BACKGROUND Globally,obesity and diabetes mellitus(DM)are emergent public health concerns in the adolescent population.India,home to the largest adolescent population and the second largest diabetes cohort is experienc...BACKGROUND Globally,obesity and diabetes mellitus(DM)are emergent public health concerns in the adolescent population.India,home to the largest adolescent population and the second largest diabetes cohort is experiencing rapid but unplanned urbanization,with accompanying unhealthy nutritional transition,and sedentary lifestyle.AIM To determine prevalence and determinants of obesity and hyperglycaemia and their association among community-dwelling older adolescents(15-19 years)in India.METHODS This cross-sectional analysis from the national family health survey-5 included data of 258028 adolescents aged 15-19 across India(2019-2021).The survey employed stratified two-stage sampling,with systematic random sampling in rural and urban areas.Statistical analysis included descriptive statistics,bivariate,and multivariable logistic regression,employing generalized linear models.RESULTS The weighted prevalence of DM was 1.09%including 0.77%[95%confidence interval(CI):0.72-0.83]previously diagnosed and 0.32%(95%CI:0.29-0.35)newly diagnosed cases detected on survey screening.On adjusted analysis,increasing age,higher education levels,higher wealth index,and overweight/obesity were the factors significantly associated with presence of DM.Only 61%of the adolescents with previously diagnosed DM were on anti-diabetes treatment.The weighted prevalence of overweight/obesity among older adolescents was 6.9%with significantly higher odds in the male sex,having higher educational levels,urban residence,and those with a higher wealth index.CONCLUSION Nearly one in hundred older adolescents in India have diabetes,with one in three undiagnosed.Strengthening DM screening and treatment access among adolescents through public health programs is urgently warranted.展开更多
BACKGROUND A recent investigation showed that the prevalence of type 2 diabetes mellitus(T2DM)is 12.8%among individuals of Han ethnicity.Gut microbiota has been reported to play a central role in T2DM.Goto-Kakizaki(GK...BACKGROUND A recent investigation showed that the prevalence of type 2 diabetes mellitus(T2DM)is 12.8%among individuals of Han ethnicity.Gut microbiota has been reported to play a central role in T2DM.Goto-Kakizaki(GK)rats show differences in gut microbiota compared to non-diabetic rats.Previous studies have indicated that berberine could be successfully used to manage T2DM.We sought to understand its hypoglycaemic effect and role in the regulation of the gut microbiota.AIM To determine whether berberine can regulate glucose metabolism in GK rats via the gut microbiota.METHODS GK rats were acclimatized for 1 wk.The GK rats were randomly divided into three groups and administered saline(Mo),metformin(Me),or berberine(Be).The observation time was 8 wk,and weight,fasting blood glucose(FBG),insulin,and glucagon-like peptide-1(GLP-1)were measured.Pancreatic tissue was observed for pathological changes.Additionally,we sequenced the 16S rRNA V3-V4 region of the gut microbiota and analysed the structure.RESULTS Compared with the Mo group,the Me and Be groups displayed significant differences in FBG(P<0.01)and GLP-1(P<0.05).A significant decrease in weight and homeostatic model assessment-insulin resistance was noted in the Be group compared with those in the Me group(P<0.01).The pancreatic islets of the Me-and Be-treated rats showed improvement in number,shape,and necrosis compared with those of Mo-treated rats.A total of 580 operational taxonomic units were obtained in the three groups.Compared to the Mo group,the Me and Be groups showed a shift in the structure of the