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Mapping Supergene/Hypogene Alteration Signatures with Landsat ETM+ Data: Paishanlou Gold Mine, Liaoning Province, China
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作者 Malogo J M Kongola 《Journal of China University of Geosciences》 SCIE CSCD 2005年第1期38-44,共7页
Noise removal routines (destriping) were performed on Landsat ETM+ data as adjustments for atmospheric and distortion factors, prior to further image enhancement and interpretation. The image enhancement techniques w... Noise removal routines (destriping) were performed on Landsat ETM+ data as adjustments for atmospheric and distortion factors, prior to further image enhancement and interpretation. The image enhancement techniques were contrast stretching, density slicing, spatial filtering, Fourier analysis, brightness inversion, band combinations, and band ratioing. It has been revealed that, owing to the presence of gossans at Paishanlou, the mixture of iron oxide and clay minerals affects the spectral reflectance in satellite data. The mineral and hydrothermal composite images with band ratios 5/7+5/4+3/1 RGB and 5/7+3/1+4/3 RGB, respectively, yielded the best results for their sensitivity to lithologic variables, and lack of statistical redundancy. Ratio 3/1 clearly highlighted ferric (Fe 3+ ) iron; 5/4 depicted ferrous (Fe 2+ ) iron, and 5/7 depicted clays, carbonates, and hydroxyl bearing minerals. Vegetation was also successfully discriminated by ratio 5/7. Finally, coupled with field surveys, petrographical and geochemical data, the observed anomalies led to the discovery of three new sites, which are gold mineralized. The prime objective of this study was to map supergene and/or hypogene signatures in the gold mineralized areas using Landsat ETM+ data at Paishanlou. 展开更多
关键词 GOLD SIGNATURES hypogene/supergene alteration Landsat ETM+.
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Transition from the Sedimentary Manganese Deposit to Supergene Manganese Ore in Eastern Hebei,North China:Evidences from Mineralogy and Geochemistry 被引量:1
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作者 Lingtong Xu Wenchao Yu +4 位作者 Song Jin Hua Guo Pengfei Ma Yuansheng Du Cailong Zhang 《Journal of Earth Science》 2025年第1期11-28,共18页
Original sedimentary manganese(Mn)deposits and supergene Mn ores are important Mn resources in China.However,the geochemical information from Chinese supergene Mn ores is scarce,and the relationship between sedimentar... Original sedimentary manganese(Mn)deposits and supergene Mn ores are important Mn resources in China.However,the geochemical information from Chinese supergene Mn ores is scarce,and the relationship between sedimentary Mn deposits and supergene Mn ores is ambiguous.In this study,we collected the original Mn-bearing dolomitic sandstones(ZK20-3 drillcore)and supergene Mn ores(Longmen Section)from eastern Hebei,North China