端负荷不平衡率可控制在25%以内,实现了按需供冷和供热。该研究对夏热冬冷地区地源热泵的推广和应用具有一定的指导意义。 展开更多
关键词 地源热泵 热平衡指数 负荷不平衡率 最优运行
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语言有机观下的英语小句类型
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作者 何伟 《外语教学》 北大核心 2026年第1期29-37,共9页
语言有机观认为,语言的普遍特征是言语的复杂性。作为言语的“副现象”,语法具有复杂系统的特性;对其进行描写,应遵循有机范畴化原则,即坚持语言现象的本质在于功能,语言现象是不平衡的,相互之间呈现连续统及网络体系特点。为揭示语言... 语言有机观认为,语言的普遍特征是言语的复杂性。作为言语的“副现象”,语法具有复杂系统的特性;对其进行描写,应遵循有机范畴化原则,即坚持语言现象的本质在于功能,语言现象是不平衡的,相互之间呈现连续统及网络体系特点。为揭示语言中小句类型的复杂性,本文在有机观下,以英语为例,描写了关涉交换内容及识解视角的小句类型连续统及基础网络体系;在此前提下,立足于功能,描写了关涉宏观结构及微观结构的小句类型复杂网络体系。有机观下的小句类型描写一方面反映了言语的复杂性,另一方面为人们不时发现的难以范畴化的个别语言现象提供了描写上的原则遵循。 展开更多
关键词 语言有机观 小句类型 不平衡 连续统 网络体系
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基于周期阻滞和氧化⁃抗氧化失衡研究槟榔碱致小鼠骨髓细胞DNA损伤的机制
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作者 于蕾 于晶涵 +6 位作者 宋辉 郎朗 马瑗晗 龚艳朝 张小坡 张彩云 王正文 《海南医科大学学报》 北大核心 2026年第2期89-95,共7页
目的:研究槟榔碱(arecoline,ARC)体内对小鼠骨髓细胞DNA的损伤作用,并探讨其作用机制。方法:采用单细胞凝胶电泳实验分析ARC对小鼠骨髓细胞DNA损伤作用。采用流式细胞术、DCFH-DA荧光染色、罗丹明123染色等方法对小鼠骨髓细胞的细胞周期... 目的:研究槟榔碱(arecoline,ARC)体内对小鼠骨髓细胞DNA的损伤作用,并探讨其作用机制。方法:采用单细胞凝胶电泳实验分析ARC对小鼠骨髓细胞DNA损伤作用。采用流式细胞术、DCFH-DA荧光染色、罗丹明123染色等方法对小鼠骨髓细胞的细胞周期,超氧化物歧化酶(superoxide dismutase,SOD)活性和谷胱甘肽(glutathione,GSH)、丙二醛(malondial dehyde,MDA)、活性氧(reactive oxygen species,ROS)含量,线粒体膜电位(Δψm),p53蛋白含量进行分析。结果:给予ARC1/2 LD_(50)剂量可引起小鼠骨髓细胞DNA损伤,与空白组相比拖尾现象较严重。随着ARC给药剂量的增加,G_(0)/G_(1)期的细胞比例明显增加(P<0.01),使骨髓细胞周期停滞在G_(0)/G_(1)期。ARC作用小鼠骨髓细胞后,SOD活性和GSH含量明显降低(P<0.01),MDA和ROS含量明显升高(P<0.01),并且随着ARC浓度增加,Δψm明显降低(P<0.01)。ARC给药组骨髓细胞内p53蛋白含量随给药剂量的增加而明显升高(P<0.01),呈一定的剂量依赖关系。结论:ARC能造成小鼠骨髓细胞DNA损伤,可增加p53蛋白表达诱导小鼠骨髓细胞周期阻滞在G_(0)/G_(1)期,引起Δψm降低,ROS增加,脂质过氧化增强,抗氧化功能受到严重损害,氧化和抗氧化失衡,这些是ARC引起小鼠骨髓细胞DNA损伤的机制。 展开更多
关键词 槟榔碱 骨髓细胞 DNA损伤 G_(0)/G_(1)期阻滞 氧化-抗氧化失衡
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火针温通法、苍耳子酊与复方甘草酸苷联合应用对白癜风患者皮损及Th17/Treg免疫失衡的影响
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作者 刘可 朱红柳 +1 位作者 毛秋霞 高以红 《中国美容医学》 2026年第2期93-97,共5页
目的:研究火针温通法、苍耳子酊与复方甘草酸苷联合应用对白癜风患者皮损及Th17/Treg免疫失衡的影响。方法:选取2023年12月1日-2024年4月30日于笔者医院就诊的符合研究条件的70例白癜风患者,以随机数字表法随机分为对照组和观察组,各35... 目的:研究火针温通法、苍耳子酊与复方甘草酸苷联合应用对白癜风患者皮损及Th17/Treg免疫失衡的影响。方法:选取2023年12月1日-2024年4月30日于笔者医院就诊的符合研究条件的70例白癜风患者,以随机数字表法随机分为对照组和观察组,各35例。对照组采用苍耳子酊与复方甘草酸苷治疗,观察组在对照组基础上采用火针温通法进行联合治疗。治疗过程持续12周。比较两组皮损情况[白癜风面积评分指数(VASI)、皮损色素积分]、免疫炎症相关指标[辅助性T细胞17(Th17)、调节性T细胞(Treg)、Th17/Treg和干扰素-γ(IFN-γ)、白介素-17(IL-17)]、氧化应激指标[超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、血红素氧合酶-1(HO-1)];统计两组患者不良反应发生率和复发率。结果:治疗后,观察组VASI下降且低于对照组,皮损色素积分升高且高于对照组(P<0.05);两组Th17细胞含量、IFN-γ和IL-17治疗后下降,Treg细胞含量上升,观察组变化幅度高于对照组(P<0.05);观察组SOD、CAT和HO-1水平治疗后高于对照组(P<0.05)。观察组不良反应发生率和复发率与对照组差异无统计学意义(P>0.05)。结论:火针温通法协同苍耳子酊外用,同时口服复方甘草酸苷可显著减少白癜风患者皮损面积,降低免疫反应和活性氧对色素细胞损伤。 展开更多
关键词 白癜风 复方甘草酸苷 火针温通法 苍耳子酊 免疫失衡
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