Recent studies indicate that millions of individuals suffer from renal diseases,with renal carcinoma,a type of kidney cancer,emerging as both a chronic illness and a significant cause of mortality.Magnetic Resonance I...Recent studies indicate that millions of individuals suffer from renal diseases,with renal carcinoma,a type of kidney cancer,emerging as both a chronic illness and a significant cause of mortality.Magnetic Resonance Imaging(MRI)and Computed Tomography(CT)have become essential tools for diagnosing and assessing kidney disorders.However,accurate analysis of thesemedical images is critical for detecting and evaluating tumor severity.This study introduces an integrated hybrid framework that combines three complementary deep learning models for kidney tumor segmentation from MRI images.The proposed framework fuses a customized U-Net and Mask R-CNN using a weighted scheme to achieve semantic and instance-level segmentation.The fused outputs are further refined through edge detection using Stochastic FeatureMapping Neural Networks(SFMNN),while volumetric consistency is ensured through Improved Mini-Batch K-Means(IMBKM)clustering integrated with an Encoder-Decoder Convolutional Neural Network(EDCNN).The outputs of these three stages are combined through a weighted fusion mechanism,with optimal weights determined empirically.Experiments on MRI scans from the TCGA-KIRC dataset demonstrate that the proposed hybrid framework significantly outperforms standalone models,achieving a Dice Score of 92.5%,an IoU of 87.8%,a Precision of 93.1%,a Recall of 90.8%,and a Hausdorff Distance of 2.8 mm.These findings validate that the weighted integration of complementary architectures effectively overcomes key limitations in kidney tumor segmentation,leading to improved diagnostic accuracy and robustness in medical image analysis.展开更多
Organoids possess immense potential for unraveling the intricate functions of human tissues and facilitating preclinical disease treatment.Their applications span from high-throughput drug screening to the modeling of...Organoids possess immense potential for unraveling the intricate functions of human tissues and facilitating preclinical disease treatment.Their applications span from high-throughput drug screening to the modeling of complex diseases,with some even achieving clinical translation.Changes in the overall size,shape,boundary,and other morphological features of organoids provide a noninvasive method for assessing organoid drug sensitivity.However,the precise segmentation of organoids in bright-field microscopy images is made difficult by the complexity of the organoid morphology and interference,including overlapping organoids,bubbles,dust particles,and cell fragments.This paper introduces the precision organoid segmentation technique(POST),which is a deep-learning algorithm for segmenting challenging organoids under simple bright-field imaging conditions.Unlike existing methods,POST accurately segments each organoid and eliminates various artifacts encountered during organoid culturing and imaging.Furthermore,it is sensitive to and aligns with measurements of organoid activity in drug sensitivity experiments.POST is expected to be a valuable tool for drug screening using organoids owing to its capability of automatically and rapidly eliminating interfering substances and thereby streamlining the organoid analysis and drug screening process.展开更多
Microscopy imaging is fundamental in analyzing bacterial morphology and dynamics,offering critical insights into bacterial physiology and pathogenicity.Image segmentation techniques enable quantitative analysis of bac...Microscopy imaging is fundamental in analyzing bacterial morphology and dynamics,offering critical insights into bacterial physiology and pathogenicity.Image segmentation techniques enable quantitative analysis of bacterial structures,facilitating precise measurement of morphological variations and population behaviors at single-cell resolution.This paper reviews advancements in bacterial image segmentation,emphasizing the shift from traditional thresholding and watershed methods to deep learning-driven approaches.Convolutional neural networks(CNNs),U-Net architectures,and three-dimensional(3D)frameworks excel at segmenting dense biofilms and resolving antibiotic-induced morphological changes.These methods combine automated feature extraction with physics-informed postprocessing.Despite progress,challenges persist in computational efficiency,cross-species generalizability,and integration with multimodal experimental workflows.Future progress will depend on improving model robustness across species and imaging modalities,integrating multimodal data for phenotype-function mapping,and developing standard pipelines that link computational tools with clinical diagnostics.These innovations will expand microbial phenotyping beyond structural analysis,enabling deeper insights into bacterial physiology and ecological interactions.展开更多
Medical image segmentation is of critical importance in the domain of contemporary medical imaging.However,U-Net and its variants exhibit limitations in capturing complex nonlinear patterns and global contextual infor...Medical image segmentation is of critical importance in the domain of contemporary medical imaging.However,U-Net and its variants exhibit limitations in capturing complex nonlinear patterns and global contextual information.Although the subsequent U-KAN model enhances nonlinear representation capabilities,it still faces challenges such as gradient vanishing during deep network training and spatial detail loss during feature downsampling,resulting in insufficient segmentation accuracy for edge structures and minute lesions.To address these challenges,this paper proposes the RE-UKAN model,which innovatively improves upon U-KAN.Firstly,a residual network is introduced into the encoder to effectively mitigate gradient vanishing through cross-layer identity mappings,thus enhancing modelling capabilities for complex pathological structures.Secondly,Efficient Local Attention(ELA)is integrated to suppress spatial detail loss during downsampling,thereby improving the perception of edge structures and minute lesions.Experimental results on four public datasets demonstrate that RE-UKAN outperforms existing medical image segmentation methods across multiple evaluation metrics,with particularly outstanding performance on the TN-SCUI 2020 dataset,achieving IoU of 88.18%and Dice of 93.57%.Compared to the baseline model,it achieves improvements of 3.05%and 1.72%,respectively.These results fully demonstrate RE-UKAN’s superior detail retention capability and boundary recognition accuracy in complex medical image segmentation tasks,providing a reliable solution for clinical precision segmentation.展开更多
This article studies the problem of image segmentation-based semantic communication in autonomous driving.In real traffic scenes,the detecting of objects(e.g.,vehicles and pedestrians)is more important to guarantee dr...This article studies the problem of image segmentation-based semantic communication in autonomous driving.In real traffic scenes,the detecting of objects(e.g.,vehicles and pedestrians)is more important to guarantee driving safety,which is always ignored in existing works.Therefore,we propose a vehicular image segmentation-oriented semantic communication system,termed VIS-SemCom,focusing on transmitting and recovering image semantic features of high-important objects to reduce transmission redundancy.First,we develop a semantic codec based on Swin Transformer architecture,which expands the perceptual field thus improving the segmentation accuracy.To highlight the important objects'accuracy,we propose a multi-scale semantic extraction method by assigning the number of Swin Transformer blocks for diverse resolution semantic features.Also,an importance-aware loss incorporating important levels is devised,and an online hard example mining(OHEM)strategy is proposed to handle small sample issues in the dataset.Finally,experimental results demonstrate that the proposed VIS-SemCom can achieve a significant mean intersection over union(mIoU)performance in the SNR regions,a reduction of transmitted data volume by about 60%at 60%mIoU,and improve the segmentation accuracy of important objects,compared to baseline image communication.展开更多