for systematic petrographic,mineralogical and geochemical analyses.Our new data help us to figure out the transformation from original Mn-bearing deposits to supergene ores.The main minerals of original Mn-bearing dolomitic sandstones are quartz and feldspar,with minor muscovite,dolomite,rhodochrosite,ankerite,and kutnohorite.Supergene Mn-oxide ores only emerged in the middle part of the Longmen(LM)Section,and mainly contain quartz,pyrolusite,cryptomelane,todorokite and occasional dolomite.The possible transformation sequence of Mn minerals is:kutnohorite/rhodochrosite→pyrolusite(Ⅰ)→cryptomelane(todorokite)→todorokite(cryptomelane)→pyrolusite(Ⅱ).For Mn-oxide ores,Fe,Na and Si are enriched but Al,Ca,Mg and K are depleted with the enrichment of Mn.For original and supergene ores,the total rare earth element+ytterbium(∑REY)contents range from 105.68×10^(-6)to 250.56×10^(-6)and from 18.08×10^(-6)to 176.60×10^(-6),respectively.Original Mn ores have similar slightly LREE-enriched patterns,but the purer Mn-oxide ore shows a HREE-enriched pattern.In the middle part of the LM Section,positive Ce anomalies in Mn-oxide ores indicate the precipitation of Ce-bearing minerals.It implies the existence of geochemical barriers,which changed p H and Eh values due to the long-time influence of groundwater. 展开更多
关键词 supergene manganese ore GEOCHEMISTRY Gaoyuzhuang Formation North China
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Growth Rate Estimates of Supergene Manganese Nodule by ^(40)Ar/^( 39)Ar Isotopic Dating 被引量:3
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作者 LiJianwei VasconcelosPM 《Journal of China University of Geosciences》 SCIE CSCD 2004年第3期312-323,共12页
Increasing world-class, high-grade, and metals-enriched supergene manganese ore deposits have been discovered in the last two decades, making them more and more economically important. However, data on the timing and ... Increasing world-class, high-grade, and metals-enriched supergene manganese ore deposits have been discovered in the last two decades, making them more and more economically important. However, data on the timing and duration of their formation are sparse, mainly due to the difficulties extracting datable minerals suited to traditional radiometric dating methods. Hollandite, cryptomelane, coronadite, todorokite, and manjiroite are common manganese oxide minerals in supergene environments. These minerals host potassium of variable amounts from 0.1 wt% to 5.0 wt% in their structural sites. This geochemical property provides possibility to date supergene manganese ores by using K-Ar and 40Ar/ 39Ar methods. In this study, we perform 40Ar/ 39Ar dating on a 7.1-cm-thick botryoidal manganese nodule from an ancient weathering profile at Mount Tabor, central Queensland, Australia. Laser microprobe incremental analyses of distinct growth bands, from the inner core through the intermediate bands to the outermost