The International Telecommunication Union(ITU)has introduced the concept of“intelligent connectivity for 2030”,which is driving the development of 6G technology.This next-generation wireless network is finding appli...The International Telecommunication Union(ITU)has introduced the concept of“intelligent connectivity for 2030”,which is driving the development of 6G technology.This next-generation wireless network is finding applications across various sectors,including smart cities,autonomous driving,holographic imaging,and satellite communications.When compared to 5G,the demands for higher data transmission rates,lower latency,and more efficient use of spectrum have become even more critical.展开更多
Structured light beams have significant application value in fields like optical communication,microscopic imaging,and biomedicine due to their unique spatial field distribution characteristics.However,traditional str...Structured light beams have significant application value in fields like optical communication,microscopic imaging,and biomedicine due to their unique spatial field distribution characteristics.However,traditional structured beam generation systems based on discrete optical components have inherent drawbacks such as strict alignment requirements and poor tunability,which severely limit their practical applications.This paper proposes a new method for broadband bifunctional generation of structured beams based on fiber-integrated metasurfaces:by integrating spin-multiplexing bifunctional phase metasurfaces with the end faces of optical fibers,broadband sub-wavelength Bessel beams and focused vortex beams were,respectively,generated on demand in an all-fiber configuration when different circularly polarized light was input.The experimental measurements showed that the transmission characteristics of the generated beams were highly consistent with the numerical simulation results.Our scheme fully exploits the flexible waveguide(bendable)advantage of fibers,breaking through the constraint of poor optical path tunability in traditional“hard connection”systems due to strict alignment requirements.Since the implemented device simultaneously possesses broadband operation,sub-wavelength-scale field control,and spin-multiplexing characteristics,this study provides a new paradigm for multidimensional and multifunctional dynamic light field manipulation,and it holds significant application potential in fields such as fiber-optic imaging and fiber sensing.展开更多
Accurate tracking of labile Zn^(^(2+))fluctuation in vivo is essential for understanding the physiological and pathological functions of Zn^(^(2+)).Photoacoustic(PA)Zn^(^(2+))imaging is an attractive alternative for i...Accurate tracking of labile Zn^(^(2+))fluctuation in vivo is essential for understanding the physiological and pathological functions of Zn^(^(2+)).Photoacoustic(PA)Zn^(^(2+))imaging is an attractive alternative for in vivo labile Zn^(^(2+))tracking due to its larger tissue imaging depth than optical imaging,and exploring reliable design strategies to construct ratiometric sensors for Zn^(^(2+)).展开更多
3d transition metal complexes are increasingly valued for their theranostic roles in cancer,owing to their biocompatibility,cost-effectiveness,and multifunctional capabilities.We report a glucose-conjugated Fe(Ⅲ)comp...3d transition metal complexes are increasingly valued for their theranostic roles in cancer,owing to their biocompatibility,cost-effectiveness,and multifunctional capabilities.We report a glucose-conjugated Fe(Ⅲ)complex,Fe2,designed as a cancer theranostic agent by uniquely integrating four distinct functionalities:glucose-driven targeting,photodynamic therapy,optical imaging,and MRI contrast enhancement.Fe2 selectively targets cervical and breast cancer cells by capitalizing on the overexpression of glucose transporter-1(GLUT-1)transmembrane protein.Its distinct ligand-to-metal charge transfer(LMCT)absorption band in the red region enables effective red-light photodynamic therapy for deep-tissue penetration,while its emission band supports optical cellular imaging.Additionally,its high-spin paramagnetic Fe(Ⅲ)center facilitates T1-weighted MRI contrast enhancement.Fe2 demonstrates good water solubility and high aqueous stability under dark and irradiated conditions and in reducing environments,such as in the presence of reduced glutathione(GSH).Fe2 shows significant red-light phototoxicity in cervical(HeLa)and breast(MCF-7)cancer cells(IC50∼14.1 and 9.2μM,respectively)while being non-toxic in the dark or healthy breast epithelial cells(MCF-10A,IC50>200μM).Cytotoxicity and cellular uptake studies confirm GLUT-1-mediated selective uptake of Fe2 in cancer cells over normal cells.Fe2 induces apoptosis via oxidative stress,activating both type-I and type-II photophysical pathways upon irradiation.Optical imaging studies confirm Fe2’s mitochondrial localization in HeLa and MCF-7 cells.Fe2 exhibits impressive relaxivity(r1p=5.2 mM^(-1)s^(-1)),attributed to interactions with human serum,and MRI phantom studies confirm significant contrast enhancement in MCF-7 cells.To our knowledge,Fe2 is the first complex to uniquely integrate these four functionalities,establishing it as a promising theranostic candidate and paving the way for designing carbohydrate-conjugated,photoactive paramagnetic complexes for targeted cancer theranostics.展开更多