gut microbiota.Correlation analysis indicated that FBG was strongly positively correlated with Clostridia_UCG-014(P<0.01)and negatively correlated with Allobaculum(P<0.01).Body weight showed a positive correlation with Desulfovibrionaceae(P<0.01)and a negative correlation with Akkermansia(P<0.01).Importantly,our results demonstrated that Me and Be could significantly decrease Bacteroidetes(P<0.01)and the Bacteroidetes/Firmicutes ratio(P<0.01).Furthermore,Muribaculaceae(P<0.01;P<0.05)was significantly decreased in the Me and Be groups,and Allobaculum(P<0.01)was significantly increased.CONCLUSION Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM rats.展开更多
There is conflicting scientific data about the link between, high homocysteine (Hcy) levels in the general population, and obesity. This is a case-control study aimed to assess the role of hyperhomocysteinemia in obes...There is conflicting scientific data about the link between, high homocysteine (Hcy) levels in the general population, and obesity. This is a case-control study aimed to assess the role of hyperhomocysteinemia in obesity and its associated illnesses, including hypertension, dyslipidemia, and hyperglycemia in Gezira state, Sudan. Two hundred and eleven participants were included in the study, 140 were obese (117 females and 23 males) and 71 were normal weight control, the obese median age was 49.49 ± 12.2 years. The control group consisted of 71 individuals with an average age of 45.78 ± 17.67 years. Among those who were already known to be obese, 67 (47.9%) reported having type II diabetes mellitus, 71 (50.7%) reported having hypertension, and 35 (25%) were obese without having either diabetes or hypertension. Three mls of venous blood from each participant were collected in the morning after a 12 h overnight fasting in Lithium heparin containers then the plasma was separated and stored at -80°C for analysis. Serum Hcy and lipid profile were measured using the enzymatic method by Cobas C 411 analyzer. In comparison to obese non-hypertensive, the results showed that obese hypertensive with Hcy levels > 15 mol/L had a considerably increased risk (OR 1.12). When Hcy levels > 15 mol/L were compared to obese diabetics and obese non-diabetics, insignificant difference was shown (P: 0.345). Males had a higher likelihood of having hyperhomocysteinemia than females did (OR 1.2). Homocysteine, cholesterol triglyceride, LDL, and HDL mean values were compared between case and control groups using the independent sample t-test, and the results revealed statistically significant (P: <0.05). Relationships between hyperhomocysteinaemia and cholesterol, triglycerides, LDL, and HDL in the group of obese individuals were not statistically significant (P: 0.574, 0.265, 0.748, and 0.14), respectively. Obesity and Hcyconcentrations were shown to be substantially correlated. However, there was no statistically significant association between baseline plasma Hcy levels and hyperglycemia, hypertension, or dyslipidemia.展开更多
目的 探讨中国成人血清铁蛋白(serum ferritin,SF)与糖代谢相关指标(空腹血糖、空腹胰岛素、糖化血红蛋白、胰岛素抵抗指数等)的关联。方法 以2009年中国居民健康与营养调查(China Health and Nutrition Survey,CHNS)的人群为研究对象,...目的 探讨中国成人血清铁蛋白(serum ferritin,SF)与糖代谢相关指标(空腹血糖、空腹胰岛素、糖化血红蛋白、胰岛素抵抗指数等)的关联。方法 以2009年中国居民健康与营养调查(China Health and Nutrition Survey,CHNS)的人群为研究对象,研究对象按性别分层,根据SF水平的四分位数分为四组。采用Logistic回归研究SF与糖代谢相关指标的风险关联,限制性立方样条法探索其剂量反应关系。结果 本研究总共纳入了7271名研究对象,其中男性3276人,女性3995人,男性SF水平显著高于女性;在男性中,与最低SF水平组(Q1)相比,最高SF水平组(Q4)发生高血糖、糖化血红蛋白异常、胰岛素抵抗风险更高(P_(trend)<0.05),且存在线性剂量反应关联(P_(overall)<0.05,P_(nonlinear)>0.05);在女性中,与较低SF水平组(Q2)相比,最高SF水平组(Q4)发生高血糖、胰岛素抵抗、高胰岛素血症以及糖化血红蛋白异常风险更高(P_(trend)<0.05),且SF与前三个指标存在非线性剂量反应关联(P_(overall)<0.05,P_(nonlinear)<0.05),但与糖化血红蛋白异常之间存在线性剂量反应关联(P_(trend)<0.05,P_(nonlinear)>0.05)。结论 中国成年人SF水平与糖代谢相关指标之间存在剂量反应关联;对于高血糖者,建议SF应维持在现行正常范围内的较低水平。[营养学报,2025,47(3):223-227,233]展开更多
