A previous paper showed that the real numbers between 0 and 1 could be represented by an infinite tree structure, called the ‘infinity tree’, which contains only a countably infinite number of nodes and arcs. This p...A previous paper showed that the real numbers between 0 and 1 could be represented by an infinite tree structure, called the ‘infinity tree’, which contains only a countably infinite number of nodes and arcs. This paper discusses how a finite-state Turing machine could, in a countably infinite number of state transitions, write all the infinite paths in the infinity tree to a countably infinite tape. Hence it is argued that the real numbers in the interval [0, 1] are countably infinite in a non-Cantorian theory of infinity based on Turing machines using countably infinite space and time. In this theory, Cantor’s Continuum Hypothesis can also be proved. And in this theory, it follows that the power set of the natural numbers P(ℕ) is countably infinite, which contradicts the claim of Cantor’s Theorem for the natural numbers. However, this paper does not claim there is an error in Cantor’s arguments that [0, 1] is uncountably infinite. Rather, this paper considers the situation as a paradox, resulting from different choices about how to represent and count the continuum of real numbers.展开更多
This study uses Baidu News data and introduces a novel proxy for the rate of information flow to examine its relationship with return volatility in Chinese commodity futures and to test two competing hypotheses.We exa...This study uses Baidu News data and introduces a novel proxy for the rate of information flow to examine its relationship with return volatility in Chinese commodity futures and to test two competing hypotheses.We examine the contemporaneous relationships using correlation coefficient analysis,and find apparent differences between the information flow-return volatility relationship and the information flowtrading volume relationship.The empirical evidence contradicts the mixture of distribution hypothesis(MDH)and suggests that the rate of information flow distinctly affects trading volume and volatility.We conducted linear and nonlinear Granger causality tests to explore the sequential information arrival hypothesis(SIAH).The empirical results prove that a lead-lag linear and nonlinear causality exists between the information flow and return volatility of commodity futures,which is consistent with SIAH.In other words,a partial equilibrium exists before reaching the ultimate equilibrium when the new information arrives in the market.Finally,these findings are robust to alternative measurement of return volatility and subperiod analysis.Our findings reject the MDH and support the SIAH in the context of Chinese commodity futures.展开更多
This paper attempts to form a bridge between a sum of the divisors function and the gamma function, proposing a novel approach that could have significant implications for classical problems in number theory, specific...This paper attempts to form a bridge between a sum of the divisors function and the gamma function, proposing a novel approach that could have significant implications for classical problems in number theory, specifically the Robin inequality and the Riemann hypothesis. The exploration of using invariant properties of these functions to derive insights into twin primes and sequential primes is a potentially innovative concept that deserves careful consideration by the mathematical community.展开更多
Dilatancy is referred to the phenomenon of volume increase that occurs when a material is deformed.Dilatancy theory originated in geomechanics for the study of the behavior of granular materials.Later it is expanded t...Dilatancy is referred to the phenomenon of volume increase that occurs when a material is deformed.Dilatancy theory originated in geomechanics for the study of the behavior of granular materials.Later it is expanded to the case of more brittle materials like rocks when it is subjected to the load of varying effective stress and starts to crack and deform,then named the dilatancy-diffusion hypothesis.This hypothesis was developed to explain the changes in rock volume and pore pressure that occur prior to and during fault slip,which can influence earthquake dynamics.Dilatancy-fluid diffusion is a significant concept in understanding the seismogenic process and has served as the major theoretical pillar for earthquake prediction by its classic definition.This paper starts with the recount of fundamental laboratory experiments on granular materials and rocks,then conducts review and examination of the history for using the dilatancy-diffusion hypothesis to interpret the‘prediction’of the 1975 Haicheng Earthquake and other events.The Haicheng Earthquake is the first significant event to be interpreted with the dilatancy-diffusion hypothesis in the world.As one pivotal figure in the development of the dilatancy-diffusion hypothesis for earthquake prediction Professor Amos Nur of Stanford University worked tirelessly to attract societal attention to this important scientific and humanistic issue.As a deterministic physical model the dilatancy-diffusion hypothesis intrinsically bears the deficit to interpret the stochastic seismogenic process.With the emergence of deep learning and its successful applications to many science and technology fields,we may see a possibility to overcome the shortcoming of the current state of the theory with the addition of empirical statistics to push the operational earthquake forecasting approach with the addition of the physicallyinformed neural networks which adopt the dilatancy-diffusion hypothesis as one of its embedded physical relations,to uplift the seismic risk reduction to a new level for saving lives and reducing the losses.展开更多