Room-temperature(RT)terahertz(THz)detection finds widespread applications in security inspection,communication,biomedical imaging,and scientific research.However,the state-of-the-art detection strategies are still lim...Room-temperature(RT)terahertz(THz)detection finds widespread applications in security inspection,communication,biomedical imaging,and scientific research.However,the state-of-the-art detection strategies are still limited by issues such as low sensitivity,narrow response range,slow response speed,complex fabrication techniques,and difficulties in scaling up to large arrays.Here,we present a high-sensitivity,broadband-response,and high-speed RT THz detection strategy by utilizing a deep subwavelength metal–semiconductor–metal(MSM)structure.The spontaneously formed 2-dimensional electron gas(2DEG)at the CdTe/PbTe interface provides a superior transport channel characterized by high carrier concentration,low scattering,and high mobility.The synergy of the electromagnetic induced well effect formed in the MSM structure,and the efficient and rapid transport capabilities of the 2DEG channel give rise to an impressive performance improvement.The proposed 2DEG photodetector exhibits a broad frequency range from 22 to 519 GHz,an ultralow noise equivalent power of 3.0×10^(−14)W Hz^(−1/2)at 166 GHz,and a short response time of 6.7μs.This work provides an effective route for the development of high-performance RT THz detection strategies,paving the way for enhanced THz technology applications.展开更多
基金supported by the National Key R&D Program of China(Grant No.2023YFB2905600)the National Natural Science Foundation of China(Grant Nos.62127802,62331004,62305067,U24B20142,U24B20168,62427815)the Key Project of Jiangsu Province of China(Grant No.BE2023001-4)。
文摘The International Telecommunication Union(ITU)has introduced the concept of“intelligent connectivity for 2030”,which is driving the development of 6G technology.This next-generation wireless network is finding applications across various sectors,including smart cities,autonomous driving,holographic imaging,and satellite communications.When compared to 5G,the demands for higher data transmission rates,lower latency,and more efficient use of spectrum have become even more critical.
基金Natural Science Foundation of Guangxi(2024GXNSFDA010062)Guangxi Science and Technology Program Project(AD25069073)+3 种基金National Natural Science Foundation of China(62205079,62125503,62261160388)Innovation Project of Guangxi Graduate Education(YCSW2024332)Natural Science Foundation of Hubei Province of China(2023AFA028)Hubei Optical Fundamental Research Center(HBO2025TQ004)。
文摘Structured light beams have significant application value in fields like optical communication,microscopic imaging,and biomedicine due to their unique spatial field distribution characteristics.However,traditional structured beam generation systems based on discrete optical components have inherent drawbacks such as strict alignment requirements and poor tunability,which severely limit their practical applications.This paper proposes a new method for broadband bifunctional generation of structured beams based on fiber-integrated metasurfaces:by integrating spin-multiplexing bifunctional phase metasurfaces with the end faces of optical fibers,broadband sub-wavelength Bessel beams and focused vortex beams were,respectively,generated on demand in an all-fiber configuration when different circularly polarized light was input.The experimental measurements showed that the transmission characteristics of the generated beams were highly consistent with the numerical simulation results.Our scheme fully exploits the flexible waveguide(bendable)advantage of fibers,breaking through the constraint of poor optical path tunability in traditional“hard connection”systems due to strict alignment requirements.Since the implemented device simultaneously possesses broadband operation,sub-wavelength-scale field control,and spin-multiplexing characteristics,this study provides a new paradigm for multidimensional and multifunctional dynamic light field manipulation,and it holds significant application potential in fields such as fiber-optic imaging and fiber sensing.
基金supported by the Natural Science Foundation of China(Grants 21977044,21731004,21907050,91953201)the Natural Science Foundation of Jiangsu Province(BK20190282,BK20202004)+3 种基金the Excellent Research Program of Nanjing University(ZYJH004)the Fundamental Research Funds for the Central Universities(090314380036)the National Postdoctoral Program for Innovative Talents(BX2021123)the China Postdoctoral Science Foundation(2021M691505).
文摘Accurate tracking of labile Zn^(^(2+))fluctuation in vivo is essential for understanding the physiological and pathological functions of Zn^(^(2+)).Photoacoustic(PA)Zn^(^(2+))imaging is an attractive alternative for in vivo labile Zn^(^(2+))tracking due to its larger tissue imaging depth than optical imaging,and exploring reliable design strategies to construct ratiometric sensors for Zn^(^(2+)).
