Hepatitis C virus （HCV） is an important etiologic agent of hepatitis and a major cause of chronic liver infection that often leads to cirrhosis, fibrosis and hepatocel-lular carcinoma. Although, HCV is a hepatotropi...Hepatitis C virus （HCV） is an important etiologic agent of hepatitis and a major cause of chronic liver infection that often leads to cirrhosis, fibrosis and hepatocel-lular carcinoma. Although, HCV is a hepatotropic virus, there is strong evidence that HCV could replicate extra-hepatic in the gastrointestinal tissue which could serve as a reservoir for HCV. The outcome of HCV infection depends mainly on the host innate and adaptive im-mune responses. Innate immunity against HCV includes mainly nuclear factor cells and activation of IFN-related genes. There is an immunologic link between the gut and the liver through a population of T-cells that are ca-pable of homing to both the liver and gut via the portal circulation. However, little is known on the role of Gut immune response in HCV. In this review we discussed the immune regulation of Gut immune cells and its as-sociation with HCV pathogenesis, various outcomes of anti-HCV therapy, viral persistence and degree of liver infammation. Additionally, we investigated the relation-ship between Gut immune responses to HCV and IL28B genotypes, which were identifed as a strong predictor for HCV pathogenesis and treatment outcome after acute infection.展开更多
To study immune reactions and the mechanism of anergy induced by recombinant enterotoxin A (rSEA) of Staphylococcus aureus. The gene encoding SEA was cloned from standard strain of S. aureus and high efficiently expre...To study immune reactions and the mechanism of anergy induced by recombinant enterotoxin A (rSEA) of Staphylococcus aureus. The gene encoding SEA was cloned from standard strain of S. aureus and high efficiently expressed in E. coli. After immunization with purified rSEA, mice were examined for production of specific antibody, subtype of IgG, cytokine mRNA levels such as IFN-γ, IL-2 secretion and T-cell surface PD-1 expression. Results showed that high levels of specific antibodies were produced in two weeks of primary immunization shot. During this time, humoral immune reactions prevailed (IgG2a/ IgG1 【1). During the early phase, Th1 type cytokine mRNA is expressed at a higher level than Th2 type, indicating cellular immune reaction prevailed. Splen- ocyte IFN-γ secretion was significantly decreased after boosting immunization. The PD-1 expression was detected by a flow cytometry examination in the surface of T- lymphocytes which were induced by rSEA, and the expression of PD-1 molecules increased along with the number of boosting and the time after immunization.展开更多
Hallux valgus is a relatively common and multifaceted complex deformity of the front part of the foot. It is the result of multiple effects of innate (endogenous) and exogenous etiological factors with different degre...Hallux valgus is a relatively common and multifaceted complex deformity of the front part of the foot. It is the result of multiple effects of innate (endogenous) and exogenous etiological factors with different degrees of influence. The degree of hallux valgus deformity is usually assessed by radiological values of hallux valgus (HV) and intermetatarsal (IM) angles. The aim of the paper is to justify the definition of hallux valgus deformity as a function of one angle, (HVA or IMA), and then to determine the functional connection and the most suitable function equalizing the values of the angles IMA and HVA. As hallux valgus is a double angulation deformity, the analytically determined connection between the HVA and IMA angles reduces the study of the deformity to the study of function with one argument, and makes the analysis of deformity changes before and after operative treatment simpler. For the determined connections between the angles, the values of linear proportionality coefficients and regression coefficients of corresponding linear functions of analytical equalization of the value of the IM angle and the degree of deformity for a given value of the HV angle were experimentally determined. The obtained results were checked on a sample of 396 operatively treated hallux valgus deformities. The presented analytical approach and the obtained functional links of IMA and HVA enable quantitative observation of the change in the degree of deformity based on the radiologically determined value of these angles, and the established nonlinear function will be useful for evaluating the expected value of the IM angle and the degree of deformity based only on the measured value of the HV angle. .展开更多
In this paper we study the uniqueness of certain meromorphic functions. It is shown that any two nonconstant meromorphic functions of order less than one, that share four values IM or six values SCM, must be identical...In this paper we study the uniqueness of certain meromorphic functions. It is shown that any two nonconstant meromorphic functions of order less than one, that share four values IM or six values SCM, must be identical. As a consequence, a result due to W. W. Adams and E. G. Straus is generalized.展开更多