Magnetic Resonance Imaging(MRI)has a pivotal role in medical image analysis,for its ability in supporting disease detection and diagnosis.Fuzzy C-Means(FCM)clustering is widely used for MRI segmentation due to its abi...Magnetic Resonance Imaging(MRI)has a pivotal role in medical image analysis,for its ability in supporting disease detection and diagnosis.Fuzzy C-Means(FCM)clustering is widely used for MRI segmentation due to its ability to handle image uncertainty.However,the latter still has countless limitations,including sensitivity to initialization,susceptibility to local optima,and high computational cost.To address these limitations,this study integrates Grey Wolf Optimization(GWO)with FCM to enhance cluster center selection,improving segmentation accuracy and robustness.Moreover,to further refine optimization,Fuzzy Entropy Clustering was utilized for its distinctive features from other traditional objective functions.Fuzzy entropy effectively quantifies uncertainty,leading to more well-defined clusters,improved noise robustness,and better preservation of anatomical structures in MRI images.Despite these advantages,the iterative nature of GWO and FCM introduces significant computational overhead,which restricts their applicability to high-resolution medical images.To overcome this bottleneck,we propose a Parallelized-GWO-based FCM(P-GWO-FCM)approach using GPU acceleration,where both GWO optimization and FCM updates(centroid computation and membership matrix updates)are parallelized.By concurrently executing these processes,our approach efficiently distributes the computational workload,significantly reducing execution time while maintaining high segmentation accuracy.The proposed parallel method,P-GWO-FCM,was evaluated on both simulated and clinical brain MR images,focusing on segmenting white matter,gray matter,and cerebrospinal fluid regions.The results indicate significant improvements in segmentation accuracy,achieving a Jaccard Similarity(JS)of 0.92,a Partition Coefficient Index(PCI)of 0.91,a Partition Entropy Index(PEI)of 0.25,and a Davies-Bouldin Index(DBI)of 0.30.Experimental comparisons demonstrate that P-GWO-FCM outperforms existing methods in both segmentation accuracy and computational efficiency,making it a promising solution for real-time medical image segmentation.展开更多
High-resolution remote sensing images(HRSIs)are now an essential data source for gathering surface information due to advancements in remote sensing data capture technologies.However,their significant scale changes an...High-resolution remote sensing images(HRSIs)are now an essential data source for gathering surface information due to advancements in remote sensing data capture technologies.However,their significant scale changes and wealth of spatial details pose challenges for semantic segmentation.While convolutional neural networks(CNNs)excel at capturing local features,they are limited in modeling long-range dependencies.Conversely,transformers utilize multihead self-attention to integrate global context effectively,but this approach often incurs a high computational cost.This paper proposes a global-local multiscale context network(GLMCNet)to extract both global and local multiscale contextual information from HRSIs.A detail-enhanced filtering module(DEFM)is proposed at the end of the encoder to refine the encoder outputs further,thereby enhancing the key details extracted by the encoder and effectively suppressing redundant information.In addition,a global-local multiscale transformer block(GLMTB)is proposed in the decoding stage to enable the modeling of rich multiscale global and local information.We also design a stair fusion mechanism to transmit deep semantic information from deep to shallow layers progressively.Finally,we propose the semantic awareness enhancement module(SAEM),which further enhances the representation of multiscale semantic features through spatial attention and covariance channel attention.Extensive ablation analyses and comparative experiments were conducted to evaluate the performance of the proposed method.Specifically,our method achieved a mean Intersection over Union(mIoU)of 86.89%on the ISPRS Potsdam dataset and 84.34%on the ISPRS Vaihingen dataset,outperforming existing models such as ABCNet and BANet.展开更多
Automatic and accurate medical image segmentation remains a fundamental task in computer-aided diagnosis and treatment planning.Recent advances in foundation models,such as the medical-focused Segment AnythingModel(Me...Automatic and accurate medical image segmentation remains a fundamental task in computer-aided diagnosis and treatment planning.Recent advances in foundation models,such as the medical-focused Segment AnythingModel(MedSAM),have demonstrated strong performance but face challenges inmanymedical applications due to anatomical complexity and a limited domain-specific prompt.Thiswork introduces amethodology that enhances segmentation robustness and precision by automatically generating multiple informative point prompts,rather than relying on single inputs.The proposed approach randomly samples sets of spatially distributed point prompts based on image features,enabling MedSAM to better capture fine-grained anatomical structures and boundaries.During inference,probability maps are aggregated to reduce local misclassifications without additional model training.Extensive experiments on various computed tomography(CT)and magnetic resonance imaging(MRI)datasets demonstrate improvements in Dice Similarity Coefficient(DSC)and Normalized Surface Dice(NSD)metrics compared to baseline SAM and Scribble Prompt models.A semi-automatic point sampling version based on the ground truth segmentations yielded enhanced results,achieving up to 92.1%DSC and 86.6%NSD,with significant gains in delineating complex organs such as the pancreas,colon,kidney,and brain tumours.The main novelty of our method consists of effectively combining the results of multiple point prompts into the medical segmentation pipeline so that single-point prompt methods are outperformed.Overall,the proposed model offers a straightforward yet effective approach to improve medical image segmentation performance while maintaining computational efficiency.展开更多
Background:Diabetic macular edema is a prevalent retinal condition and a leading cause of visual impairment among diabetic patients’Early detection of affected areas is beneficial for effective diagnosis and treatmen...Background:Diabetic macular edema is a prevalent retinal condition and a leading cause of visual impairment among diabetic patients’Early detection of affected areas is beneficial for effective diagnosis and treatment.Traditionally,diagnosis relies on optical coherence tomography imaging technology interpreted by ophthalmologists.However,this manual image interpretation is often slow and subjective.Therefore,developing automated segmentation for macular edema images is essential to enhance to improve the diagnosis efficiency and accuracy.Methods:In order to improve clinical diagnostic efficiency and accuracy,we proposed a SegNet network structure integrated with a convolutional block attention module(CBAM).This network introduces a multi-scale input module,the CBAM attention mechanism,and jump connection.The multi-scale input module enhances the network’s perceptual capabilities,while the lightweight CBAM effectively fuses relevant features across channels and spatial dimensions,allowing for better learning of varying information levels.Results:Experimental results demonstrate that the proposed network achieves an IoU of 80.127%and an accuracy of 99.162%.Compared to the traditional segmentation network,this model has fewer parameters,faster training and testing speed,and superior performance on semantic segmentation tasks,indicating its highly practical applicability.Conclusion:The C-SegNet proposed in this study enables accurate segmentation of Diabetic macular edema lesion images,which facilitates quicker diagnosis for healthcare professionals.展开更多