Aiming at gradually developing and perfecting the task-based teaching method, the essay, with enlightment from the Krashen＇s Input Hypothesis, discusses some issues about input, output, activities and teacher＇s role...Aiming at gradually developing and perfecting the task-based teaching method, the essay, with enlightment from the Krashen＇s Input Hypothesis, discusses some issues about input, output, activities and teacher＇s role in this method.展开更多
Aim To study the rules governing pressure distribution of traveling charge under the condition of Lagrange hypothesis. Methods\ The study is based on the laws of conservation of momentum and energy. Results\ The gas ...Aim To study the rules governing pressure distribution of traveling charge under the condition of Lagrange hypothesis. Methods\ The study is based on the laws of conservation of momentum and energy. Results\ The gas flow velocity distribution formula at the back of a projectile and the momentum equation of a traveling charge are deduced, and rules governing their pressure distribution under the Lagrange hypothesis conditions are established. The pressure distribution of a traveling charge is compared with that of a conventional charge. Conclusion\ The pressure distribution in the bore of a traveling charge can be accurately predicted. A parabolic pressure distribution type is revealed.展开更多
Amyloid-β(Aβ)and tau,the two hallmark proteins associated with Alzheimer’s disease(AD),exhibit distinct toxic effects but also interact synergistically within the disease pathology.The prevailing theory in AD patho...Amyloid-β(Aβ)and tau,the two hallmark proteins associated with Alzheimer’s disease(AD),exhibit distinct toxic effects but also interact synergistically within the disease pathology.The prevailing theory in AD pathology-the amyloid cascade hypothesis-highlights the pivotal role of increased processing of the amyloid precursor protein(APP).Initially cleaved by the majorβ-secretase(β-amyloid cleaving enzyme-1,BACE1)in the brain,then undergoes further cleavage by theγ-secretase complex,resulting in the production of Aβ_(40-42)and a set of intracellular C-terminal peptides known as Aβand APP intracellular domain(β-AICDs)and soluble amyloid precursor proteinβ(sAPPβ)(Orobets and Karamyshev,2023).展开更多
Currently,our understanding of the pathogenesis of major neurodegenerative disorders,such as Alzheimer's,Parkinson's,and Huntington's diseases,is largely shaped by the amyloid cascade hypothesis.Pa rticula...Currently,our understanding of the pathogenesis of major neurodegenerative disorders,such as Alzheimer's,Parkinson's,and Huntington's diseases,is largely shaped by the amyloid cascade hypothesis.Pa rticularly,this hypothesis posits that in Alzheimer's disease,the aggregation of amyloid-beta peptide initiates a series of pathological processes leading to neuronal dysfunction and death(Zhang et al.,2024).展开更多
“Sapir-Whorf hypothesis"holds that human thoughts are shaped by their native languages,and speakers of different languages think differently relevantly.The hypothesis is controversial partly because it seems to ...“Sapir-Whorf hypothesis"holds that human thoughts are shaped by their native languages,and speakers of different languages think differently relevantly.The hypothesis is controversial partly because it seems to deny the possibility of a general principle for human cognition,and partly because some findings taken to support it have not reliably replicated.The author argued that considering this hypothesis through the lens of probabilistic inference has the potential to figure out both issues,at least with respect to certain prominent findings in the two languages—Chinese and English.After exploring on the inner relationship among language,thought and culture with the comparison between English and Chinese based on a series of examples including“numbers,Wuhan dialect and some different understandings of idioms”,the author made an inference that language can somewhat affect human thought under the different culture contexts.Besides,it also provides some reference for educators to take in-depth studies on the relationship among language,thought and culture,which is vitally significant for ESL educators and learners.展开更多
