On the basis of systematic modification of the structure of componds of antiepilepsirine type, more than 200 cinnamamides were synthesized and tested by animal assay (maximal electroshock seizure, MES). Pharmacologica...On the basis of systematic modification of the structure of componds of antiepilepsirine type, more than 200 cinnamamides were synthesized and tested by animal assay (maximal electroshock seizure, MES). Pharmacological evaluation showed that the configuration and the substituents on the phenyl ring and the nitrogen of amides, and substituents on the double bond displayed an important effect on the anticonvulsant activity.For studying the effect of the modification of structure to anticonvulsant activity, Hansch approach was employed to study the QSAR among 38 cinnamamides, and Hopfinger' s MSA was employed to study the MSA-QSAR among 26 cinnamamides.展开更多
In F. Scott Fitzgerald's world famous novel The Great Gatsby, Nicolas"Nick"Carraway is not only a first-person narrator, but also a convincing narrator, an emotion depositor, and a structure organizer. H...In F. Scott Fitzgerald's world famous novel The Great Gatsby, Nicolas"Nick"Carraway is not only a first-person narrator, but also a convincing narrator, an emotion depositor, and a structure organizer. He is the figure of equal weight with Jay Gatsby and Daisy Buchanan, the two conceived protagonists in this book.展开更多
基金Projects Supported by the National Fund of Natural Sciences
文摘On the basis of systematic modification of the structure of componds of antiepilepsirine type, more than 200 cinnamamides were synthesized and tested by animal assay (maximal electroshock seizure, MES). Pharmacological evaluation showed that the configuration and the substituents on the phenyl ring and the nitrogen of amides, and substituents on the double bond displayed an important effect on the anticonvulsant activity.For studying the effect of the modification of structure to anticonvulsant activity, Hansch approach was employed to study the QSAR among 38 cinnamamides, and Hopfinger' s MSA was employed to study the MSA-QSAR among 26 cinnamamides.
文摘In F. Scott Fitzgerald's world famous novel The Great Gatsby, Nicolas"Nick"Carraway is not only a first-person narrator, but also a convincing narrator, an emotion depositor, and a structure organizer. He is the figure of equal weight with Jay Gatsby and Daisy Buchanan, the two conceived protagonists in this book.
