Hypopigmented mycosis fungoides (HMF) is an uncommon variant of cutaneous T-cell lymphoma. It is more frequent in dark-skinned people, particularly children. The HMF diagnose is difficult, especially in early stages b...Hypopigmented mycosis fungoides (HMF) is an uncommon variant of cutaneous T-cell lymphoma. It is more frequent in dark-skinned people, particularly children. The HMF diagnose is difficult, especially in early stages because this condition resembles benign skin diseases. Thus is histopathological analysis very important for the diagnosis. We report a case of a 7-year-old child with widespread HMF confirmed by histopathology that showed cells tagging along the dermal/epidermal junction and extending into the epidermis in a pattern of epidermotropism and focal cell aggregates in the epidermis (Pautrier’s microabscess). We demonstrate the importance of clinical suspicion for this cutaneous neoplasia in patients with hypopigmentated lesions.展开更多
Objective:Pityriasis versicolor(PV)is usually a clinical diagnosis.In uncertain cases,PV is confirmed by microscopic examination with 10%potassium hydroxide(KOH).However,the KOH test is not 100%sensitive in diagnosing...Objective:Pityriasis versicolor(PV)is usually a clinical diagnosis.In uncertain cases,PV is confirmed by microscopic examination with 10%potassium hydroxide(KOH).However,the KOH test is not 100%sensitive in diagnosing PV.Dermoscopy of PV is still an unexplored area with very little data reported.This study was planned to study the various dermoscopic features and their utility in the diagnosis of PV.Methods:This cross-sectional observational study was carried out over a 1-year period(September 2020-September 2021)among 57 patients with KOH-confirmed PV.All patients underwent dermoscopy using a handheld dermoscope(DermLite DL4;DermLite LLC).The chi-square test or Fisher’s exact test was used to analyze the data.Results:Of the 57 patients,43(75.44%)had the hypopigmented type,followed by the hyperpigmented type(n=12,21.05%)and the perifollicular type(n=2,3.51%).Nonuniform pigmentation was the most common dermoscopic finding observed in both patients with hypopigmented PV(n=42,97.67%)and hyperpigmented PV(n=12,100%)(P=0.001).Scaling was the second most commonly observed finding;patchy scaling(n=25,58.13%)and perifollicular scaling(n=13,30.23%)were commonly seen in hypopigmented PV,while hyperpigmented PV showed more diffuse scaling(n=6,50.00%)(P=0.04)followed by patchy scaling(n=5,41.66%).Dermoscopy showed unique“double-edged scales”in all lesions with furrow scaling(n=11,19.30%)after eliciting a positive evoked scale sign.Other interesting features seen in hypopigmented PV were hypopigmentation around the hair follicle(n=24,55.48%)(P=0.001)and perilesional hyperpigmentation(the halo sign)(n=15,34.88%)(P=0.04).Conclusion:We observed several dermoscopic findings in PV that can serve as useful clues for differentiating PV from other similar disorders.展开更多
文摘Hypopigmented mycosis fungoides (HMF) is an uncommon variant of cutaneous T-cell lymphoma. It is more frequent in dark-skinned people, particularly children. The HMF diagnose is difficult, especially in early stages because this condition resembles benign skin diseases. Thus is histopathological analysis very important for the diagnosis. We report a case of a 7-year-old child with widespread HMF confirmed by histopathology that showed cells tagging along the dermal/epidermal junction and extending into the epidermis in a pattern of epidermotropism and focal cell aggregates in the epidermis (Pautrier’s microabscess). We demonstrate the importance of clinical suspicion for this cutaneous neoplasia in patients with hypopigmentated lesions.
文摘Objective:Pityriasis versicolor(PV)is usually a clinical diagnosis.In uncertain cases,PV is confirmed by microscopic examination with 10%potassium hydroxide(KOH).However,the KOH test is not 100%sensitive in diagnosing PV.Dermoscopy of PV is still an unexplored area with very little data reported.This study was planned to study the various dermoscopic features and their utility in the diagnosis of PV.Methods:This cross-sectional observational study was carried out over a 1-year period(September 2020-September 2021)among 57 patients with KOH-confirmed PV.All patients underwent dermoscopy using a handheld dermoscope(DermLite DL4;DermLite LLC).The chi-square test or Fisher’s exact test was used to analyze the data.Results:Of the 57 patients,43(75.44%)had the hypopigmented type,followed by the hyperpigmented type(n=12,21.05%)and the perifollicular type(n=2,3.51%).Nonuniform pigmentation was the most common dermoscopic finding observed in both patients with hypopigmented PV(n=42,97.67%)and hyperpigmented PV(n=12,100%)(P=0.001).Scaling was the second most commonly observed finding;patchy scaling(n=25,58.13%)and perifollicular scaling(n=13,30.23%)were commonly seen in hypopigmented PV,while hyperpigmented PV showed more diffuse scaling(n=6,50.00%)(P=0.04)followed by patchy scaling(n=5,41.66%).Dermoscopy showed unique“double-edged scales”in all lesions with furrow scaling(n=11,19.30%)after eliciting a positive evoked scale sign.Other interesting features seen in hypopigmented PV were hypopigmentation around the hair follicle(n=24,55.48%)(P=0.001)and perilesional hyperpigmentation(the halo sign)(n=15,34.88%)(P=0.04).Conclusion:We observed several dermoscopic findings in PV that can serve as useful clues for differentiating PV from other similar disorders.