crusts of the nodule, have yielded high quality 40Ar/ 39Ar ages at 27.3 Ma, 20.9 Ma, 19.2 Ma, and 16.1 Ma, respectively. The age results permit preliminary estimates on the average growth rates of the nodule varying from 4.7×10 -3 mm/ka to 7.6×10 -3 mm/ka to 9.0×10 -3 mm/ka, from the core to the rim. Results of this study are of significance in our understanding of the mode, mechanism, process, and climatic conditions in the formation of supergene manganese ore deposits. 展开更多
关键词 supergene manganese nodule 40Ar/ 39Ar dating growth rates.
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Supergene Geochemistry of Gold and Oxidation Zone of the Sain Us Gold Deposit in the Inner Mongolian Arid Region
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作者 Ma Mintao and Guan Guangyue Department of Chemistry and Environment Engineering,Beijing Polytechnic University, Beijing Geological Department, Northeast University of Technology, Shenyang,Liaoning Fei Zhenbi 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 1997年第1期58-68,共11页
The Sain Us gold deposit is a typical auriferous sulphide quartz vein deposit in the InnerMongolian arid steppe climatic region. The oxidation zone has been controlled by the arid cli-mate since the beginning of the H... The Sain Us gold deposit is a typical auriferous sulphide quartz vein deposit in the InnerMongolian arid steppe climatic region. The oxidation zone has been controlled by the arid cli-mate since the beginning of the Holocene. Gold supergene evolution is characterized by enlarge-ment of gold grains, complication of the gold form, raising of the gold grade and increase of thegold fineness; besides, gold and silver have two enrichment peaks at the same depth, which is insharp contrast to the unimodal enrichment of gold and silver and the occurrence of gold aboveand silver below in a humid climatic region. Sun pumping is the main cause for the bimodalenrichment of gold and silver. Illite 2 M_1 is one of the main causes for the upper enrichment peakof gold and silver. 展开更多
关键词 arid climate gold deposit oxidation zone gold supergene enrichment PALAEOCLIMATE sun pumping
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Using homology primers to clone a novel gene of β-chemokine receptorsupergene-family
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作者 郭葆玉 久野耕嗣 +1 位作者 张淑英 松岛纲治 《Journal of Medical Colleges of PLA(China)》 CAS 1998年第3期160-163,共4页
Objective Using homology primers for clone of β-chemokine receptor supergene-family from lower level RNA expression. Methods: Through similarity alignment of the conservative transmembrane domainof human MCP-l recept... Objective Using homology primers for clone of β-chemokine receptor supergene-family from lower level RNA expression. Methods: Through similarity alignment of the conservative transmembrane domainof human MCP-l receptor, mouse MIP-lα receptor and rat IL-8 receptor. the degenerate