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Adsorption of heavy metals with hyper crosslinked polymers:Progress,challenges and perspectives
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作者 Hui Liu Baoying Xiao +2 位作者 Yaming Zhao Wei Wang Qiong Jia 《Chinese Chemical Letters》 2025年第8期39-52,共14页
Heavy metal pollution poses serious risks to the human health and the natural environment,and there is an urgent need to develop efficient heavy metal removal technologies.The adsorption strategy is one of the most fa... Heavy metal pollution poses serious risks to the human health and the natural environment,and there is an urgent need to develop efficient heavy metal removal technologies.The adsorption strategy is one of the most famous strategies for the capture of heavy metal ions.In recent years,hyper crosslinked polymers(HCPs),a kind of hyper crosslinked porous material prepared by Friedel-Crafts alkylation reaction,have attracted more and more attention because of their advantages of ultra-light framework,wide range of building monomers,easy modification and functionalization.This review focuses on the advances of HCPs in the efficient applications to the removal of heavy metal ions.The fundamentals are presented including physicochemical properties,adsorption mechanism,and preparation strategies.Subsequently,the application and influencing factors of HCPs toward heavy metal ion adsorption are discussed in detail.Furthermore,the opportunities and challenges of HCPs in this promising research field are summarized and anticipated.We are convinced that the advanced HCP-based materials will make further contributions to heavy metal removal in wastewater treatment,further paving the way of advancing researches in this field. 展开更多
关键词 Hyper crosslinked polymer Heavymetal ions ADSORPTION Mechanism Review
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Harmonization of Heart Disease Dataset for Accurate Diagnosis:A Machine Learning Approach Enhanced by Feature Engineering
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作者 Ruhul Amin Md.Jamil Khan +2 位作者 Tonway Deb Nath Md.Shamim Reza Jungpil Shin 《Computers, Materials & Continua》 2025年第3期3907-3919,共13页
Heart disease includes a multiplicity of medical conditions that affect the structure,blood vessels,and general operation of the heart.Numerous researchers have made progress in correcting and predicting early heart d... Heart disease includes a multiplicity of medical conditions that affect the structure,blood vessels,and general operation of the heart.Numerous researchers have made progress in correcting and predicting early heart disease,but more remains to be accomplished.The diagnostic accuracy of many current studies is inadequate due to the attempt to predict patients with heart disease using traditional approaches.By using data fusion from several regions of the country,we intend to increase the accuracy of heart disease prediction.A statistical approach that promotes insights triggered by feature interactions to reveal the intricate pattern in the data,which cannot be adequately captured by a single feature.We processed the data using techniques including feature scaling,outlier detection and replacement,null and missing value imputation,and more to improve the data quality.Furthermore,the proposed feature engineering method uses the correlation test for numerical features and the chi-square test for categorical features to interact with the feature.To reduce the dimensionality,we subsequently used PCA with 95%variation.To