Sapir-Whorf hypothesis has its implication in translation studies. Each language is a peculiar whole. It is a product, even an expression, of the spiritual personality and the cultural particularity. Translation is a ...Sapir-Whorf hypothesis has its implication in translation studies. Each language is a peculiar whole. It is a product, even an expression, of the spiritual personality and the cultural particularity. Translation is a kind of interlingual and intercultural communication. It involves not only the transference from one language into another, but a whole set of extra-linguistic criteria. In translating we are always crossing a greater or lesser barrier or divide.展开更多
The researches on Critical Period Hypothesis(CPH) aims to explain the importance of the age factor in the process of learning a second language.In this essay,a critical review of the theoretical issues and empirical r...The researches on Critical Period Hypothesis(CPH) aims to explain the importance of the age factor in the process of learning a second language.In this essay,a critical review of the theoretical issues and empirical research on the CPH will spread out.Meanwhile,the discussion of implication and limitation of the CPH research will be concerned as well.展开更多
Krashen has developed the Input Hypothesis, which has deep influence on teaching method of second language. This thesis focuses on the Krashen's Input Hypothesis, which includes the following five hypotheses: the ...Krashen has developed the Input Hypothesis, which has deep influence on teaching method of second language. This thesis focuses on the Krashen's Input Hypothesis, which includes the following five hypotheses: the acquisition- learning hypothesis, the monitor hypothesis, the natural order hypothesis, the input hypothesis and the effective filter hypothesis. The thesis tries to explore the pedagogical implications of Krashen's Input Hypothesis on second language teaching in the aspects of the input quantity and input quality. The thesis tries to explore the most effective methods of second language teaching, in the hope that it will help to improve the efficiency of second language teaching.展开更多
The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hyp...The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended.展开更多
AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe（TCR）-component in blood of healthy subjects andpatients,and estimate its correctness.METHODS Th...AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe（TCR）-component in blood of healthy subjects andpatients,and estimate its correctness.METHODS The pharmacokinetics（PK）of samedose of drug was studied in the animal model oftraditional Chinese syndrome（S）and healthyanimals.The classification,terminology,concept and significance of the hypothesis wereset forth with evidence provided in the presentstudy.The hypotheses consisted of traditionalChinese syndrome PK（S-PK）and traditionalChinese recipe PK（R-PK）.Firstly,the observedtetramethylpyrazine（TMP）PK in healthy,chronically reserpinized rats（rat model ofspleen deficiency syndrome,RMSDS）andRMSDS treated with Sijunzi decoction（SJZD）forconfirmation were used to verify S-PK; secondly,the ferulic acid（FA）PK in healthy andhigh molecular weight dextran（HMWD）-inducedrabbit model with blood stasis syndrome（RDBSS）was also used to verify S-PK;andlastly,TMP PK parameters in serum of healthyrats after orally taken Ligusticum wallichii（LW）,LW and Salvia miltiorrhiza（LW&SM）decoctions were compared to verify R-PK.RESULTS The apparent first-order absorption[Ka,（13.61±2.56）h<sup>-1</sup>,area under the blooddrug concentration-time curve[AUC,（24.88±9.76）μg.h<sup>-1</sup>mL<sup>-1</sup>],maximum drug concentration[C<sub>max</sub>,（4.82±1.23）μg·mL<sup>-1</sup>]of serum TMP inRMSDS were increased markedly（P【0.05）compared with those[Ka=（5.41±1.91）h<sup>-1</sup>,AUC=（5.20±2.57）μg·h<sup>-1</sup>·mL<sup>-1</sup>,C<sub>max</sub>=（2.33±1.77）μg·mL<sup>-1</sup>]of healthy rats（HR）.Theapparent first-order rate constant for α and βdistribution phase[α=（0.38±0.09）h<sup>-1</sup>,β=（0.06±0.03）h<sup>-1</sup>,the apparent first-orderintercompartmental transfer rate constants[K<sub>10</sub>=（0.24±0.07）h<sup>-1</sup>,K<sub>12</sub>=（0.11±0.02）h<sup>-1</sup>,K<sub>21</sub>=（0.11±0.02）h<sup>-1</sup>]of serum TMP in RMSDS weredecreased significantly（P【0.01）comparedwith those[K<sub>10</sub>=（0.88±0.20）h<sup>-1</sup>,K<sub>12</sub>=（1.45±0.47）h<sup>-1</sup>,K<sub>21</sub>=（0.72±0.22）h<sup>-1</sup>]of HR.However,no apparent differences occurredbetween HR and RMSDS treated with SJZD.Theserum FA concentration and its AUC[（5.6690±2.3541）μg·h<sup>-1</sup>·mL<sup>-1</sup>] in RMBSS were also higherthan those[AUC=（2.7566±0.8232）μg·h<sup>-1</sup>·mL<sup>-1</sup>]of healthy rabbits（P【0.05）.The Ka（11.51±2.82）h<sup>-1</sup>,AUC（0.84±0.17）μg·h<sup>-1</sup>·mL<sup>-1</sup>of LW & SM-derived TMP in serum weremuch lower（P【0.05）than those[Ka=（19.58±4.14）h<sup>-1</sup>,AUC=（1.27±0.26）μg·h<sup>-1</sup>·mL<sup>-1</sup>]ofLW-derived TMP in serum after oral decoctions.CONCLUSION The SDS and blood stasissyndrome state could affect significantly thepharmacokinetic parameters of drugs and theabnormal SDS pharmacokinetic parameters couldbe normalized by SJZD.The combination ofChinese medicine in TCR could reciprocallyaffect the pharmacokinetic parameters of othercomponents absorbed into the systemiccirculation.These results support the S-and R-PK hypothesis.展开更多