oligonucleotide homology primers were designed and a cDNA fragment was amplified by RT--PCR. After a new gene sequenceof chemokine receptor supergene-family in GenBank was identified, the new gene full sequence was cloned bya Marathon PCR of the specific primers. Results: Mouse CCR5 full-length cDNA with 2888 bp was cloned,including open reading frame 1065 oligonucleotides and coding 355 amino acids. This gene was a novel member of the β-chemokine receptor supergene-family confirmed by sequence analysis, ligand binding assay andinforming from GenBank. Conclusion: Using homology primers, the novel member of the supergene-familycan be captured. This method is a new cloning strategy and has extensive significance in the molecular cloningof a new gene. 展开更多
关键词 molecular cloning supergene FAMILY HOMOLOGY PRIMER
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华北晚石炭世大规模喀斯特型铝土矿成因研究进展 被引量:1
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作者 赵利华 刘学飞 +6 位作者 王庆飞 刘蕾 孙雪飞 赵军 杨淑娟 梁荣荣 张尚清 《地质学报》 北大核心 2026年第2期614-632,共19页
喀斯特铝土矿是异地物源堆积在古喀斯特洼地经过强烈化学风化作用形成。华北晚石炭世形成超过50亿t喀斯特铝土矿产,是全球最大喀斯特铝土矿成矿带。本文系统梳理了华北喀斯特型铝土矿研究进展、存在问题及未来主要研究方向,协助完善全... 喀斯特铝土矿是异地物源堆积在古喀斯特洼地经过强烈化学风化作用形成。华北晚石炭世形成超过50亿t喀斯特铝土矿产,是全球最大喀斯特铝土矿成矿带。本文系统梳理了华北喀斯特型铝土矿研究进展、存在问题及未来主要研究方向,协助完善全球同类型铝土矿成因理论体系。主要研究进展包括:(1)铝土矿规模和质量严格受控古岩溶地貌类型和矿床形成古环境条件,陆相宽广溶原是优质大规模铝土矿形成的理想场所;(2)成因母岩具有异地多来源特征,空间变化较大;北部铝土矿以白乃庙岛弧、华北克拉通北缘隆起及华北中部造山带中火成岩和变质岩为主;南部铝土矿以北秦岭造山带及华北中部造山带中火成岩和变质岩为主;中部铝土矿具有上述两者混合特征;(3)提出铁铝固溶体介导硬水铝石地表结晶成因机制,突破了传统地表风化+后期成岩变质作用的传统认识;(4)晚石炭世华北克拉通北缘大规模火山活动是促进华北克拉通短期大规模铝土矿形成的关键要素。存在的问题和研究方向:(1)巨量成矿源岩的复杂性;喀斯特型铝土矿来源在时空具有复杂多变特征,华北铝土矿源岩组成和供给情况尚需强化;(2)复杂的成矿环境条件与沉淀机制;喀斯特型铝土矿形成环境变化较大,可从陆相延伸至海相,从次氧化到还原条件,不同的环境条件中硬水铝石地表沉淀机制尚需对比研究,新提及的铁铝固溶体介导机制尚需通过实验手段进行验证;(3)共伴生资源综合利用;喀斯特型铝土矿中伴生大量的REE、Li、Ga、Sc等矿产资源,然其分布规律和赋存形式研究薄弱,制约矿石综合高效利用。 展开更多
关键词 铝土矿 成矿物源 表生成矿机制 成矿模式 成矿要素 华北
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Composition,Distribution and Constraining Factors of Fe Isotope(δ^(56)Fe) in the Surface Soils of the Tibetan Plateau
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作者 Ting Wei Zhiwen Dong +3 位作者 Eric Parteli Xiaoli Liu Shichang Kang Yaping Shao 《Journal of Earth Science》 2026年第1期280-288,共9页
Iron isotopes,represented byδ^(56)Fe,serve as valuable tools for constraining the surface iron processes and as potent tracers for studying the biogeochemical cycle of iron.Nevertheless,our comprehension of iron isot... Iron isotopes,represented byδ^(56)Fe,serve as valuable tools for constraining the surface iron processes and as potent tracers for studying the biogeochemical cycle of iron.Nevertheless,our comprehension of iron isotopes in the land surface processes of the Tibetan Plateau(TP)remains limited.In this study,we present the results of iron isotopic composition(δ^(56)Fe)in the surface soils of the TP,encompassing both glacial and non-glacial regions characterized by rugged and flat topographies.Our findings reveal that soilδ^(56)Fe values