The four-decades long exchanges with Chinese scholars has provided me with a fresh perspective.Reading history makes me feel that the talents of the historical Chinese who created the country’s glorious ancient civil...The four-decades long exchanges with Chinese scholars has provided me with a fresh perspective.Reading history makes me feel that the talents of the historical Chinese who created the country’s glorious ancient civilization are still being carried on today,and have become the foundation enabling China to build an ideal type of society.Indeed,China regards “becoming developed” as its ultimate goal and “reform and growth” as its guideline.The progress of artificial intelligence would not remove its own weakness of democracy.On the contrary,as the technology grows mature,it might steer development of socialism in a favourable direction.展开更多
目的利用磁共振功能成像非对称回波最小二乘估算法迭代水脂分离(iteraterative decomposition of water and fat with echoasymmetryandleast-squaresestimationquantitation,IDEAL-IQ)技术无创定量评估2型糖尿病(type2diabetesmellitus...目的利用磁共振功能成像非对称回波最小二乘估算法迭代水脂分离(iteraterative decomposition of water and fat with echoasymmetryandleast-squaresestimationquantitation,IDEAL-IQ)技术无创定量评估2型糖尿病(type2diabetesmellitus,T2DM)大鼠肝脏、肾脏及胰腺的脂肪沉积与铁沉积,并研究T2DM大鼠空腹血糖(fasting blood glucose,FBG)、体质量与脂肪沉积、铁沉积之间的关系,同时比较实验组和对照组大鼠肝肾功、血脂以及病理学改变的差异。材料与方法10只无特定病原体(specific pathogen free,SPF)健康雄性SD大鼠随机进行分组为实验组(n=7)和对照组(n=3)。实验组进行T2DM的模型建立。待实验组成模后,将两组大鼠进行IDEAL-IQ扫描,通过测定两组大鼠的肝脏、胰腺及肾脏的质子密度脂肪分数(proton density fat fraction,PDFF)和横向弛豫率(transverse relaxation rate,R2^(*))来评估实验组以及对照组大鼠肝脏、胰腺及肾脏的脂肪沉积及铁过载,扫描结束后心脏取血评估肝功、肾功及血脂改变。处死大鼠后取肝脏、肾脏及胰腺做常规HE染色观察细胞的变化、油红O染色观察脂肪沉积、普鲁士蓝铁染色观察铁沉积。实验数据运用SPSS 27.0软件进行统计学分析,通过Pearson相关系数分析大鼠FBG、体质量与各器官PDFF、R2^(*)值之间的相关性。结果T2DM组SD大鼠的FBG、体质量、PDFF胰腺、PDFF肝脏、PDFF右肾、PDFF左肾、R2^(*)胰腺、R2^(*)肝脏、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)均高于对照组,差异有统计学意义(P<0.05),但两组大鼠在T1 SI胰腺、T1 SI肝脏、T1 SI右肾、T1 SI左肾、T2 SI胰腺、T2 SI肝脏、T2 SI右肾、T2 SI左肾、R2^(*)右肾、R2^(*)左肾、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、尿素氮(BUN)、肌酐(Cr)等方面比较差异没有统计学意义(P>0.05)。Pearson相关性分析,FBG与PDFF肝脏(r=0.773)、PDFF胰腺(r=0.837)、PDFF右肾(r=0.895)、PDFF左肾(r=0.784)、R2^(*)肝脏(r=0.876)、体质量(r=0.980)均呈正相关(P<0.05)。体质量与PDFF胰腺(r=0.840)、PDFF右肾(r=0.854)、PDFF左肾(r=0.796)、R2^(*)肝脏(r=0.834)、R2^(*)胰腺(r=0.778)均呈正相关(P<0.05)。结论本实验通过利用MRI IDEAL-IQ技术无创定量评估T2DM大鼠肝脏及胰腺脂肪沉积与铁沉积的含量,并且同时评估了两组大鼠双肾的脂肪含量差异。这项技术有望动态随访新诊断的糖尿病患者,早期评估其肝脏、肾脏以及胰腺脂肪含量和铁含量改变,为指导临床诊断及治疗提供新的方向。展开更多
文摘The four-decades long exchanges with Chinese scholars has provided me with a fresh perspective.Reading history makes me feel that the talents of the historical Chinese who created the country’s glorious ancient civilization are still being carried on today,and have become the foundation enabling China to build an ideal type of society.Indeed,China regards “becoming developed” as its ultimate goal and “reform and growth” as its guideline.The progress of artificial intelligence would not remove its own weakness of democracy.On the contrary,as the technology grows mature,it might steer development of socialism in a favourable direction.