文摘A previous paper showed that the real numbers between 0 and 1 could be represented by an infinite tree structure, called the ‘infinity tree’, which contains only a countably infinite number of nodes and arcs. This paper discusses how a finite-state Turing machine could, in a countably infinite number of state transitions, write all the infinite paths in the infinity tree to a countably infinite tape. Hence it is argued that the real numbers in the interval [0, 1] are countably infinite in a non-Cantorian theory of infinity based on Turing machines using countably infinite space and time. In this theory, Cantor’s Continuum Hypothesis can also be proved. And in this theory, it follows that the power set of the natural numbers P(ℕ) is countably infinite, which contradicts the claim of Cantor’s Theorem for the natural numbers. However, this paper does not claim there is an error in Cantor’s arguments that [0, 1] is uncountably infinite. Rather, this paper considers the situation as a paradox, resulting from different choices about how to represent and count the continuum of real numbers.
基金supported by the National Social Science Fund of China(24CGL027)the National Natural Science Foundation of China(72101009,72141304,72201122)National Key Research and Development Program of China(2022YFC3303304).
文摘This study uses Baidu News data and introduces a novel proxy for the rate of information flow to examine its relationship with return volatility in Chinese commodity futures and to test two competing hypotheses.We examine the contemporaneous relationships using correlation coefficient analysis,and find apparent differences between the information flow-return volatility relationship and the information flowtrading volume relationship.The empirical evidence contradicts the mixture of distribution hypothesis(MDH)and suggests that the rate of information flow distinctly affects trading volume and volatility.We conducted linear and nonlinear Granger causality tests to explore the sequential information arrival hypothesis(SIAH).The empirical results prove that a lead-lag linear and nonlinear causality exists between the information flow and return volatility of commodity futures,which is consistent with SIAH.In other words,a partial equilibrium exists before reaching the ultimate equilibrium when the new information arrives in the market.Finally,these findings are robust to alternative measurement of return volatility and subperiod analysis.Our findings reject the MDH and support the SIAH in the context of Chinese commodity futures.
文摘This paper attempts to form a bridge between a sum of the divisors function and the gamma function, proposing a novel approach that could have significant implications for classical problems in number theory, specifically the Robin inequality and the Riemann hypothesis. The exploration of using invariant properties of these functions to derive insights into twin primes and sequential primes is a potentially innovative concept that deserves careful consideration by the mathematical community.
基金sponsored by the National Research Foundation of Korea(RS-2023-00220913).
文摘Dilatancy is referred to the phenomenon of volume increase that occurs when a material is deformed.Dilatancy theory originated in geomechanics for the study of the behavior of granular materials.Later it is expanded to the case of more brittle materials like rocks when it is subjected to the load of varying effective stress and starts to crack and deform,then named the dilatancy-diffusion hypothesis.This hypothesis was developed to explain the changes in rock volume and pore pressure that occur prior to and during fault slip,which can influence earthquake dynamics.Dilatancy-fluid diffusion is a significant concept in understanding the seismogenic process and has served as the major theoretical pillar for earthquake prediction by its classic definition.This paper starts with the recount of fundamental laboratory experiments on granular materials and rocks,then conducts review and examination of the history for using the dilatancy-diffusion hypothesis to interpret the‘prediction’of the 1975 Haicheng Earthquake and other events.The Haicheng Earthquake is the first significant event to be interpreted with the dilatancy-diffusion hypothesis in the world.As one pivotal figure in the development of the dilatancy-diffusion hypothesis for earthquake prediction Professor Amos Nur of Stanford University worked tirelessly to attract societal attention to this important scientific and humanistic issue.As a deterministic physical model the dilatancy-diffusion hypothesis intrinsically bears the deficit to interpret the stochastic seismogenic process.With the emergence of deep learning and its successful applications to many science and technology fields,we may see a possibility to overcome the shortcoming of the current state of the theory with the addition of empirical statistics to push the operational earthquake forecasting approach with the addition of the physicallyinformed neural networks which adopt the dilatancy-diffusion hypothesis as one of its embedded physical relations,to uplift the seismic risk reduction to a new level for saving lives and reducing the losses.