identify patients with heart disease,hyperparameter-based machine learning algorithms like RF,XGBoost,Gradient Boosting,LightGBM,CatBoost,SVM,and MLP are utilized,along with ensemble models.The model’s overall prediction performance ranges from 88%to 92%.In order to attain cutting-edge results,we then used a 1D CNN model,which significantly enhanced the prediction with an accuracy score of 96.36%,precision of 96.45%,recall of 96.36%,specificity score of 99.51%and F1 score of 96.34%.The RF model produces the best results among all the classifiers in the evaluation matrix without feature interaction,with accuracy of 90.21%,precision of 90.40%,recall of 90.86%,specificity of 90.91%,and F1 score of 90.63%.Our proposed 1D CNN model is 7%superior to the one without feature engineering when compared to the suggested approach.This illustrates how interaction-focused feature analysis can produce precise and useful insights for heart disease diagnosis. 展开更多
关键词 Heart disease HARMONIZATION feature interaction PCA model hyper tuning machine learning
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Hyper-Enrichment of Lithium,Cesium,and Tantalum in the Yichun Rare Metal Deposit:Understandings and Future Perspectives
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作者 Xi Diao Mingqian Wu +3 位作者 Yixue Gao Zeyu Yang Zhuo’er Teng Kunfeng Qiu 《Journal of Earth Science》 2025年第6期2807-2811,共5页
0 INTRODUCTION The Yichun Li-Cs-Ta deposit in SE China has received significant attention for several decades,and it represents one of the most typical granitic examples that resemble typical LCT-type mineralization i... 0 INTRODUCTION The Yichun Li-Cs-Ta deposit in SE China has received significant attention for several decades,and it represents one of the most typical granitic examples that resemble typical LCT-type mineralization in peraluminous pegmatites. 展开更多
关键词 LITHIUM peraluminous pegmatites granitic examples hyper enrichment CESIUM tantalum yichun rare metal deposit
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Performance analysis of fluid-core Whipple shields under hypervelocity impact at different projectile speeds
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作者 Anand Pai Marcos Rodriguez-Millan +3 位作者 Selim Gürgen Adithya Piccholiya Nishant Mujumdar Satish Shenoy B 《Defence Technology(防务技术)》 2025年第5期32-45,共14页
Whipple shields as sacrificial bumpers,safeguard the satellites against extremely fast,different-sized projectiles traveling through space in the low earth orbit.Typical Whipple shields comprise a front and rear plate... Whipple shields as sacrificial bumpers,safeguard the satellites against extremely fast,different-sized projectiles traveling through space in the low earth orbit.Typical Whipple shields comprise a front and rear plate,separated by a gap or space.Recent advancements have explored the use of foam,cellular cores,and alternative materials such as ceramics instead of aluminium for the plates.In the current work,the effect of including fluid cores(air/water)sandwiched between the front and rear plates,on the response to hypervelocity impact was explored through a numerical approach.The numerical simulation consisted of hypervelocity impact by a 2 mm diameter,stainless steel projectile,launched at speeds of 3 e9 km/s with a normal impact trajectory towards the Whipple shield.The front and rear bumpers,made of AA6061-T6,were each 1 mm thick.A space of 10 mm was taken between the plates(occupied by fluid).The key metrics analyzed were the perforation characteristics,stages of the debris cloud generation and propagation,energy variations(internal,kinetic and plastic work),temperature variations,and the fragmentation summary.From the computational analysis,employing water-core in Whipple shields could prevent the rear bumper perforation till 6 km/s,lower the peak temperatures at the front bumper perforation zones and debris tip,and generate fewer,larger fragments. 展开更多
