After drawbacks and shortages of using conventional kV or MV imaging mode were analyzed, this study proposes a new position verification mode with using the energy larger than 15 MeV or nominal accelerating potential ...After drawbacks and shortages of using conventional kV or MV imaging mode were analyzed, this study proposes a new position verification mode with using the energy larger than 15 MeV or nominal accelerating potential greater than 25 MV X-Ray. The new position verification mode is named HMV imaging mode. Along with the comparison of theoretical analyses, phantom experiments and clinical results to the original imaging modes, this report is going to demonstrate the HMV imaging mode is superior to traditional kV and MV imaging modes. This report first theoretically analyzed three main effects of X-ray interacting with medium by numerous equations and compared their mass attenuation coefficient with different types of tissue. X-ray irradiated on a “Catphan 500” cylinder phantom with different energies to verify these theoretical results. Furthermore, based on phantom experiments’ results, we have done numerous clinical trials and comparisons with patient’s clinical results. The theoretical and experimental results illustrate that the scanned images from HMV mode have a good quality and have ability to identify different tissue components clearly. HMV imaging mode overcomes drawbacks of position verification from both kV and MV level imaging mode as well as keeping advantages of kV and MV imaging mode. The result indicates that HMV is a good position verification mode in radiotherapy.展开更多
Oil spills pose a major threat to ocean ecosystems and their health. Synthetic aperture radar（SAR） sensors can detect oil spills on the sea surface. These oil spills appear as dark spots in SAR images. However, dark...Oil spills pose a major threat to ocean ecosystems and their health. Synthetic aperture radar（SAR） sensors can detect oil spills on the sea surface. These oil spills appear as dark spots in SAR images. However, dark formations can be caused by a number of phenomena. It is aimed to distinguishing oil spills or look-alike objects. A novel method based on a bidimensional empirical mode decomposition is proposed. The selected dark formations are first decomposed into several bidimensional intrinsic mode functions and the residue. Subsequently, 64 dimension feature sets are calculated using the Hilbert spectral analysis and five new features are extracted with a relief algorithm. Mahalanobis distances are then used for classification. Three data sets containing oil spills or look-alikes are used to test the accuracy rate of the method. The accuracy rate is more than 90%. The experimental results demonstrate that the novel method can detect oil spills validly and accurately.展开更多
Colonic mucosa-associated lymphoid tissue (MALT) lymphomas are a rare occurrence and the definitive treatment has not been established. Solitary or multiple, elevated or polypoid lesions are the usual appearances of M...Colonic mucosa-associated lymphoid tissue (MALT) lymphomas are a rare occurrence and the definitive treatment has not been established. Solitary or multiple, elevated or polypoid lesions are the usual appearances of MALT lymphoma in the large intestine and sometimes the surface may reveal abnormal vascularity. Herein, we report a case of MALT lymphoma and review the relevant literature. Upon colonoscopy, a suspected pathologic lesion was observed in the proximal transverse colon. The lesion could be distinguished more prominently after using narrow-band imaging mode and indigo carmine-dye spraying chromoendoscopy. Histopathologic examination of this biopsy specimen revealed lymphoepithelial lesions with diffuse proliferation of atypical lymphoid cells effacing the glandular architecture and centrocyte-like cells infiltrating the lamina propria. Immunohistochemical analyses showed that tumor cells were positive for CD20 and Bcl-2e, and negative for CD10, CD23, and Bcl-6. According to Ann-Arbor staging system, the patient had stage II<sub>E</sub>. A partial colectomy with dissection of the paracolic lymph nodes was performed. Until now, there is no recurrence of lymphoma at follow-up.展开更多
Crystal morphology is known to be of great importance to the end-use properties of crystal products, and to affect down-stream processing such as filtration and drying. However, it has been previously regarded as too ...Crystal morphology is known to be of great importance to the end-use properties of crystal products, and to affect down-stream processing such as filtration and drying. However, it has been previously regarded as too challenging to achieve automatic closed-loop control. Previous work has focused on controlling the crystal size distribution, where the size of a crystal is often defined as the diameter of a sphere that has the same volume as the crystal. This paper reviews the new advances in morphological population balance models for modelling and simulating the crystal shape distribution （CShD）, measuring and estimating crystal facet growth kinetics, and two- and three-dimensional imaging for on-line characterisation of the crystal morphology and CShD. A framework is presented that integrates the various components to achieve the ultimate objective of model-based closed-loop control of the CShD. The knowledge gaps and challenges that require further research are also identified.展开更多
