非洲猪瘟(ASF)是猪的一种急性,热性,高度接触性传染病,致死率可达100%。非洲猪瘟病毒(ASFV)是引起该病的病原。ASFV主要感染原代猪单核巨噬细胞系统,仅低效感染少数细胞系,这极大地制约了相应疫苗的研发及对ASFV病原生物学及致病机制的...非洲猪瘟(ASF)是猪的一种急性,热性,高度接触性传染病,致死率可达100%。非洲猪瘟病毒(ASFV)是引起该病的病原。ASFV主要感染原代猪单核巨噬细胞系统,仅低效感染少数细胞系,这极大地制约了相应疫苗的研发及对ASFV病原生物学及致病机制的探索。近期,PLoS Pathogens杂志在线发表了题为“The I7L protein of African swine fever virus is involved in viral pathogenicity by antagonizing the IFN-γ-triggered JAK-STAT signaling pathway through inhibiting the phosphorylation of STAT1”的研究论文,中国农业科学院哈尔滨兽医研究所孙元研究员、李素研究员、仇华吉研究员和李连峰研究员为该论文的共同通讯作者。研究证实,ASFV基因组编码的I7L蛋白可结合STAT1,从而抑制STAT1的磷酸化并拮抗IFN-γ介导的JAK-STAT信号通路,进而调控病毒致病力。该研究为开发ASF弱毒活疫苗提供了新靶点。展开更多
Monkeypox virus(MPXV),a member of the orthopoxvirus genus,has been endemic in parts of Africa for decades.Since 2022,MPXV has spread globally,with over 142,000 confirmed cases reported across 133 countries by 2025^([1...Monkeypox virus(MPXV),a member of the orthopoxvirus genus,has been endemic in parts of Africa for decades.Since 2022,MPXV has spread globally,with over 142,000 confirmed cases reported across 133 countries by 2025^([1]).The World Health Organization(WHO)has declared the outbreak a Public Health Emergency of International Concern(PHEIC)twice^([1]).展开更多
文摘非洲猪瘟(ASF)是猪的一种急性,热性,高度接触性传染病,致死率可达100%。非洲猪瘟病毒(ASFV)是引起该病的病原。ASFV主要感染原代猪单核巨噬细胞系统,仅低效感染少数细胞系,这极大地制约了相应疫苗的研发及对ASFV病原生物学及致病机制的探索。近期,PLoS Pathogens杂志在线发表了题为“The I7L protein of African swine fever virus is involved in viral pathogenicity by antagonizing the IFN-γ-triggered JAK-STAT signaling pathway through inhibiting the phosphorylation of STAT1”的研究论文,中国农业科学院哈尔滨兽医研究所孙元研究员、李素研究员、仇华吉研究员和李连峰研究员为该论文的共同通讯作者。研究证实,ASFV基因组编码的I7L蛋白可结合STAT1,从而抑制STAT1的磷酸化并拮抗IFN-γ介导的JAK-STAT信号通路,进而调控病毒致病力。该研究为开发ASF弱毒活疫苗提供了新靶点。
基金supported by the Key Research and Development Program,Ministry of Science and Technology of the People’s Republic of China(No.2023YFC2606500)Supported By Young Talent of Lifting engineering for Science and Technology in Shandong,China(No.SDAST2025 QTB057)。
文摘Monkeypox virus(MPXV),a member of the orthopoxvirus genus,has been endemic in parts of Africa for decades.Since 2022,MPXV has spread globally,with over 142,000 confirmed cases reported across 133 countries by 2025^([1]).The World Health Organization(WHO)has declared the outbreak a Public Health Emergency of International Concern(PHEIC)twice^([1]).