关键词 Whipple shields Fluid-filled core Hyper velocity impact Debris cloud Perforation characteristics Numerical simulation
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Progress in weldability research of super and hyper duplex stainless steels
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作者 Aiguo Liu 《China Welding》 2025年第2期159-168,共10页
Super duplex stainless steels(SDSSs)and hyper duplex stainless steels(HDSSs),with more alloying elements content,are more corrosion resistant than the standard grades.Progresses of research works on weldability of SDS... Super duplex stainless steels(SDSSs)and hyper duplex stainless steels(HDSSs),with more alloying elements content,are more corrosion resistant than the standard grades.Progresses of research works on weldability of SDSSs and HDSSs in recent years are reviewed in this paper.If proper heat input is provided,SDSSs and HDSSs can be welded with most fusion welding processes,while tungsten inert gas welding is the most popular process.SDSSs and HDSSs are more prone to secondary phases precipitation than the standard and lean grades,and heat input for SDSSs and HDSSs welding is restricted to a smaller range.Matching filler materials are usually recommended for SDSSs and HDSSs welding,rather than Ni-riched ones for standard and lean grades.Nitrogen addition in shielding gas is always beneficial.Post weld heat treatment with slow cooling rate will be harmful.Hot cracking tendency of SDSSs and HDSSs joints is not high,but sometimes they can suffer from hydrogen induced stress cracking. 展开更多
关键词 WELDABILITY Super duplex stainless steel Hyper duplex stainless steel Phases balance Secondary phase CRACKING
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Hot deformation behavior of 2707 hyper duplex stainless steel
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作者 Ai-qin Wang Pei Liu +2 位作者 Chen-lu Liu Hang Wang Jing-pei Xie 《China Foundry》 2025年第6期691-700,共10页
The hot deformation behavior of 2707 hyper duplex stainless steel(HDSS)was investigated through a hot compression test at 950℃ to 1,250℃ at strain rates of 0.01 s^(-1) to 10 s^(-1).Observations from the flow stress ... The hot deformation behavior of 2707 hyper duplex stainless steel(HDSS)was investigated through a hot compression test at 950℃ to 1,250℃ at strain rates of 0.01 s^(-1) to 10 s^(-1).Observations from the flow stress curves reveal a balance between work hardening and dynamic recovery at the beginning of the deformation and subsequently demonstrate various softening mechanisms with the increase of strain.At high strain rates,dynamic recovery is the prevailing mechanism,whereas,at medium and low strain rates,dynamic recrystallization becomes dominant.The constitutive equation was constructed,and the deformation activation energy was calculated to be 645.46 kJ·mol^(-1).The hot processing map was drawn based on the dynamic material model at a strain of 0.8.The results indicate that the hot workability of 2707 HDSS decreases due to its high alloying content.The microstructure evolution of 2707 HDSS at 1,050℃ was identified by means of electron backscatter diffraction and transmission electron microscopy.The results demonstrate that the ferrite completes dynamic recrystallization at the strain rate of 1 s^(-1).The softening process of austenite is influenced by ferrite and mainly experiences dynamic recovery.The austenite located at the α/γ phase boundaries tends to undergo dynamic recrystallization. 展开更多