This study demonstrates the synergistic integration of X-ray-induced radioluminescence(RL),persistent luminescence(PersL)and radio-photoluminescence(RPL)in a single material system,which provides innovative multimodal...This study demonstrates the synergistic integration of X-ray-induced radioluminescence(RL),persistent luminescence(PersL)and radio-photoluminescence(RPL)in a single material system,which provides innovative multimodal applications for radiometric information sensing,storage and reading,anti-counterfeiting and imaging.A novel radiation-sensing material,BaMgP_(2)O_(7):Sm,was prepared using a high temperature solid state method.Under X-ray irradiation,the pale pink phosphor shows distinct luminescence from defects.Under 365 nm ultraviolet(UV)light(bright-field),it emits bright red light,confirming trivalent samarium(Sm^(3+))reduction to divalent samarium(Sm^(2+)).In dark-field,orange fluorescence appears,indicating defect-mediated charge storage and slow release.Notably,the material enables single-irradiation multiple imaging,effectively overcoming the limitation of conventional materials that only allow single imaging per irradiation event,thereby greatly enhancing information utilization and imaging flexibility.Moreover,the flexible film based on polydimethylsiloxane(BaMgP_(2)O_(7):Sm@PDMS)demonstrates remarkable tri-mode X-ray detection and imaging capabilities,it has a high spatial resolution of 14.4 lp mm^(−1),integrating real-time readout,delayed readout,and long-term information storage.BaMgP_(2)O_(7):Sm enables dynamic anti-counterfeiting via time-dependent luminescence and precise radiation dose monitoring through X-ray responsive emission,these features make it a promising multifunctional material.展开更多
Development of tumor microenvironment responsive and multi-mode imaging guided photodynamic therapy(PDT)is highly desired.Herein,we report a MnO_(2)-coated and redox-sensitive nanoagent(DCMn-RA)by growing MnO_(2) on t...Development of tumor microenvironment responsive and multi-mode imaging guided photodynamic therapy(PDT)is highly desired.Herein,we report a MnO_(2)-coated and redox-sensitive nanoagent(DCMn-RA)by growing MnO_(2) on the surface of down-conversion nanoparticles(DCNPs)in situ for integrating GSH detection and enhanced-PDT.In tumor cells,the MnO_(2) layer can be reduced by excess intracellular glutathione(GSH)to Mn^(2+),leading to an intense magnetic resonance(MR)signal as well as recovery of fluorescence of the Ru(II)-polypyridyl alkyne complex(RA)([Ru(bpy)_(2)PIPB]·(PF6)_(2)(bpy=2,2’-bipyridine and PIPB=prop-2-yn^(-1)-yl 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)benzoate))for imaging.Meanwhile,the progress of consuming GSH is beneficial for PDT because a high concentration of GSH would eliminate reactive oxygen species(ROS)generated by PDT.In addition,DCMn-RA possesses potential for NIR-II optical imaging upon tissue-penetrable 808 nm excitation.We believe that the research outcomes reveal its promising potential as an integrating theranostic nanoprobe and nanoagent to realize the detection of GSH and enhance the efficacy of PDT.展开更多
文摘After drawbacks and shortages of using conventional kV or MV imaging mode were analyzed, this study proposes a new position verification mode with using the energy larger than 15 MeV or nominal accelerating potential greater than 25 MV X-Ray. The new position verification mode is named HMV imaging mode. Along with the comparison of theoretical analyses, phantom experiments and clinical results to the original imaging modes, this report is going to demonstrate the HMV imaging mode is superior to traditional kV and MV imaging modes. This report first theoretically analyzed three main effects of X-ray interacting with medium by numerous equations and compared their mass attenuation coefficient with different types of tissue. X-ray irradiated on a “Catphan 500” cylinder phantom with different energies to verify these theoretical results. Furthermore, based on phantom experiments’ results, we have done numerous clinical trials and comparisons with patient’s clinical results. The theoretical and experimental results illustrate that the scanned images from HMV mode have a good quality and have ability to identify different tissue components clearly. HMV imaging mode overcomes drawbacks of position verification from both kV and MV level imaging mode as well as keeping advantages of kV and MV imaging mode. The result indicates that HMV is a good position verification mode in radiotherapy.