ranged from-0.01‰±0.05‰to 0.14‰±0.01‰,with the highest values observed in eastern locations(0.14‰)and the lowest appeared in the northeast(-0.1‰).On a global scale,theδ^(56)Fe values observed in Tibetan soils exhibited relatively small variability compared to reservoirs marked by significant iron isotope fractionation.By contrast,the range of TP soils measured here was slightly larger than that of the Chinese Loess.Furthermore,we discerned noticeable spatial variations inδ^(56)Fe across the large-scale region of TP,indicating a gradual increase trend from the northeast to the south and from the west to the east.These regional disparities inδ^(56)Fe likely arise from a combination of constraining factors,including differences in mineralogy,lithological variations,organic matter content,and variations in chemical weathering intensity.This study is pivotal in advancing our understanding of land surface iron isotope dynamics and its role in the biogeochemical cycle within the TP region. 展开更多
关键词 Fe isotopes Tibetan Plateau surface soils glaciers heavy metals glaciated areas supergene processes constraining factors
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滇西离子吸附型稀土矿床成矿规律研究进展
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作者 杨心茹 《四川有色金属》 2026年第1期9-11,共3页
稀土是高新技术与清洁能源转型的战略性矿产,离子吸附型稀土矿为我国特有优势资源,传统研究与勘探集中于华南丘陵区。滇西高原作为该类型矿床重要新区,腾冲、临沧等地工业矿床的发现,突破了“高原环境不利于离子相稀土大规模富集”的传... 稀土是高新技术与清洁能源转型的战略性矿产,离子吸附型稀土矿为我国特有优势资源,传统研究与勘探集中于华南丘陵区。滇西高原作为该类型矿床重要新区,腾冲、临沧等地工业矿床的发现,突破了“高原环境不利于离子相稀土大规模富集”的传统认知。本文系统梳理滇西离子吸附型稀土矿床最新研究成果,剖析其区域成矿背景、成矿母岩属性、表生富集过程及多因素耦合控矿规律,明晰当前研究共识与争议,展望后续机理深化与技术绿色化的研究方向,为该类型矿床的理论研究与勘查实践提供参考。 展开更多
关键词 滇西 离子吸附型稀土矿 成矿规律 表生风化
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“SuperGen Marine”:英国海洋可再生能源研究的加速器 被引量:2
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作者 孙晓晶 I.G.Bryden 《可再生能源》 CAS 2008年第4期118-121,共4页
英国拥有特殊的地理位置,其海洋能极其丰富。结合这一优势,英国政府把大力开发利用波浪能和潮汐能做为减少对传统能源的依赖,实现能源结构多元化,减少本国废气排放量的一项重要举措。"SuperGen Marine"是英国政府支持的一项... 英国拥有特殊的地理位置,其海洋能极其丰富。结合这一优势,英国政府把大力开发利用波浪能和潮汐能做为减少对传统能源的依赖,实现能源结构多元化,减少本国废气排放量的一项重要举措。"SuperGen Marine"是英国政府支持的一项正在进行的大型海洋可再生能源研究项目,其主要目的是增加对海洋能资源的认知和减少海洋能开发利用中的风险。该项目使科研院所与企业紧密协作,覆盖了能源转化、传输和存储等各个方面,其完整的研究模式及方法对我国海洋可再生能源的探索具有非常重要的借鉴意义。 展开更多
关键词 海洋能 可再生能源 supergen MARINE
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Animal life in the chemoautotrophic ecosystem of the hypogenic groundwater cave of Ayyalon (Israel): A summing up
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作者 F. D. Por Ch. Dimentman +1 位作者 A. Frumkin I. Naaman 《Natural Science》 2013年第4期7-13,共7页