关键词 hyper duplex stainless steel hot deformation constitutive equation softening mechanism
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Extreme gradient boosting with Shapley Additive Explanations for landslide susceptibility at slope unit and hydrological response unit scales
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作者 Ananta Man Singh Pradhan Pramit Ghimire +3 位作者 Suchita Shrestha Ji-Sung Lee Jung-Hyun Lee Hyuck-Jin Park 《Geoscience Frontiers》 2025年第4期357-372,共16页
This study provides an in-depth comparative evaluation of landslide susceptibility using two distinct spatial units:and slope units(SUs)and hydrological response units(HRUs),within Goesan County,South Korea.Leveraging... This study provides an in-depth comparative evaluation of landslide susceptibility using two distinct spatial units:and slope units(SUs)and hydrological response units(HRUs),within Goesan County,South Korea.Leveraging the capabilities of the extreme gradient boosting(XGB)algorithm combined with Shapley Additive Explanations(SHAP),this work assesses the precision and clarity with which each unit predicts areas vulnerable to landslides.SUs focus on the geomorphological features like ridges and valleys,focusing on slope stability and landslide triggers.Conversely,HRUs are established based on a variety of hydrological factors,including land cover,soil type and slope gradients,to encapsulate the dynamic water processes of the region.The methodological framework includes the systematic gathering,preparation and analysis of data,ranging from historical landslide occurrences to topographical and environmental variables like elevation,slope angle and land curvature etc.The XGB algorithm used to construct the Landslide Susceptibility Model(LSM)was combined with SHAP for model interpretation and the results were evaluated using Random Cross-validation(RCV)to ensure accuracy and reliability.To ensure optimal model performance,the XGB algorithm’s hyperparameters were tuned using Differential Evolution,considering multicollinearity-free variables.The results show that SU and HRU are effective for LSM,but their effectiveness varies depending on landscape characteristics.The XGB algorithm demonstrates strong predictive power and SHAP enhances model transparency of the influential variables involved.This work underscores the importance of selecting appropriate assessment units tailored to specific landscape characteristics for accurate LSM.The integration of advanced machine learning techniques with interpretative tools offers a robust framework for landslide susceptibility assessment,improving both predictive capabilities and model interpretability.Future research should integrate broader data sets and explore hybrid analytical models to strengthen the generalizability of these findings across varied geographical settings. 展开更多
关键词 Landslide susceptibility mapping Hydrological response units Slope units Extreme gradient boosting Hyper parameter tuning Shapley additive explanations
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YOLO-SIFD:YOLO with Sliced Inference and Fractal Dimension Analysis for Improved Fire and Smoke Detection