Satellite image segmentation plays a crucial role in remote sensing,supporting applications such as environmental monitoring,land use analysis,and disaster management.However,traditional segmentation methods often rel...Satellite image segmentation plays a crucial role in remote sensing,supporting applications such as environmental monitoring,land use analysis,and disaster management.However,traditional segmentation methods often rely on large amounts of labeled data,which are costly and time-consuming to obtain,especially in largescale or dynamic environments.To address this challenge,we propose the Semi-Supervised Multi-View Picture Fuzzy Clustering(SS-MPFC)algorithm,which improves segmentation accuracy and robustness,particularly in complex and uncertain remote sensing scenarios.SS-MPFC unifies three paradigms:semi-supervised learning,multi-view clustering,and picture fuzzy set theory.This integration allows the model to effectively utilize a small number of labeled samples,fuse complementary information from multiple data views,and handle the ambiguity and uncertainty inherent in satellite imagery.We design a novel objective function that jointly incorporates picture fuzzy membership functions across multiple views of the data,and embeds pairwise semi-supervised constraints(must-link and cannot-link)directly into the clustering process to enhance segmentation accuracy.Experiments conducted on several benchmark satellite datasets demonstrate that SS-MPFC significantly outperforms existing state-of-the-art methods in segmentation accuracy,noise robustness,and semantic interpretability.On the Augsburg dataset,SS-MPFC achieves a Purity of 0.8158 and an Accuracy of 0.6860,highlighting its outstanding robustness and efficiency.These results demonstrate that SSMPFC offers a scalable and effective solution for real-world satellite-based monitoring systems,particularly in scenarios where rapid annotation is infeasible,such as wildfire tracking,agricultural monitoring,and dynamic urban mapping.展开更多
Multilevel image segmentation is a critical task in image analysis,which imposes high requirements on the global search capability and convergence efficiency of segmentation algorithms.In this paper,an improved Artifi...Multilevel image segmentation is a critical task in image analysis,which imposes high requirements on the global search capability and convergence efficiency of segmentation algorithms.In this paper,an improved Artificial Protozoa Optimization algorithm,termed the two-stage Taguchi-assisted Gaussian–Levy Artificial Protozoa Optimization(TGAPO)algorithm,is proposed and applied tomultilevel image segmentation.The proposed algorithm adopts a two-stage evolutionary mechanism.In the first stage,Gaussian perturbation is introduced to enhance local search capability;in the second stage,Levy flight is incorporated to expand the global search range;and finally,the Taguchi strategy is employed to further refine the optimal solution.Consequently,the global optimization performance and robustness of the algorithm are significantly improved.To evaluate the effectiveness of the proposed TGAPO algorithm,comparative experiments are conducted with representative optimization algorithms,including the Grey Wolf Optimizer(GWO)and Particle Swarm Optimization(PSO),in the context ofmultilevel image segmentation.The segmentation quality is assessed using the minimum cross-entropy function as the performance metric.Experimental results demonstrate that the TGAPO algorithm outperforms the comparison algorithms in terms of segmentation accuracy and convergence speed,and exhibits superior stability in high-threshold segmentation tasks.Furthermore,the proposedmethod achieves excellentmulti-threshold segmentation performance for color images and shows strong potential for practical applications.展开更多
Alzheimer’s Disease(AD)is a progressive neurodegenerative disorder that significantly affects cognitive function,making early and accurate diagnosis essential.Traditional Deep Learning(DL)-based approaches often stru...Alzheimer’s Disease(AD)is a progressive neurodegenerative disorder that significantly affects cognitive function,making early and accurate diagnosis essential.Traditional Deep Learning(DL)-based approaches often struggle with low-contrast MRI images,class imbalance,and suboptimal feature extraction.This paper develops a Hybrid DL system that unites MobileNetV2 with adaptive classification methods to boost Alzheimer’s diagnosis by processing MRI scans.Image enhancement is done using Contrast-Limited Adaptive Histogram Equalization(CLAHE)and Enhanced Super-Resolution Generative Adversarial Networks(ESRGAN).A classification robustness enhancement system integrates class weighting techniques and a Matthews Correlation Coefficient(MCC)-based evaluation method into the design.The trained and validated model gives a 98.88%accuracy rate and 0.9614 MCC score.We also performed a 10-fold cross-validation experiment with an average accuracy of 96.52%(±1.51),a loss of 0.1671,and an MCC score of 0.9429 across folds.The proposed framework outperforms the state-of-the-art models with a 98%weighted F1-score while decreasing misdiagnosis results for every AD stage.The model demonstrates apparent separation abilities between AD progression stages according to the results of the confusion matrix analysis.These results validate the effectiveness of hybrid DL models with adaptive preprocessing for early and reliable Alzheimer’s diagnosis,contributing to improved computer-aided diagnosis(CAD)systems in clinical practice.展开更多
Brain tumor segmentation is critical in clinical diagnosis and treatment planning.Existing methods for brain tumor segmentation with missing modalities often struggle when dealing with multiple missing modalities,a co...Brain tumor segmentation is critical in clinical diagnosis and treatment planning.Existing methods for brain tumor segmentation with missing modalities often struggle when dealing with multiple missing modalities,a common scenario in real-world clinical settings.These methods primarily focus on handling a single missing modality at a time,making them insufficiently robust for the additional complexity encountered with incomplete data containing various missing modality combinations.Additionally,most existing methods rely on single models,which may limit their performance and increase the risk of overfitting the training data.This work proposes a novel method called the ensemble adversarial co-training neural network(EACNet)for accurate brain tumor segmentation from multi-modal magnetic resonance imaging(MRI)scans with multiple missing modalities.The proposed method consists of three key modules:the ensemble of pre-trained models,which captures diverse feature representations from the MRI data by employing an ensemble of pre-trained models;adversarial learning,which leverages a competitive training approach involving two models;a generator model,which creates realistic missing data,while sub-networks acting as discriminators learn to distinguish real data from the generated“fake”data.Co-training framework utilizes the information extracted by the multimodal path(trained on complete scans)to guide the learning process in the path handling missing modalities.The model potentially compensates for missing information through co-training interactions by exploiting the relationships between available modalities and the tumor segmentation task.EACNet was evaluated on the BraTS2018 and BraTS2020 challenge datasets and achieved state-of-the-art and competitive performance respectively.Notably,the segmentation results for the whole tumor(WT)dice similarity coefficient(DSC)reached 89.27%,surpassing the performance of existing methods.The analysis suggests that the ensemble approach offers potential benefits,and the adversarial co-training contributes to the increased robustness and accuracy of EACNet for brain tumor segmentation of MRI scans with missing modalities.The experimental results show that EACNet has promising results for the task of brain tumor segmentation of MRI scans with missing modalities and is a better candidate for real-world clinical applications.展开更多