文摘Aiming at gradually developing and perfecting the task-based teaching method, the essay, with enlightment from the Krashen＇s Input Hypothesis, discusses some issues about input, output, activities and teacher＇s role in this method.
文摘Aim To study the rules governing pressure distribution of traveling charge under the condition of Lagrange hypothesis. Methods\ The study is based on the laws of conservation of momentum and energy. Results\ The gas flow velocity distribution formula at the back of a projectile and the momentum equation of a traveling charge are deduced, and rules governing their pressure distribution under the Lagrange hypothesis conditions are established. The pressure distribution of a traveling charge is compared with that of a conventional charge. Conclusion\ The pressure distribution in the bore of a traveling charge can be accurately predicted. A parabolic pressure distribution type is revealed.
文摘Amyloid-β(Aβ)and tau,the two hallmark proteins associated with Alzheimer’s disease(AD),exhibit distinct toxic effects but also interact synergistically within the disease pathology.The prevailing theory in AD pathology-the amyloid cascade hypothesis-highlights the pivotal role of increased processing of the amyloid precursor protein(APP).Initially cleaved by the majorβ-secretase(β-amyloid cleaving enzyme-1,BACE1)in the brain,then undergoes further cleavage by theγ-secretase complex,resulting in the production of Aβ_(40-42)and a set of intracellular C-terminal peptides known as Aβand APP intracellular domain(β-AICDs)and soluble amyloid precursor proteinβ(sAPPβ)(Orobets and Karamyshev,2023).
基金funded by the Russian Science Foundation(grant No.23-74-10092)(to AIS)。
文摘Currently,our understanding of the pathogenesis of major neurodegenerative disorders,such as Alzheimer's,Parkinson's,and Huntington's diseases,is largely shaped by the amyloid cascade hypothesis.Pa rticularly,this hypothesis posits that in Alzheimer's disease,the aggregation of amyloid-beta peptide initiates a series of pathological processes leading to neuronal dysfunction and death(Zhang et al.,2024).
基金国家自然科学基金面上项目“基于高压人群身心健康的工作环境绿色空间体系研究”(编号51978364)国家自然科学基金青年科学基金项目“北京地区城市森林疗养空间特征识别及健康效益定量评价”(编号51908310)Tsinghua-Toyota Joint Research Institute Cross discipline Program共同资助。
文摘“Sapir-Whorf hypothesis"holds that human thoughts are shaped by their native languages,and speakers of different languages think differently relevantly.The hypothesis is controversial partly because it seems to deny the possibility of a general principle for human cognition,and partly because some findings taken to support it have not reliably replicated.The author argued that considering this hypothesis through the lens of probabilistic inference has the potential to figure out both issues,at least with respect to certain prominent findings in the two languages—Chinese and English.After exploring on the inner relationship among language,thought and culture with the comparison between English and Chinese based on a series of examples including“numbers,Wuhan dialect and some different understandings of idioms”,the author made an inference that language can somewhat affect human thought under the different culture contexts.Besides,it also provides some reference for educators to take in-depth studies on the relationship among language,thought and culture,which is vitally significant for ESL educators and learners.
文摘Sapir-Whorf hypothesis has its implication in translation studies. Each language is a peculiar whole. It is a product, even an expression, of the spiritual personality and the cultural particularity. Translation is a kind of interlingual and intercultural communication. It involves not only the transference from one language into another, but a whole set of extra-linguistic criteria. In translating we are always crossing a greater or lesser barrier or divide.
文摘The researches on Critical Period Hypothesis(CPH) aims to explain the importance of the age factor in the process of learning a second language.In this essay,a critical review of the theoretical issues and empirical research on the CPH will spread out.Meanwhile,the discussion of implication and limitation of the CPH research will be concerned as well.