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作者 Mariam Ishtiaq Jong-Un Won 《Computers, Materials & Continua》 2025年第3期5343-5361,共19页
Fire detection has held stringent importance in computer vision for over half a century.The development of early fire detection strategies is pivotal to the realization of safe and smart cities,inhabitable in the futu... Fire detection has held stringent importance in computer vision for over half a century.The development of early fire detection strategies is pivotal to the realization of safe and smart cities,inhabitable in the future.However,the development of optimal fire and smoke detection models is hindered by limitations like publicly available datasets,lack of diversity,and class imbalance.In this work,we explore the possible ways forward to overcome these challenges posed by available datasets.We study the impact of a class-balanced dataset to improve the fire detection capability of state-of-the-art(SOTA)vision-based models and propose the use of generative models for data augmentation,as a future work direction.First,a comparative analysis of two prominent object detection architectures,You Only Look Once version 7(YOLOv7)and YOLOv8 has been carried out using a balanced dataset,where both models have been evaluated across various evaluation metrics including precision,recall,and mean Average Precision(mAP).The results are compared to other recent fire detection models,highlighting the superior performance and efficiency of the proposed YOLOv8 architecture as trained on our balanced dataset.Next,a fractal dimension analysis gives a deeper insight into the repetition of patterns in fire,and the effectiveness of the results has been demonstrated by a windowing-based inference approach.The proposed Slicing-Aided Hyper Inference(SAHI)improves the fire and smoke detection capability of YOLOv8 for real-life applications with a significantly improved mAP performance over a strict confidence threshold.YOLOv8 with SAHI inference gives a mAP:50-95 improvement of more than 25%compared to the base YOLOv8 model.The study also provides insights into future work direction by exploring the potential of generative models like deep convolutional generative adversarial network(DCGAN)and diffusion models like stable diffusion,for data augmentation. 展开更多
关键词 Fire detection smoke detection class-balanced dataset you only look once(YOLO) slicing-aided hyper inference(SAHI) fractal dimension generative adversarial network(GAN) diffusion models
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新型高性能互连技术Hyper Transport研究 被引量:6
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作者 裘嵘 郭御风 +1 位作者 江泓 杨长兴 《计算机应用研究》 CSCD 北大核心 2004年第5期258-260,共3页
HyperTransport(HT)是一种新型用于板级集成电路互连的、高性能、点到点、基于报文交换的互连技术。HyperTransport提供了用途广泛的连接,以减少系统内的总线数,为嵌入系统应用提供高性能的连接,可以实现高度可伸缩的多处理系统。对Hype... HyperTransport(HT)是一种新型用于板级集成电路互连的、高性能、点到点、基于报文交换的互连技术。HyperTransport提供了用途广泛的连接,以减少系统内的总线数,为嵌入系统应用提供高性能的连接,可以实现高度可伸缩的多处理系统。对Hyper Transport的一些关键技术进行了介绍,并设计了一个HT的HOST桥。 展开更多
关键词 HYPER Transport Host桥 虚信道
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基于HyperMesh的某航天产品结构螺栓连接处理方法研究 被引量:3
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作者 刘磊 马爱军 +4 位作者 刘洪英 冯雪梅 石蒙 董睿 赵亚雄 《航天医学与医学工程》 CAS CSCD 北大核心 2015年第6期441-444,共4页
目的为具有多螺栓连接复杂结构、处于在研阶段的某航天产品提供螺栓连接处理方法。方法利用Hyper Mesh软件,选择4种螺栓连接处理方法,建立组件有限元模型,进行模态分析,比对其固有频率与振型;对具有螺栓连接的简单结构,采用同样计算方法... 目的为具有多螺栓连接复杂结构、处于在研阶段的某航天产品提供螺栓连接处理方法。方法利用Hyper Mesh软件,选择4种螺栓连接处理方法,建立组件有限元模型,进行模态分析,比对其固有频率与振型;对具有螺栓连接的简单结构,采用同样计算方法,比对计算和试验验证结果。结果 4种螺栓连接处理方法得到的低阶振型一致,但固有频率有所区别。结论实体螺栓处理方法适合于该产品改进设计需求,该方法可为类似结构的建模及分析提供参考。 展开更多