Image segmentation is attracting increasing attention in the field of medical image analysis.Since widespread utilization across various medical applications,ensuring and improving segmentation accuracy has become a c...Image segmentation is attracting increasing attention in the field of medical image analysis.Since widespread utilization across various medical applications,ensuring and improving segmentation accuracy has become a crucial topic of research.With advances in deep learning,researchers have developed numerous methods that combine Transformers and convolutional neural networks(CNNs)to create highly accurate models for medical image segmentation.However,efforts to further enhance accuracy by developing larger and more complex models or training with more extensive datasets,significantly increase computational resource consumption.To address this problem,we propose BiCLIP-nnFormer(the prefix"Bi"refers to the use of two distinct CLIP models),a virtual multimodal instrument that leverages CLIP models to enhance the segmentation performance of a medical segmentation model nnFormer.Since two CLIP models(PMC-CLIP and CoCa-CLIP)are pre-trained on large datasets,they do not require additional training,thus conserving computation resources.These models are used offline to extract image and text embeddings from medical images.These embeddings are then processed by the proposed 3D CLIP adapter,which adapts the CLIP knowledge for segmentation tasks by fine-tuning.Finally,the adapted embeddings are fused with feature maps extracted from the nnFormer encoder for generating predicted masks.This process enriches the representation capabilities of the feature maps by integrating global multimodal information,leading to more precise segmentation predictions.We demonstrate the superiority of BiCLIP-nnFormer and the effectiveness of using CLIP models to enhance nnFormer through experiments on two public datasets,namely the Synapse multi-organ segmentation dataset(Synapse)and the Automatic Cardiac Diagnosis Challenge dataset(ACDC),as well as a self-annotated lung multi-category segmentation dataset(LMCS).展开更多
Data augmentation plays an important role in training deep neural model by expanding the size and diversity of the dataset.Initially,data augmentation mainly involved some simple transformations of images.Later,in ord...Data augmentation plays an important role in training deep neural model by expanding the size and diversity of the dataset.Initially,data augmentation mainly involved some simple transformations of images.Later,in order to increase the diversity and complexity of data,more advanced methods appeared and evolved to sophisticated generative models.However,these methods required a mass of computation of training or searching.In this paper,a novel training-free method that utilises the Pre-Trained Segment Anything Model(SAM)model as a data augmentation tool(PTSAM-DA)is proposed to generate the augmented annotations for images.Without the need for training,it obtains prompt boxes from the original annotations and then feeds the boxes to the pre-trained SAM to generate diverse and improved annotations.In this way,annotations are augmented more ingenious than simple manipulations without incurring huge computation for training a data augmentation model.Multiple comparative experiments on three datasets are conducted,including an in-house dataset,ADE20K and COCO2017.On this in-house dataset,namely Agricultural Plot Segmentation Dataset,maximum improvements of 3.77%and 8.92%are gained in two mainstream metrics,mIoU and mAcc,respectively.Consequently,large vision models like SAM are proven to be promising not only in image segmentation but also in data augmentation.展开更多
Karst fractures serve as crucial seepage channels and storage spaces for carbonate natural gas reservoirs,and electrical image logs are vital data for visualizing and characterizing such fractures.However,the conventi...Karst fractures serve as crucial seepage channels and storage spaces for carbonate natural gas reservoirs,and electrical image logs are vital data for visualizing and characterizing such fractures.However,the conventional approach of identifying fractures using electrical image logs predominantly relies on manual processes that are not only time-consuming but also highly subjective.In addition,the heterogeneity and strong dissolution tendency of karst carbonate reservoirs lead to complexity and variety in fracture geometry,which makes it difficult to accurately identify fractures.In this paper,the electrical image logs network(EILnet)da deep-learning-based intelligent semantic segmentation model with a selective attention mechanism and selective feature fusion moduledwas created to enable the intelligent identification and segmentation of different types of fractures through electrical logging images.Data from electrical image logs representing structural and induced fractures were first selected using the sliding window technique before image inpainting and data augmentation were implemented for these images to improve the generalizability of the model.Various image-processing tools,including the bilateral filter,Laplace operator,and Gaussian low-pass filter,were also applied to the electrical logging images to generate a multi-attribute dataset to help the model learn the semantic features of the fractures.The results demonstrated that the EILnet model outperforms mainstream deep-learning semantic segmentation models,such as Fully Convolutional Networks(FCN-8s),U-Net,and SegNet,for both the single-channel dataset and the multi-attribute dataset.The EILnet provided significant advantages for the single-channel dataset,and its mean intersection over union(MIoU)and pixel accuracy(PA)were 81.32%and 89.37%,respectively.In the case of the multi-attribute dataset,the identification capability of all models improved to varying degrees,with the EILnet achieving the highest MIoU and PA of 83.43%and 91.11%,respectively.Further,applying the EILnet model to various blind wells demonstrated its ability to provide reliable fracture identification,thereby indicating its promising potential applications.展开更多
基金funded by the Ongoing Research Funding Program-Research Chairs(ORF-RC-2025-2400),King Saud University,Riyadh,Saudi Arabia。
文摘Recent studies indicate that millions of individuals suffer from renal diseases,with renal carcinoma,a type of kidney cancer,emerging as both a chronic illness and a significant cause of mortality.Magnetic Resonance Imaging(MRI)and Computed Tomography(CT)have become essential tools for diagnosing and assessing kidney disorders.However,accurate analysis of thesemedical images is critical for detecting and evaluating tumor severity.This study introduces an integrated hybrid framework that combines three complementary deep learning models for kidney tumor segmentation from MRI images.The proposed framework fuses a customized U-Net and Mask R-CNN using a weighted scheme to achieve semantic and instance-level segmentation.The fused outputs are further refined through edge detection using Stochastic FeatureMapping Neural Networks(SFMNN),while volumetric consistency is ensured through Improved Mini-Batch K-Means(IMBKM)clustering integrated with an Encoder-Decoder Convolutional Neural Network(EDCNN).The outputs of these three stages are combined through a weighted fusion mechanism,with optimal weights determined empirically.Experiments on MRI scans from the TCGA-KIRC dataset demonstrate that the proposed hybrid framework significantly outperforms standalone models,achieving a Dice Score of 92.5%,an IoU of 87.8%,a Precision of 93.1%,a Recall of 90.8%,and a Hausdorff Distance of 2.8 mm.These findings validate that the weighted integration of complementary architectures effectively overcomes key limitations in kidney tumor segmentation,leading to improved diagnostic accuracy and robustness in medical image analysis.