文摘Krashen has developed the Input Hypothesis, which has deep influence on teaching method of second language. This thesis focuses on the Krashen's Input Hypothesis, which includes the following five hypotheses: the acquisition- learning hypothesis, the monitor hypothesis, the natural order hypothesis, the input hypothesis and the effective filter hypothesis. The thesis tries to explore the pedagogical implications of Krashen's Input Hypothesis on second language teaching in the aspects of the input quantity and input quality. The thesis tries to explore the most effective methods of second language teaching, in the hope that it will help to improve the efficiency of second language teaching.
文摘The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended.
基金National Natural Science Foundation of China,No.398709323967086539570870 and 39100139.
文摘AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe（TCR）-component in blood of healthy subjects andpatients,and estimate its correctness.METHODS The pharmacokinetics（PK）of samedose of drug was studied in the animal model oftraditional Chinese syndrome（S）and healthyanimals.The classification,terminology,concept and significance of the hypothesis wereset forth with evidence provided in the presentstudy.The hypotheses consisted of traditionalChinese syndrome PK（S-PK）and traditionalChinese recipe PK（R-PK）.Firstly,the observedtetramethylpyrazine（TMP）PK in healthy,chronically reserpinized rats（rat model ofspleen deficiency syndrome,RMSDS）andRMSDS treated with Sijunzi decoction（SJZD）forconfirmation were used to verify S-PK; secondly,the ferulic acid（FA）PK in healthy andhigh molecular weight dextran（HMWD）-inducedrabbit model with blood stasis syndrome（RDBSS）was also used to verify S-PK;andlastly,TMP PK parameters in serum of healthyrats after orally taken Ligusticum wallichii（LW）,LW and Salvia miltiorrhiza（LW&SM）decoctions were compared to verify R-PK.RESULTS The apparent first-order absorption[Ka,（13.61±2.56）h<sup>-1</sup>,area under the blooddrug concentration-time curve[AUC,（24.88±9.76）μg.h<sup>-1</sup>mL<sup>-1</sup>],maximum drug concentration[C<sub>max</sub>,（4.82±1.23）μg·mL<sup>-1</sup>]of serum TMP inRMSDS were increased markedly（P【0.05）compared with those[Ka=（5.41±1.91）h<sup>-1</sup>,AUC=（5.20±2.57）μg·h<sup>-1</sup>·mL<sup>-1</sup>,C<sub>max</sub>=（2.33±1.77）μg·mL<sup>-1</sup>]of healthy rats（HR）.Theapparent first-order rate constant for α and βdistribution phase[α=（0.38±0.09）h<sup>-1</sup>,β=（0.06±0.03）h<sup>-1</sup>,the apparent first-orderintercompartmental transfer rate constants[K<sub>10</sub>=（0.24±0.07）h<sup>-1</sup>,K<sub>12</sub>=（0.11±0.02）h<sup>-1</sup>,K<sub>21</sub>=（0.11±0.02）h<sup>-1</sup>]of serum TMP in RMSDS weredecreased significantly（P【0.01）comparedwith those[K<sub>10</sub>=（0.88±0.20）h<sup>-1</sup>,K<sub>12</sub>=（1.45±0.47）h<sup>-1</sup>,K<sub>21</sub>=（0.72±0.22）h<sup>-1</sup>]of HR.However,no apparent differences occurredbetween HR and RMSDS treated with SJZD.Theserum FA concentration and its AUC[（5.6690±2.3541）μg·h<sup>-1</sup>·mL<sup>-1</sup>] in RMBSS were also higherthan those[AUC=（2.7566±0.8232）μg·h<sup>-1</sup>·mL<sup>-1</sup>]of healthy rabbits（P【0.05）.The Ka（11.51±2.82）h<sup>-1</sup>,AUC（0.84±0.17）μg·h<sup>-1</sup>·mL<sup>-1</sup>of LW & SM-derived TMP in serum weremuch lower（P【0.05）than those[Ka=（19.58±4.14）h<sup>-1</sup>,AUC=（1.27±0.26）μg·h<sup>-1</sup>·mL<sup>-1</sup>]ofLW-derived TMP in serum after oral decoctions.CONCLUSION The SDS and blood stasissyndrome state could affect significantly thepharmacokinetic parameters of drugs and theabnormal SDS pharmacokinetic parameters couldbe normalized by SJZD.The combination ofChinese medicine in TCR could reciprocallyaffect the pharmacokinetic parameters of othercomponents absorbed into the systemiccirculation.These results support the S-and R-PK hypothesis.
