Adverse maternal and offspring reproductive outcomes,such as congenital disabilities,spontaneous pregnancy loss(SPL),preterm birth,gestational diabetes,and gestational hypertension,affect up to 20%of pregnancies[1–3]...Adverse maternal and offspring reproductive outcomes,such as congenital disabilities,spontaneous pregnancy loss(SPL),preterm birth,gestational diabetes,and gestational hypertension,affect up to 20%of pregnancies[1–3].Although the evidence remains elusive,a potential link emerged with the inappropriate periconceptional folate status[4].Folate belongs to one-carbon metabolism(OCM),playing pivotal roles in biological processes during the early development of humans,such as generating methyl groups for use in DNA synthesis,amino acid homeostasis,antioxidant generation,and epigenetic regulation[5,6].展开更多
基金supported by the National Key Research and Development Program(2021YFC2701004 and 2024YFC2707602)the Natural Science Foundation of China(82070323,82373584,and 82204051)+2 种基金Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-002)Shanghai Sailing Program(22YF1403900)Research Project of Shanghai Municipal Health Commission(202140444).
文摘Adverse maternal and offspring reproductive outcomes,such as congenital disabilities,spontaneous pregnancy loss(SPL),preterm birth,gestational diabetes,and gestational hypertension,affect up to 20%of pregnancies[1–3].Although the evidence remains elusive,a potential link emerged with the inappropriate periconceptional folate status[4].Folate belongs to one-carbon metabolism(OCM),playing pivotal roles in biological processes during the early development of humans,such as generating methyl groups for use in DNA synthesis,amino acid homeostasis,antioxidant generation,and epigenetic regulation[5,6].