Seven years after the discovery of the chemoautotrophic sulfidic groundwater site of the Ayyalon cave, its macrofauna can be fully reviewed. It consists of six endemic stygobiont and troglo-biont crustaceans and other... Seven years after the discovery of the chemoautotrophic sulfidic groundwater site of the Ayyalon cave, its macrofauna can be fully reviewed. It consists of six endemic stygobiont and troglo-biont crustaceans and other arthropods and two species still with unclear status. The taxonomic list is followed by brief discussions on the systematics of the species as well as by a few comments concerning the eventual broader zoogeographical and speleological implications of the Ayyalon faunistic findings, as they appeared in literature. 展开更多
关键词 Chemoautotrophy Sulfidic GROUNDWATERS hypogenic POOL Ophel BIOME Extremophily Anaerobism Ayyalon CAVE Thermosbaenacea
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SUPERGEN 2009征稿通知
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《电力系统自动化》 EI CSCD 北大核心 2008年第16期107-107,共1页
关键词 supergen 2009 邮箱 南京市 协作网
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第一届可持续发电与供电国际会议(SUPERGEN2009)征稿通知
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《中国电机工程学报》 EI CSCD 北大核心 2008年第24期38-38,共1页
第一届可持续发电与供电国际会议(the First International Conference on Sustainable Power Generation and Supply, SUPERGEN 2009)将于2009年4月6-7日在中国江苏省南京市举行。本次会议由英中清洁能源研究协作网(UK-China
关键词 可持续 supergen2009
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第一届可持续发电与供电国际会议(SUPERGEN 2009)征稿通知
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《电网技术》 EI CSCD 北大核心 2008年第17期57-57,共1页
第一届可持续发电与供电国际会议(the First International Conference on Sustainable Power Generation and Supply,SUPERGEN 2009)将于2009年4月6-7日在中国江苏省南京市举行。
关键词 可持续 supergen 2009
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第一届可持续发电与供电国际会议(SUPERGEN2009)征稿通知
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《电力自动化设备》 EI CSCD 北大核心 2008年第9期100-100,共1页
第一届可持续发电与供电国际会议(the First International Conference on Sustainable Power Generation and Supply,SUPERGEN2009)将于2009年4月6~7日在中国江苏省南京市举行。
关键词 可持续 supergen2009
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SuperGen将提交Orathecin申请
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作者 刘英鑫 《国外药讯》 2003年第3期18-18,共1页
关键词 supergen公司 美国 胰腺癌 第二代拓朴异构酶抑制剂
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黔东石阡震旦系陡山沱组钴锰矿床地质、地球化学特征及其地质意义
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作者 徐海 周许梅 +5 位作者 高军波 杨瑞东 尹润生 徐进鸿 薛忠喜 徐莉莉 《地质论评》 北大核心 2025年第6期1925-1942,共18页
沉积-风化型钴锰矿被视为重要的钴矿类型之一,然而对于钴的来源、赋存状态及成矿过程等长期以来缺乏深入系统的研究。黔东石阡震旦系陡山沱组底部发育沉积-风化型钴锰矿床,矿体主要由似层状、透镜状次生钴锰黏土岩组成。钴锰矿MnO及Co... 沉积-风化型钴锰矿被视为重要的钴矿类型之一,然而对于钴的来源、赋存状态及成矿过程等长期以来缺乏深入系统的研究。黔东石阡震旦系陡山沱组底部发育沉积-风化型钴锰矿床,矿体主要由似层状、透镜状次生钴锰黏土岩组成。钴锰矿MnO及Co含量分别介于3.57%~34.3%(平均11.72%)及131×10^(-6)~537×10^(-6)(平均346×10^(-6)),且发育Ba-Ni-Cu-Zn等多金属异常富集。含钴锰矿层中原生条带状构造,锰碳酸盐残余物被次生Fe-Mn氧化物包裹等证据揭示钴锰黏土岩是由锰碳酸盐表生风化而形成。钴锰矿中含锰矿物主要由锰氧化物(如钡锰矿及水锰矿等)组成,且锰氧化物能谱中可见Co峰值,结合Co与Mn、Ba强烈正相关(R^(2)=0.80),表明锰氧化物矿物是主要的载Co矿物。元素比值、判别图解及稀土元素分异特征集中表明钴、锰的富集矿化主要来源于热液系统的贡献。钴锰矿内部残余的锰碳酸盐矿物、钴锰矿石Ce正异常及显著的微量金属元素富集(如Ba、Co、Ni、Cu及Zn),结合周边陡山沱组底部普遍发育水平藻叠层白云岩,暗示锰碳酸盐岩是通过成岩转化形成的。综合全球及区域古构造-古地理及古海洋演化分析,Rodinia超大陆裂解引起裂陷盆地的形成及伴生的热液活动可能为钴锰富集和矿化提供了必要的容矿空间及成矿物源。Marinoan冰期前后显著的古海洋氧化还原扰动引起含钴锰氧化物沉淀,并在成岩过程中转化为锰碳酸盐胚胎层,最终在后期表生风化过程中形成钴锰黏土岩。本研究强调黔东-湘西区域陡山沱组含钴锰白云岩产出稳定且广泛分布,具有潜在的表生风化型钴锰矿找矿前景。 展开更多