基金supported by the National Key R&D Program of China(No.2022YFC2504403)the National Natural Science Foundation of China(No.62172202)+1 种基金the Experiment Project of China Manned Space Program(No.HYZHXM01019)the Fundamental Research Funds for the Central Universities from Southeast University(No.3207032101C3)。
文摘Organoids possess immense potential for unraveling the intricate functions of human tissues and facilitating preclinical disease treatment.Their applications span from high-throughput drug screening to the modeling of complex diseases,with some even achieving clinical translation.Changes in the overall size,shape,boundary,and other morphological features of organoids provide a noninvasive method for assessing organoid drug sensitivity.However,the precise segmentation of organoids in bright-field microscopy images is made difficult by the complexity of the organoid morphology and interference,including overlapping organoids,bubbles,dust particles,and cell fragments.This paper introduces the precision organoid segmentation technique(POST),which is a deep-learning algorithm for segmenting challenging organoids under simple bright-field imaging conditions.Unlike existing methods,POST accurately segments each organoid and eliminates various artifacts encountered during organoid culturing and imaging.Furthermore,it is sensitive to and aligns with measurements of organoid activity in drug sensitivity experiments.POST is expected to be a valuable tool for drug screening using organoids owing to its capability of automatically and rapidly eliminating interfering substances and thereby streamlining the organoid analysis and drug screening process.
基金financially supported by the Open Project Program of Wuhan National Laboratory for Optoelectronics(No.2022WNLOKF009)the National Natural Science Foundation of China(No.62475216)+2 种基金the Key Research and Development Program of Shaanxi(No.2024GH-ZDXM-37)the Fujian Provincial Natural Science Foundation of China(No.2024J01060)the Startup Program of XMU,and the Fundamental Research Funds for the Central Universities.
文摘Microscopy imaging is fundamental in analyzing bacterial morphology and dynamics,offering critical insights into bacterial physiology and pathogenicity.Image segmentation techniques enable quantitative analysis of bacterial structures,facilitating precise measurement of morphological variations and population behaviors at single-cell resolution.This paper reviews advancements in bacterial image segmentation,emphasizing the shift from traditional thresholding and watershed methods to deep learning-driven approaches.Convolutional neural networks(CNNs),U-Net architectures,and three-dimensional(3D)frameworks excel at segmenting dense biofilms and resolving antibiotic-induced morphological changes.These methods combine automated feature extraction with physics-informed postprocessing.Despite progress,challenges persist in computational efficiency,cross-species generalizability,and integration with multimodal experimental workflows.Future progress will depend on improving model robustness across species and imaging modalities,integrating multimodal data for phenotype-function mapping,and developing standard pipelines that link computational tools with clinical diagnostics.These innovations will expand microbial phenotyping beyond structural analysis,enabling deeper insights into bacterial physiology and ecological interactions.
文摘Medical image segmentation is of critical importance in the domain of contemporary medical imaging.However,U-Net and its variants exhibit limitations in capturing complex nonlinear patterns and global contextual information.Although the subsequent U-KAN model enhances nonlinear representation capabilities,it still faces challenges such as gradient vanishing during deep network training and spatial detail loss during feature downsampling,resulting in insufficient segmentation accuracy for edge structures and minute lesions.To address these challenges,this paper proposes the RE-UKAN model,which innovatively improves upon U-KAN.Firstly,a residual network is introduced into the encoder to effectively mitigate gradient vanishing through cross-layer identity mappings,thus enhancing modelling capabilities for complex pathological structures.Secondly,Efficient Local Attention(ELA)is integrated to suppress spatial detail loss during downsampling,thereby improving the perception of edge structures and minute lesions.Experimental results on four public datasets demonstrate that RE-UKAN outperforms existing medical image segmentation methods across multiple evaluation metrics,with particularly outstanding performance on the TN-SCUI 2020 dataset,achieving IoU of 88.18%and Dice of 93.57%.Compared to the baseline model,it achieves improvements of 3.05%and 1.72%,respectively.These results fully demonstrate RE-UKAN’s superior detail retention capability and boundary recognition accuracy in complex medical image segmentation tasks,providing a reliable solution for clinical precision segmentation.
基金National Natural Science Foundation of China under Grants No.62171047,U22B2001,62271065,62001051Beijing Natural Science Foundation under Grant L223027BUPT Excellent Ph.D Students Foundation under Grants CX2021114。
文摘This article studies the problem of image segmentation-based semantic communication in autonomous driving.In real traffic scenes,the detecting of objects(e.g.,vehicles and pedestrians)is more important to guarantee driving safety,which is always ignored in existing works.Therefore,we propose a vehicular image segmentation-oriented semantic communication system,termed VIS-SemCom,focusing on transmitting and recovering image semantic features of high-important objects to reduce transmission redundancy.First,we develop a semantic codec based on Swin Transformer architecture,which expands the perceptual field thus improving the segmentation accuracy.To highlight the important objects'accuracy,we propose a multi-scale semantic extraction method by assigning the number of Swin Transformer blocks for diverse resolution semantic features.Also,an importance-aware loss incorporating important levels is devised,and an online hard example mining(OHEM)strategy is proposed to handle small sample issues in the dataset.Finally,experimental results demonstrate that the proposed VIS-SemCom can achieve a significant mean intersection over union(mIoU)performance in the SNR regions,a reduction of transmitted data volume by about 60%at 60%mIoU,and improve the segmentation accuracy of important objects,compared to baseline image communication.