基金the Department of Biotechnology(DBT),Ministry of Science and Technology,Government of India,for funding this research through Grant No.BT/401/NE/U-Excel/2013 and BT/PR25668/NER/95/1278/2017S.B.thanks Department of Science and Technology(DST),Government of India,for the INSPIRE Faculty Fellowship(DST/INSPIRE/04/2019/000492)T.S.thanks DBT,the Council of Scientific and Industrial Research(CSIR,direct-SRF scheme),New Delhi,for the research fellowships.R.K.thanks the Ministry of Education,Government of India for the PMRF fellowship.
文摘3d transition metal complexes are increasingly valued for their theranostic roles in cancer,owing to their biocompatibility,cost-effectiveness,and multifunctional capabilities.We report a glucose-conjugated Fe(Ⅲ)complex,Fe2,designed as a cancer theranostic agent by uniquely integrating four distinct functionalities:glucose-driven targeting,photodynamic therapy,optical imaging,and MRI contrast enhancement.Fe2 selectively targets cervical and breast cancer cells by capitalizing on the overexpression of glucose transporter-1(GLUT-1)transmembrane protein.Its distinct ligand-to-metal charge transfer(LMCT)absorption band in the red region enables effective red-light photodynamic therapy for deep-tissue penetration,while its emission band supports optical cellular imaging.Additionally,its high-spin paramagnetic Fe(Ⅲ)center facilitates T1-weighted MRI contrast enhancement.Fe2 demonstrates good water solubility and high aqueous stability under dark and irradiated conditions and in reducing environments,such as in the presence of reduced glutathione(GSH).Fe2 shows significant red-light phototoxicity in cervical(HeLa)and breast(MCF-7)cancer cells(IC50∼14.1 and 9.2μM,respectively)while being non-toxic in the dark or healthy breast epithelial cells(MCF-10A,IC50>200μM).Cytotoxicity and cellular uptake studies confirm GLUT-1-mediated selective uptake of Fe2 in cancer cells over normal cells.Fe2 induces apoptosis via oxidative stress,activating both type-I and type-II photophysical pathways upon irradiation.Optical imaging studies confirm Fe2’s mitochondrial localization in HeLa and MCF-7 cells.Fe2 exhibits impressive relaxivity(r1p=5.2 mM^(-1)s^(-1)),attributed to interactions with human serum,and MRI phantom studies confirm significant contrast enhancement in MCF-7 cells.To our knowledge,Fe2 is the first complex to uniquely integrate these four functionalities,establishing it as a promising theranostic candidate and paving the way for designing carbohydrate-conjugated,photoactive paramagnetic complexes for targeted cancer theranostics.
基金supported by the National Natural Science Foundation of China(11933006,61805060,U2141240,and 62175045)National Key Research and Development Project of China(2023YFB2806700)+5 种基金Zhejiang Provincial Natural Science Foundation of China(LGF21F050001)Hangzhou Science and Technology Bureau of Zhejiang Province(TD2020002)Hangzhou Key Research and Development Program(2024SZD1A39)Research Funds of Hangzhou Institute for Advanced Study(B02006C019019 and 2022ZZ01007)Zhejiang Provincial Natural Science Foundation of China(no.LD25F040001)Hangzhou Joint Fund of the Zhejiang Provincial Natural Science Foundation of China(no.LHZQN25F050001).
文摘Room-temperature(RT)terahertz(THz)detection finds widespread applications in security inspection,communication,biomedical imaging,and scientific research.However,the state-of-the-art detection strategies are still limited by issues such as low sensitivity,narrow response range,slow response speed,complex fabrication techniques,and difficulties in scaling up to large arrays.Here,we present a high-sensitivity,broadband-response,and high-speed RT THz detection strategy by utilizing a deep subwavelength metal–semiconductor–metal(MSM)structure.The spontaneously formed 2-dimensional electron gas(2DEG)at the CdTe/PbTe interface provides a superior transport channel characterized by high carrier concentration,low scattering,and high mobility.The synergy of the electromagnetic induced well effect formed in the MSM structure,and the efficient and rapid transport capabilities of the 2DEG channel give rise to an impressive performance improvement.The proposed 2DEG photodetector exhibits a broad frequency range from 22 to 519 GHz,an ultralow noise equivalent power of 3.0×10^(−14)W Hz^(−1/2)at 166 GHz,and a short response time of 6.7μs.This work provides an effective route for the development of high-performance RT THz detection strategies,paving the way for enhanced THz technology applications.