目的了解我国中老年高血糖、血脂异常、高血压人群健康体检服务利用现状并分析其影响因素,为优化“三高共管”策略和卫生服务体系改革提供依据。方法依托中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS...目的了解我国中老年高血糖、血脂异常、高血压人群健康体检服务利用现状并分析其影响因素,为优化“三高共管”策略和卫生服务体系改革提供依据。方法依托中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)于2020年开展的第五轮调查数据,共筛选中老年高血糖、血脂异常、高血压患者8227人作为研究对象,基于安德森模型框架,采用χ2检验和多因素Logistic回归分析影响我国中老年高血糖、血脂异常、高血压人群健康体检服务利用的主要因素。结果研究对象体检服务利用率为54.13%。多因素Logistic回归分析结果显示年龄(≥65岁:OR=2.024,95%CI=1.831~2.236,P<0.001)、受教育程度(高中及以上:OR=1.303,95%CI=1.123~1.511,P<0.001)、个人收入(有:OR=1.440,95%CI=1.285~1.614,P<0.001)、养老保险类别(企业职工养老保险:OR=0.655,95%CI=0.516~0.833,P<0.001;城镇居民/城乡居民养老保险:OR=0.633,95%CI=0.493~0.813,P<0.001;新型农村居民社会养老保险:OR=0.602,95%CI=0.466~0.778,P<0.001;其他养老保险:OR=0.549,95%CI=0.390~0.772,P<0.001;无养老保险:OR=0.473,95%CI=0.361~0.619,P<0.001)、医保类别(新农合、其他医保、无医保:OR=0.834,95%CI=0.726~0.959,P=0.011)、抑郁症状(是:OR=0.885,95%CI=0.804~0.975,P=0.014)、慢性病患病数量(2种:OR=1.158,95%CI=1.004~1.337,P=0.045;3种:OR=1.273,95%CI=1.099~1.475,P=0.001;≥4种:OR=1.282,95%CI=1.117~1.472,P<0.001)、社交情况(有:OR=1.396,95%CI=1.274~1.530,P<0.001)、住院服务利用(利用/需求:OR=1.207,95%CI:1.080~1.348,P<0.001)、饮酒(是:OR=1.127,95%CI=1.019~1.246,P=0.020)及吸烟(是:OR=0.761,95%CI=0.681~0.849,P<0.001)是影响我国中老年高血糖、血脂异常、高血压人群健康体检服务利用的主要因素。结论我国中老年高血糖、血脂异常、高血压人群体检服务利用率有待提高,建议将45~64岁人群纳入弹性体检补贴范围,推动体检费用医保报销,减轻贫困人群经费负担;深化医防融合机制,创新技术赋能,简化体检流程;加强慢性病防控政策及健康宣教,提升居民健康素养水平和健康管理依从性;针对低收入、低教育水平、有抑郁症状等人群,制定定向干预方案,实现慢性病防控关口前移,促进健康老龄化。展开更多
Rising incidence of a complicated disorder with a multifarious etiology is acute pancreatitis.Growing numbers of cases of acute pancreatitis are linked to obesity,hyperlipidemia,hyperglycemia,hypertension,and other me...Rising incidence of a complicated disorder with a multifarious etiology is acute pancreatitis.Growing numbers of cases of acute pancreatitis are linked to obesity,hyperlipidemia,hyperglycemia,hypertension,and other metabolic diseases.Trends driven by better living standards and unhealthy lifestyle choices both in China and abroad.Furthermore common diagnosis for many patients is metabolic syndrome.Predicting the adverse effect of metabolic syndrome on the severity and prognosis of acute pancreatitis is a main focus of present clinical research.Our next studies seek to investigate the fundamental causes of this link and create preventative plans meant to lower the incidence of pancreatitis linked to meta-bolic syndrome and enhance the prognosis.展开更多
BACKGROUND Non-ketotic hyperglycaemic(NKH)seizures are a rare neurological complication of diabetes caused by hyperglycaemia in non-ketotic and non-hyperosmotic states.The clinical characteristics of NKH seizures are ...BACKGROUND Non-ketotic hyperglycaemic(NKH)seizures are a rare neurological complication of diabetes caused by hyperglycaemia in non-ketotic and non-hyperosmotic states.The clinical characteristics of NKH seizures are atypical and lack unified diagnostic criteria,leading to potential misdiagnoses in the early stages of the disease.CASE SUMMARY This report presents a rare case of NKH seizures in a 52-year-old male patient with a history of type 2 diabetes mellitus.We performed comprehensive magnetic resonance imaging(MRI)studies at admission,12 d post-admission,and 20 d post-discharge.The imaging techniques included contrast-enhanced head MRI,T2-weighted imaging(T2WI),fluid-attenuated inversion recovery(FLAIR),diffusion-weighted imaging,susceptibility-weighted imaging,magnetic reso-nance spectroscopy(MRS),and magnetic resonance venography.At the time of admission,T2WI and FLAIR of the cranial MRI showed that the left parieto-occipital cortex had gyrus-like swelling and high signal,and subcortical stripes had low signal.MRS showed a reduced N-acetylaspartate peak and increased creatine and choline peaks in the affected areas.A follow-up MRI 20 d later showed that the swelling and high signal of the left parieto-occipital cortex had disappeared,and the low signal of the subcortex had disappeared.CONCLUSION This case study provides valuable insights into the potential pathogenesis,diagnosis,and treatment of NKH seizures.The comprehensive MRI findings highlight the potential utility of various MRI sequences in diagnosing and characterizing NKH seizures.展开更多
Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin.Compared with individuals without diabetes,patients with type 2 diabetes mellitus have a considera...Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin.Compared with individuals without diabetes,patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality,and are disproportionately affected by cardiovascular disease.Most of this excess risk is it associated with an augmented prevalence of well-known risk factors such as hypertension,dyslipidaemia and obesity in these patients.However the improved cardiovascular disease in type 2 diabetes mellitus patients can not be attributed solely to the higher prevalence of traditional risk factors.Therefore other non-traditional risk factors may be important in people with type 2 diabetes mellitus.Cardiovascular disease is increased in type 2 diabetes mellitus subjects due to a complex combination of various traditional and non-traditional risk factors that have an important role to play in the beginning and the evolution of atherosclerosis over its long natural history from endothelial function to clinical events.Many of these risk factors could be common history for both di-abetes mellitus and cardiovascular disease,reinforcing the postulate that both disorders come independently from"common soil".The objective of this review is to highlight the weight of traditional and non-traditional risk factors for cardiovascular disease in the setting of type 2 diabetes mellitus and discuss their position in the pathogenesis of the excess cardiovascular disease mortality and morbidity in these patients.展开更多
文摘BACKGROUND Globally,obesity and diabetes mellitus(DM)are emergent public health concerns in the adolescent population.India,home to the largest adolescent population and the second largest diabetes cohort is experiencing rapid but unplanned urbanization,with accompanying unhealthy nutritional transition,and sedentary lifestyle.AIM To determine prevalence and determinants of obesity and hyperglycaemia and their association among community-dwelling older adolescents(15-19 years)in India.METHODS This cross-sectional analysis from the national family health survey-5 included data of 258028 adolescents aged 15-19 across India(2019-2021).The survey employed stratified two-stage sampling,with systematic random sampling in rural and urban areas.Statistical analysis included descriptive statistics,bivariate,and multivariable logistic regression,employing generalized linear models.RESULTS The weighted prevalence of DM was 1.09%including 0.77%[95%confidence interval(CI):0.72-0.83]previously diagnosed and 0.32%(95%CI:0.29-0.35)newly diagnosed cases detected on survey screening.On adjusted analysis,increasing age,higher education levels,higher wealth index,and overweight/obesity were the factors significantly associated with presence of DM.Only 61%of the adolescents with previously diagnosed DM were on anti-diabetes treatment.The weighted prevalence of overweight/obesity among older adolescents was 6.9%with significantly higher odds in the male sex,having higher educational levels,urban residence,and those with a higher wealth index.CONCLUSION Nearly one in hundred older adolescents in India have diabetes,with one in three undiagnosed.Strengthening DM screening and treatment access among adolescents through public health programs is urgently warranted.