文摘Magnetic Resonance Imaging(MRI)has a pivotal role in medical image analysis,for its ability in supporting disease detection and diagnosis.Fuzzy C-Means(FCM)clustering is widely used for MRI segmentation due to its ability to handle image uncertainty.However,the latter still has countless limitations,including sensitivity to initialization,susceptibility to local optima,and high computational cost.To address these limitations,this study integrates Grey Wolf Optimization(GWO)with FCM to enhance cluster center selection,improving segmentation accuracy and robustness.Moreover,to further refine optimization,Fuzzy Entropy Clustering was utilized for its distinctive features from other traditional objective functions.Fuzzy entropy effectively quantifies uncertainty,leading to more well-defined clusters,improved noise robustness,and better preservation of anatomical structures in MRI images.Despite these advantages,the iterative nature of GWO and FCM introduces significant computational overhead,which restricts their applicability to high-resolution medical images.To overcome this bottleneck,we propose a Parallelized-GWO-based FCM(P-GWO-FCM)approach using GPU acceleration,where both GWO optimization and FCM updates(centroid computation and membership matrix updates)are parallelized.By concurrently executing these processes,our approach efficiently distributes the computational workload,significantly reducing execution time while maintaining high segmentation accuracy.The proposed parallel method,P-GWO-FCM,was evaluated on both simulated and clinical brain MR images,focusing on segmenting white matter,gray matter,and cerebrospinal fluid regions.The results indicate significant improvements in segmentation accuracy,achieving a Jaccard Similarity(JS)of 0.92,a Partition Coefficient Index(PCI)of 0.91,a Partition Entropy Index(PEI)of 0.25,and a Davies-Bouldin Index(DBI)of 0.30.Experimental comparisons demonstrate that P-GWO-FCM outperforms existing methods in both segmentation accuracy and computational efficiency,making it a promising solution for real-time medical image segmentation.
基金provided by the Science Research Project of Hebei Education Department under grant No.BJK2024115.
文摘High-resolution remote sensing images(HRSIs)are now an essential data source for gathering surface information due to advancements in remote sensing data capture technologies.However,their significant scale changes and wealth of spatial details pose challenges for semantic segmentation.While convolutional neural networks(CNNs)excel at capturing local features,they are limited in modeling long-range dependencies.Conversely,transformers utilize multihead self-attention to integrate global context effectively,but this approach often incurs a high computational cost.This paper proposes a global-local multiscale context network(GLMCNet)to extract both global and local multiscale contextual information from HRSIs.A detail-enhanced filtering module(DEFM)is proposed at the end of the encoder to refine the encoder outputs further,thereby enhancing the key details extracted by the encoder and effectively suppressing redundant information.In addition,a global-local multiscale transformer block(GLMTB)is proposed in the decoding stage to enable the modeling of rich multiscale global and local information.We also design a stair fusion mechanism to transmit deep semantic information from deep to shallow layers progressively.Finally,we propose the semantic awareness enhancement module(SAEM),which further enhances the representation of multiscale semantic features through spatial attention and covariance channel attention.Extensive ablation analyses and comparative experiments were conducted to evaluate the performance of the proposed method.Specifically,our method achieved a mean Intersection over Union(mIoU)of 86.89%on the ISPRS Potsdam dataset and 84.34%on the ISPRS Vaihingen dataset,outperforming existing models such as ABCNet and BANet.
基金supported by the Autonomous Government of Andalusia(Spain)under project UMA20-FEDERJA-108also by the Ministry of Science and Innovation of Spain,grant number PID2022-136764OA-I00+1 种基金It includes funds fromthe European Regional Development Fund(ERDF),It is also partially supported by the Fundación Unicaja(PUNI-003_2023)the Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND(ATECH-25-02).
文摘Automatic and accurate medical image segmentation remains a fundamental task in computer-aided diagnosis and treatment planning.Recent advances in foundation models,such as the medical-focused Segment AnythingModel(MedSAM),have demonstrated strong performance but face challenges inmanymedical applications due to anatomical complexity and a limited domain-specific prompt.Thiswork introduces amethodology that enhances segmentation robustness and precision by automatically generating multiple informative point prompts,rather than relying on single inputs.The proposed approach randomly samples sets of spatially distributed point prompts based on image features,enabling MedSAM to better capture fine-grained anatomical structures and boundaries.During inference,probability maps are aggregated to reduce local misclassifications without additional model training.Extensive experiments on various computed tomography(CT)and magnetic resonance imaging(MRI)datasets demonstrate improvements in Dice Similarity Coefficient(DSC)and Normalized Surface Dice(NSD)metrics compared to baseline SAM and Scribble Prompt models.A semi-automatic point sampling version based on the ground truth segmentations yielded enhanced results,achieving up to 92.1%DSC and 86.6%NSD,with significant gains in delineating complex organs such as the pancreas,colon,kidney,and brain tumours.The main novelty of our method consists of effectively combining the results of multiple point prompts into the medical segmentation pipeline so that single-point prompt methods are outperformed.Overall,the proposed model offers a straightforward yet effective approach to improve medical image segmentation performance while maintaining computational efficiency.
基金supported by the Guangdong Pharmaceutical University 2024 Higher Education Research Projects(GKP202403,GMP202402)the Guangdong Pharmaceutical University College Students’Innovation and Entrepreneurship Training Programs(Grant No.202504302033,202504302034,202504302036,and 202504302244).