关键词 钴锰矿 表生风化 含锰白云岩 沉淀机制 震旦系 陡山沱组 黔东
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陕西省佛坪县朱家垭-石泉县水井沟一带锰矿矿化带特征及矿床成因 被引量:1
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作者 吴启慧 柳国良 《中国锰业》 2025年第1期50-55,共6页
陕西省佛坪县朱家垭-石泉县水井沟一带锰矿成矿地质条件优越,找矿潜力大,但勘查程度尚浅。在研究区域基础地质和前人工作的基础上,通过野外地质调查、采样与测试分析等手段,研究了佛坪县朱家垭-石泉县水井沟一带锰矿矿床地质特征,探讨... 陕西省佛坪县朱家垭-石泉县水井沟一带锰矿成矿地质条件优越,找矿潜力大,但勘查程度尚浅。在研究区域基础地质和前人工作的基础上,通过野外地质调查、采样与测试分析等手段,研究了佛坪县朱家垭-石泉县水井沟一带锰矿矿床地质特征,探讨了矿床成因。研究结果表明:勘查区锰矿体主要赋存于寒武系下统一岩性段(∈^(1)_(1))含锰灰岩中,围岩为含锰灰岩及炭质片岩,矿体主要受层位和岩性控制。矿石中主要锰矿物为硬锰矿、软锰矿,少量水锰矿、褐锰矿。矿石自然类型为氧化锰矿石,是碳酸锰矿在地表氧化条件下形成的,其化学成分受原生矿石的制约,且具次生氧化作用的特征。矿床成因类型属于浅海相沉积-变质叠加表生氧化型碳酸锰矿床。 展开更多
关键词 陕西 锰矿 地质特征 表生氧化 矿床成因
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基于地球化学过程的环境预测预警研究现状与发展趋势
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作者 谢俊德 徐雪生 +2 位作者 骆检兰 李明陆 刘铁标 《国土资源导刊》 2025年第2期34-46,共13页
随着全球环境问题日益严峻,基于地球化学过程的环境预测预警方法近年来成为生态环境保护的重要工具。文章系统回顾了这一领域的研究进展,并对相关成果进行了分类梳理和总结。首先,阐述了元素表生地球化学循环的基本过程及其在环境预测... 随着全球环境问题日益严峻,基于地球化学过程的环境预测预警方法近年来成为生态环境保护的重要工具。文章系统回顾了这一领域的研究进展,并对相关成果进行了分类梳理和总结。首先,阐述了元素表生地球化学循环的基本过程及其在环境预测预警中的意义。其次,介绍了目前广泛采用的数据采集方法和技术手段,包括传统采样、遥感定量反演、便携式快速检测方法、生物传感器,并按照机理模型与数据驱动模型两大类对预测方法进行了详细分析。再次,重点归纳了针对不同对象的预警指标,并详细介绍了参照标准值、综合评价这两类预警等级的划分方法。最后,通过对现有研究成果的总结与分析,指出了当前研究中的不足之处,并对未来研究方向进行了展望:(1)应注重数据获取新方法的研究;(2)应加强元素在复杂介质中的迁移演化机制研究;(3)需要进一步完善基于地球化学过程的预测预警方法。 展开更多
关键词 环境预测 环境预警 表生地球化学 机理模型 数据驱动模型
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非硫化物型锌-铅矿床研究现状及其进展 被引量:8
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作者 范廷宾 李昊 +1 位作者 徐兴旺 董连慧 《西北地质》 CAS CSCD 北大核心 2018年第2期147-159,共13页
非硫化物型锌-铅矿床主要由一系列锌、铅"氧化物"组成。非硫化物型锌-铅矿床可以分为表生和深成2种类型。表生非硫化物矿床的形成主要与表生的氧化作用有关,主要含有菱锌矿、异极矿、白铅矿等;根据成矿方式的不同分为直接交... 非硫化物型锌-铅矿床主要由一系列锌、铅"氧化物"组成。非硫化物型锌-铅矿床可以分为表生和深成2种类型。表生非硫化物矿床的形成主要与表生的氧化作用有关,主要含有菱锌矿、异极矿、白铅矿等;根据成矿方式的不同分为直接交代型、围岩交代型、残余-岩溶充填型。深成非硫化物矿床的形成主要与热液流体的有关,主要含有硅锌矿、菱锌矿、白铅矿等;根据形成的不同方式被分为构造控制型矿床与层状矿床。深成矿床显示与表生矿床不同的C-O同位素特点。笔者主要讨论非硫化物型铅锌矿床的特征及成因机制,并介绍中国火烧云锌-铅矿床的研究进展。火烧云铅锌矿已探明锌-铅金属资源量大于1 700万t,已成为中国新的最大铅锌矿。矿床成矿矿物以菱锌矿、白铅矿、方铅矿与闪锌矿为主,最新研究结果表明矿床主要经历2期成矿作用:早期的铅锌碳酸盐阶段(主要)与晚期的铅锌硫化物阶段。其矿床地质特征及稳定同位素特征显示火烧云铅锌矿床为深成层状(喷流)的非硫化物型锌-铅矿床。 展开更多
关键词 非硫化物 锌-铅矿床 表生 深成 火烧云
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基于药效团模型及虚拟筛选方法发现EphB4全新抑制剂 被引量:8
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作者 邵鑫 衣倩颖 杨春蕾 《中国药科大学学报》 CAS CSCD 北大核心 2016年第1期38-47,共10页
采用计算机模拟手段,通过建立3D-QSAR模型、虚拟筛选及分子对接方法发现恶性肿瘤治疗靶标EphB4潜在的抑制剂。首先,通过Catalyst/HypoGen算法建立药效团模型。其中最好的模型Hypo1具有最高的科雷尔值(Correl值):0.96,最低的RMS值:0.89,... 采用计算机模拟手段,通过建立3D-QSAR模型、虚拟筛选及分子对接方法发现恶性肿瘤治疗靶标EphB4潜在的抑制剂。首先,通过Catalyst/HypoGen算法建立药效团模型。其中最好的模型Hypo1具有最高的科雷尔值(Correl值):0.96,最低的RMS值:0.89,与固定消耗值(fixed cost):89.20最接近的总消耗值(total cost):101.26,和最高的Δ消耗值(Δcost值):89.14。随后,Hypo1经过测试集验证及Fischer随机验证,并用于筛选化合物数据库。然后利用类药性筛选及分子对接手段进一步减少分子数量。最终,根据预测活性分析、对接得分值及结合模式分析,得到23个具有全新骨架的化合物作为Eph B4的潜在抑制剂可用于后续研究。 展开更多
关键词 EPHB4 3D-QSAR模型 虚拟筛选 分子对接 Catalyst/hypogen算法 肿瘤靶标
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