基金National Natural Science Foundation of China,No.81603574 and No.81774286National Key Research and Development Program,No.2018YFC1704202 and No.2020YFE0201800+1 种基金University Scientific Research Projects of Anhui,No.KJ2020A0401 and No.KJ2019A0442Province Science Foundation of Anhui,No.1708085QH213.
文摘BACKGROUND A recent investigation showed that the prevalence of type 2 diabetes mellitus(T2DM)is 12.8%among individuals of Han ethnicity.Gut microbiota has been reported to play a central role in T2DM.Goto-Kakizaki(GK)rats show differences in gut microbiota compared to non-diabetic rats.Previous studies have indicated that berberine could be successfully used to manage T2DM.We sought to understand its hypoglycaemic effect and role in the regulation of the gut microbiota.AIM To determine whether berberine can regulate glucose metabolism in GK rats via the gut microbiota.METHODS GK rats were acclimatized for 1 wk.The GK rats were randomly divided into three groups and administered saline(Mo),metformin(Me),or berberine(Be).The observation time was 8 wk,and weight,fasting blood glucose(FBG),insulin,and glucagon-like peptide-1(GLP-1)were measured.Pancreatic tissue was observed for pathological changes.Additionally,we sequenced the 16S rRNA V3-V4 region of the gut microbiota and analysed the structure.RESULTS Compared with the Mo group,the Me and Be groups displayed significant differences in FBG(P<0.01)and GLP-1(P<0.05).A significant decrease in weight and homeostatic model assessment-insulin resistance was noted in the Be group compared with those in the Me group(P<0.01).The pancreatic islets of the Me-and Be-treated rats showed improvement in number,shape,and necrosis compared with those of Mo-treated rats.A total of 580 operational taxonomic units were obtained in the three groups.Compared to the Mo group,the Me and Be groups showed a shift in the structure of the gut microbiota.Correlation analysis indicated that FBG was strongly positively correlated with Clostridia_UCG-014(P<0.01)and negatively correlated with Allobaculum(P<0.01).Body weight showed a positive correlation with Desulfovibrionaceae(P<0.01)and a negative correlation with Akkermansia(P<0.01).Importantly,our results demonstrated that Me and Be could significantly decrease Bacteroidetes(P<0.01)and the Bacteroidetes/Firmicutes ratio(P<0.01).Furthermore,Muribaculaceae(P<0.01;P<0.05)was significantly decreased in the Me and Be groups,and Allobaculum(P<0.01)was significantly increased.CONCLUSION Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM rats.
文摘There is conflicting scientific data about the link between, high homocysteine (Hcy) levels in the general population, and obesity. This is a case-control study aimed to assess the role of hyperhomocysteinemia in obesity and its associated illnesses, including hypertension, dyslipidemia, and hyperglycemia in Gezira state, Sudan. Two hundred and eleven participants were included in the study, 140 were obese (117 females and 23 males) and 71 were normal weight control, the obese median age was 49.49 ± 12.2 years. The control group consisted of 71 individuals with an average age of 45.78 ± 17.67 years. Among those who were already known to be obese, 67 (47.9%) reported having type II diabetes mellitus, 71 (50.7%) reported having hypertension, and 35 (25%) were obese without having either diabetes or hypertension. Three mls of venous blood from each participant were collected in the morning after a 12 h overnight fasting in Lithium heparin containers then the plasma was separated and stored at -80°C for analysis. Serum Hcy and lipid profile were measured using the enzymatic method by Cobas C 411 analyzer. In comparison to obese non-hypertensive, the results showed that obese hypertensive with Hcy levels > 15 mol/L had a considerably increased risk (OR 1.12). When Hcy levels > 15 mol/L were compared to obese diabetics and obese non-diabetics, insignificant difference was shown (P: 0.345). Males had a higher likelihood of having hyperhomocysteinemia than females did (OR 1.2). Homocysteine, cholesterol triglyceride, LDL, and HDL mean values were compared between case and control groups using the independent sample t-test, and the results revealed statistically significant (P: <0.05). Relationships between hyperhomocysteinaemia and cholesterol, triglycerides, LDL, and HDL in the group of obese individuals were not statistically significant (P: 0.574, 0.265, 0.748, and 0.14), respectively. Obesity and Hcyconcentrations were shown to be substantially correlated. However, there was no statistically significant association between baseline plasma Hcy levels and hyperglycemia, hypertension, or dyslipidemia.