文摘Background:Diabetic macular edema is a prevalent retinal condition and a leading cause of visual impairment among diabetic patients’Early detection of affected areas is beneficial for effective diagnosis and treatment.Traditionally,diagnosis relies on optical coherence tomography imaging technology interpreted by ophthalmologists.However,this manual image interpretation is often slow and subjective.Therefore,developing automated segmentation for macular edema images is essential to enhance to improve the diagnosis efficiency and accuracy.Methods:In order to improve clinical diagnostic efficiency and accuracy,we proposed a SegNet network structure integrated with a convolutional block attention module(CBAM).This network introduces a multi-scale input module,the CBAM attention mechanism,and jump connection.The multi-scale input module enhances the network’s perceptual capabilities,while the lightweight CBAM effectively fuses relevant features across channels and spatial dimensions,allowing for better learning of varying information levels.Results:Experimental results demonstrate that the proposed network achieves an IoU of 80.127%and an accuracy of 99.162%.Compared to the traditional segmentation network,this model has fewer parameters,faster training and testing speed,and superior performance on semantic segmentation tasks,indicating its highly practical applicability.Conclusion:The C-SegNet proposed in this study enables accurate segmentation of Diabetic macular edema lesion images,which facilitates quicker diagnosis for healthcare professionals.
基金funded by the Research Project:THTETN.05/24-25,VietnamAcademy of Science and Technology.
文摘Satellite image segmentation plays a crucial role in remote sensing,supporting applications such as environmental monitoring,land use analysis,and disaster management.However,traditional segmentation methods often rely on large amounts of labeled data,which are costly and time-consuming to obtain,especially in largescale or dynamic environments.To address this challenge,we propose the Semi-Supervised Multi-View Picture Fuzzy Clustering(SS-MPFC)algorithm,which improves segmentation accuracy and robustness,particularly in complex and uncertain remote sensing scenarios.SS-MPFC unifies three paradigms:semi-supervised learning,multi-view clustering,and picture fuzzy set theory.This integration allows the model to effectively utilize a small number of labeled samples,fuse complementary information from multiple data views,and handle the ambiguity and uncertainty inherent in satellite imagery.We design a novel objective function that jointly incorporates picture fuzzy membership functions across multiple views of the data,and embeds pairwise semi-supervised constraints(must-link and cannot-link)directly into the clustering process to enhance segmentation accuracy.Experiments conducted on several benchmark satellite datasets demonstrate that SS-MPFC significantly outperforms existing state-of-the-art methods in segmentation accuracy,noise robustness,and semantic interpretability.On the Augsburg dataset,SS-MPFC achieves a Purity of 0.8158 and an Accuracy of 0.6860,highlighting its outstanding robustness and efficiency.These results demonstrate that SSMPFC offers a scalable and effective solution for real-world satellite-based monitoring systems,particularly in scenarios where rapid annotation is infeasible,such as wildfire tracking,agricultural monitoring,and dynamic urban mapping.
文摘Multilevel image segmentation is a critical task in image analysis,which imposes high requirements on the global search capability and convergence efficiency of segmentation algorithms.In this paper,an improved Artificial Protozoa Optimization algorithm,termed the two-stage Taguchi-assisted Gaussian–Levy Artificial Protozoa Optimization(TGAPO)algorithm,is proposed and applied tomultilevel image segmentation.The proposed algorithm adopts a two-stage evolutionary mechanism.In the first stage,Gaussian perturbation is introduced to enhance local search capability;in the second stage,Levy flight is incorporated to expand the global search range;and finally,the Taguchi strategy is employed to further refine the optimal solution.Consequently,the global optimization performance and robustness of the algorithm are significantly improved.To evaluate the effectiveness of the proposed TGAPO algorithm,comparative experiments are conducted with representative optimization algorithms,including the Grey Wolf Optimizer(GWO)and Particle Swarm Optimization(PSO),in the context ofmultilevel image segmentation.The segmentation quality is assessed using the minimum cross-entropy function as the performance metric.Experimental results demonstrate that the TGAPO algorithm outperforms the comparison algorithms in terms of segmentation accuracy and convergence speed,and exhibits superior stability in high-threshold segmentation tasks.Furthermore,the proposedmethod achieves excellentmulti-threshold segmentation performance for color images and shows strong potential for practical applications.
基金funded by the Deanship of Graduate Studies and Scientific Research at Jouf University under grant No.(DGSSR-2025-02-01295).
文摘Alzheimer’s Disease(AD)is a progressive neurodegenerative disorder that significantly affects cognitive function,making early and accurate diagnosis essential.Traditional Deep Learning(DL)-based approaches often struggle with low-contrast MRI images,class imbalance,and suboptimal feature extraction.This paper develops a Hybrid DL system that unites MobileNetV2 with adaptive classification methods to boost Alzheimer’s diagnosis by processing MRI scans.Image enhancement is done using Contrast-Limited Adaptive Histogram Equalization(CLAHE)and Enhanced Super-Resolution Generative Adversarial Networks(ESRGAN).A classification robustness enhancement system integrates class weighting techniques and a Matthews Correlation Coefficient(MCC)-based evaluation method into the design.The trained and validated model gives a 98.88%accuracy rate and 0.9614 MCC score.We also performed a 10-fold cross-validation experiment with an average accuracy of 96.52%(±1.51),a loss of 0.1671,and an MCC score of 0.9429 across folds.The proposed framework outperforms the state-of-the-art models with a 98%weighted F1-score while decreasing misdiagnosis results for every AD stage.The model demonstrates apparent separation abilities between AD progression stages according to the results of the confusion matrix analysis.These results validate the effectiveness of hybrid DL models with adaptive preprocessing for early and reliable Alzheimer’s diagnosis,contributing to improved computer-aided diagnosis(CAD)systems in clinical practice.