基金The National Science and Technology Support Project under contract No.2014BAB12B02the Natural Science Foundation of Liaoning Province under contract No.201602042
文摘Oil spills pose a major threat to ocean ecosystems and their health. Synthetic aperture radar（SAR） sensors can detect oil spills on the sea surface. These oil spills appear as dark spots in SAR images. However, dark formations can be caused by a number of phenomena. It is aimed to distinguishing oil spills or look-alike objects. A novel method based on a bidimensional empirical mode decomposition is proposed. The selected dark formations are first decomposed into several bidimensional intrinsic mode functions and the residue. Subsequently, 64 dimension feature sets are calculated using the Hilbert spectral analysis and five new features are extracted with a relief algorithm. Mahalanobis distances are then used for classification. Three data sets containing oil spills or look-alikes are used to test the accuracy rate of the method. The accuracy rate is more than 90%. The experimental results demonstrate that the novel method can detect oil spills validly and accurately.
文摘Colonic mucosa-associated lymphoid tissue (MALT) lymphomas are a rare occurrence and the definitive treatment has not been established. Solitary or multiple, elevated or polypoid lesions are the usual appearances of MALT lymphoma in the large intestine and sometimes the surface may reveal abnormal vascularity. Herein, we report a case of MALT lymphoma and review the relevant literature. Upon colonoscopy, a suspected pathologic lesion was observed in the proximal transverse colon. The lesion could be distinguished more prominently after using narrow-band imaging mode and indigo carmine-dye spraying chromoendoscopy. Histopathologic examination of this biopsy specimen revealed lymphoepithelial lesions with diffuse proliferation of atypical lymphoid cells effacing the glandular architecture and centrocyte-like cells infiltrating the lamina propria. Immunohistochemical analyses showed that tumor cells were positive for CD20 and Bcl-2e, and negative for CD10, CD23, and Bcl-6. According to Ann-Arbor staging system, the patient had stage II<sub>E</sub>. A partial colectomy with dissection of the paracolic lymph nodes was performed. Until now, there is no recurrence of lymphoma at follow-up.
基金Financial support from the following projects and organisa- tions are acknowledged： the China One Thousand Talent Scheme, the National Natural Science Foundation of China （NNSFC） under its Major Research Scheme of Meso-scale Mechanism and Control in Multi-phase Reaction Processes （project reference： 91434126）, the Natural Science Foundation of Guangdong Province （project reference： 2014A030313228）, the UK Engineering and Physical Sciences Research Council （EPSRC） for the projects of Shape （EP/C009541） and StereoVision （EP/E045707）, and the Technology Strategy Board （TSB） for the project of High Value Manufacturing CGM （TP/BD059E）.
文摘Crystal morphology is known to be of great importance to the end-use properties of crystal products, and to affect down-stream processing such as filtration and drying. However, it has been previously regarded as too challenging to achieve automatic closed-loop control. Previous work has focused on controlling the crystal size distribution, where the size of a crystal is often defined as the diameter of a sphere that has the same volume as the crystal. This paper reviews the new advances in morphological population balance models for modelling and simulating the crystal shape distribution （CShD）, measuring and estimating crystal facet growth kinetics, and two- and three-dimensional imaging for on-line characterisation of the crystal morphology and CShD. A framework is presented that integrates the various components to achieve the ultimate objective of model-based closed-loop control of the CShD. The knowledge gaps and challenges that require further research are also identified.