文章针对IP多媒体系统(IP multimedia subsystem,IMS)应用于电力行业与普通商用领域时,在用户容量、话务模型等方面存在的差异性,研究电力IMS网络功能虚拟化(network function virtualization,NFV)的单节点硬件部署方案。第一阶段,在商...文章针对IP多媒体系统(IP multimedia subsystem,IMS)应用于电力行业与普通商用领域时,在用户容量、话务模型等方面存在的差异性,研究电力IMS网络功能虚拟化(network function virtualization,NFV)的单节点硬件部署方案。第一阶段,在商用IMS的标准配置基础上,逐步缩减硬件资源,直至业务受损;第二阶段,根据电力系统的业务安全性要求,增加适当冗余度。规模化试点测试表明在20万用户、5000并发量下,电力IMS虚拟化硬件资源可压缩至商用配置的70.59%。研究结果可支撑国家电网IMS虚拟化演进工程设计。展开更多
基金Supported by Egyptian Government Scholarship for Helal HettaMerck Investigator Initiated Studies(IIS)IISP,No.40458(Shata)
文摘Hepatitis C virus （HCV） is an important etiologic agent of hepatitis and a major cause of chronic liver infection that often leads to cirrhosis, fibrosis and hepatocel-lular carcinoma. Although, HCV is a hepatotropic virus, there is strong evidence that HCV could replicate extra-hepatic in the gastrointestinal tissue which could serve as a reservoir for HCV. The outcome of HCV infection depends mainly on the host innate and adaptive im-mune responses. Innate immunity against HCV includes mainly nuclear factor cells and activation of IFN-related genes. There is an immunologic link between the gut and the liver through a population of T-cells that are ca-pable of homing to both the liver and gut via the portal circulation. However, little is known on the role of Gut immune response in HCV. In this review we discussed the immune regulation of Gut immune cells and its as-sociation with HCV pathogenesis, various outcomes of anti-HCV therapy, viral persistence and degree of liver infammation. Additionally, we investigated the relation-ship between Gut immune responses to HCV and IL28B genotypes, which were identifed as a strong predictor for HCV pathogenesis and treatment outcome after acute infection.
文摘To study immune reactions and the mechanism of anergy induced by recombinant enterotoxin A (rSEA) of Staphylococcus aureus. The gene encoding SEA was cloned from standard strain of S. aureus and high efficiently expressed in E. coli. After immunization with purified rSEA, mice were examined for production of specific antibody, subtype of IgG, cytokine mRNA levels such as IFN-γ, IL-2 secretion and T-cell surface PD-1 expression. Results showed that high levels of specific antibodies were produced in two weeks of primary immunization shot. During this time, humoral immune reactions prevailed (IgG2a/ IgG1 【1). During the early phase, Th1 type cytokine mRNA is expressed at a higher level than Th2 type, indicating cellular immune reaction prevailed. Splen- ocyte IFN-γ secretion was significantly decreased after boosting immunization. The PD-1 expression was detected by a flow cytometry examination in the surface of T- lymphocytes which were induced by rSEA, and the expression of PD-1 molecules increased along with the number of boosting and the time after immunization.
文摘Hallux valgus is a relatively common and multifaceted complex deformity of the front part of the foot. It is the result of multiple effects of innate (endogenous) and exogenous etiological factors with different degrees of influence. The degree of hallux valgus deformity is usually assessed by radiological values of hallux valgus (HV) and intermetatarsal (IM) angles. The aim of the paper is to justify the definition of hallux valgus deformity as a function of one angle, (HVA or IMA), and then to determine the functional connection and the most suitable function equalizing the values of the angles IMA and HVA. As hallux valgus is a double angulation deformity, the analytically determined connection between the HVA and IMA angles reduces the study of the deformity to the study of function with one argument, and makes the analysis of deformity changes before and after operative treatment simpler. For the determined connections between the angles, the values of linear proportionality coefficients and regression coefficients of corresponding linear functions of analytical equalization of the value of the IM angle and the degree of deformity for a given value of the HV angle were experimentally determined. The obtained results were checked on a sample of 396 operatively treated hallux valgus deformities. The presented analytical approach and the obtained functional links of IMA and HVA enable quantitative observation of the change in the degree of deformity based on the radiologically determined value of these angles, and the established nonlinear function will be useful for evaluating the expected value of the IM angle and the degree of deformity based only on the measured value of the HV angle. .
文摘In this paper we study the uniqueness of certain meromorphic functions. It is shown that any two nonconstant meromorphic functions of order less than one, that share four values IM or six values SCM, must be identical. As a consequence, a result due to W. W. Adams and E. G. Straus is generalized.
文摘文章针对IP多媒体系统(IP multimedia subsystem,IMS)应用于电力行业与普通商用领域时,在用户容量、话务模型等方面存在的差异性,研究电力IMS网络功能虚拟化(network function virtualization,NFV)的单节点硬件部署方案。第一阶段,在商用IMS的标准配置基础上,逐步缩减硬件资源,直至业务受损;第二阶段,根据电力系统的业务安全性要求,增加适当冗余度。规模化试点测试表明在20万用户、5000并发量下,电力IMS虚拟化硬件资源可压缩至商用配置的70.59%。研究结果可支撑国家电网IMS虚拟化演进工程设计。