关键词 HYPER MESH 航天产品 模态分析 螺栓连接处理
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基于HBF神经网络的自适应观测器 被引量:7
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作者 闻新 张兴旺 张威 《电子学报》 EI CAS CSCD 北大核心 2015年第7期1315-1319,共5页
传统的RBF(Radial Basis Function)神经元基函数通常把高斯类型与单一宽度作为每个神经元的激活函数,这些特性限制了网络神经元的性能,特别是在处理复杂的非线性建模问题上.为了克服这个限制,本文应用了具有类似RBF网络,但激活函数不同... 传统的RBF(Radial Basis Function)神经元基函数通常把高斯类型与单一宽度作为每个神经元的激活函数,这些特性限制了网络神经元的性能,特别是在处理复杂的非线性建模问题上.为了克服这个限制,本文应用了具有类似RBF网络,但激活函数不同-超基函数HBF(Hyper Basis Function)的网络.结合RBF网络,分析了HBF网络的结构、基函数形式及基函数对网络的影响,利用决策树算法计算了网络中心.在此基础上,提出了一种基于HBF神经网络的自适应观测器设计方法,并通过引入Lyapunov函数,证明了这种观测器设计方法的稳定性;最后通过仿真验证了这种HBF神经网络观测器能很好地观测系统的状态值. 展开更多
关键词 状态估计 HBF(Hyper BASIS Function)神经网络 非线性系统 决策树
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基于HyperXtrude铝型材挤压模具优化设计 被引量:11
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作者 王赫男 王孟君 +2 位作者 刘超 乔磊 葛鹏 《铝加工》 CAS 2012年第6期11-15,共5页
运用Hyper Xtrude对某壁厚不均的工业铝型材挤压过程进行仿真模拟,获得了金属流动的速度场,分析了型材挤压时的变形情况。根据型材的流动变形情况对模具结构进行了优化,通过焊合阻流块以降低型材流速快的部位的流动速度,型材的"起... 运用Hyper Xtrude对某壁厚不均的工业铝型材挤压过程进行仿真模拟,获得了金属流动的速度场,分析了型材挤压时的变形情况。根据型材的流动变形情况对模具结构进行了优化,通过焊合阻流块以降低型材流速快的部位的流动速度,型材的"起浪"现象得到明显改善。上机试模结果表明,试模情况与模拟结果基本一致,基于Hyper Xtrude的数值模拟,预测实际挤压过程中可能出现的变形缺陷,对挤压模具设计和优化有很重要的指导意义。 展开更多
关键词 铝型材 模具设计 HYPER Xtrude 数值模拟
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CAE在汽车座椅轻量化设计中的应用 被引量:12
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作者 杨天云 张晴朗 +1 位作者 杨兵 余瑾 《精密成形工程》 2012年第1期73-77,共5页
以汽车座椅靠背为研究对象,利用材料力学原理分别设计3种不同截面形状的钢制座椅靠背圆钢管,基于HyperWorks有限元软件对3种方案进行静强度模拟分析,运用密度法对新型铝合金座椅骨架进行拓扑优化设计。结果表明:截面为椭圆型的钢管比等... 以汽车座椅靠背为研究对象,利用材料力学原理分别设计3种不同截面形状的钢制座椅靠背圆钢管,基于HyperWorks有限元软件对3种方案进行静强度模拟分析,运用密度法对新型铝合金座椅骨架进行拓扑优化设计。结果表明:截面为椭圆型的钢管比等截面面积的圆形钢管具有更大的抗弯强度,拓扑优化是一种有效的结构概念设计方法,使铝合金座椅靠背质量减轻16.5%,从结构和材料2方面实现了汽车座椅轻量化的目的。 展开更多
关键词 汽车座椅骨架 轻量化 HYPER WORKS 静强度 拓扑优化
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Hyper-CVAD/MA方案治疗高度侵袭性非霍奇金淋巴瘤临床观察 被引量:5
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作者 潘佳 李国杰 +1 位作者 丁辉 程传耀 《中国当代医药》 2012年第25期34-35,共2页
目的观察Hyper—CVAD/MA方案治疗高度侵袭性非霍奇金淋巴瘤疗效及毒副反应。方法选取高度侵袭性非霍奇金淋巴瘤患者12例.予以Hyper—CVAD/MA方案治疗,Hyper—CVAD方案:环磷酰胺300mg/m。静脉注射,2次/d,dl~3;长春新碱1.4mg... 目的观察Hyper—CVAD/MA方案治疗高度侵袭性非霍奇金淋巴瘤疗效及毒副反应。方法选取高度侵袭性非霍奇金淋巴瘤患者12例.予以Hyper—CVAD/MA方案治疗,Hyper—CVAD方案:环磷酰胺300mg/m。静脉注射,2次/d,dl~3;长春新碱1.4mg/m2,静脉注射,d4、d11;多柔比星16.6mg/(m2.d),持续静脉输注72h,d4;地塞米松40mg/d,静脉滴注d1~4、d11~14。MA方案:氨甲喋呤1.0g/m2,持续静脉滴注24h,dl;阿糖胞苷3.0g/m2,静脉滴注,每12小时1次,d2.3。结果12例总有效率为100%,完全缓解(CR)8例,部分缓解(PR)4例,1年无进展生存(PFS)率为58_3%,1年生存率为75%。主要毒副反应为血液学毒性。结论Hyper—CVAD/MA方案治疗高度侵袭性非霍奇金淋巴瘤近期疗效满意,治疗相关不良反应可控制。 展开更多
关键词 Hyper—CVAD/MA方案 化疗 非霍金淋巴瘤 疗效 毒副反应
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Design and Simulation of Controller for Hyper Velocity Kinetic Energy Missile 被引量:2
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作者 康长赓 雷成 刘藻珍 《Journal of Beijing Institute of Technology》 EI CAS 2000年第1期107-112,共6页
The controller design and digital simulation for the hyper velocity kinetic energy missile is investigated. A mathematical model of the trajectory deviation from the line of sight was established, the guidance closed ... The controller design and digital simulation for the hyper velocity kinetic energy missile is investigated. A mathematical model of the trajectory deviation from the line of sight was established, the guidance closed loop was compensated with a phase advance lag corrective network, a selecting algorithm of the attitude control motors used to steer the missile's attitude was presented. In the presence of a wide variety of disturbances the results of digital simulation are satisfactory to circular error probability(CEP) being less than 0 5?m. The steering scheme utilizing attitude control motors as actuators to control the attitude of the missile is feasible. 展开更多