基金supported by the National Natural Science Foundation of China(Grant No.12475311,12375209,12075221,12035002,11905122,and 23-GJRC-01-02)the Innovation and Development Fund of China Academy of Engineering Physics(Grant No.CX20210019)+2 种基金the National Natural Science Foundation Major Scientific Research Instrument Development Project(Grant No.12127810)Central Government Guided Local Science and Technology Development Fund Project(Grant No.ZY22096009)supported by the BL13HB beam line at the Shanghai Synchrotron Radiation Facility(SSRF),and by Dongtai Yaoqiang Machinery Manufacturing Co.,Ltd and Sicheng New Materials(Dongtai)Co.,Ltd.
文摘This study demonstrates the synergistic integration of X-ray-induced radioluminescence(RL),persistent luminescence(PersL)and radio-photoluminescence(RPL)in a single material system,which provides innovative multimodal applications for radiometric information sensing,storage and reading,anti-counterfeiting and imaging.A novel radiation-sensing material,BaMgP_(2)O_(7):Sm,was prepared using a high temperature solid state method.Under X-ray irradiation,the pale pink phosphor shows distinct luminescence from defects.Under 365 nm ultraviolet(UV)light(bright-field),it emits bright red light,confirming trivalent samarium(Sm^(3+))reduction to divalent samarium(Sm^(2+)).In dark-field,orange fluorescence appears,indicating defect-mediated charge storage and slow release.Notably,the material enables single-irradiation multiple imaging,effectively overcoming the limitation of conventional materials that only allow single imaging per irradiation event,thereby greatly enhancing information utilization and imaging flexibility.Moreover,the flexible film based on polydimethylsiloxane(BaMgP_(2)O_(7):Sm@PDMS)demonstrates remarkable tri-mode X-ray detection and imaging capabilities,it has a high spatial resolution of 14.4 lp mm^(−1),integrating real-time readout,delayed readout,and long-term information storage.BaMgP_(2)O_(7):Sm enables dynamic anti-counterfeiting via time-dependent luminescence and precise radiation dose monitoring through X-ray responsive emission,these features make it a promising multifunctional material.
基金supported by the National Nature Science Foundation of China(21877084,21671150,81171646,31170776,and 21472139)the Science and Technology Commission of Shanghai Municipality(14DZ2261100)the Fundamental Research Funds for the Central Universities.
文摘Development of tumor microenvironment responsive and multi-mode imaging guided photodynamic therapy(PDT)is highly desired.Herein,we report a MnO_(2)-coated and redox-sensitive nanoagent(DCMn-RA)by growing MnO_(2) on the surface of down-conversion nanoparticles(DCNPs)in situ for integrating GSH detection and enhanced-PDT.In tumor cells,the MnO_(2) layer can be reduced by excess intracellular glutathione(GSH)to Mn^(2+),leading to an intense magnetic resonance(MR)signal as well as recovery of fluorescence of the Ru(II)-polypyridyl alkyne complex(RA)([Ru(bpy)_(2)PIPB]·(PF6)_(2)(bpy=2,2’-bipyridine and PIPB=prop-2-yn^(-1)-yl 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)benzoate))for imaging.Meanwhile,the progress of consuming GSH is beneficial for PDT because a high concentration of GSH would eliminate reactive oxygen species(ROS)generated by PDT.In addition,DCMn-RA possesses potential for NIR-II optical imaging upon tissue-penetrable 808 nm excitation.We believe that the research outcomes reveal its promising potential as an integrating theranostic nanoprobe and nanoagent to realize the detection of GSH and enhance the efficacy of PDT.
