Objective: to explore the methods of drug adjustment and pharmaceutical care for the anti-infection treatment plan of clinical pharmacists for methicillin-sensitive staphylococcus aureus bacteremia patients with renal...Objective: to explore the methods of drug adjustment and pharmaceutical care for the anti-infection treatment plan of clinical pharmacists for methicillin-sensitive staphylococcus aureus bacteremia patients with renal hyperfunction. Methods: clinical pharmacists analyzed the three aspects of knowledge-knowledge of bacteria, medicine and people. Identify bacteria, pathogen distribution, drug resistance mechanism. Identify drugs, pharmacokinetics and pharmacodynamics of drugs, etc. Identify person, pathophysiological changes in patients, severity. Through the comprehensive analysis of multiple factors, the individual drug administration plan was formulated. Results Although the initial treatment failed, clinical pharmacists focused on the analysis of factors such as insufficient blood concentration and rapid metabolism of β -lactam antibiotics in patients with renal hyperfunction from the perspective of renal hyperfunction. Through individual drug administration, patients received timely and effective anti-infection treatment and pharmaceutical care. Conclusion Clinical pharmacists should analyze the causes of anti-infection failure in various aspects when participating in the formulation and adjustment of clinical treatment plans, especially for patients with renal hyperfunction, the effectiveness of anti-infection can be guaranteed only when the characteristics of metabolic distribution are fully considered.展开更多
文摘Objective: to explore the methods of drug adjustment and pharmaceutical care for the anti-infection treatment plan of clinical pharmacists for methicillin-sensitive staphylococcus aureus bacteremia patients with renal hyperfunction. Methods: clinical pharmacists analyzed the three aspects of knowledge-knowledge of bacteria, medicine and people. Identify bacteria, pathogen distribution, drug resistance mechanism. Identify drugs, pharmacokinetics and pharmacodynamics of drugs, etc. Identify person, pathophysiological changes in patients, severity. Through the comprehensive analysis of multiple factors, the individual drug administration plan was formulated. Results Although the initial treatment failed, clinical pharmacists focused on the analysis of factors such as insufficient blood concentration and rapid metabolism of β -lactam antibiotics in patients with renal hyperfunction from the perspective of renal hyperfunction. Through individual drug administration, patients received timely and effective anti-infection treatment and pharmaceutical care. Conclusion Clinical pharmacists should analyze the causes of anti-infection failure in various aspects when participating in the formulation and adjustment of clinical treatment plans, especially for patients with renal hyperfunction, the effectiveness of anti-infection can be guaranteed only when the characteristics of metabolic distribution are fully considered.