基金supported by Gansu Natural Science Foundation Programme(No.24JRRA231)National Natural Science Foundation of China(No.62061023)Gansu Provincial Education,Science and Technology Innovation and Industry(No.2021CYZC-04)。
文摘Brain tumor segmentation is critical in clinical diagnosis and treatment planning.Existing methods for brain tumor segmentation with missing modalities often struggle when dealing with multiple missing modalities,a common scenario in real-world clinical settings.These methods primarily focus on handling a single missing modality at a time,making them insufficiently robust for the additional complexity encountered with incomplete data containing various missing modality combinations.Additionally,most existing methods rely on single models,which may limit their performance and increase the risk of overfitting the training data.This work proposes a novel method called the ensemble adversarial co-training neural network(EACNet)for accurate brain tumor segmentation from multi-modal magnetic resonance imaging(MRI)scans with multiple missing modalities.The proposed method consists of three key modules:the ensemble of pre-trained models,which captures diverse feature representations from the MRI data by employing an ensemble of pre-trained models;adversarial learning,which leverages a competitive training approach involving two models;a generator model,which creates realistic missing data,while sub-networks acting as discriminators learn to distinguish real data from the generated“fake”data.Co-training framework utilizes the information extracted by the multimodal path(trained on complete scans)to guide the learning process in the path handling missing modalities.The model potentially compensates for missing information through co-training interactions by exploiting the relationships between available modalities and the tumor segmentation task.EACNet was evaluated on the BraTS2018 and BraTS2020 challenge datasets and achieved state-of-the-art and competitive performance respectively.Notably,the segmentation results for the whole tumor(WT)dice similarity coefficient(DSC)reached 89.27%,surpassing the performance of existing methods.The analysis suggests that the ensemble approach offers potential benefits,and the adversarial co-training contributes to the increased robustness and accuracy of EACNet for brain tumor segmentation of MRI scans with missing modalities.The experimental results show that EACNet has promising results for the task of brain tumor segmentation of MRI scans with missing modalities and is a better candidate for real-world clinical applications.
基金funded by the National Natural Science Foundation of China(Grant No.6240072655)the Hubei Provincial Key Research and Development Program(Grant No.2023BCB151)+1 种基金the Wuhan Natural Science Foundation Exploration Program(Chenguang Program,Grant No.2024040801020202)the Natural Science Foundation of Hubei Province of China(Grant No.2025AFB148).
文摘Image segmentation is attracting increasing attention in the field of medical image analysis.Since widespread utilization across various medical applications,ensuring and improving segmentation accuracy has become a crucial topic of research.With advances in deep learning,researchers have developed numerous methods that combine Transformers and convolutional neural networks(CNNs)to create highly accurate models for medical image segmentation.However,efforts to further enhance accuracy by developing larger and more complex models or training with more extensive datasets,significantly increase computational resource consumption.To address this problem,we propose BiCLIP-nnFormer(the prefix"Bi"refers to the use of two distinct CLIP models),a virtual multimodal instrument that leverages CLIP models to enhance the segmentation performance of a medical segmentation model nnFormer.Since two CLIP models(PMC-CLIP and CoCa-CLIP)are pre-trained on large datasets,they do not require additional training,thus conserving computation resources.These models are used offline to extract image and text embeddings from medical images.These embeddings are then processed by the proposed 3D CLIP adapter,which adapts the CLIP knowledge for segmentation tasks by fine-tuning.Finally,the adapted embeddings are fused with feature maps extracted from the nnFormer encoder for generating predicted masks.This process enriches the representation capabilities of the feature maps by integrating global multimodal information,leading to more precise segmentation predictions.We demonstrate the superiority of BiCLIP-nnFormer and the effectiveness of using CLIP models to enhance nnFormer through experiments on two public datasets,namely the Synapse multi-organ segmentation dataset(Synapse)and the Automatic Cardiac Diagnosis Challenge dataset(ACDC),as well as a self-annotated lung multi-category segmentation dataset(LMCS).
基金Natural Science Foundation of Zhejiang Province,Grant/Award Number:LY23F020025Science and Technology Commissioner Program of Huzhou,Grant/Award Number:2023GZ42Sichuan Provincial Science and Technology Support Program,Grant/Award Numbers:2023ZHCG0005,2023ZHCG0008。
文摘Data augmentation plays an important role in training deep neural model by expanding the size and diversity of the dataset.Initially,data augmentation mainly involved some simple transformations of images.Later,in order to increase the diversity and complexity of data,more advanced methods appeared and evolved to sophisticated generative models.However,these methods required a mass of computation of training or searching.In this paper,a novel training-free method that utilises the Pre-Trained Segment Anything Model(SAM)model as a data augmentation tool(PTSAM-DA)is proposed to generate the augmented annotations for images.Without the need for training,it obtains prompt boxes from the original annotations and then feeds the boxes to the pre-trained SAM to generate diverse and improved annotations.In this way,annotations are augmented more ingenious than simple manipulations without incurring huge computation for training a data augmentation model.Multiple comparative experiments on three datasets are conducted,including an in-house dataset,ADE20K and COCO2017.On this in-house dataset,namely Agricultural Plot Segmentation Dataset,maximum improvements of 3.77%and 8.92%are gained in two mainstream metrics,mIoU and mAcc,respectively.Consequently,large vision models like SAM are proven to be promising not only in image segmentation but also in data augmentation.
基金the National Natural Science Foundation of China(42472194,42302153,and 42002144)the Fundamental Research Funds for the Central Univer-sities(22CX06002A).
文摘Karst fractures serve as crucial seepage channels and storage spaces for carbonate natural gas reservoirs,and electrical image logs are vital data for visualizing and characterizing such fractures.However,the conventional approach of identifying fractures using electrical image logs predominantly relies on manual processes that are not only time-consuming but also highly subjective.In addition,the heterogeneity and strong dissolution tendency of karst carbonate reservoirs lead to complexity and variety in fracture geometry,which makes it difficult to accurately identify fractures.In this paper,the electrical image logs network(EILnet)da deep-learning-based intelligent semantic segmentation model with a selective attention mechanism and selective feature fusion moduledwas created to enable the intelligent identification and segmentation of different types of fractures through electrical logging images.Data from electrical image logs representing structural and induced fractures were first selected using the sliding window technique before image inpainting and data augmentation were implemented for these images to improve the generalizability of the model.Various image-processing tools,including the bilateral filter,Laplace operator,and Gaussian low-pass filter,were also applied to the electrical logging images to generate a multi-attribute dataset to help the model learn the semantic features of the fractures.The results demonstrated that the EILnet model outperforms mainstream deep-learning semantic segmentation models,such as Fully Convolutional Networks(FCN-8s),U-Net,and SegNet,for both the single-channel dataset and the multi-attribute dataset.The EILnet provided significant advantages for the single-channel dataset,and its mean intersection over union(MIoU)and pixel accuracy(PA)were 81.32%and 89.37%,respectively.In the case of the multi-attribute dataset,the identification capability of all models improved to varying degrees,with the EILnet achieving the highest MIoU and PA of 83.43%and 91.11%,respectively.Further,applying the EILnet model to various blind wells demonstrated its ability to provide reliable fracture identification,thereby indicating its promising potential applications.