文摘目的 探讨中国成人血清铁蛋白(serum ferritin,SF)与糖代谢相关指标(空腹血糖、空腹胰岛素、糖化血红蛋白、胰岛素抵抗指数等)的关联。方法 以2009年中国居民健康与营养调查(China Health and Nutrition Survey,CHNS)的人群为研究对象,研究对象按性别分层,根据SF水平的四分位数分为四组。采用Logistic回归研究SF与糖代谢相关指标的风险关联,限制性立方样条法探索其剂量反应关系。结果 本研究总共纳入了7271名研究对象,其中男性3276人,女性3995人,男性SF水平显著高于女性;在男性中,与最低SF水平组(Q1)相比,最高SF水平组(Q4)发生高血糖、糖化血红蛋白异常、胰岛素抵抗风险更高(P_(trend)<0.05),且存在线性剂量反应关联(P_(overall)<0.05,P_(nonlinear)>0.05);在女性中,与较低SF水平组(Q2)相比,最高SF水平组(Q4)发生高血糖、胰岛素抵抗、高胰岛素血症以及糖化血红蛋白异常风险更高(P_(trend)<0.05),且SF与前三个指标存在非线性剂量反应关联(P_(overall)<0.05,P_(nonlinear)<0.05),但与糖化血红蛋白异常之间存在线性剂量反应关联(P_(trend)<0.05,P_(nonlinear)>0.05)。结论 中国成年人SF水平与糖代谢相关指标之间存在剂量反应关联;对于高血糖者,建议SF应维持在现行正常范围内的较低水平。[营养学报,2025,47(3):223-227,233]
文摘目的了解我国中老年高血糖、血脂异常、高血压人群健康体检服务利用现状并分析其影响因素,为优化“三高共管”策略和卫生服务体系改革提供依据。方法依托中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)于2020年开展的第五轮调查数据,共筛选中老年高血糖、血脂异常、高血压患者8227人作为研究对象,基于安德森模型框架,采用χ2检验和多因素Logistic回归分析影响我国中老年高血糖、血脂异常、高血压人群健康体检服务利用的主要因素。结果研究对象体检服务利用率为54.13%。多因素Logistic回归分析结果显示年龄(≥65岁:OR=2.024,95%CI=1.831~2.236,P<0.001)、受教育程度(高中及以上:OR=1.303,95%CI=1.123~1.511,P<0.001)、个人收入(有:OR=1.440,95%CI=1.285~1.614,P<0.001)、养老保险类别(企业职工养老保险:OR=0.655,95%CI=0.516~0.833,P<0.001;城镇居民/城乡居民养老保险:OR=0.633,95%CI=0.493~0.813,P<0.001;新型农村居民社会养老保险:OR=0.602,95%CI=0.466~0.778,P<0.001;其他养老保险:OR=0.549,95%CI=0.390~0.772,P<0.001;无养老保险:OR=0.473,95%CI=0.361~0.619,P<0.001)、医保类别(新农合、其他医保、无医保:OR=0.834,95%CI=0.726~0.959,P=0.011)、抑郁症状(是:OR=0.885,95%CI=0.804~0.975,P=0.014)、慢性病患病数量(2种:OR=1.158,95%CI=1.004~1.337,P=0.045;3种:OR=1.273,95%CI=1.099~1.475,P=0.001;≥4种:OR=1.282,95%CI=1.117~1.472,P<0.001)、社交情况(有:OR=1.396,95%CI=1.274~1.530,P<0.001)、住院服务利用(利用/需求:OR=1.207,95%CI:1.080~1.348,P<0.001)、饮酒(是:OR=1.127,95%CI=1.019~1.246,P=0.020)及吸烟(是:OR=0.761,95%CI=0.681~0.849,P<0.001)是影响我国中老年高血糖、血脂异常、高血压人群健康体检服务利用的主要因素。结论我国中老年高血糖、血脂异常、高血压人群体检服务利用率有待提高,建议将45~64岁人群纳入弹性体检补贴范围,推动体检费用医保报销,减轻贫困人群经费负担;深化医防融合机制,创新技术赋能,简化体检流程;加强慢性病防控政策及健康宣教,提升居民健康素养水平和健康管理依从性;针对低收入、低教育水平、有抑郁症状等人群,制定定向干预方案,实现慢性病防控关口前移,促进健康老龄化。
基金Supported by The National Health Commission's Key Laboratory of Gastrointestinal Tumor Diagnosis and Treatment for The Year 2022,National Health Commission's Master's and Doctoral/Postdoctoral Fund Project,No.NHCDP2022001(to Yang XJ)Gansu Provincial People's Hospital Doctoral Supervisor Training Project,No.22GSSYA-3(to Yang XJ).
