Introduction Septic shock remains highly lethal,with a 30-day mortality of approximately 35%.[1]Vascular dysfunction is a key mechanism underlying hemodynamic failure in this context.In addition to microcirculatory ab...Introduction Septic shock remains highly lethal,with a 30-day mortality of approximately 35%.[1]Vascular dysfunction is a key mechanism underlying hemodynamic failure in this context.In addition to microcirculatory abnormalities,[2]vascular dysfunction is characterized by a reduction in vascular tone,which is associated with a diminished responsiveness to vasoconstrictive agents.[3]This leads to arterial hypotension.When severe hypotension impairs the perfusion of vital organs and results in multiorgan failure,even in the presence of normal or elevated cardiac output(CO).展开更多
文摘Introduction Septic shock remains highly lethal,with a 30-day mortality of approximately 35%.[1]Vascular dysfunction is a key mechanism underlying hemodynamic failure in this context.In addition to microcirculatory abnormalities,[2]vascular dysfunction is characterized by a reduction in vascular tone,which is associated with a diminished responsiveness to vasoconstrictive agents.[3]This leads to arterial hypotension.When severe hypotension impairs the perfusion of vital organs and results in multiorgan failure,even in the presence of normal or elevated cardiac output(CO).