关键词 hyper velocity missile guidance missile control attitude control motor SIMULATION
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一种高性能I/O互连协议链路接口的实现 被引量:2
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作者 刘涛 刘光明 郭御风 《计算机工程与科学》 CSCD 2006年第4期130-132,142,共4页
随着计算机技术的发展,传统的PCI总线已难以满足应用的要求,HyperTransport采用低电压差分信号传输、点到点互连,可提供更高的数据传输率和可扩展性,满足各种不同的需求。本文对HyperTransport链路接口的链路初始化、错误处理和高速链... 随着计算机技术的发展,传统的PCI总线已难以满足应用的要求,HyperTransport采用低电压差分信号传输、点到点互连,可提供更高的数据传输率和可扩展性,满足各种不同的需求。本文对HyperTransport链路接口的链路初始化、错误处理和高速链路源同步关键技术进行了研究,提出了相应的实现方法。 展开更多
关键词 HYPER TRANSPORT CRC 源同步
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铝型材挤压金属流速数学模型的建立 被引量:6
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作者 陈欣怡 王孟君 +4 位作者 乔磊 陈新欢 王迎新 袁玉宝 潘学著 《铝加工》 CAS 2015年第3期4-8,共5页
针对不同的模孔形状、尺寸及分布,运用挤压模拟有限元软件Hyper Xtrude对所设计的模具进行仿真模拟,分析了模孔长度、周长、壁厚、距挤压中心的距离以及工作带长度等结构参数对金属流速的影响,获得了各参数的影响因子,建立了金属流速和... 针对不同的模孔形状、尺寸及分布,运用挤压模拟有限元软件Hyper Xtrude对所设计的模具进行仿真模拟,分析了模孔长度、周长、壁厚、距挤压中心的距离以及工作带长度等结构参数对金属流速的影响,获得了各参数的影响因子,建立了金属流速和工作带长度的数学模型。根据所建立的工作带长度数学模型,设计了某型材挤压平模工作带尺寸,通过实际挤压试验验证,挤出型材尺寸合格,所建立的工作带数学模型对铝型材挤压模具的设计有指导意义。 展开更多
关键词 铝型材 模具结构参数 金属流速 工作带 HYPER Xtrude
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Hyper-CVAD方案治疗高度侵袭性非霍奇金淋巴瘤的疗效分析 被引量:2
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作者 袁志平 姚文秀 +4 位作者 吴亚琳 贾钰铭 雷开键 陈昕 彭生才 《肿瘤预防与治疗》 2009年第3期272-276,260,共6页
目的:观察Hyper-CVAD化疗方案治疗高度侵袭性非霍奇金淋巴瘤的治疗效果。方法:47例高度恶性NHL患者,其中T母细胞淋巴瘤39例和Burkitt's淋巴瘤8例。所有患者接受Hyper-CVAD化疗方案治疗6个周期-8个周期。根据中枢神经系统复发情况,... 目的:观察Hyper-CVAD化疗方案治疗高度侵袭性非霍奇金淋巴瘤的治疗效果。方法:47例高度恶性NHL患者,其中T母细胞淋巴瘤39例和Burkitt's淋巴瘤8例。所有患者接受Hyper-CVAD化疗方案治疗6个周期-8个周期。根据中枢神经系统复发情况,给予氨甲喋呤和阿糖胞苷进行鞘内治疗(IT)4次-16次。对早期患者(受累区域)和有大肿块或者有残留灶的晚期患者给予30Gy-40Gy的剂量常规放疗。结果:中位随访时间36个月(12个月-53个月),所有患者接受了平均6.8个周期化疗(总共319个周期),41例(87.2%)取得完全缓解(CR);26例患者无病生存,中位生存时间34个月(3个月-51个月),中位复发时间为9月(3个月-23个月),1年无病生存率与总生存率分别为81.0%和91.4%,3年为53.2%和57.4%。高龄、IPI指数高和伴有大肿块、骨髓受侵犯、B症状,晚期患者具有较低的CR率和较差的预后。接受鞘内治疗后中枢神经系统(CNS)复发率10.6%。主要不良反应为骨髓抑制,Ⅲ度-Ⅳ度白细胞和血小板减少的发生率分别为100%和36.2%。结论:Hyper-CVAD方案治疗配合鞘内化疗与局部放疗是治疗高度侵袭性NHL的有效的方案,具有较高的缓解率和3年生存率。 展开更多
关键词 非霍奇金淋巴瘤 高度侵袭性 Hyper—CVAD方案 鞘内注射 放疗
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基于HyperWorks的进给箱体拓扑优化设计 被引量:3
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作者 胡世军 张富 +1 位作者 邓洋 韩健 《机械与电子》 2011年第9期28-30,共3页
为提高Φ630 mm球面车磨床进给箱体的结构刚度,以HyperWorks-Optistruct软件为平台,建立了以结构的相对密度为设计变量,以一阶固有频率最大化为目标的拓扑优化模型,实现了移频和质量减轻的优化目标,并给出了进给箱材料的最优分布图,为... 为提高Φ630 mm球面车磨床进给箱体的结构刚度,以HyperWorks-Optistruct软件为平台,建立了以结构的相对密度为设计变量,以一阶固有频率最大化为目标的拓扑优化模型,实现了移频和质量减轻的优化目标,并给出了进给箱材料的最优分布图,为改善球面车磨床的动态特性提供了理论依据。 展开更多
关键词 进给箱 模态分析 拓扑优化 Hyper— WORKS
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双峰驼精清诱导排卵活性因子的阴离子交换柱Q Hyper D层析分离及生物活性鉴定 被引量:1
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作者 李喜龙 赵兴绪 陈北亨 《畜牧兽医学报》 CAS CSCD 北大核心 2002年第3期226-229,共4页
利用阴离子交换柱QHyperD对双峰驼精清进行分离 ,大鼠垂体组织培养及母驼肌注活性组分 ,RIA法测定垂体组织培养液和母驼血浆中LH及FSH的浓度。实验结果表明 ,驼精清经QHyperD柱层析后 ,共得到 6个组分 (F1~F6 ) ,其中F3和F5在大鼠垂体... 利用阴离子交换柱QHyperD对双峰驼精清进行分离 ,大鼠垂体组织培养及母驼肌注活性组分 ,RIA法测定垂体组织培养液和母驼血浆中LH及FSH的浓度。实验结果表明 ,驼精清经QHyperD柱层析后 ,共得到 6个组分 (F1~F6 ) ,其中F3和F5在大鼠垂体组织培养实验中具有生物活性 ,可引起LH的明显释放 (P <0 .0 5 )。在体实验时给卵巢上有成熟卵泡的母驼分别肌注F3或F5 ,肌注后 5~ 7h ,LH的释放也明显增加 (P <0 .0 5 )。F3可引起母驼发生排卵 ,F5则不能 ,说明F3可能就是驼精清中的诱导排卵活性因子或其成分之一。另外 ,无论是F3或是F5 。 展开更多
关键词 双峰驼 精添 排卵活性因子 阴离子交换柱 Q HYPER D层析分离 生物活性 鉴定
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