文摘Rising incidence of a complicated disorder with a multifarious etiology is acute pancreatitis.Growing numbers of cases of acute pancreatitis are linked to obesity,hyperlipidemia,hyperglycemia,hypertension,and other metabolic diseases.Trends driven by better living standards and unhealthy lifestyle choices both in China and abroad.Furthermore common diagnosis for many patients is metabolic syndrome.Predicting the adverse effect of metabolic syndrome on the severity and prognosis of acute pancreatitis is a main focus of present clinical research.Our next studies seek to investigate the fundamental causes of this link and create preventative plans meant to lower the incidence of pancreatitis linked to meta-bolic syndrome and enhance the prognosis.
基金Supported by Four"Batches"Innovation Project of Invigorating Medical Through Science and Technology of Shanxi Province,No.2023XM016.
文摘BACKGROUND Non-ketotic hyperglycaemic(NKH)seizures are a rare neurological complication of diabetes caused by hyperglycaemia in non-ketotic and non-hyperosmotic states.The clinical characteristics of NKH seizures are atypical and lack unified diagnostic criteria,leading to potential misdiagnoses in the early stages of the disease.CASE SUMMARY This report presents a rare case of NKH seizures in a 52-year-old male patient with a history of type 2 diabetes mellitus.We performed comprehensive magnetic resonance imaging(MRI)studies at admission,12 d post-admission,and 20 d post-discharge.The imaging techniques included contrast-enhanced head MRI,T2-weighted imaging(T2WI),fluid-attenuated inversion recovery(FLAIR),diffusion-weighted imaging,susceptibility-weighted imaging,magnetic reso-nance spectroscopy(MRS),and magnetic resonance venography.At the time of admission,T2WI and FLAIR of the cranial MRI showed that the left parieto-occipital cortex had gyrus-like swelling and high signal,and subcortical stripes had low signal.MRS showed a reduced N-acetylaspartate peak and increased creatine and choline peaks in the affected areas.A follow-up MRI 20 d later showed that the swelling and high signal of the left parieto-occipital cortex had disappeared,and the low signal of the subcortex had disappeared.CONCLUSION This case study provides valuable insights into the potential pathogenesis,diagnosis,and treatment of NKH seizures.The comprehensive MRI findings highlight the potential utility of various MRI sequences in diagnosing and characterizing NKH seizures.
文摘Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin.Compared with individuals without diabetes,patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality,and are disproportionately affected by cardiovascular disease.Most of this excess risk is it associated with an augmented prevalence of well-known risk factors such as hypertension,dyslipidaemia and obesity in these patients.However the improved cardiovascular disease in type 2 diabetes mellitus patients can not be attributed solely to the higher prevalence of traditional risk factors.Therefore other non-traditional risk factors may be important in people with type 2 diabetes mellitus.Cardiovascular disease is increased in type 2 diabetes mellitus subjects due to a complex combination of various traditional and non-traditional risk factors that have an important role to play in the beginning and the evolution of atherosclerosis over its long natural history from endothelial function to clinical events.Many of these risk factors could be common history for both di-abetes mellitus and cardiovascular disease,reinforcing the postulate that both disorders come independently from"common soil".The objective of this review is to highlight the weight of traditional and non-traditional risk factors for cardiovascular disease in the setting of type 2 diabetes mellitus and discuss their position in the pathogenesis of the excess cardiovascular disease mortality and morbidity in these patients.
