Embryo models derived from pluripotent stem cells(PSCs)have become powerful tools for dissecting mammalian embryonic development and advancing regenerative medicine.Two recent studies in Cell and Cell Stem Cell report...Embryo models derived from pluripotent stem cells(PSCs)have become powerful tools for dissecting mammalian embryonic development and advancing regenerative medicine.Two recent studies in Cell and Cell Stem Cell report major advances in generating mouse embryo models that replicate development up to early organogenesis(equivalent to embryonic day 8.5~8.75).Li et al.describe a purely chemical strategy to reprogram mouse embryonic stem cells(mESCs)into induced embryo founder cells(iEFCs)capable of forming complete embryo models(iEFC-EMs).In parallel,Yilmaz et al.demonstrate transgene-free generation of post-gastrulation models(TF-SEMs)from naive mESCs and induced pluripotent stem cells(iPSCs)using a similar chemical cocktail.Both models faithfully recapitulate key developmental events,including gastrulation,neural tube formation,cardiogenesis,and somitogenesis.These advances not only deepen understanding of early mammalian development but also pave the way for applications in regenerative medicine and disease modeling.展开更多
基金supported by grants from the National Natural Science Foundation of China(32270844 and 32325017 to J.W.,32300668 to X.Y.)Natural Science Foundation of Guangdong Province(2024A1515012311 to X.Y.).
文摘Embryo models derived from pluripotent stem cells(PSCs)have become powerful tools for dissecting mammalian embryonic development and advancing regenerative medicine.Two recent studies in Cell and Cell Stem Cell report major advances in generating mouse embryo models that replicate development up to early organogenesis(equivalent to embryonic day 8.5~8.75).Li et al.describe a purely chemical strategy to reprogram mouse embryonic stem cells(mESCs)into induced embryo founder cells(iEFCs)capable of forming complete embryo models(iEFC-EMs).In parallel,Yilmaz et al.demonstrate transgene-free generation of post-gastrulation models(TF-SEMs)from naive mESCs and induced pluripotent stem cells(iPSCs)using a similar chemical cocktail.Both models faithfully recapitulate key developmental events,including gastrulation,neural tube formation,cardiogenesis,and somitogenesis.These advances not only deepen understanding of early mammalian development but also pave the way for applications in regenerative medicine and disease modeling.
